LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: DIO1 Gene Polymorphism Is Associated with Thyroid Profiles and Reproductive Performance in Dairy Cows

    Kostyunina, Olga V. / Mityashova, Olga S. / Bardukov, Nikolay V. / Aleynikova, Olga V. / Lebedeva, Irina Y.

    Agriculture. 2023 Feb. 08, v. 13, no. 2

    2023  

    Abstract: Thyroid hormones mediate the interaction between the metabolic and reproductive systems, while their metabolism is controlled by different deiodinases. The present study aimed to search for associations of cow genotypes with SNPs in the deiodinase type 1 ...

    Abstract Thyroid hormones mediate the interaction between the metabolic and reproductive systems, while their metabolism is controlled by different deiodinases. The present study aimed to search for associations of cow genotypes with SNPs in the deiodinase type 1 gene (DIO1) with thyroid profiles and reproductive traits. The blood was sampled from Russian black-and-white cows 2–6 weeks before calving and 1–13 weeks after calving to measure the hormonal levels by ELISA. RT-PCR analysis was performed for known mutations in the bovine DIO1 gene, and a polymorphism at position 13,149 was found. In animals with the CG genotype, the blood concentration of reverse triiodothyronine 6 weeks prepartum was higher and decreased much earlier than in animals with the CC genotype. Furthermore, 1 week after calving, the total triiodothyronine to reverse triiodothyronine ratio in cows with the CG genotype was higher than in cows with the CC genotype. A higher proportion of animals with better values of fertility traits was revealed in the CC group compared to the CG group. Thus, cows with the CC genotype of the DIO1 gene more often have a high reproductive ability, which may be associated with the rT3 profile features during the prepartum and early postpartum periods.
    Keywords agriculture ; blood ; cows ; genes ; genetic polymorphism ; genotype ; metabolism ; reproductive performance ; reverse transcriptase polymerase chain reaction ; triiodothyronine
    Language English
    Dates of publication 2023-0208
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2651678-0
    ISSN 2077-0472
    ISSN 2077-0472
    DOI 10.3390/agriculture13020398
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: DNA analysis of the Russian populations of Aberdeen Angus, Hereford and Belgian Blue cattle.

    Konovalova, Elena N / Romanenkova, Olga S / Volkova, Valeria V / Kostyunina, Olga V

    Archives animal breeding

    2020  Volume 63, Issue 2, Page(s) 409–416

    Abstract: The use of specialized meat breeds in cattle breeding programs is considered very promising for improving herds' productivity. However, in animal genotype, along with genes that positively affect the productivity signs, there are genes whose mutations, ... ...

    Abstract The use of specialized meat breeds in cattle breeding programs is considered very promising for improving herds' productivity. However, in animal genotype, along with genes that positively affect the productivity signs, there are genes whose mutations, known as genetic defects, negatively affect the health of animals. The aim of the study was the screening of the Russian populations of Aberdeen Angus, Hereford and Belgian Blue cattle on gene mutations associated with the genetic defects of arthrogryposis multiplex (AM), osteopetrosis (OS), developmental duplication (DD), double muscling (M1), hypotrichosis (HY) and maple syrup urine disease (MSUD) as well as the
    Language English
    Publishing date 2020-11-16
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9822
    ISSN (online) 2363-9822
    DOI 10.5194/aab-63-409-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Development of a low-density panel for genomic selection of pigs in Russia.

    Shashkova, Tatiana I / Martynova, Elena U / Ayupova, Asiya F / Shumskiy, Artemy A / Ogurtsova, Polina A / Kostyunina, Olga V / Khaitovich, Philipp E / Mazin, Pavel V / Zinovieva, Natalia A

    Translational animal science

    2019  Volume 4, Issue 1, Page(s) 264–274

    Abstract: Genomic selection is routinely used worldwide in agricultural breeding. However, in Russia, it is still not used to its full potential partially due to high genotyping costs. The use of genotypes imputed from the low-density chips (LD-chip) provides a ... ...

    Abstract Genomic selection is routinely used worldwide in agricultural breeding. However, in Russia, it is still not used to its full potential partially due to high genotyping costs. The use of genotypes imputed from the low-density chips (LD-chip) provides a valuable opportunity for reducing the genotyping costs. Pork production in Russia is based on the conventional 3-tier pyramid involving 3 breeds; therefore, the best option would be the development of a single LD-chip that could be used for all of them. Here, we for the first time have analyzed genomic variability in 3 breeds of Russian pigs, namely, Landrace, Duroc, and Large White and generated the LD-chip that can be used in pig breeding with the negligible loss in genotyping quality. We have demonstrated that out of the 3 methods commonly used for LD-chip construction, the block method shows the best results. The imputation quality depends strongly on the presence of close ancestors in the reference population. We have demonstrated that for the animals with both parents genotyped using high-density panels high-quality genotypes (allelic discordance rate < 0.05) could be obtained using a 300 single nucleotide polymorphism (SNP) chip, while in the absence of genotyped ancestors at least 2,000 SNP markers are required. We have shown that imputation quality varies between chromosomes, and it is lower near the chromosome ends and drops with the increase in minor allele frequency. Imputation quality of the individual SNPs correlated well across breeds. Using the same LD-chip, we were able to obtain comparable imputation quality in all 3 breeds, so it may be suggested that a single chip could be used for all of them. Our findings also suggest that the presence of markers with extremely low imputation quality is likely to be explained by wrong mapping of the markers to the chromosomal positions.
    Language English
    Publishing date 2019-11-29
    Publishing country England
    Document type Journal Article
    ISSN 2573-2102
    ISSN (online) 2573-2102
    DOI 10.1093/tas/txz182
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Whole-genome SNP analysis elucidates the genetic structure of Russian cattle and its relationship with Eurasian taurine breeds.

    Sermyagin, Alexander A / Dotsev, Arsen V / Gladyr, Elena A / Traspov, Alexey A / Deniskova, Tatiana E / Kostyunina, Olga V / Reyer, Henry / Wimmers, Klaus / Barbato, Mario / Paronyan, Ivan A / Plemyashov, Kirill V / Sölkner, Johann / Popov, Ruslan G / Brem, Gottfried / Zinovieva, Natalia A

    Genetics, selection, evolution : GSE

    2018  Volume 50, Issue 1, Page(s) 37

    Abstract: Background: The origin of native and locally developed Russian cattle breeds is linked to the historical, social, cultural, and climatic features of the diverse geographical regions of Russia. In the present study, we investigated the population ... ...

    Abstract Background: The origin of native and locally developed Russian cattle breeds is linked to the historical, social, cultural, and climatic features of the diverse geographical regions of Russia. In the present study, we investigated the population structure of nine Russian cattle breeds and their relations to the cattle breeds from around the world to elucidate their origin. Genotyping of single nucleotide polymorphisms (SNPs) in Bestuzhev (n = 26), Russian Black-and-White (n = 21), Kalmyk (n = 14), Kholmogor (n = 25), Kostromsky (n = 20), Red Gorbatov (n = 23), Suksun (n = 20), Yakut (n = 25), and Yaroslavl cattle breeds (n = 21) was done using the Bovine SNP50 BeadChip. SNP profiles from an additional 70 breeds were included in the analysis as references.
    Results: The observed heterozygosity levels were quite similar in eight of the nine studied breeds (H
    Conclusions: Whole-genome SNP analysis revealed that Russian native and locally developed breeds have conserved authentic genetic patterns in spite of the considerable influence of Eurasian taurine cattle. In this paper, we provide fundamental genomic information that will contribute to the development of more accurate breed conservation programs and genetic improvement strategies.
    MeSH term(s) Animals ; Cattle/classification ; Cattle/genetics ; Genetics, Population ; Genotyping Techniques/veterinary ; Heterozygote ; Inbreeding ; Polymorphism, Single Nucleotide ; Russia ; Whole Genome Sequencing/veterinary
    Language English
    Publishing date 2018-07-11
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1005838-2
    ISSN 1297-9686 ; 0754-0264 ; 0999-193X
    ISSN (online) 1297-9686
    ISSN 0754-0264 ; 0999-193X
    DOI 10.1186/s12711-018-0408-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2610: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top