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  1. Article ; Online: Relationship of anti-SARS-CoV-2 IgG antibodies with Vitamin D and inflammatory markers in COVID-19 patients.

    Latifi-Pupovci, Hatixhe / Namani, Sadie / Pajaziti, Artina / Ahmetaj-Shala, Blerina / Ajazaj, Lindita / Kotori, Afrim / Haxhibeqiri, Valdete / Gegaj, Valentin / Bunjaku, Gramoz

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5699

    Abstract: Several studies have found an association of COVID-19 disease severity with Vitamin D deficiency and higher levels of anti-SARS-CoV-2 IgGs. The aim of this study was to determine whether levels of Vitamin D and "inflammatory state" influence the ... ...

    Abstract Several studies have found an association of COVID-19 disease severity with Vitamin D deficiency and higher levels of anti-SARS-CoV-2 IgGs. The aim of this study was to determine whether levels of Vitamin D and "inflammatory state" influence the magnitude of anti-SARS-CoV-2 IgGs levels in COVID-19 patients. For this purpose, in 67 patients levels of anti-SARS-CoV-2 IgG were measured in week 4 whereas in 52 patients levels of Vitamin D were measured in week 1 after symptom onset. We found that low Vitamin D levels were significantly associated with age and disease severity whereas there was a trend without significance, towards negative correlation of Vitamin D with anti-SARS-CoV-2 IgG. Anti-SARS-CoV-2 IgG were significantly higher in older ages, patients with severe disease, diabetes and those who received corticosteroid and antibiotic therapy. There was a positive correlation of anti-SARS-CoV-2 IgG with IL-6, CRP, LDH, ESR and with percentages of granulocytes. In conclusion, Vitamin D and anti-SARS-CoV-2 IgG share common parameters associated with inflammatory state. However, even though Vitamin D protects against severe forms of COVID-19 it could not directly affect anti-SARS-CoV-2 IgG production.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Vitamin D
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09785-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo.

    Latifi-Pupovci, Hatixhe / Namani, Sadie / Ahmetaj-Shala, Blerina / Pajaziti, Artina / Bunjaku, Gramoz / Ajazaj Berisha, Lindita / Gegaj, Valentin / Kotori, Afrim

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2022  Volume 2022, Page(s) 4461647

    Abstract: SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of ... ...

    Abstract SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-6) levels and other inflammatory and hematological parameters were analyzed in 86 adult patients diagnosed with SARS-CoV-2 infection in Kosovo. The median age of patients was 61.50 (49.75-67.25) years. Over half of patients were categorised as severe (58%) and had comorbidities (69%) with hypertension being the most common. The overall mortality rate was 4.7%. The distribution of biochemical parameters across disease severity groups was significantly different for C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and granulocytes with higher median values in more severe and critically ill patients whereas lower percentage of lymphocytes, monocytes, and platelet count in severe and critically ill patients. IL-6 levels were increased in 63% of patients with significant differences in the distribution across the following groups; age, disease severity, hospitalisation status, pulmonary infiltrates, oxygen therapy, and hypertension status. IL-6 significantly correlated with CRP, LDH, CK, ESR, and percentages of granulocytes. IL-6 and other inflammatory and hematological parameters were strongly associated with disease severity and may predict the outcome of the SARS-CoV-2 infection.
    Language English
    Publishing date 2022-07-15
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2022/4461647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3099: Show issues Location:
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  3. Article ; Online: Serum S100B Levels Can Predict Computed Tomography Findings in Paediatric Patients with Mild Head Injury.

    Kelmendi, Fatos M / Morina, Arsim A / Mekaj, Agon Y / Blyta, Afrim / Alimehmeti, Ridvan / Dragusha, Shefki / Ahmeti, Feti / Morina, Qamile / Kotori, Afrim

    BioMed research international

    2018  Volume 2018, Page(s) 6954045

    Abstract: Introduction: Traumatic brain injuries (TBIs) are very common in paediatric populations, in which they are also a leading cause of death. Computed tomography (CT) overuse in these populations results in ionization radiation exposure, which can lead to ... ...

    Abstract Introduction: Traumatic brain injuries (TBIs) are very common in paediatric populations, in which they are also a leading cause of death. Computed tomography (CT) overuse in these populations results in ionization radiation exposure, which can lead to lethal malignancies. The aims of this study were to investigate the accuracy of serum S100B levels with respect to the detection of cranial injury in children with mild TBI and to determine whether decisions regarding the performance of CT can be made based on biomarker levels alone.
    Materials and methods: This was a single-center prospective cohort study that was carried out from December 2016 to December 2017. A total of 80 children with mild TBI who met the inclusion criteria were included in the study. The patients were between 2 and 16 years of age. We determined S100B protein levels and performed head CTs in all the patients.
    Results: Patients with cranial injury, as detected by CT, had higher S100B protein levels than those without cranial injury (
    Conclusion: Serum S100B levels cannot replace clinical examinations or CT as tools for identifying paediatric patients with mild head injury; however, serum S100B levels can be used to identify low-risk patients to prevent such patients from being exposed to radiation unnecessarily.
    MeSH term(s) Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Craniocerebral Trauma/blood ; Craniocerebral Trauma/diagnostic imaging ; Craniocerebral Trauma/epidemiology ; Female ; Head/diagnostic imaging ; Humans ; Male ; Prospective Studies ; ROC Curve ; S100 Calcium Binding Protein beta Subunit/blood ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/6954045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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