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  1. Article: Added value of 3D echocardiography in the diagnosis and prognostication of patients with right ventricular dysfunction.

    Randazzo, Michael / Maffessanti, Francesco / Kotta, Alekhya / Grapsa, Julia / Lang, Roberto M / Addetia, Karima

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1263864

    Abstract: Recent inroads into percutaneous-based options for the treatment of tricuspid valve disease has brought to light how little we know about the behavior of the right ventricle in both health and disease and how incomplete our assessment of right ... ...

    Abstract Recent inroads into percutaneous-based options for the treatment of tricuspid valve disease has brought to light how little we know about the behavior of the right ventricle in both health and disease and how incomplete our assessment of right ventricular (RV) physiology and function is using current non-invasive technology, in particular echocardiography. The purpose of this review is to provide an overview of what three-dimensional echocardiography (3DE) can offer currently to enhance RV evaluation and what the future may hold if we continue to improve the 3D evaluation of the right heart.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1263864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Frailty predicts poor longer-term outcomes in patients following lower limb open surgical revascularization.

    Kalyanasundaram, Asanish / Choy, Matthew / Kotta, Alekhya / Zielinski, Lukasz P / Coughlin, Patrick A

    The Journal of cardiovascular surgery

    2022  Volume 63, Issue 6, Page(s) 716–723

    Abstract: Background: Frailty in vascular surgery patients is increasingly recognized as a marker of poor outcome. This provides particular challenges for patients with lower limb peripheral arterial disease who require surgical revascularization. This study ... ...

    Abstract Background: Frailty in vascular surgery patients is increasingly recognized as a marker of poor outcome. This provides particular challenges for patients with lower limb peripheral arterial disease who require surgical revascularization. This study aimed to assess the impact of frailty on short- and long-term outcome in this specific patient group using a specialty specific frailty score.
    Methods: Patients undergoing open surgical revascularization for chronic limb ischemia (January 2015-December 2016) were assessed. Demographics, mode of admission, diagnosis, and site of surgery were recorded alongside a variety of frailty-specific characteristics. We calculated the previously validated Addenbrookes Vascular Frailty Score (AVFS) and Long AVFS (LAVFS). Primary outcome was 3-year mortality.
    Results: Two hundred and sixty-one patients (75% men, median age 69 years) were studied. The median length of stay was 6 days with a 3-year mortality of 23%. The predictive power of vascular frailty scores showed that for 3-year mortality, area under the receiver operator curve values (AUROC) were specific for both the AVFS score (AUROC: 0.724, 95% CI: 0.654-0.794) and LAVFS Score (AUROC: 0.741, 95%CI: 0.670-0.813). Furthermore, the cumulative AVFS and LAVFS scores both predicted mortality over the follow-up period (P=0.0001) with increased mortality among patients with higher scores.
    Conclusions: Incremental worsening of frailty, determined using a specialty specific frailty score, predicts mortality risk in patients undergoing lower limb surgical revascularization.
    Language English
    Publishing date 2022-09-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    DOI 10.23736/S0021-9509.22.11895-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Extrafollicular IgD

    Allard-Chamard, Hugues / Kaneko, Naoki / Bertocchi, Alice / Sun, Na / Boucau, Julie / Kuo, Hsiao-Hsuan / Farmer, Jocelyn R / Perugino, Cory / Mahajan, Vinay S / Murphy, Samuel J H / Premo, Katherine / Diefenbach, Thomas / Ghebremichael, Musie / Yuen, Grace / Kotta, Alekhya / Akman, Zafer / Lichterfeld, Mathias / Walker, Bruce D / Yu, Xu G /
    Moriyama, Masafumi / Maehara, Takashi / Nakamura, Seiji / Stone, John H / Padera, Robert F / Pillai, Shiv

    Cell reports

    2023  Volume 42, Issue 6, Page(s) 112630

    Abstract: Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been ... ...

    Abstract Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)
    MeSH term(s) Humans ; COVID-19 ; Fibrosis ; Immunoglobulin D ; Immunoglobulin G4-Related Disease ; Inflammation ; Receptors, CXCR5 ; B-Lymphocyte Subsets/metabolism ; B-Lymphocyte Subsets/pathology
    Chemical Substances CXCR5 protein, human ; Immunoglobulin D ; Receptors, CXCR5
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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