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  1. Article: Gilteritinib monotherapy as a transplant bridging option for high risk

    Day, James W / Fox, Thomas A / Gupta, Rajeev / Khwaja, Asim / Wilson, Andrew J / Kottaridis, Panagiotis D

    Leukemia research reports

    2022  Volume 17, Page(s) 100291

    Abstract: We report a case ... ...

    Abstract We report a case of
    Language English
    Publishing date 2022-02-07
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2022.100291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement.

    Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

    British journal of haematology

    2020  Volume 190, Issue 2, Page(s) e80–e83

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Leukemia/drug therapy ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16873
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  3. Article ; Online: Concerns about how to use established minimal residual disease monitoring in the treatment of NPM1-mutant acute myeloid leukaemia (AML) following reduced intensity chemotherapy protocols for AML given as a result of the COVID-19 pandemic.

    Farah, Nadine / Burt, Richard / Ibrahim, Amr R / Baker, Robert / Kottaridis, Panagiotis D

    British journal of haematology

    2020  Volume 190, Issue 4, Page(s) e208–e210

    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/genetics ; Cytarabine/administration & dosage ; Daunorubicin/administration & dosage ; Gemtuzumab/administration & dosage ; Humans ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Male ; Mutation ; Neoplasm, Residual ; Nuclear Proteins/genetics ; Nucleophosmin ; SARS-CoV-2
    Chemical Substances NPM1 protein, human ; Nuclear Proteins ; Cytarabine (04079A1RDZ) ; Nucleophosmin (117896-08-9) ; Gemtuzumab (93NS566KF7) ; Daunorubicin (ZS7284E0ZP)
    Keywords covid19
    Language English
    Publishing date 2020-07-26
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16985
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  4. Article: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement

    Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

    Br J Haematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327255
    Database COVID19

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  5. Article: Concerns about how to use established minimal residual disease monitoring in the treatment of NPM1-mutant acute myeloid leukaemia (AML) following reduced intensity chemotherapy protocols for AML given as a result of the COVID-19 pandemic

    Farah, Nadine / Burt, Richard / Ibrahim, Amr R / Baker, Robert / Kottaridis, Panagiotis D

    Br. j. haematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #622731
    Database COVID19

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  6. Article ; Online: Concerns about how to use established minimal residual disease monitoring in the treatment of NPM1 ‐mutant acute myeloid leukaemia (AML) following reduced intensity chemotherapy protocols for AML given as a result of the COVID‐19 pandemic

    Farah, Nadine / Burt, Richard / Ibrahim, Amr R. / Baker, Robert / Kottaridis, Panagiotis D.

    British Journal of Haematology

    2020  Volume 190, Issue 4

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16985
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  7. Article ; Online: Interleukin‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement

    Day, James W. / Fox, Thomas A. / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D.

    British Journal of Haematology

    2020  Volume 190, Issue 2

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16873
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Measurable residual disease (MRD) status before allogeneic hematopoietic cell transplantation impact on secondary acute myeloid leukemia outcome. A Study from the Acute Leukemia Working Party (ALWP) of the European society for Blood and Marrow Transplantation (EBMT).

    Maffini, Enrico / Labopin, Myriam / Beelen, Dietrich Wilhelm / Kroeger, Nicolaus / Arat, Mutlu / Wilson, Keith M O / Bay, Jacques-Olivier / Ganser, Arnold / Martin, Hans / Passweg, Jakob / Kottaridis, Panagiotis D / Yakoub-Agha, Ibrahim / Porras, Rocio Parody / Wagner, Eva Maria / Esteve, Jordi / Lanza, Francesco / Nagler, Arnon / Mohty, Mohamad

    Bone marrow transplantation

    2022  Volume 57, Issue 10, Page(s) 1556–1563

    Abstract: Measurable residual disease (MRD) assessment before allogeneic hematopoietic cell transplantation (HCT) may help physicians to identify a subgroup of patients at high risk of relapse for de novo acute myeloid leukemia (AML) but its relevance among ... ...

    Abstract Measurable residual disease (MRD) assessment before allogeneic hematopoietic cell transplantation (HCT) may help physicians to identify a subgroup of patients at high risk of relapse for de novo acute myeloid leukemia (AML) but its relevance among patients affected by secondary AML (sAML) is still unknown. We assessed the impact of MRD among 318 adult patients with sAML who received an allogeneic HCT in first complete remission. At the time of HCT, a total of 208 (65%) patients achieved MRD negativity, while 110 (35%) had positive MRD. 2-year overall survival (OS) was 58.8 % (95% CI 52.2-64.9) with leukemia-free survival (LFS) of 50.0 % (95% CI 43.7-56.1), relapse incidence of 34.2% (95% CI 28.4-40.1) and non-relapse mortality (NRM) of 23.3 % (95% CI 19-27.7) for the entire cohort. In multivariate analysis, HCT recipients with KPS ≥ 90 experienced less disease recurrence (HR 0.61, 95% CI 0.4-0.94) with better LFS (HR 0.63, 95% CI 0.44-0.89) and OS (HR 0.58, 95% CI 0.39-0.86). There were no differences in major clinical endpoints between patients with MRD-positive and MRD-negative status at the time of HCT. Pre-transplantation assessment of MRD was not informative on post-HCT outcomes in this retrospective registry-based analysis among patients affected by sAML.
    MeSH term(s) Acute Disease ; Adult ; Bone Marrow ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual ; Neoplasms, Second Primary ; Recurrence ; Retrospective Studies ; Transplantation Conditioning
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01748-w
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    Zs.A 2168: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article: The allogeneic effect in non-Hodgkin's lymphoma.

    Goldstone, Anthony H / Kottaridis, Panagiotis D

    Leukemia & lymphoma

    2004  Volume 44 Suppl 3, Page(s) S91–7

    Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) has been restricted to medically fit patients under the age of 55 years due to adverse effects of the intensive conditioning regimens. Autologous HSCT has not proven to be a particularly effective ...

    Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) has been restricted to medically fit patients under the age of 55 years due to adverse effects of the intensive conditioning regimens. Autologous HSCT has not proven to be a particularly effective treatment for patients with low-grade non-Hodgkin's lymphoma (NHL). Much of the benefit of allogeneic HSCT appears to be mediated by a graft-vs.-tumor (GVT) effect. Reduced-intensity regimens in allogeneic HSCT have been developed to minimize conditioning regimen-related toxicities and to control the malignancy until a GVT effect is established. A number of studies investigating reduced-intensity allogeneic HSCT are discussed. Results from these studies suggest that indications for allogeneic transplant include patients with low-grade NHL with a sibling or matched donor who are under 60 years of age; young patients with mantle cell lymphoma who are in first remission and have a sibling or matched donor; patients with high-grade NHL who have already failed an autograft but have chemosensitive disease, and those under 30 years of age who have poor-risk disease and are in first remission. It is concluded that reduction in treatment-related mortality with reduced-intensity HSCT and the presence of GVT effects increases the applicability of allogeneic transplantation for NHL. However, treatment will be improved by optimizating conditioning regimens and a better understanding of patient selection criteria and the immune processes involved in graft-vs.-host disease and GVT.
    MeSH term(s) Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Lymphoma, Non-Hodgkin/mortality ; Lymphoma, Non-Hodgkin/therapy ; Transplantation Immunology ; Transplantation, Homologous ; Treatment Outcome
    Language English
    Publishing date 2004-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428190310001623702
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    Zs.A 2997: Show issues Location:
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  10. Article: Development of squamous cell carcinoma of the skin during induction chemotherapy for acute myeloid leukemia.

    Kottaridis, Panagiotis D / Goldstone, Anthony H

    Leukemia & lymphoma

    2002  Volume 43, Issue 2, Page(s) 459–460

    MeSH term(s) Acute Disease ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Humans ; Leukemia, Myeloid/drug therapy ; Leukemia, Myeloid/pathology ; Neoplasms, Second Primary/chemically induced ; Neoplasms, Second Primary/etiology ; Neoplasms, Second Primary/radiotherapy ; Remission Induction/methods ; Skin Neoplasms/chemically induced ; Skin Neoplasms/etiology ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2002-02
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428190290006369
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