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  1. AU="Kou, Zhi-Yong"
  2. AU="Hoang, Linda"
  3. AU="Richard W G Caldow"
  4. AU="Marina, Ljiljana"
  5. AU="Fu, Jingde" AU="Fu, Jingde"
  6. AU="Zhang, Eunice J"
  7. AU="Shidong Lv"
  8. AU=Sydow M
  9. AU="Fernandez-Guzmán, Daniel"
  10. AU="Jarc, Erika"
  11. AU="Vincent Assey"
  12. AU="Taylor, Marisa"
  13. AU="Shanto, Hasibul Hasan"
  14. AU="Ahmad Khanshour"

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  1. Artikel ; Online: Genotype-Phenotype Correlations in Autosomal Dominant and Recessive APC Mutation-Negative Colorectal Adenomatous Polyposis.

    Zhu, Li-Hua / Dong, Jian / Li, Wen-Liang / Kou, Zhi-Yong / Yang, Jun

    Digestive diseases and sciences

    2023  Band 68, Heft 7, Seite(n) 2799–2810

    Abstract: The most prevalent type of intestinal polyposis, colorectal adenomatous polyposis (CAP), is regarded as a precancerous lesion of colorectal cancer with obvious genetic characteristics. Early screening and intervention can significantly improve patients' ... ...

    Abstract The most prevalent type of intestinal polyposis, colorectal adenomatous polyposis (CAP), is regarded as a precancerous lesion of colorectal cancer with obvious genetic characteristics. Early screening and intervention can significantly improve patients' survival and prognosis. The adenomatous polyposis coli (APC) mutation is believed to be the primary cause of CAP. There is, however, a subset of CAP with undetectable pathogenic mutations in APC, known as APC (-)/CAP. The genetic predisposition to APC (-)/CAP has largely been associated with germline mutations in some susceptible genes, including the human mutY homologue (MUTYH) gene and the Nth-like DNA glycosylase 1 (NTHL1) gene, and DNA mismatch repair (MMR) can cause autosomal recessive APC (-)/CAP. Furthermore, autosomal dominant APC (-)/CAP could occur as a result of DNA polymerase epsilon (POLE)/DNA polymerase delta 1 (POLD1), axis inhibition protein 2 (AXIN2), and dual oxidase 2 (DUOX2) mutations. The clinical phenotypes of these pathogenic mutations vary greatly depending on their genetic characteristics. Therefore, in this study, we present a comprehensive review of the association between autosomal recessive and dominant APC (-)/CAP genotypes and clinical phenotypes and conclude that APC (-)/CAP is a disease caused by multiple genes with different phenotypes and interaction exists in the pathogenic genes.
    Mesh-Begriff(e) Humans ; Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Mutation ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Germ-Line Mutation ; Phenotype ; Genes, APC
    Sprache Englisch
    Erscheinungsdatum 2023-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07890-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma.

    Miao, Yan-Dong / Kou, Zhi-Yong / Wang, Jiang-Tao / Mi, Deng-Hai

    World journal of clinical cases

    2021  Band 9, Heft 29, Seite(n) 8671–8693

    Abstract: Background: Colon adenocarcinoma (COAD) is one of the most common and fatal malignant tumors, which increases the difficulty of prognostic predictions. Thus, new biomarkers for the diagnosis and prognosis of COAD should be explored. Ferroptosis is a ... ...

    Abstract Background: Colon adenocarcinoma (COAD) is one of the most common and fatal malignant tumors, which increases the difficulty of prognostic predictions. Thus, new biomarkers for the diagnosis and prognosis of COAD should be explored. Ferroptosis is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide accumulation. However, the predictive value of ferroptosis-related genes (FRGs) for COAD still needs to be further clarified.
    Aim: To identify some critical FRGs and construct a COAD patient prognostic signature for clinical utilization.
    Methods: The Cancer Genome Atlas database (TCGA) and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical information. Differentially expressed FRGs were recognized using R and Perl software. We constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression analysis. COAD patients from the Gene Expression Omnibus cohort were utilized for verification.
    Results: Our research showed that most of the FRGs (85%) were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD cohort. Seven FRGs were related to overall survival (OS) in the univariate Cox analysis (all
    Conclusion: In conclusion, a novel five FRG model can be utilized for predicting prognosis in COAD. Targeting ferroptosis may be a treatment option for COAD.
    Sprache Englisch
    Erscheinungsdatum 2021-10-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i29.8671
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Identification of driving genes of familial adenomatous polyposis by differential gene expression analysis and weighted gene co-expression network analysis.

    Lin, Wan-Rong / Liu, Wei-Qing / Meng, Xuan-Yu / Liu, Xiao-Ting / Kou, Zhi-Yong / Li, Wen-Liang / Yang, Jun

    Technology and health care : official journal of the European Society for Engineering and Medicine

    2023  Band 32, Heft 3, Seite(n) 1675–1696

    Abstract: Background: Despite the advancement of new screening strategies and the advances in pharmacological therapies, the cancerization rates of familial adenomatous polyposis (FAP) are stable and even increased in the last years. Therefore, it necessitates ... ...

    Abstract Background: Despite the advancement of new screening strategies and the advances in pharmacological therapies, the cancerization rates of familial adenomatous polyposis (FAP) are stable and even increased in the last years. Therefore, it necessitates additional research to characterize and understand the underlying mechanisms of FAP.
    Objective: To determine the genes that drive the pathogenesis of familial adenomatous polyposis (FAP).
    Methods: We performed on a cohort (GSE111156) gene profile, which consist of four group of gene expressions (the gene expressions of cancer, adenoma and normal tissue of duodenal cancer from patients with FAP were defined as Case N, Case A and Case C respectively, while that of adenoma tissue from patients with FAP who did not have duodenal cancer was Ctrl A). Tracking Tumor Immunophenotype (TIP) website was applied to reveal immune infiltration profile and signature genes of FAP. We merged the genes of key module (pink and midnight module) with signature genes to obtained the biomarkers related with FAP pathogenesis. The expression of these five biomarkers in FAP intratumoral region (IT) and tumor rim (TR) was detected with Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR).
    Results: In total, 220, 23 and 63 DEGs were determined in Cases C, A and N, in comparison to Ctrl A. In total, 196 and 10 DEGs were determined in Cases C and A, separately, as compared to Case N. A total of four biomarkers including CCL5, CD3G, CD2 and TLR3 were finally identified associated with pink module, while only one biomarker (KLF2) associated with midnight module was identified. All biomarkers were evidently raised in FAP IT tissues utilizing qRT-PCR.
    Conclusion: We identified five potential biomarkers for pathogenesis of FAP to understand the fundamental mechanisms of FAP progression and revealed some probable targets for the diagnosis or treatment of FAP.
    Mesh-Begriff(e) Humans ; Adenomatous Polyposis Coli/genetics ; Gene Regulatory Networks ; Gene Expression Profiling/methods ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Real-Time Polymerase Chain Reaction
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1159961-3
    ISSN 1878-7401 ; 0928-7329
    ISSN (online) 1878-7401
    ISSN 0928-7329
    DOI 10.3233/THC-230719
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Discovery of core gene families associated with liver metastasis in colorectal cancer and regulatory roles in tumor cell immune infiltration.

    Liu, Wei-Qing / Li, Wen-Liang / Ma, Shu-Min / Liang, Lei / Kou, Zhi-Yong / Yang, Jun

    Translational oncology

    2021  Band 14, Heft 3, Seite(n) 101011

    Abstract: In this study, we aimed to uncover genes that drive the pathogenesis of liver metastasis in colorectal cancer (CRC), and identify effective genes that could serve as potential therapeutic targets for treating with colorectal liver metastasis patients ... ...

    Abstract In this study, we aimed to uncover genes that drive the pathogenesis of liver metastasis in colorectal cancer (CRC), and identify effective genes that could serve as potential therapeutic targets for treating with colorectal liver metastasis patients based on two GEO datasets. Several bioinformatics approaches were implemented. First, differential expression analysis screened out key differentially expressed genes (DEGs) across the two GEO datasets. Based on gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, we identified the enrichment functions and pathways of the DEGs that were associated with liver metastasis in CRC. Second, immune infiltration analysis identified key immune signature gene sets associated with CRC liver metastasis, among which two key immune gene families (CD and CCL) identified as key DEGs were filtered by protein-protein interaction (PPI) network. Some of the members in these gene families were associated with disease free survival (DFS) or overall survival (OS) in two subtypes of CRC, namely COAD and READ. Finally, functional enrichment analysis of the two gene families and their neighboring genes revealed that they were closely associated with cytokine, leukocyte proliferation and chemotaxis. These results are valuable in comprehending the pathogenesis of liver metastasis in CRC, and are of seminal importance in understanding the role of immune tumor infiltration in CRC. Our study also identified potentially effective therapeutic targets for liver metastasis in CRC including CCL20, CCL24 and CD70.
    Sprache Englisch
    Erscheinungsdatum 2021-01-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2021.101011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer.

    Liu, Xiao-Ting / Kou, Zhi-Yong / Zhang, Hushan / Dong, Jian / Zhang, Jian-Hua / Peng, You-Jun / Ma, Shu Min / Liang, Lei / Meng, Xuan-Yu / Zhou, Yuan / Yang, Jun

    PeerJ

    2023  Band 11, Seite(n) e15261

    Abstract: The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 ... ...

    Abstract The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein are unknown in HER2-amplified colorectal cancer (HACC). In order to explore these characteristics along with their correlation with clinicopathological factors and prognosis in HACC. Samples of 812 CRC patients was collected. After immunohistochemistry (IHC), 59 of 812 were found to be HER2-positive, then 26 of 59 samples were further determined to be HER2 amplification by fluorescence in situ hybridization (FISH). Somatic mutation profiling of HACC was analysed using whole exome sequencing (WES). Multiplex fluorescence immunohistochemistry (mIHC) was used for tumor-infiltrating leukocytes and tertiary lymphoid structures (TLSs), while PD-L1 protein was detected by IHC. Our results indicate that the detection rates of HER2 positivity by IHC and FISH were 7.3% and 3.2% respectively, and HER2 amplification is correlated with distant tumour metastasis. The somatic mutation profiling revealed no differences between HACC and HER2-negative CRC. However, TP 53 strongly correlated with poor prognosis in HACC. Furthermore, tumor-infiltrating T cells and TLSs in the tumor immune microenvironment, as well as PD-L1 expression, were higher in HACC than in HER2-negative controls. However, none of them were associated with the prognosis of HACC. In all, HER2 amplification is correlated with distant metastasis and TP53 gene mutation may be a potential protective mechanism of HACC.
    Mesh-Begriff(e) Humans ; B7-H1 Antigen/genetics ; In Situ Hybridization, Fluorescence ; Tertiary Lymphoid Structures/genetics ; Colorectal Neoplasms/genetics ; Mutation ; Tumor Microenvironment
    Chemische Substanzen ERBB2 protein, human (EC 2.7.10.1) ; B7-H1 Antigen
    Sprache Englisch
    Erscheinungsdatum 2023-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15261
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Preoperative therapy with sunitinib malate in a patient with a gastrointestinal stromal tumor and liver metastases: A case report.

    Wang, Zhi-Qiang / Wen, Zheng-Qi / Yang, Jun / Zhang, Hong-Bin / Kou, Zhi-Yong / Zhou, Rui-Ze / Li, Wen-Liang

    Medicine

    2020  Band 98, Heft 51, Seite(n) e14222

    Abstract: Rationale: Patients with gastrointestinal stromal tumors (GISTs) are often found to have liver metastases at their 1st presentation. Most patients need preoperative treatment to reduce the size of the liver metastases to increase the possibility of ... ...

    Abstract Rationale: Patients with gastrointestinal stromal tumors (GISTs) are often found to have liver metastases at their 1st presentation. Most patients need preoperative treatment to reduce the size of the liver metastases to increase the possibility of surgical resection. Currently, imatinib mesylate is the drug of 1st choice for preoperative treatment and sunitinib malate (SM) is seldom used. Here we report a case of GIST with liver metastases where SM was used as a preoperative treatment.
    Patient concerns: A 56-year-old worker presented with intermittent abdominal pain and eating difficulties.
    Diagnoses: An enhanced computed tomography scan showed a 15 × 15 × 10 cm malignant mass in the upper abdomen, and 2 metastases (15.1 × 13.1 cm and 14.8 × 8.8 cm) in the liver. The postcaval and middle hepatic veins were compressed by the liver metastases, making radical resection very difficult.
    Interventions: First the primary tumor in the jejunum was resected, and then SM was used as a preoperative treatment to reduce the size of the liver metastases to improve the possibility of surgical resection.
    Outcomes: Both liver metastases regressed considerably in size and it was then possible to perform a radical resection.
    Lessons: The SM has the potential to be used as preoperative therapy for GIST with large liver metastases. This method provides a new option for the preoperative treatment of GIST with liver metastases.
    Mesh-Begriff(e) Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Follow-Up Studies ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Hepatectomy/methods ; Humans ; Jejunal Neoplasms/drug therapy ; Jejunal Neoplasms/pathology ; Jejunal Neoplasms/surgery ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoadjuvant Therapy/methods ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Preoperative Care/methods ; Sunitinib/therapeutic use ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemische Substanzen Sunitinib (V99T50803M)
    Sprache Englisch
    Erscheinungsdatum 2020-01-02
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000014222
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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