Article ; Online: New insights into the DNA repair pathway choice with NuA4/TIP60.
2022 Volume 113, Page(s) 103315
Abstract: In eukaryotic cells, DNA double-strand breaks (DSBs) can be repaired through two main pathways, non-homologous end-joining (NHEJ) or homologous recombination (HR). The selection of the repair pathway choice is governed by an antagonistic relationship ... ...
Abstract | In eukaryotic cells, DNA double-strand breaks (DSBs) can be repaired through two main pathways, non-homologous end-joining (NHEJ) or homologous recombination (HR). The selection of the repair pathway choice is governed by an antagonistic relationship between repair factors specific to each pathway, in a cell cycle-dependent manner. The molecular mechanisms of this decision implicate post-translational modifications of chromatin surrounding the break. Here, we discuss the recent advances regarding the function of the NuA4/TIP60 histone acetyltransferase/chromatin remodeling complex during DSBs repair. In particular, we emphasise the contribution of NuA4/TIP60 in repair pathway choice, in collaboration with the SAGA acetyltransferase complex, and how they regulate chromatin dynamics, modify non-histone substrates to allow DNA end resection and recombination. |
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Language | English |
Publishing date | 2022-03-03 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 2071608-4 |
ISSN | 1568-7856 ; 1568-7864 |
ISSN (online) | 1568-7856 |
ISSN | 1568-7864 |
DOI | 10.1016/j.dnarep.2022.103315 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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