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Article ; Online: Mycotic aortic aneurysms: characteristic macroscopic findings in a case series.

Somers, Tim / Nies, Hedwig M J M / Kouijzer, Ilse J E / Lee, Pui Yuen / Morshuis, Wim J / Geuzebroek, Guillaume S C

Scandinavian cardiovascular journal : SCJ

2024 Volume 58, Issue 1, Page(s) 2341696

Abstract: Infected or mycotic aortic aneurysms (MAAs) are a rare type of aneurysms. Due to the high risk of rupture, MAAs are life-threatening conditions. Early diagnosis and treatment are necessary, yet MAAs are usually found coincidentally. We report 10 patients ...

Abstract	Infected or mycotic aortic aneurysms (MAAs) are a rare type of aneurysms. Due to the high risk of rupture, MAAs are life-threatening conditions. Early diagnosis and treatment are necessary, yet MAAs are usually found coincidentally. We report 10 patients with MAAs in whom macroscopically, similar coined-sized lesions of the inner aortic wall were seen in all cases. When a coin-sized lesion in the inner aortic wall is seen during open surgical repair of an aortic aneurysm, the surgeon should consider an infectious cause. Microbiological tissue samples should be collected, and additional targeted antibiotic therapy should be started.
MeSH term(s)	Humans ; Aorta ; Surgeons
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1379906-x
ISSN	1651-2006 ; 1401-7431
ISSN (online)	1651-2006
ISSN	1401-7431
DOI	10.1080/14017431.2024.2341696
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Zs.A 638: Show issues

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Article ; Online: Redefining Staphylococcus aureus bacteremia: A structured approach guiding diagnostic and therapeutic management.

Kouijzer, Ilse J E / Fowler, Vance G / Ten Oever, Jaap

The Journal of infection

2022 Volume 86, Issue 1, Page(s) 9–13

Abstract: The current duration of therapy in patients with Staphylococcus aureus bacteremia (SAB) is based on differentiating complicated from uncomplicated disease. While this approach allows clinicians and investigators to group SAB patients into broadly similar ...

Abstract	The current duration of therapy in patients with Staphylococcus aureus bacteremia (SAB) is based on differentiating complicated from uncomplicated disease. While this approach allows clinicians and investigators to group SAB patients into broadly similar clinical categories, it fails to account for the intrinsic heterogeneity of SAB. This is due in part to the fact that risk factors for metastatic infection and confirmed metastatic infection are considered as equivalent in most scoring systems. In this viewpoint, we propose a two-step system of categorizing patients with SAB. Initially, patients with SAB would be categorized as 'high risk' or 'low risk' for metastatic infection based upon an initial set of diagnostic procedures. In the second step, patients identified as 'high-risk' would undergo additional diagnostic evaluation. The results of this stepwise diagnostic evaluation would define a 'final clinical diagnosis' to inform an individualized final treatment plan.
MeSH term(s)	Humans ; Staphylococcus aureus ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/complications ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/complications ; Risk Factors
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.10.042
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

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Article ; Online: Surviving the nonsurvivable combination of a mycotic aneurysm progressing into a concomitant aorto-bronchial- and aorto-esophageal fistula, a case report.

Somers, Tim / Klarenbeek, Bastiaan R / Kouijzer, Ilse J E / Verhagen, Ad F T M / Verkroost, Michel W A

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 289

Abstract: Background: Aortic mycotic aneurysms are a rare but life-threatening condition and may be associated with aorto-bronchial- and aorto-esophageal fistulas. Although both very rare, they carry a high mortality and require (urgent) surgical intervention. ... ...

Abstract	Background: Aortic mycotic aneurysms are a rare but life-threatening condition and may be associated with aorto-bronchial- and aorto-esophageal fistulas. Although both very rare, they carry a high mortality and require (urgent) surgical intervention. Surviving all three conditions concomitantly is extraordinary. We describe a patient who underwent staged repair of such combined defects.
MeSH term(s)	Humans ; Aneurysm, Infected/diagnostic imaging ; Aneurysm, Infected/surgery ; Aortic Diseases/surgery ; Esophageal Fistula/diagnosis ; Esophageal Fistula/surgery
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02387-y
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Article: Postoperative Inflammation and Fever After Elective Aortic Valve and Aortic Root Replacement: A Retrospective Cohort Study.

Keijmel, Stephan P / Zwartkruis, Iris M M / Jongenotter, Jochem / Geuzebroek, Guillaume S C / Kouijzer, Ilse J E

Open forum infectious diseases

2023 Volume 10, Issue 1, Page(s) ofad015

Abstract: Background: Fever after cardiac surgery is common. More knowledge of postoperative fever could lead to better patient selection for diagnostic workup and empirical antibiotic treatment. We aimed to analyze the postoperative course of inflammation and ... ...

Abstract	Background: Fever after cardiac surgery is common. More knowledge of postoperative fever could lead to better patient selection for diagnostic workup and empirical antibiotic treatment. We aimed to analyze the postoperative course of inflammation and fever after elective aortic valve and aortic root replacement. Methods: In a retrospective single-center cohort study, we included 3 groups of patients after elective cardiac surgery: aortic root with aortic valve replacement (Bentall procedure, from 2014 to 2021), valve-sparing root replacement (VSRR, from 2014 to 2021), and isolated surgical aortic valve replacement (SAVR, from 2018 to 2021). Exclusion criteria were age <18 years, cardiac surgery other than described, use of deep-hypothermic circulatory arrest, reoperations, and preexisting infections. Primary outcome measure was the number of patients per group with postoperative fever (≥38°C). Secondary outcome measures were the percentage of patients per group with infections and outcome. Results: Among 307 patients included (76 Bentall, 40 VSRR, 191 SAVR), 71% had postoperative fever. Fever occurred significantly more often in the Bentall (84%) and VSRR group (83%) compared with patients after SAVR (64%, Conclusions: Postoperative fever is more often observed after Bentall procedure and VSRR compared to SAVR. In diagnoses of infection, there is a higher and prolonged fever.
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad015
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Article ; Online: Vascular infection with outside-in vertebral destruction in chronic Q fever.

Kouijzer, Ilse J E / Oyen, Wim J G / Bleeker-Rovers, Chantal P

The Lancet. Infectious diseases

2018 Volume 18, Issue 6, Page(s) 603

MeSH term(s)	Humans ; Q Fever ; Spine
Language	English
Publishing date	2018-05-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(18)30272-X
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Zs.A 5743: Show issues

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Article ; Online: Outcome in Patients after Autologous Femoral Vein Reconstruction for Primary Aortic Infection and Aortic Graft Infection: A Case Series.

Kouijzer, Ilse J E / Van der Jagt, Michel F P / Bleeker-Rovers, Chantal P / Dirven, Mark / de Mast, Quirijn / Poyck, Paul Pc

Annals of vascular surgery

2021 Volume 83, Page(s) 240–250

Abstract: Background: For surgical treatment of primary aortic infection and aortic graft infection, in situ reconstruction with autologous vein(s) has the lowest rates of re-infection and of graft thrombosis. In this study, we have assessed the outcome after ... ...

Abstract	Background: For surgical treatment of primary aortic infection and aortic graft infection, in situ reconstruction with autologous vein(s) has the lowest rates of re-infection and of graft thrombosis. In this study, we have assessed the outcome after autologous femoral vein reconstruction in patients with aortic (graft) infection and we provide insights into the specific technical surgical considerations of the procedure. Methods: In this retrospective single-center study, all patients who underwent autologous femoral vein reconstruction because of primary aortic infection or aortic graft infection between January 2012 and January 2020 were included. The primary outcome parameter was 30-day mortality. Results: Twenty-nine patients with autologous femoral vein reconstruction for a primary aortic infection (n = 3) or aortic graft infection (n = 26) were included. An aorto-enteral fistula was detected in 13 patients (49%). Venous reconstruction of the aorta was performed with a single femoral vein in 17 patients (59%), and two femoral veins in 12 patients (41%). Thirty-day mortality was 17%. Relapse of infection occurred in two patients (7%) and no amputations were needed. One year after surgery, only three patients (10%) still needed stockings and after 2 years none of the patients used stockings. Conclusions: Central aortic reconstruction with femoral veins is a durable solution for primary aortic and aortoiliac graft infections with a low incidence of reinfections, amputations, and venous hypertension.
MeSH term(s)	Aorta/diagnostic imaging ; Aorta/surgery ; Blood Vessel Prosthesis/adverse effects ; Blood Vessel Prosthesis Implantation/adverse effects ; Femoral Vein/surgery ; Femoral Vein/transplantation ; Humans ; Prosthesis-Related Infections/diagnostic imaging ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/surgery ; Reoperation ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-12-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2021.11.012
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Zs.A 2882: Show issues

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Article ; Online: Mycotic aneurysm of the infrarenal abdominal aorta infected by Mycoplasma hyorhinis diagnosed with direct 16S ribosomal DNA sequencing.

Keijmel, Stephan P / Kuipers, Saskia / van der Jagt, Michel F P / Melchers, Willem J G / Kouijzer, Ilse J E / Oever, Jaap Ten

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2021 Volume 27, Issue 9, Page(s) 1356–1357

MeSH term(s)	Aged ; Aneurysm, Infected/diagnosis ; Aorta, Abdominal ; DNA, Ribosomal ; Humans ; Male ; Mycoplasma hyorhinis ; Sequence Analysis, DNA
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2021-04-24
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2021.04.011
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Thoracic aortic vascular graft infection: outcome after conservative treatment without graft removal.

Kouijzer, Ilse J E / Baranelli, Celine T / Maat, Ianthe / van den Heuvel, Frederik M A / Aarntzen, Erik H J G / Smith, Tim / de Mast, Quirijn / Geuzebroek, Guillaume S C

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2022 Volume 63, Issue 1

Abstract: Objectives: Surgical debridement with aortic graft removal is considered the preferred treatment for thoracic aortic vascular graft infection (VGI). Conservative treatment with antibiotics only is usually reserved for inoperable patients. Due to ... ...

Abstract	Objectives: Surgical debridement with aortic graft removal is considered the preferred treatment for thoracic aortic vascular graft infection (VGI). Conservative treatment with antibiotics only is usually reserved for inoperable patients. Due to Outpatient Parenteral Antimicrobial Therapy (OPAT) and better understanding of the antibiotic impact on biofilms, long-term targeted antibiotic therapy without graft removal may be an alternative treatment option for selected thoracic aortic VGI patients. The aim of this case series was to evaluate the outcome in patients with thoracic aortic VGI who were treated without graft removal. Methods: This single-centre retrospective cohort study evaluated patients with a thoracic aortic VGI diagnosed between 2008 and 2021 and who were treated without graft removal. The primary outcome parameter was the 6-month mortality rate after VGI diagnosis. Secondary outcome parameters were cure rates and relapse of infection. Results: Twenty-four patients with thoracic aortic VGI who were managed without graft removal were identified. The mortality rate 6 months after VGI diagnosis was 8% (2/24); one of these deaths was infection related. The median antibiotic treatment duration was 13 months (interquartile range 15). A total of 16 patients (67%) were cured. No relapses occurred after a median of 24-month (interquartile range 32) follow-up. Conclusions: Intensive antibiotic treatment, without graft removal, may be a non-inferior option in patients with a thoracic aortic VGI who are not considered for surgery.
MeSH term(s)	Humans ; Conservative Treatment ; Retrospective Studies ; Prosthesis-Related Infections/drug therapy ; Neoplasm Recurrence, Local/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Vascular Diseases/surgery ; Blood Vessel Prosthesis/adverse effects ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-11-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezac551
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Article ; Online: Clinically unsuspected orthopedic implants during S. aureus bacteremia do not require additional diagnostic work-up.

Kouijzer, Ilse J E / Speijker, L T D / Aarntzen, E H J G / Rijnen, W H C / Somford, M P / Maat, I / van Meer, M P A / Oever, J Ten / Gisolf, E H

Infection

2022 Volume 51, Issue 3, Page(s) 743–747

Abstract: Purpose: To assess the likelihood of occult infection in patients with clinically unsuspected orthopedic implants during Staphylococcus aureus bacteremia (SAB).: Methods: In a retrospective study in two Dutch hospitals, we included all patients with ... ...

Abstract	Purpose: To assess the likelihood of occult infection in patients with clinically unsuspected orthopedic implants during Staphylococcus aureus bacteremia (SAB). Methods: In a retrospective study in two Dutch hospitals, we included all patients with SAB between 2013 and 2020 with one or more orthopedic implants in whom [ Results: Fifty-five of 191 (29%) orthopedic implants in 118 SAB patients included had clinical signs of infection. Of all 136 unsuspected implants, 5 (3%, all arthroplasties), showed increased [ Conclusion: Although orthopedic implants are evidently a risk factor for metastatic infection during SAB, the absence of clinical symptoms obviate the need of additional investigations or prolonged antibiotic treatment.
MeSH term(s)	Humans ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Bacteremia/drug therapy ; Staphylococcal Infections/diagnosis ; Prostheses and Implants
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-022-01913-9
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article ; Online: Individualizing the use of [

van Leerdam, Eline J / Gompelman, Michelle / Tuinte, Renée A M / Aarntzen, Erik H J G / Berrevoets, Marvin A H / Maat, Ianthe / Bleeker-Rovers, Chantal P / van Crevel, Reinout / Ten Oever, Jaap / Kouijzer, Ilse J E

Infection

2021 Volume 50, Issue 2, Page(s) 491–498

Abstract: Purpose: [: Methods: In a retrospective single-center cohort study, we included all consecutive adult patients with SAB between 2013 and 2020 if an [: Results: Among 132 patients included, the original treatment plan was changed after [: ... ...

Abstract	Purpose: [ Methods: In a retrospective single-center cohort study, we included all consecutive adult patients with SAB between 2013 and 2020 if an [ Results: Among 132 patients included, the original treatment plan was changed after [ Conclusion: [
MeSH term(s)	Adult ; Bacteremia/drug therapy ; Cohort Studies ; Fluorodeoxyglucose F18/therapeutic use ; Humans ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Staphylococcus aureus ; Tertiary Care Centers
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-021-01740-4
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