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Article: Evidence of Transmission of

Ossè, Razaki A / Tokponnon, Filémon / Padonou, Germain Gil / Glitho, Mariette E / Sidick, Aboubakar / Fassinou, Arsène / Koukpo, Come Z / Akinro, Bruno / Sovi, Arthur / Akogbéto, Martin

Insects

2023 Volume 14, Issue 3

Abstract: Current diagnostic and surveillance systems in Benin are not designed to accurately identify or report non- ...

Abstract	Current diagnostic and surveillance systems in Benin are not designed to accurately identify or report non-
Language	English
Publishing date	2023-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14030231
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Article ; Online: The impact of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr long-lasting insecticidal nets on density of primary malaria vectors Anopheles gambiae s.s. and Anopheles coluzzii in Benin: a secondary analysis of a cluster randomised controlled trial.

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 7

Abstract: Background: Long-lasting insecticidal nets (LLINs) may have different impacts on distinct mosquito vector species. We assessed the efficacy of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr LLINs on the density of Anopheles gambiae s.s. and An. ... ...

Abstract	Background: Long-lasting insecticidal nets (LLINs) may have different impacts on distinct mosquito vector species. We assessed the efficacy of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr LLINs on the density of Anopheles gambiae s.s. and An. coluzzii compared to pyrethroid-only nets in a three-arm cluster randomised control trial in Benin. Methods: Indoor and outdoor collections of adult mosquitoes took place in 60 clusters using human landing catches at baseline and every 3 months for 2 years. After morphological identification, around 15% of randomly selected samples of An. gambiae s.l. were dissected to determine parity, species (using PCR). Results: Overall, a total of 46,613 mosquito specimens were collected at baseline and 259,250 in the eight quarterly collections post-net distribution. Post-net distribution, approximately 70% of the specimens of An. gambiae s.l. speciated were An. coluzzii, while the rest were mostly composed of An. gambiae s.s. with a small proportion (< 1%) of hybrids (An. gambiae/coluzzii). There was no evidence of a significant reduction in vector density indoors in either primary vector species [An. coluzzii: DR (density ratio) = 0.62 (95% CI 0.21-1.77), p = 0.3683 for the pyrethroid-pyriproxyfen LLIN and DR = 0.56 (95% CI 0.19-1.62), p = 0.2866 for the pyrethroid-chlorfenapyr LLIN, An. gambiae s.s.: DR = 0.52 (95% CI 0.18-1.46), p = 0.2192 for the pyrethroid-pyriproxyfen LLIN and DR = 0.53 (95% CI 0.19-1.46), p = 0.2222 for the pyrethroid-chlorfenapyr]. The same trend was observed outdoors. Parity rates of An. gambiae s.l. were also similar across study arms. Conclusions: Compared with pyrethroid-only LLINs, pyrethroid-chlorfenapyr LLINs and pyrethroid-pyriproxyfen LLINs performed similarly against the two primary mosquito species An. gambiae s.s. and An. coluzzii in Benin.
MeSH term(s)	Animals ; Humans ; Anopheles ; Benin ; Insecticide Resistance ; Insecticide-Treated Bednets ; Insecticides/pharmacology ; Malaria/prevention & control ; Mosquito Control ; Mosquito Vectors ; Pyrethrins/pharmacology
Chemical Substances	chlorfenapyr (NWI20P05EB) ; Insecticides ; Pyrethrins ; pyriproxyfen (3Q9VOR705O)
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-023-06104-5
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Article: Entomological Characteristics of Malaria Transmission across Benin: An Essential Element for Improved Deployment of Vector Control Interventions.

Tokponnon, Tatchémè Filémon / Ossè, Razaki / Padonou, Germain Gil / Affoukou, Cyriaque Dossou / Sidick, Aboubakar / Sewade, Wilfried / Fassinou, Arsène / Koukpo, Côme Z / Akinro, Bruno / Messenger, Louisa A / Okê, Mariam / Tchévoédé, Alexis / Ogouyemi-Hounto, Aurore / Gazard, Dorothée Kinde / Akogbeto, Martin

Insects

2023 Volume 14, Issue 1

Abstract: Entomological surveillance in Benin has historically been limited to zones where indoor residual spraying was performed or where long-standing sentinel surveillance sites existed. However, there are significant country-wide gaps in entomological ... ...

Abstract	Entomological surveillance in Benin has historically been limited to zones where indoor residual spraying was performed or where long-standing sentinel surveillance sites existed. However, there are significant country-wide gaps in entomological knowledge. The National Malaria Control Program (NMCP) assessed population dynamics of Anopheles vectors and malaria transmission in each of Benin’s 12 departments to create an entomological risk profile. Two communes per department (24/77 communes) were chosen to reflect diverse geographies, ecologies and malaria prevalence. Two villages per commune were selected from which four households (HH) per village were used for human landing catches (HLCs). In each HH, an indoor and outdoor HLC occurred between 7 p.m. and 7 a.m. on two consecutive nights between July−September 2017. Captured Anopheles were identified, and ovaries were dissected to determine parous rate. Heads and thoraces were tested for Plasmodium falciparum sporozoites by ELISA. The Entomological Inoculation Rate (EIR) was calculated as the product of mosquito bite rate and sporozoite index. Bite rates from An. gambiae s.l., the primary vector species complex, differed considerably between communes; average sporozoite infection index was 3.5%. The EIR ranged from 0.02 infectious bites (ib) per human per night in the departments of Ouémé and Plateau to 1.66 ib/human/night in Collines. Based on transmission risk scales, Avrankou, Sakété and Nikki are areas of low transmission (0 < EIR < 3 ib/human/year), Adjarra, Adja Ouèrè, Zè, Toffo, Bopa, Pehunco, Pèrèrè and Kandi are of medium transmission (3 < EIR < 30 ib/human/year), and the other remaining districts are high transmission (EIR > 30 ib/human/year). The heterogeneous and diverse nature of malaria transmission in Benin was not readily apparent when only assessing entomological surveillance from sentinel sites. Prospectively, the NMCP will use study results to stratify and deploy targeted vector control interventions in districts with high EIRs to better protect populations most at-risk.
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects14010052
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Article ; Online: Resistance status of Anopheles gambiae s.l. to insecticides following the 2011 mass distribution campaign of long-lasting insecticidal nets (LLINs) in the Plateau Department, south-eastern Benin.

Sovi, Arthur / Govoétchan, Renaud / Ossé, Razaki / Koukpo, Come Z / Salako, Albert S / Syme, Thomas / Anagonou, Rodrigue / Fongnikin, Augustin / Nwangwu, Udoka C / Oké-Agbo, Frédéric / Tokponnon, Filémon / Padonou, Gil Germain / Akogbeto, Martin Codjo

Malaria journal

2020 Volume 19, Issue 1, Page(s) 26

Abstract: Background: In 2011, Benin's National Malaria Control Programme (NMCP) organized a nationwide mass distribution campaign of LLINs throughout the country. Following this intervention, it was important to assess whether the level of susceptibility of ... ...

Abstract	Background: In 2011, Benin's National Malaria Control Programme (NMCP) organized a nationwide mass distribution campaign of LLINs throughout the country. Following this intervention, it was important to assess whether the level of susceptibility of malaria vectors to insecticides had remained the same as compared to the pre-intervention period. The current study investigated this. Methods: Larval collections were conducted in Ifangni, Sakété, Pobè and Kétou districts located in Plateau department, Southeastern Benin before (2009) and after (2012-2013) LLIN distribution. Anopheles gambiae sensu lato (s.l.) larvae from the 4 study districts were reared to adulthood and WHO susceptibility tests were conducted. The insecticides tested were deltamethrin (0.05%), permethrin (0.75%), bendiocarb (0.1%) and DDT (4%). Molecular species identification as well as, the characterization of the kdr L1014F mutation were also performed in the An. gambiae s.l. complex using PCR method. Results: Overall, a significant decrease in mortality rates of An. gambiae s.l. to deltamethrin (0.05%), permethrin (0.75%) and DDT (4%) was observed post-LLIN distribution, respectively: (100% vs 80.9%, p < 0.0001), (77.5% vs 70%, p = 0.01) and, (47.8% vs 4.4%, p < 0.0001). By contrast, susceptibility of vectors to bendiocarb (0.1%) remained the same (100% mortality in the WHO susceptibility tube tests) pre- and post-intervention. An increase in the kdr L1014F frequency was observed post-LLIN distribution [F(kdr) = 0.91)] compared to the pre-intervention period [F(kdr) = 0.56], p < 0.0001. Anopheles coluzzii and An. gambiae were the two molecular species identified in the study area. Conclusion: The decrease susceptibility to pyrethroids and DDT as well as, the increase in the frequency of the kdr L1014F mutation after the intervention stressed at the time, the need for the development and implementation of effective insecticide resistance management strategies. At present, an update of the vectors resistance status in the area is also necessary for decision-making.
MeSH term(s)	Animals ; Anopheles/growth & development ; Benin ; DDT ; Female ; Humans ; Insecticide Resistance ; Insecticide-Treated Bednets/statistics & numerical data ; Likelihood Functions ; Logistic Models ; Malaria, Falciparum/prevention & control ; Malaria, Falciparum/transmission ; Mosquito Vectors/growth & development ; Mutation Rate ; Nitriles ; Permethrin ; Phenylcarbamates ; Pyrethrins ; World Health Organization
Chemical Substances	Nitriles ; Phenylcarbamates ; Pyrethrins ; decamethrin (2JTS8R821G) ; Permethrin (509F88P9SZ) ; DDT (CIW5S16655) ; bendiocarb (QFH0ZU0A5U)
Language	English
Publishing date	2020-01-15
Publishing country	England
Document type	Journal Article
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-020-3116-0
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Article ; Online: Involvement of Anopheles nili in Plasmodium falciparum transmission in North Benin.

Ossè, Razaki A / Tokponnon, Filémon / Padonou, Germain Gil / Sidick, Aboubakar / Aïkpon, Rock / Fassinou, Arsène / Koukpo, Come Z / Sèwadé, Wilfrid / Akinro, Bruno / Sovi, Arthur / Aïssi, Melchior / Akogbéto, Martin C

Malaria journal

2019 Volume 18, Issue 1, Page(s) 152

Abstract: Background: Several studies carried out in Benin have shown the involvement of Anopheles gambiae sensu lato (s.l.), the Anopheles funestus group in malaria transmission, but none of them reported the contribution of the Anopheles nili group to the ... ...

Abstract	Background: Several studies carried out in Benin have shown the involvement of Anopheles gambiae sensu lato (s.l.), the Anopheles funestus group in malaria transmission, but none of them reported the contribution of the Anopheles nili group to the transmission of this disease. The current study investigated the question through an entomological cross-sectional survey performed in Northern Benin. Methods: Mosquito samplings were performed in September and October 2017 in 4 villages located in two districts: Bambaba and Wodara (Kérou district) and, Péhunco 2 and Béké (Péhunco district). The collections were carried out indoors and outdoors using human landing catches (HLC) to assess the human biting rate (HBR) and pyrethrum spray catches (PSC) to evaluate the blood feeding rate and the blood meal origin using the ELISA test. All collected mosquitoes were morphologically identified and, the polymerase chain reaction (PCR) technique was used for molecular identification of sibling species of An. gambiae s.l., An. funestus group and An. nili group sporozoite index (SI) was also assessed by the ELISA test. Results: Overall, An. gambiae s.l., An. funestus group and An. nili group were the three vectors found in the study area. A significantly higher human biting rate (HBR) was recorded in An. nili group (5 bites/human/night) compared to An. funestus group (0.656 bites/human/night) in the Kérou district (p < 0.0001). Anopheles gambiae s.l. displayed the highest HBR (26.19 bites/human/night) in the same district. The entomological inoculation rate (EIR) was 1.875 infected bites/human/month in An. nili group against 13.05 infected bites/human/month in An. gambiae s.l. and 0.938 infected bites/human/month in An. funestus group in Kérou. In Péhunco, the EIR was 1.02 infected bites/human/month in An. gambiae s.l. PCR results showed that An. nili sensu stricto (s.s.) and An. funestus s.s. were the only species of the An. nili and An. funestus groups, respectively. The anthropophagic character of An. gambiae s.l. was also highlighted. Conclusion: This study provides useful information on the contribution of An. nili group as secondary vector to malaria transmission in northern Benin. Broader studies must also be carried out in a larger study area to assess the involvement of other Anopheles species to malaria transmission. This will aid to better plan malaria vector control interventions.
MeSH term(s)	Animals ; Anopheles/classification ; Anopheles/parasitology ; Benin/epidemiology ; Bites and Stings ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Feeding Behavior ; Humans ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/transmission ; Mosquito Vectors/classification ; Mosquito Vectors/parasitology ; Plasmodium falciparum ; Polymerase Chain Reaction ; Seasons ; Sporozoites
Language	English
Publishing date	2019-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2091229-8
ISSN	1475-2875 ; 1475-2875
ISSN (online)	1475-2875
ISSN	1475-2875
DOI	10.1186/s12936-019-2792-0
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Article: Genetic structure of

Fassinou, Arsène Jacques Y H / Koukpo, Come Z / Ossè, Razaki A / Agossa, Fiacre R / Assogba, Benoit S / Sidick, Aboubakar / Sèwadé, Wilfrid T / Akogbéto, Martin C / Sèzonlin, Michel

Tropical medicine and health

2019 Volume 47, Page(s) 23

Abstract: Background: Several studies have reported the strong resistance of : Methods: The characterization of : Results: During the study period, : Conclusion: This study revealed that the use of insecticides in Benin for years has altered the genetic ... ...

Abstract	Background: Several studies have reported the strong resistance of Methods: The characterization of Results: During the study period, Conclusion: This study revealed that the use of insecticides in Benin for years has altered the genetic structure of
Language	English
Publishing date	2019-04-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2209835-5
ISSN	1349-4147 ; 1348-8945
ISSN (online)	1349-4147
ISSN	1348-8945
DOI	10.1186/s41182-019-0151-z
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Article ; Online: Pesticides and the evolution of the genetic structure of Anopheles coluzzii populations in some localities in Benin (West Africa).

Fassinou, Arsène Jacques Y H / Koukpo, Come Z / Ossè, Razaki A / Agossa, Fiacre R / Azondékon, Roseric / Sominahouin, André / Kpanou, Casimir / Sagbohan, Hermann / Yovogan, Boulais / Akogbéto, Martin C / Sezonlin, Michel

Malaria journal

2019 Volume 18, Issue 1, Page(s) 407

Abstract: Background: Changes in the natural habitats of insect groups are determined the genetic polymorphisms between individuals. The objective of this study was to establish the genetic structure of the Anopheles coluzzii populations in four localities of ... ...

Abstract	Background: Changes in the natural habitats of insect groups are determined the genetic polymorphisms between individuals. The objective of this study was to establish the genetic structure of the Anopheles coluzzii populations in four localities of Benin. Methods: Insecticide surveys and larval sampling were conducted on 4 study localities, including Cotonou, Ketou, Zagnanado, and Sô-Ava. Molecular characterizations were performed on the Anopheles mosquitoes collected with the allelic and genotypic frequencies of kdr gene determined. The multiple comparison Chi square test for proportions was performed with R version 3.3.3. Next, the observed heterozygosity, expected heterozygosity, and indices of fixation, and genetic differentiation were estimated. Finally, the Hardy-Weinberg equilibrium (EHW) was determined to assess whether panmixia exists in the different populations of mosquitoes of the agroecological zones under study. Results: Carbamates, pyrethroids, organophosphorus and organochlorines use have been reported in all localities except Sô-Ava. Anopheles coluzzii was strongly represented across all study localities. The L1014F allele was observed in the localities of Kétou, Cotonou and Zagnanado. Likewise, insecticide selection pressure of homozygous resistant individuals (L1014F/L1014F) was significantly higher in Kétou, Cotonou and Zagnanado (p value < 0.05). Surprisingly in Sô-Ava, a relatively high frequency of the L1014F allele despite the reported absence of pesticide use was observed. All mosquito populations were found to be deficient in heterozygosity across the study sites (F Conclusion: The survey on the use of insecticides showed that insecticide selection pressures differ across the investigated localities. It would be desirable to rotate or apply formulations of combined products with different modes of action. Doing so would enable a better management of resistant homozygous individuals, and mitigate the resistance effect of commonly used insecticides.
MeSH term(s)	Alleles ; Animals ; Anopheles/drug effects ; Anopheles/genetics ; Anopheles/growth & development ; Benin ; Ecosystem ; Genetic Variation/drug effects ; Genotype ; Insecticides/pharmacology ; Larva/drug effects ; Larva/genetics ; Larva/growth & development
Chemical Substances	Insecticides
Language	English
Publishing date	2019-12-05
Publishing country	England
Document type	Journal Article
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-019-3036-z
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Article ; Online: The current distribution and characterization of the L1014F resistance allele of the kdr gene in three malaria vectors (Anopheles gambiae, Anopheles coluzzii, Anopheles arabiensis) in Benin (West Africa).

Koukpo, Come Z / Fassinou, Arsène Jacques Y H / Ossè, Razaki A / Agossa, Fiacre R / Sovi, Arthur / Sewadé, Wilfrid T / Aboubakar, Sidick / Assogba, Bénoît S / Akogbeto, Martin C / Sezonlin, Michel

Malaria journal

2019 Volume 18, Issue 1, Page(s) 175

Abstract: Background: The fight against malaria faces various biological obstacles, including the resistance of parasites to anti-malarial drugs and the resistance of mosquito vectors to insecticides. The resistance of Anopheles gambiae sensu lato (s.l.) to ... ...

Abstract	Background: The fight against malaria faces various biological obstacles, including the resistance of parasites to anti-malarial drugs and the resistance of mosquito vectors to insecticides. The resistance of Anopheles gambiae sensu lato (s.l.) to pyrethroids, the only class of insecticides used to impregnate mosquito nets, is known in Benin; the expansion of this resistance is influenced by the existence of gene flow between species, otherwise by the presence or absence of the kdr mutation in them. The objective of this study is to determine the spatial distribution of An. gambiae and the level of expression of the pyrethroid resistance kdr gene in seven agro-ecological zones of Benin. Methods: The study was conducted in 18 localities belonging to seven agro-ecological zones where environmental parameters varied. The sites represent the main areas of eco-epidemiological malaria in Benin. Anopheles gambiae larvae were collected in natural breeding sites using ladles and dipping method and reared under standard conditions. These larvae were reared under standard conditions of temperature and humidity (26 to 30 °C and 60 to 90%) at the insectarium of the Centre de Recherche Entomologique de Cotonou (CREC). Adult female mosquitoes having emerged are morphologically and molecularly identified. Homozygous resistant (1014F/1014F), homozygous sensitive (1014L/1014L) and heterozygous (1014F/1014L) genotypes of the L1014F kdr gene mutation are determined by PCR. Results: A total of 677 An. gambiae was subjected at the PCR. The results revealed the presence of three vector species of the An. gambiae complex, of which 409 Anopheles coluzzii, 259 An. gambiae, 5 hybrids (An. coluzzii/An. gambiae) and 4 Anopheles arabiensis in the different agro-ecological zones. The four An. arabiensis were only found in Dassa, a locality in the cotton zone of central Benin. The frequency of distribution of the L1014F allele of the kdr gene varies from 84.48 to 100% in An. gambiae, from 80 to 100% in An. coluzzii and from 0 to 75% in An. arabiensis in the different agro-ecological zones. Moreover, a significant difference is generally observed in the distribution of the L1014F allele (P < 0.05). By comparing in pairs the distribution frequencies of this allele in the two species by agro-ecological zone, only a significant difference is noted in the central cotton and fishery zones (P = 0.0496). Conclusion: In summary, even if the data are in small portions, the An. Arabiensis species was found only in central Benin and the L1014F allele of the kdr gene is widespread and seems to fix in all the species recorded in the different agro-ecological zones. This situation amplifies the problem of resistance, which could eventually be a significant obstacle for the malaria vectors control. Similarly, a study of their genetic structure via the L1014F allele is necessary in order to put in place strategies to manage this resistance. These strategies will take into account both the ecology and the genetic diversity of the organisms involved to preserve the effectiveness of pyrethroids, the only insecticides used for the impregnation of mosquito nets.
MeSH term(s)	Africa, Western ; Alleles ; Animal Distribution ; Animals ; Anopheles/genetics ; Benin ; Female ; Gene Frequency ; Genes, Insect ; Genetic Variation ; Genotype ; Insecticide Resistance/genetics ; Insecticides ; Larva ; Mosquito Vectors/genetics ; Mutation ; Polymerase Chain Reaction
Chemical Substances	Insecticides
Language	English
Publishing date	2019-05-21
Publishing country	England
Document type	Journal Article
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-019-2808-9
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Article: Efficacy of a novel mode of action of an indoor residual spraying product, SumiShield® 50WG against susceptible and resistant populations of Anopheles gambiae (s.l.) in Benin, West Africa

Agossa, Fiacre R / Ahoga, Juniace / Akinro, Bruno / Akogbeto, Martin C / Akuoko, Osei K / Azondekon, Roseric / Fassinou, Arsene Jacques Y. H / Koukpo, Come Z / N’dombidje, Boris / Padonou, Gil G / Sezonlin, Michel / Zola-Sahossi, Jacques

Parasites & vectors. 2018 Dec., v. 11, no. 1

2018

Abstract: BACKGROUND: Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan ... ...

Abstract	BACKGROUND: Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan Africa. Due to the increasing pyrethroid resistance intensity and the spread of carbamate resistance in Anopheles gambiae (s.s.) mosquitoes and the limited number of insecticides recommended by the WHO for vector control, alternative insecticide formulations for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries. METHODS: SumiShield 50WG (clothianidin 300 mg ai/m2) developed by Sumitomo Chemical was evaluated alongside deltamethrin 25 mg ai/m2 (K-Othrine 250 WG) against a pyrethroid resistant Anopheles gambiae (s.l.) population in experimental huts in Covè, Benin. Residual activity was also tested in cone bioassays with the susceptible An. gambiae “Kisumu” strain and the local wild resistant population. RESULTS: The results showed very low toxicity from deltamethrin (mortality rates ranged between 1–40%) against host-seeking resistant Anopheles populations. SumiShield in contrast gave an overall mean mortality of 91.7% at the 120 h observation across the eight- month observation period following spraying. The residual activity measured using cone tests was over the 80% WHO threshold for 24 weeks for resistant wild Anopheles population and 32 weeks for the susceptible strain “Kisumu” after the spraying. CONCLUSIONS: SumiShield is a good candidate for IRS in areas of permanent malaria transmission and where Anopheles populations are resistant to other conventional insecticides such as pyrethroids. It would be interesting to complete experimental huts studies by assessing the efficacy and residual effect of SumiShield 50WG at community level (small-scale field testing) in an area where vectors are highly resistant to insecticides.
Keywords	Anopheles gambiae ; bed nets ; bioassays ; clothianidin ; deltamethrin ; host seeking ; malaria ; mechanism of action ; morbidity ; mortality ; pesticide application ; pesticide formulations ; pyrethrins ; residual effects ; spraying ; toxicity ; vector control ; World Health Organization ; Benin
Language	English
Dates of publication	2018-12
Size	p. 293.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2409480-8
ISSN	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-018-2869-6
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Article ; Online: Efficacy of a novel mode of action of an indoor residual spraying product, SumiShield® 50WG against susceptible and resistant populations of Anopheles gambiae (s.l.) in Benin, West Africa.

Agossa, Fiacre R / Padonou, Gil G / Koukpo, Come Z / Zola-Sahossi, Jacques / Azondekon, Roseric / Akuoko, Osei K / Ahoga, Juniace / N'dombidje, Boris / Akinro, Bruno / Fassinou, Arsene Jacques Y H / Sezonlin, Michel / Akogbeto, Martin C

Parasites & vectors

2018 Volume 11, Issue 1, Page(s) 293

Abstract: Background: Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan ... ...

Abstract	Background: Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan Africa. Due to the increasing pyrethroid resistance intensity and the spread of carbamate resistance in Anopheles gambiae (s.s.) mosquitoes and the limited number of insecticides recommended by the WHO for vector control, alternative insecticide formulations for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries. Methods: SumiShield 50WG (clothianidin 300 mg ai/m Results: The results showed very low toxicity from deltamethrin (mortality rates ranged between 1-40%) against host-seeking resistant Anopheles populations. SumiShield in contrast gave an overall mean mortality of 91.7% at the 120 h observation across the eight- month observation period following spraying. The residual activity measured using cone tests was over the 80% WHO threshold for 24 weeks for resistant wild Anopheles population and 32 weeks for the susceptible strain "Kisumu" after the spraying. Conclusions: SumiShield is a good candidate for IRS in areas of permanent malaria transmission and where Anopheles populations are resistant to other conventional insecticides such as pyrethroids. It would be interesting to complete experimental huts studies by assessing the efficacy and residual effect of SumiShield 50WG at community level (small-scale field testing) in an area where vectors are highly resistant to insecticides.
MeSH term(s)	Africa, Western/epidemiology ; Animals ; Anopheles/drug effects ; Benin/epidemiology ; Biological Assay ; Guanidines/pharmacology ; Insecticide Resistance/drug effects ; Insecticides/chemistry ; Insecticides/pharmacology ; Malaria/epidemiology ; Malaria/parasitology ; Malaria/prevention & control ; Mosquito Control/methods ; Mosquito Vectors/drug effects ; Neonicotinoids/pharmacology ; Nitriles/pharmacology ; Pyrethrins/pharmacology ; Thiazoles/pharmacology
Chemical Substances	Guanidines ; Insecticides ; Neonicotinoids ; Nitriles ; Pyrethrins ; Thiazoles ; decamethrin (2JTS8R821G) ; clothianidin (2V9906ABKQ)
Language	English
Publishing date	2018-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-018-2869-6
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Inter-library loan at ZB MED

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Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito