Article ; Online: Successful Treatment of a Locally Recurrent and Metastatic Malignant Phyllodes Tumor with Accelerated Radiotherapy and Nab-Paclitaxel, Cisplatin, and Liposomal Doxorubicin Chemotherapy.
2021 Volume 66, Issue 3, Page(s) 82–86
Abstract: Phyllodes tumors are rare breast lesions of fibroepithelial origin. Malignant transformation with metastases is linked with poor prognosis. We present a case of a 62-year-old woman with a recurrent malignant phyllodes tumor of the breast and lung ... ...
| Abstract | Phyllodes tumors are rare breast lesions of fibroepithelial origin. Malignant transformation with metastases is linked with poor prognosis. We present a case of a 62-year-old woman with a recurrent malignant phyllodes tumor of the breast and lung metastases. The patient was originally presented with a borderline phyllodes tumor (7.4 cm) of the left breast, treated with wide local excision. A year later, the patient returned with palpable left breast masses. On PET-CT, increased uptake of 18F-FDG by large breast tumors was evident. A right lung lesion of metastatic origin was also present. A simple left breast mastectomy was performed. Histopathological report described 2 malignant phyllodes tumors (7 cm and 6.5 cm). One month later, during the CT simulation for radiotherapy planning, encysted fluid in the chest wall and 2 additional pulmonary lesions of the right lung were identified, confirming progressive lung metastatic disease. Both the chest wall and the regional lymph node area were irradiated with hypofractionated and accelerated radiotherapy. Biweekly chemotherapy with albumin-bound paclitaxel, cisplatin, and liposomal doxorubicin was also prescribed at the start of radiotherapy for 12 cycles. At the end of chemotherapy, complete regression of lung metastases was achieved, and there was no evidence of local recurrence. Within 2 years of follow-up, the patient is free of disease and treatment-related toxicities. Accelerated hypofractionated radiotherapy is effective in the locoregional control of malignant phyllodes tumors. The combination of cisplatin with nab-paclitaxel and liposomal doxorubicin chemotherapy has acceptable toxicity and is highly effective in eradicating metastatic lesions. |
|---|---|
| MeSH term(s) | Albumins/therapeutic use ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Cisplatin/therapeutic use ; Doxorubicin/analogs & derivatives ; Doxorubicin/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Paclitaxel/therapeutic use ; Phyllodes Tumor/drug therapy ; Phyllodes Tumor/pathology ; Phyllodes Tumor/radiotherapy ; Polyethylene Glycols/therapeutic use ; Positron Emission Tomography Computed Tomography ; Remission Induction |
| Chemical Substances | 130-nm albumin-bound paclitaxel ; Albumins ; Antineoplastic Agents ; liposomal doxorubicin ; Polyethylene Glycols (3WJQ0SDW1A) ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D) ; Cisplatin (Q20Q21Q62J) |
| Language | English |
| Publishing date | 2021-07-07 |
| Publishing country | Switzerland |
| Document type | Case Reports |
| ZDB-ID | 6708-8 |
| ISSN | 1421-9794 ; 0009-3157 |
| ISSN (online) | 1421-9794 |
| ISSN | 0009-3157 |
| DOI | 10.1159/000517246 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uf I Zs.174: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.