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  1. Article ; Online: A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response.

    Leli, Nektaria Maria / Koumenis, Constantinos

    Cancer discovery

    2023  Volume 13, Issue 3, Page(s) 535–537

    Abstract: Summary: Tumor fitness coessentiality gene analysis that aims to expand the repertoire of druggable targets reveals a novel ubiquitin ligase complex, the BICR6 module. Along with the other complex members (UBA6, KCMF1, and UBR4), BIRC6 selectively ... ...

    Abstract Summary: Tumor fitness coessentiality gene analysis that aims to expand the repertoire of druggable targets reveals a novel ubiquitin ligase complex, the BICR6 module. Along with the other complex members (UBA6, KCMF1, and UBR4), BIRC6 selectively contributes to the survival of a subset of epithelial tumors with a high degree of aneuploidy by ubiquitinating and suppressing HRI, a component of the integrated stress response adaptive pathway. See related article by Cervia et al., p. 766 (2).
    MeSH term(s) Humans ; Ubiquitin ; Ubiquitination ; Carcinoma ; Aneuploidy
    Chemical Substances Ubiquitin
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-1440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6916: Show issues Location:
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  2. Book: Tumor microenvironment

    Koumenis, Constantinos / Coussens, Lisa M. / Giaccia, Amato / Hammond, Ester

    study protocols

    (Advances in experimental medicine and biology ; 899)

    2016  

    Author's details Constantinos Koumenis, Lisa M. Coussens, Amato Giaccia, Ester Hammond editors
    Series title Advances in experimental medicine and biology ; 899
    Collection
    Keywords hypoxia ; angiogenesis ; cancer stem cells ; metastasis ; Tumorigenesis
    Language English
    Size viii, 297 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019027949
    ISBN 978-3-319-26664-0 ; 9783319266664 ; 3-319-26664-0 ; 3319266667
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Online ; E-Book: Tumor microenvironment

    Koumenis, Constantinos / Coussens, Lisa M. / Giaccia, Amato / Hammond, Ester

    study protocols

    (Advances in experimental medicine and biology ; 899)

    2016  

    Author's details Constantinos Koumenis, Lisa M. Coussens, Amato Giaccia, Ester Hammond editors
    Series title Advances in experimental medicine and biology ; 899
    Collection
    Keywords hypoxia ; angiogenesis ; cancer stem cells ; metastasis ; Tumorigenesis
    Language English
    Size 1 Online-Ressource (viii, 297 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019030491
    ISBN 978-3-319-26666-4 ; 9783319266640 ; 3-319-26666-7 ; 3319266640
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity.

    Maity, Amit / Koumenis, Constantinos

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 17, Page(s) 3636–3638

    Abstract: A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered ... ...

    Abstract A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814.
    MeSH term(s) Animals ; Carcinoma, Squamous Cell ; Cats ; Radiation Oncology ; Radiotherapy Dosage ; Swine ; Swine, Miniature
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-1255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  5. Book ; Conference proceedings: Tumor microenvironment and cellular stress

    Koumenis, Constantinos / Hammond, Ester / Giaccia, Amato J.

    signaling, metabolism, imaging, and therapeutic targets

    (Advances in experimental medicine and biology ; 772 ; Aegean Conferences)

    2014  

    Event/congress Aegean Meeting on the Tumor Microenvironment and Cellular Stress (1, 2012, Kreta)
    Author's details Constantinos Koumenis ; Ester Hammond ; Amato Giaccia ed
    Series title Advances in experimental medicine and biology ; 772
    Aegean Conferences
    Collection
    Keywords Tumors ; Pathology, Cellular ; Stress (Physiology)
    Subject code 616.99407
    Language English
    Size X, 290 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT018170212
    ISBN 978-1-4614-5914-9 ; 9781461459156 ; 1-4614-5914-1 ; 146145915X
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Pro-tumorigenic AMPK in glioblastoma.

    Leli, Nektaria Maria / Koumenis, Constantinos

    Nature cell biology

    2018  Volume 20, Issue 7, Page(s) 736–737

    MeSH term(s) AMP-Activated Protein Kinases ; Adenylate Kinase ; Carcinogenesis ; Energy Metabolism ; Glioblastoma ; Humans
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Adenylate Kinase (EC 2.7.4.3)
    Language English
    Publishing date 2018-06-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-018-0129-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  7. Article ; Online: Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach.

    Tan, Hai Siong / Teo, Kevin Boon Keng / Dong, Lei / Friberg, Andrew / Koumenis, Constantinos / Diffenderfer, Eric / Zou, Jennifer Wei

    Physics in medicine and biology

    2023  Volume 68, Issue 14

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Animals ; Mice ; Protons ; Electrons ; Proton Therapy/methods ; Radiotherapy Dosage ; Oxygen
    Chemical Substances Protons ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ace14d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 199: Show issues Location:
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  8. Article ; Online: Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair.

    Nikitaki, Zacharenia / Velalopoulou, Anastasia / Zanni, Vassiliki / Tremi, Ioanna / Havaki, Sophia / Kokkoris, Michael / Gorgoulis, Vassilis G / Koumenis, Constantinos / Georgakilas, Alexandros G

    Expert reviews in molecular medicine

    2022  Volume 24, Page(s) e15

    Abstract: DNA damage and repair studies are at the core of the radiation biology field and represent also the fundamental principles informing radiation therapy (RT). DNA damage levels are a function of radiation dose, whereas the type of damage and biological ... ...

    Abstract DNA damage and repair studies are at the core of the radiation biology field and represent also the fundamental principles informing radiation therapy (RT). DNA damage levels are a function of radiation dose, whereas the type of damage and biological effects such as DNA damage complexity, depend on radiation quality that is linear energy transfer (LET). Both levels and types of DNA damage determine cell fate, which can include necrosis, apoptosis, senescence or autophagy. Herein, we present an overview of current RT modalities in the light of DNA damage and repair with emphasis on medium to high-LET radiation. Proton radiation is discussed along with its new adaptation of FLASH RT. RT based on α-particles includes brachytherapy and nuclear-RT, that is proton-boron capture therapy (PBCT) and boron-neutron capture therapy (BNCT). We also discuss carbon ion therapy along with combinatorial immune-based therapies and high-LET RT. For each RT modality, we summarise relevant DNA damage studies. Finally, we provide an update of the role of DNA repair in high-LET RT and we explore the biological responses triggered by differential LET and dose.
    MeSH term(s) Boron Neutron Capture Therapy ; DNA Damage ; DNA Repair ; Humans ; Linear Energy Transfer ; Radiation, Ionizing
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1462-3994
    ISSN (online) 1462-3994
    DOI 10.1017/erm.2022.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regulation of autophagy by canonical and non-canonical ER stress responses.

    Bhardwaj, Monika / Leli, Nektaria Maria / Koumenis, Constantinos / Amaravadi, Ravi K

    Seminars in cancer biology

    2019  Volume 66, Page(s) 116–128

    Abstract: Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor microenviroment stresses that perturb protein homeostasis can produce endoplasmic reticulum (ER) stress, which can be counterbalanced by triggering the unfolded protein ... ...

    Abstract Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor microenviroment stresses that perturb protein homeostasis can produce endoplasmic reticulum (ER) stress, which can be counterbalanced by triggering the unfolded protein response (UPR) which is considered the canonical ER stress response. The UPR is characterized by three major proteins that lead to specific changes in transcriptional and translational programs in stressed cells. Activation of the UPR can induce apoptosis, but also can induce cytoprotective programs such as autophagy. There is increasing appreciation for the role that UPR-induced autophagy plays in supporting tumorigenesis and cancer therapy resistance. More recently several new pathways that connect cell stresses, components of the UPR and autophagy have been reported, which together can be viewed as non-canonical ER stress responses. Here we review recent findings on the molecular mechanisms by which canonical and non-canonical ER stress responses can activate cytoprotective autophagy and contribute to tumor growth and therapy resistance. Autophagy has been identified as a druggable pathway, however the components of autophagy (ATG genes) have proven difficult to drug. It may be the case that targeting the UPR or non-canonical ER stress programs can more effectively block cytoprotective autophagy to enhance cancer therapy. A deeper understanding of these pathways could provide new therapeutic targets in cancer.
    MeSH term(s) Animals ; Autophagy/physiology ; Endoplasmic Reticulum/physiology ; Endoplasmic Reticulum Stress/physiology ; Humans ; Neoplasms/pathology ; Signal Transduction/physiology ; Unfolded Protein Response/physiology
    Language English
    Publishing date 2019-12-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2019.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2922: Show issues Location:
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  10. Article ; Online: Precision Cardio-Oncology.

    Dreyfuss, Alexandra D / Bravo, Paco E / Koumenis, Constantinos / Ky, Bonnie

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2019  Volume 60, Issue 4, Page(s) 443–450

    Abstract: Modern oncologic therapies and care have resulted in a growing population of cancer survivors with comorbid, chronic health conditions. As an example, many survivors have an increased risk of cardiovascular complications secondary to cardiotoxic systemic ...

    Abstract Modern oncologic therapies and care have resulted in a growing population of cancer survivors with comorbid, chronic health conditions. As an example, many survivors have an increased risk of cardiovascular complications secondary to cardiotoxic systemic and radiation therapies. In response, the field of cardio-oncology has emerged as an integral component of oncologic patient care, committed to the early diagnosis and treatment of adverse cardiac events. However, as current clinical management of cancer therapy-related cardiovascular disease remains limited by a lack of phenotypic data, implementation of precision medicine approaches has become a focal point for deep phenotyping strategies. In particular, -omics approaches (a field of study in biology ending in -omic, such as genomics, proteomics, or metabolomics) have shown enormous potential in identifying sensitive biomarkers of cardiovascular disease, applying sophisticated, pattern-revealing technologies to growing databases of biologic molecules. Moreover, the use of -omics to inform radiologic strategies may add a dimension to future clinical practices. In this review, we present a paradigm for a precision medicine approach to the care of cardiotoxin-exposed cancer patients. We discuss the role of current imaging techniques; demonstrate how -omics can advance our understanding of disease phenotypes; and describe how molecular imaging can be integrated to personalize surveillance and therapeutics, ultimately reducing cardiovascular morbidity and mortality in cancer patients and survivors.
    MeSH term(s) Biomarkers/metabolism ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Cardiotoxicity/metabolism ; Humans ; Medical Oncology ; Molecular Imaging ; Precision Medicine ; Radiation Injuries/diagnostic imaging ; Radiation Injuries/etiology ; Radiation Injuries/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.118.220137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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