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Article ; Online: Modeling p

Glasovac, Zoran / Kovačević, Borislav

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: A simple but efficient computational approach to calculate ... ...

Abstract	A simple but efficient computational approach to calculate p
MeSH term(s)	Acetonitriles/chemistry ; Carbon ; Chlormerodrin/analogs & derivatives ; Nitrogen ; Phosphorus ; Protons ; Thermodynamics
Chemical Substances	Acetonitriles ; Protons ; Phosphorus (27YLU75U4W) ; IPCM (39877-25-3) ; Carbon (7440-44-0) ; Chlormerodrin (99T5TWO621) ; Nitrogen (N762921K75) ; acetonitrile (Z072SB282N)
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810576
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Article ; Online: Endoscopic ultrasound-guided biopsies vs surgical specimens for establishing patient-derived pancreatic cancer organoids: A systematic review and meta-analysis.

Grützmeier, Simon Ezban / Sodal, Hafsa Mahad Mahamud / Kovacevic, Bojan / Vilmann, Peter / Karstensen, John Gásdal / Klausen, Pia

Gastrointestinal endoscopy

2024

Abstract: Background and aims: Patient-Derived Tumor Organoids (PDTOs) is a promising new disease model in pancreatic cancer for use in personalized medicine, but overall success rate (SR) of establishing these cultures from endoscopic ultrasound-guided biopsies ... ...

Abstract	Background and aims: Patient-Derived Tumor Organoids (PDTOs) is a promising new disease model in pancreatic cancer for use in personalized medicine, but overall success rate (SR) of establishing these cultures from endoscopic ultrasound-guided biopsies is unknown. Methods: We searched relevant databases publications reporting SR of PDTO establishment from pancreatic cancer. The primary outcome was SR stratified on tissue acquisition method (EUS-guided biopsies, percutaneous biopsies, and surgical specimens). Results: We identified 24 studies including 1,053 attempts at establishing PDTOs. Overall SR was 63% (95% CI: 54%-72%). Pooled SR of PDTO establishment from EUS-guided biopsies, percutaneous biopsies, and surgical specimens were 60% (95% CI: 43-76%), 36% (95% CI: 14-61%) and 62% (95% CI: 48-75%), respectively and did not differ significantly (p = 0.1975). Conclusion: The SR of PDTO establishment from EUS-guided biopsies is comparable to surgical specimens. Both techniques are suitable for tissue acquisition for PDTOs in clinical and research settings.
Language	English
Publishing date	2024-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2024.04.012
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Article ; Online: [No title information]

Jansen, Cecilie / Vilmann, Peter / Brink, Lene / Olafsson, Lydur / Kovacevic, Bojan

Ugeskrift for laeger

2023 Volume 185, Issue 12

Abstract: This case report describes the first Danish case of endoluminal radiofrequency ablation (RFA) of malignant biliary obstruction due to a Klatskin tumour in a 59-year-old male undergoing neoadjuvant therapy. The treatment was interrupted several times due ... ...

Title translation	Endoluminal radiofrequency ablation of malignant biliary obstruction.
Abstract	This case report describes the first Danish case of endoluminal radiofrequency ablation (RFA) of malignant biliary obstruction due to a Klatskin tumour in a 59-year-old male undergoing neoadjuvant therapy. The treatment was interrupted several times due to recurrent occlusions of the bile duct stents. The patient was offered endoluminal RFA of the central bile ducts in order to reduce his tumour burden and possibly achieve longer stent patency, so the palliative therapy could be resumed. The procedure was performed successfully without any adverse events achieving access to previously occluded left hepatic duct.
MeSH term(s)	Male ; Humans ; Middle Aged ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/complications ; Treatment Outcome ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Radiofrequency Ablation/adverse effects ; Cholestasis/etiology ; Cholestasis/surgery ; Stents/adverse effects
Language	Danish
Publishing date	2023-03-31
Publishing country	Denmark
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article: EUS tissue acquisition: From A to B.

Kovacevic, Bojan / Vilmann, Peter

Endoscopic ultrasound

2020 Volume 9, Issue 4, Page(s) 225–231

Abstract: EUS-guided tissue acquisition (EUS-TA) has made rapid development since its introduction in the early 1990s. The technique is widely accepted and invaluable for staging and diagnosis of a variety of upper gastrointestinal and mediastinal lesions. Fine- ... ...

Abstract	EUS-guided tissue acquisition (EUS-TA) has made rapid development since its introduction in the early 1990s. The technique is widely accepted and invaluable for staging and diagnosis of a variety of upper gastrointestinal and mediastinal lesions. Fine-needle aspiration (FNA) has long been the gold standard, but due to its limitations such as the inability to retain stroma and associated cellular architecture, novel biopsy needles (FNB) were designed. Overall, FNA and FNB needles perform seemingly equally in terms of diagnostic accuracy, however, the second-generation FNB needles require less passes. The third-generation FNB needles (crown-cut needle types) seem to be preferable to FNA needles as well as to the second-generation FNB needles, when larger histological specimens and preserved tissue architecture are required. EUS-TA is constantly under development, and new applications of this technique include tumor risk stratification according to its genetic profile as well as minimally invasive creation of patient-derived organoids, hallmarks of personized medicine. It remains yet to be shown, whether these applications will lead to a decisive shift from aspiration to biopsy, i.e., from A to B.
Language	English
Publishing date	2020-07-10
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2998317-4
ISSN	2226-7190 ; 2303-9027
ISSN (online)	2226-7190
ISSN	2303-9027
DOI	10.4103/eus.eus_21_20
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Article ; Online: EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype.

Kovacevic, Bozidar / Caramelo, Ana / Skuletic, Vesna / Cerovic, Snezana / Eloy, Catarina

Bosnian journal of basic medical sciences

2022 Volume 22, Issue 1, Page(s) 54–63

Abstract: The EWSR1 rearrangements with unknown genes were detected in a high percentage of classic variants of papillary thyroid carcinoma. The small-cell carcinoma of the thyroid with Ewing family tumor elements (CEFTE) typically presents with EWSR1-FLI1 ... ...

Abstract	The EWSR1 rearrangements with unknown genes were detected in a high percentage of classic variants of papillary thyroid carcinoma. The small-cell carcinoma of the thyroid with Ewing family tumor elements (CEFTE) typically presents with EWSR1-FLI1 rearrangement suggesting the possible role of EWSR-FLI1 translocation in the loss of thyroid differentiation and acquisition of a small-cell phenotype. In order to determine the frequency and association of EWSR1 rearrangements, particularly the EWSR1-FLI1 fusion with clinicopathological features of papillary thyroid microcarcinoma (m-PTC) and the presence of small cells, we analyzed a series of 99 m-PTCs using the fluorescence in situ hybridization method. Ninety cases (90.9%) of m-PTC were positive for small cells. This group of m-PTC has shown more often invasive growth, lymphatics invasion, and moderate/extended intratumoral fibrosis. Three cases out of 99 were inconclusive for EWSR1 rearrangement. Eighty-nine (92.7%) and twenty-seven (28.1%) out of 96 m-PTC cases were positive for EWSR1 rearrangement and EWSR1-FLI1 fusion, respectively. m-PTC with classical architectural pattern presented more frequently with EWSR1 rearrangement relative to m-PTC with other patterns (p = 0.005). Other clinicopathological features were not related to the presence of EWSR1 rearrangement or EWSR1-FLI1 fusion. The percentage of small cells present significantly correlated with the percentage of cells positive for EWSR1-FLI1 fusion (p = 0.05) and EWSR1 rearrangement (p <0.001). EWSR1-FLI1 fusion is not rare in m-PTC and it is associated with the acquisition of small-cell phenotype. The EWSR1 gene rearrangement is a frequent event in m-PTC and is related to the classical pattern of m-PTC.
MeSH term(s)	Carcinoma, Papillary/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Oncogene Proteins, Fusion/genetics ; Phenotype ; RNA-Binding Protein EWS/genetics ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology
Chemical Substances	EWSR1 protein, human ; EWSR1-FLI1 fusion protein, human ; Oncogene Proteins, Fusion ; RNA-Binding Protein EWS
Language	English
Publishing date	2022-02-01
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	2240029-1
ISSN	1840-4812 ; 1512-8601
ISSN (online)	1840-4812
ISSN	1512-8601
DOI	10.17305/bjbms.2021.6181
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Article ; Online: Peripheral Versus Intraparenchymal Papillary Thyroid Microcarcinoma: Different Morphologies and PD-L1 Expression.

Kovacevic, Bozidar / Vucevic, Dragana / Cerovic, Snezana / Eloy, Catarina

Head and neck pathology

2021 Volume 16, Issue 1, Page(s) 200–212

Abstract: Peripheral localisation of papillary thyroid microcarcinoma (PTMC), in comparison with intraparenchymal PTMC (i-PTMC) is related to some clinicopathological features related with biological aggressiveness, including lymph node metastasis (LNM). The ... ...

Abstract	Peripheral localisation of papillary thyroid microcarcinoma (PTMC), in comparison with intraparenchymal PTMC (i-PTMC) is related to some clinicopathological features related with biological aggressiveness, including lymph node metastasis (LNM). The expression of PD-L1 in tumour cell has been associated with increased tumour survival, progression, and potentially an aggressive clinical course. This study evaluates the relation between clinicopathological features of PTMC, including tumour localisation, with PD-L1 immunoexpression. The study included 99 patients with the histological diagnosis of PTMC (≥ 5 mm). PD-L1 protein expression was assessed by immunohistochemistry. PTMCs were divided into the four following groups: G1- peripherally localised PTMC (p-PTMC) with PD-L1 expression; G2-p-PTMC without PD-L1 expression; G3-i-PTMC with PD-L1 expression and G4-i-PTMC without PD-L1 expression. G1 was the most frequent (n = 46; 46.5%), followed by G4 (n = 25; 25.3%) and similar distribution of G3 (n = 15; 15.2%) and G2 (n = 13; 13.1%). In comparison with other groups, G1 was significantly associated with classical morphology, invasive growth, lymphatic invasion (LI), vascular invasion (VI), psammoma bodies, intratumoral fibrosis, PD-L1 positive tumour-infiltrating lymphocytes, and multinuclear giant cells (MGCs). G4 more commonly exhibited follicular morphology, expansive/circumscribed growth, and absence of the following: intratumoural fibrosis, LI, VI, psammoma bodies, PD-L1 positive tumour-infiltrating lymphocytes, and MGCs. LNMs were significantly more frequent in G1 in comparison with the other groups (p = 0.000). In conclusion, morphology and tumour microenvironment of p-PTMC with PD-L1 expression is different from i-PTMC without PD-L1 expression. The differences between these two groups of PTMC include clinicopathological features related with biological aggressiveness such as the occurrence of LNM.
MeSH term(s)	B7-H1 Antigen/metabolism ; Carcinoma, Papillary/pathology ; Fibrosis ; Humans ; Lymphatic Metastasis ; Retrospective Studies ; Thyroid Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; CD274 protein, human
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-021-01337-1
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Article ; Online: [Workup and treatment of patients with obstructive cholestasis].

Hertervig, Frederik / Vilmann, Peter / Kovacevic, Bojan

Ugeskrift for laeger

2021 Volume 183, Issue 10

Abstract: The causes of cholestasis range from intrinsic hepatocellular disease to extrahepatic mechanical obstruction of the bile tree. Gallstones are the most common cause of obstructive cholestasis, but it is not seldomly associated with malignant disease. A ... ...

Abstract	The causes of cholestasis range from intrinsic hepatocellular disease to extrahepatic mechanical obstruction of the bile tree. Gallstones are the most common cause of obstructive cholestasis, but it is not seldomly associated with malignant disease. A systematic approach to diagnosing cholestatic liver disease, including thorough patient history, clinical examination, lab-panels and proper use of imaging and treatment alternatives, starting from least invasive and most cost-effective, ensures efficient patient outcomes and minimises the risk of complications as summarised in this review.
MeSH term(s)	Cholestasis/etiology ; Cholestasis/therapy ; Gallstones/complications ; Gallstones/therapy ; Humans ; Liver Diseases
Language	Danish
Publishing date	2021-03-18
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article: Association of HOTAIR, MIR155HG, TERC, miR-155, -196a2, and -146a Genes Polymorphisms with Papillary Thyroid Cancer Susceptibility and Prognosis.

Karajovic, Jelena / Kovacevic, Bozidar / Uzelac, Bojana / Stefik, Debora / Jovanovic, Bojana / Ristic, Petar / Cerovic, Snezana / Supic, Gordana

Cancers

2024 Volume 16, Issue 3

Abstract: Polymorphisms in long non-coding RNA and microRNA genes may play a significant role in the susceptibility and progression of papillary thyroid carcinoma (PTC). The current study investigates the polymorphisms HOTAIR rs920778, MIR155HG rs1893650, TERC ... ...

Abstract	Polymorphisms in long non-coding RNA and microRNA genes may play a significant role in the susceptibility and progression of papillary thyroid carcinoma (PTC). The current study investigates the polymorphisms HOTAIR rs920778, MIR155HG rs1893650, TERC rs10936599, miR-155 rs767649, miR-196a2 rs11614913 and miR-146a rs2910164 in 102 PTC patients and 106 age- and sex-matched controls of the Caucasian Serbian population, using real-time PCR. We observed differences in genotype distributions of the HOTAIR rs920778 (
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030485
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Article ; Online: Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review.

Ionescu, Corina M / Jones, Melissa A / Wagle, Susbin R / Kovacevic, Bozica / Foste, Thomas / Mikov, Momir / Mooranian, Armin / Al-Salami, Hani

Current drug targets

2024

Abstract: Bile acids play important roles in the human body, and changes in their pool can be used as markers for various liver pathologies. In addition to their functional effects in modulating inflammatory responses and cellular survivability, the unconjugated ... ...

Abstract	Bile acids play important roles in the human body, and changes in their pool can be used as markers for various liver pathologies. In addition to their functional effects in modulating inflammatory responses and cellular survivability, the unconjugated or conjugated, secondary, or primary nature of bile acids accounts for their various ligand effects. The common hydrophilic bile acids have been used successfully as local treatment to resolve drug-induced cell damage or to ameliorate hearing loss. From various literature references, bile acids show concentration and tissue-dependent effects. Some hydrophobic bile acids act as ligands modulating vitamin D receptors, muscarinic receptors, and calcium-activated potassium channels, important proteins in the inner ear system. Currently, there are limited resources investigating the therapeutic effects of bile acid on hearing loss and little to no information on detecting bile acids in the remote ear system, let alone baseline bile acid levels and their prevalence in healthy and disease conditions. This review presents both hydrophilic and hydrophobic human bile acids and their tissue-specific effects in modulating cellular integrity, thus considering the possible effects and extended therapeutic applicability of bile acids to the inner ear tissue.
Language	English
Publishing date	2024-01-08
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/0113894501278292231223035733
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Article ; Online: Overestimation of 3α- over 3β

Schorr, Pascal / Kovačević, Borislav / Volmer, Dietrich A

Journal of the American Society for Mass Spectrometry

2021 Volume 32, Issue 4, Page(s) 1116–1125

Abstract: The metabolism of vitamin ... ...

Abstract	The metabolism of vitamin D
MeSH term(s)	Calcifediol/blood ; Calcifediol/chemistry ; Chromatography, Liquid/methods ; Density Functional Theory ; Gases ; Molecular Structure ; Protons ; Solvents ; Stereoisomerism ; Tandem Mass Spectrometry/methods
Chemical Substances	Gases ; Protons ; Solvents ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2021-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.1c00054
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