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  1. Article ; Online: Advancements in ocular gene therapy delivery: vectors and subretinal, intravitreal, and suprachoroidal techniques.

    Kovacs, Kyle D / Ciulla, Thomas A / Kiss, Szilárd

    Expert opinion on biological therapy

    2022  Volume 22, Issue 9, Page(s) 1193–1208

    Abstract: Introduction: Ocular gene therapy represents fertile ground for rapid innovation, with ever-expanding therapeutic strategies, molecular targets, and indications.: Areas covered: Potential indications for ocular gene therapy have classically focused ... ...

    Abstract Introduction: Ocular gene therapy represents fertile ground for rapid innovation, with ever-expanding therapeutic strategies, molecular targets, and indications.
    Areas covered: Potential indications for ocular gene therapy have classically focused on inherited retinal disease (IRD) but more recently include acquired retinal diseases, such as neovascular age-related macular degeneration, geographic atrophy, and diabetic retinopathy. Ocular gene therapy strategies have proliferated recently, and include gene augmentation, gene inactivation, gene editing, RNA modulation, and gene-independent gene augmentation. Viral vector therapeutic constructs include adeno-associated virus and lentivirus and continue to evolve through directed evolution and rationale design. Ocular gene therapy administration techniques have expanded beyond pars plana vitrectomy with subretinal injection to intravitreal injection and suprachoroidal injection.
    Expert opinion: The success of treatment for IRD, paired with the promise of clinical research in acquired retinal diseases and in administration techniques, has raised the possibility of in-office gene therapy for common retinal disorders within the next 5 to 10 years.
    MeSH term(s) Dependovirus/genetics ; Gene Transfer Techniques ; Genetic Therapy/methods ; Genetic Vectors ; Humans ; Intravitreal Injections ; Retinal Diseases/genetics ; Retinal Diseases/therapy
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2022.2121646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TECHNIQUE FOR REMOVAL OF A GANCICLOVIR IMPLANT DISLOCATED IN THE VITREOUS CAVITY.

    Lenis, Tamara L / Botsford, Benjamin E / Kovacs, Kyle D / Papakostas, Thanos D

    Retinal cases & brief reports

    2022  Volume 18, Issue 1, Page(s) 91–93

    Abstract: Purpose: To report a technique to remove a dislocated ganciclovir implant in the vitreous cavity.: Methods: Retrospective case series. Two patients with dislocated ganciclovir implants in the vitreous cavity.: Results: A 6-mm pars plana incision ... ...

    Abstract Purpose: To report a technique to remove a dislocated ganciclovir implant in the vitreous cavity.
    Methods: Retrospective case series. Two patients with dislocated ganciclovir implants in the vitreous cavity.
    Results: A 6-mm pars plana incision was made; the soft tip was used to elevate the implant behind the intraocular lens and then 0.12-mm forceps were used to externalize the implant. The implant was successfully removed in both patients.
    Conclusion: Removal of a dislocated ganciclovir implant with its encasing strut can be effectively retrieved using a bimanual approach.
    MeSH term(s) Humans ; Ganciclovir ; Retrospective Studies ; Lenses, Intraocular ; Vitrectomy/methods
    Chemical Substances Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: OCT Findings in Presumed Digoxin Retinal Toxicity.

    Capellan, Pamela / Mahrous, M Abdallah / Kovacs, Kyle D

    Ophthalmology. Retina

    2021  Volume 5, Issue 11, Page(s) 1173–1175

    MeSH term(s) Aged, 80 and over ; Cardiotonic Agents/adverse effects ; Digoxin/adverse effects ; Female ; Humans ; Retina/diagnostic imaging ; Retina/drug effects ; Retinal Diseases/chemically induced ; Retinal Diseases/diagnosis ; Tomography, Optical Coherence/methods
    Chemical Substances Cardiotonic Agents ; Digoxin (73K4184T59)
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2021.04.019
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  4. Article ; Online: Quantitative Modeling of Ultra-Widefield Choroidal Indocyanine Green Angiography in Systemic Vascular Diseases.

    Kovacs, Kyle D / Young, Benjamin / Adelman, Ron A

    Ophthalmic surgery, lasers & imaging retina

    2021  Volume 52, Issue 5, Page(s) 281–287

    Abstract: Background and objective: To evaluate quantitative measurements of choroidal vasculature as obtained via ultra-widefield indocyanine green angiography (ICGA) in patients with systemic vascular diseases.: Patients and methods: Retrospective chart ... ...

    Abstract Background and objective: To evaluate quantitative measurements of choroidal vasculature as obtained via ultra-widefield indocyanine green angiography (ICGA) in patients with systemic vascular diseases.
    Patients and methods: Retrospective chart review and image analysis of 38 eyes from 21 patients with ICGA as part of routine retinal care. Images were binarized with lines drawn at specific antero-posterior landmarks. The vessel density and mean vessel caliber were measured along these lines and correlated with systemic vascular disease status.
    Results: Unlike those with other systemic vascular diseases, patients with obstructive sleep apnea (OSA) were found to have increased choroidal vascular density and vessel caliber in all measurements of the peripheral choroid compared with those patients without (
    Conclusions: Patients with OSA may have increased vascular density secondary to increased choroidal vessel caliber. Further work is needed to validate the modeling and confirm the association.
    MeSH term(s) Choroid ; Coloring Agents ; Fluorescein Angiography ; Humans ; Indocyanine Green ; Retrospective Studies ; Vascular Diseases
    Chemical Substances Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2021-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20210429-06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 756: Show issues Location:
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  5. Article: Fractal Dimension Analysis of Widefield Choroidal Vasculature as Predictor of Stage of Macular Degeneration.

    Young, Benjamin K / Kovacs, Kyle D / Adelman, Ron A

    Translational vision science & technology

    2020  Volume 9, Issue 7, Page(s) 22

    Abstract: Purpose: To evaluate the fractal dimension (: Methods: Widefield ICG angiography performed on 38 eyes was retrospectively analyzed using the FracLac application within the National Institutes of Health ImageJ software to determine regional fractal ... ...

    Abstract Purpose: To evaluate the fractal dimension (
    Methods: Widefield ICG angiography performed on 38 eyes was retrospectively analyzed using the FracLac application within the National Institutes of Health ImageJ software to determine regional fractal dimensions in the macular field and widefield. These values were then associated with a diagnosis of no AMD, non-exudative AMD (subdivided into early/intermediate stage vs. advanced stage), or exudative AMD (subdivided into with or without geographic atrophy). The mean values were compared using Wilcoxon's test.
    Results: Early/intermediate non-exudative AMD and exudative AMD without geographic atrophy were found to have statistically significantly lower
    Conclusions: Advanced stages of macular degeneration were found to have significantly decreased the fractal dimensions of choroidal vasculature on widefield ICG compared to early/intermediate stages, possibly implying a generalized reduction in complexity and/or vessel caliber of the choroid with advancing stage of AMD. This finding agrees with previous understanding of the development of choriocapillaris atrophy in advanced macular degeneration.
    Translational relevance: These findings suggest that using automated fractal analysis techniques can aid in differentiating stages of macular degeneration and, with further study, may be used to predict advancement of macular degeneration.
    MeSH term(s) Choroid/diagnostic imaging ; Fluorescein Angiography ; Fractals ; Humans ; Macular Degeneration/diagnosis ; Retrospective Studies ; United States
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2674602-5
    ISSN 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.9.7.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A 4-Year-Old Girl With Earache and Double Vision.

    Feng, Paula W / Kovacs, Kyle D / Fisayo, Adeniyi A

    JAMA ophthalmology

    2020  Volume 139, Issue 2, Page(s) 232–233

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Child, Preschool ; Diplopia/etiology ; Diplopia/physiopathology ; Diplopia/therapy ; Earache/etiology ; Earache/therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Ear Ventilation ; Otitis Media, Suppurative/complications ; Otitis Media, Suppurative/diagnosis ; Otitis Media, Suppurative/therapy ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/etiology ; Sinus Thrombosis, Intracranial/therapy ; Spinal Puncture ; Treatment Outcome ; Vision, Ocular
    Chemical Substances Anti-Bacterial Agents ; Anticoagulants
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.4057
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    Ul I Zs.26: Show issues Location:
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  7. Article ; Online: NOVEL MFRP MUTATION WITH NANOPHTHALMOS, OPTIC DISK DRUSEN, AND PERIPHERAL RETINOSCHISIS IMAGED WITH ULTRA-WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY.

    Kovacs, Kyle D / Van Tassel, Sarah H / Gupta, Mrinali P

    Retinal cases & brief reports

    2021  Volume 17, Issue 3, Page(s) 269–272

    Abstract: Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled- ... ...

    Abstract Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein).
    Methods: Case report of a single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services, and review of the relevant literature.
    Results: A patient with a novel homozygous mutation in the MFRP gene (c.472C>T) presented with nanophthalmos, optic disk drusen, foveal hypoplasia, and extensive peripheral retinoschisis, which was revealed to be multilevel retinoschisis on ultra-widefield optical coherence tomography. Unlike other reported cases, the findings associated with this novel mutation did not include foveoschisis or clinically obvious retinitis pigmentosa. The patient underwent prophylactic peripheral laser iridotomy in both eyes.
    Conclusion: Here, we present a patient with nanophthalmos, optic disk drusen, and foveal hypoplasia associated with extensive peripheral retinoschisis imaged by ultra-widefield optical coherence tomography, but not foveal retinoschisis or prominent retinitis pigmentosa. The findings may expand the clinical spectrum of MFRP -associated nanophthalmos.
    MeSH term(s) Humans ; Microphthalmos ; Optic Disk Drusen ; Retinoschisis/complications ; Tomography, Optical Coherence ; Retinitis Pigmentosa/genetics ; Retina ; Mutation ; Membrane Proteins/genetics
    Chemical Substances MFRP protein, human ; Membrane Proteins
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001179
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  8. Article ; Online: Cicatricial Eyelid Paralysis Secondary to Trigeminal Trophic Syndrome.

    Kovacs, Kyle D / Ehrlich, Michael S

    Ophthalmic plastic and reconstructive surgery

    2017  Volume 33, Issue 3, Page(s) e78

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/IOP.0000000000000766
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    Zs.A 2159: Show issues Location:
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  9. Article ; Online: Hypopyon following selective laser trabeculoplasty.

    Koenig, Lisa R / Kovacs, Kyle D / Gupta, Mrinali P / Van Tassel, Sarah H

    American journal of ophthalmology case reports

    2020  Volume 18, Page(s) 100675

    Abstract: Purpose: To report a hypopyon following selective laser trabeculoplasty (SLT).: Observations: An 85-year-old woman with primary open-angle glaucoma underwent routine SLT. In the early post-procedural period, she presented with pain and decreased ... ...

    Abstract Purpose: To report a hypopyon following selective laser trabeculoplasty (SLT).
    Observations: An 85-year-old woman with primary open-angle glaucoma underwent routine SLT. In the early post-procedural period, she presented with pain and decreased vision, and she was found to have hypopyon, trabeculitis, and corneal edema. The patient was treated with prednisolone acetate and empirically with valacyclovir due to the possibility of herpetic keratouveitis. Work-up for potential etiologies was unrevealing. Her symptoms resolved with treatment, and at eight months follow-up her visual acuity and intraocular pressure had stabilized to her baseline.
    Conclusions: Though safe, SLT may be associated with rare adverse events requiring intervention. Hypopyon following SLT is extremely rare, and investigation for causes unrelated to the history of SLT should be undertaken as appropriate.
    Importance: To the best of our knowledge, this is the first report of a hypopyon following SLT in a patient with no history of inflammatory intra-ocular disease.
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2020.100675
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  10. Article ; Online: Viscostretch: A Novel Surgical Technique for Refractory Macular Holes.

    Kovacs, Kyle D / Gonzalez, Luis A / Mahrous, Abdallah / D'Amico, Donald J

    Journal of vitreoretinal diseases

    2020  Volume 4, Issue 3, Page(s) 239–242

    Abstract: Purpose: We present a novel technique of subretinal viscodissection for addressing refractory macular holes (MHs).: Methods: A case report and surgical technique description are provided.: Results: In this technique, standard pars plana vitrectomy ...

    Abstract Purpose: We present a novel technique of subretinal viscodissection for addressing refractory macular holes (MHs).
    Methods: A case report and surgical technique description are provided.
    Results: In this technique, standard pars plana vitrectomy with internal limiting membrane peeling (unless previously peeled) is performed. A cohesive ophthalmic viscosurgical device (OVD) is injected through the MH, focally detaching the parafoveal retinal tissue around the hole. The OVD is removed at the conclusion of the air-fluid exchange. We provide an example of a recurrent 833-µm MH that was successfully closed despite failing initial surgery. There was no retention of subretinal OVD, and anatomic closure was achieved in this patient with a refractory MH.
    Conclusions: In refractory holes with adhesions at the MH base, this technique mobilizes the adjacent retinal tissue and uses the air's surface tension to facilitate closure. Surgeons can consider using this technique as part of their MH arsenal.
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Case Reports
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/2474126420910914
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