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  1. Book ; Online ; E-Book: Genome stability

    Kovalchuk, Igor / Kovalchuk, Olga

    from virus to human application

    (Translational epigenetics ; 26)

    2021  

    Author's details edited by Igor Kovalchuk, Olga Kovalchuk
    Series title Translational epigenetics ; 26
    Translational epigenetics series
    Collection Translational epigenetics series
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xviii, 741 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020999983
    ISBN 978-0-323-85680-5 ; 9780323856799 ; 0-323-85680-2 ; 0323856799
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract.

    Cherkasova, Viktoriia / Ilnytskyy, Yaroslav / Kovalchuk, Olga / Kovalchuk, Igor

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scientists to look for ...

    Abstract Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scientists to look for alternatives or synergistic combinations with other drugs. In this work, we attempted to find a potential synergistic effect between cisplatin and cannabinoid delta-9-THC, as well as the high-THC
    MeSH term(s) Humans ; Cisplatin/pharmacology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Dronabinol/pharmacology ; Cannabis/chemistry ; Plant Extracts/pharmacology ; Transcriptome/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; HT29 Cells ; Gene Expression Profiling/methods ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Apoptosis/drug effects
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Dronabinol (7J8897W37S) ; Plant Extracts ; Antineoplastic Agents
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells.

    Cherkasova, Viktoriia / Ilnytskyy, Yaroslav / Kovalchuk, Olga / Kovalchuk, Igor

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the development of drug resistance and multiple adverse effects remain common in clinical ... ...

    Abstract Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the development of drug resistance and multiple adverse effects remain common in clinical settings. Thus, there is a necessity to find novel treatments and drug combinations that could effectively target colorectal cancer cells and lower the probability of disease relapse. To find potential synergistic interaction, we designed multiple different combinations between cisplatin, cannabidiol, and intermittent serum starvation on colorectal cancer cell lines. Based on the cell viability assay, we found that combinations between cannabidiol and intermittent serum starvation, cisplatin and intermittent serum starvation, as well as cisplatin, cannabidiol, and intermittent serum starvation can work in a synergistic fashion on different colorectal cancer cell lines. Furthermore, we analyzed differentially expressed genes and affected pathways in colorectal cancer cell lines to understand further the potential molecular mechanisms behind the treatments and their interactions. We found that synergistic interaction between cannabidiol and intermittent serum starvation can be related to changes in the transcription of genes responsible for cell metabolism and cancer's stress pathways. Moreover, when we added cisplatin to the treatments, there was a strong enrichment of genes taking part in G2/M cell cycle arrest and apoptosis.
    MeSH term(s) Humans ; Cisplatin/pharmacology ; Cannabidiol/pharmacology ; Cell Line, Tumor ; Apoptosis/genetics ; Gene Expression Profiling ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Drug Synergism
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Cannabidiol (19GBJ60SN5) ; Antineoplastic Agents
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Impact of Psilocybin on High Glucose/Lipid-Induced Changes in INS-1 Cell Viability and Dedifferentiation.

    Gojani, Esmaeel Ghasemi / Wang, Bo / Li, Dong-Ping / Kovalchuk, Olga / Kovalchuk, Igor

    Genes

    2024  Volume 15, Issue 2

    Abstract: Serotonin emerges as a pivotal factor influencing the growth and functionality of β-cells. Psilocybin, a natural compound derived from mushrooms of ... ...

    Abstract Serotonin emerges as a pivotal factor influencing the growth and functionality of β-cells. Psilocybin, a natural compound derived from mushrooms of the
    MeSH term(s) Animals ; Rats ; Psilocybin/pharmacology ; Cell Survival ; Serotonin ; Diabetes Mellitus, Type 2 ; Glucose/pharmacology ; Lipids ; Cell Cycle Proteins
    Chemical Substances Psilocybin (2RV7212BP0) ; Serotonin (333DO1RDJY) ; Glucose (IY9XDZ35W2) ; Lipids ; TXNIP protein, rat ; Cell Cycle Proteins
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15020183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: High-CBD cannabis extracts inhibit the expression of proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cells.

    Wang, Bo / Li, Dongping / Fiselier, Anna / Kovalchuk, Igor / Kovalchuk, Olga

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18817

    Abstract: The incidence of chronic inflammatory disorders and autoimmune diseases is rapidly growing. To date, the COVID-19 pandemic caused by SARS-CoV-2 has killed over 6,209,000 people globally, while no drug has been proven effective for the disease. Screening ... ...

    Abstract The incidence of chronic inflammatory disorders and autoimmune diseases is rapidly growing. To date, the COVID-19 pandemic caused by SARS-CoV-2 has killed over 6,209,000 people globally, while no drug has been proven effective for the disease. Screening natural anti-inflammatory compounds for clinical application has drawn much attention. In this study, we showed that high-CBD cannabis extracts #1, #5, #7, #169, and #317 suppressed the levels of expression of proinflammatory cyclooxygenase 2 (COX2) and increased the expression of the anti-inflammatory suppressor of cytokine signaling 3 (SOCS3) in human small intestinal epithelial cells (HSIEC) in TNFα/IFNγ-triggered inflammation. We revealed that these extracts, with the exception of extract #169, also profoundly attenuated induction of proinflammatory cytokines interleukin-6 (IL-6) and/or IL-8 proteins through miR-760- and miR-302c-3p-mediated silencing. The prevalent components in extracts #1 and #7 influenced the levels of IL-8 both individually as well as in combination with each other. However, the high-dose cannabis extracts displayed an inhibitory effect in the growth of HSIEC cells. These results show that our high-CBD cannabis extracts decrease the levels of proinflammatory molecules COX2, IL-6, and IL-8 via transcriptional suppression or miRNA-mediated silencing, highlighting their potential against COVID-19-associated cytokine storm syndrome.
    Language English
    Publishing date 2023-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stress, diet, exercise: Common environmental factors and their impact on epigenetic age.

    Galkin, Fedor / Kovalchuk, Olga / Koldasbayeva, Diana / Zhavoronkov, Alex / Bischof, Evelyne

    Ageing research reviews

    2023  Volume 88, Page(s) 101956

    Abstract: Epigenetic aging clocks have gained significant attention as a tool for predicting age-related health conditions in clinical and research settings. They have enabled geroscientists to study the underlying mechanisms of aging and assess the effectiveness ... ...

    Abstract Epigenetic aging clocks have gained significant attention as a tool for predicting age-related health conditions in clinical and research settings. They have enabled geroscientists to study the underlying mechanisms of aging and assess the effectiveness of anti-aging therapies, including diet, exercise and environmental exposures. This review explores the effects of modifiable lifestyle factors' on the global DNA methylation landscape, as seen by aging clocks. We also discuss the underlying mechanisms through which these factors contribute to biological aging and provide comments on what these findings mean for people willing to build an evidence-based pro-longevity lifestyle.
    MeSH term(s) Humans ; Epigenesis, Genetic ; Aging/genetics ; Longevity/genetics ; DNA Methylation ; Diet
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.101956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Medical Cannabis in Pediatric Oncology: Friend or Foe?

    Malach, Megan / Kovalchuk, Igor / Kovalchuk, Olga

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 3

    Abstract: The antineoplastic effects of cannabis have been known since 1975. Since the identification of the components of the endogenous cannabinoid system (ECS) in the 1990s, research into the potential of cannabinoids as medicine has exploded, including in anti- ...

    Abstract The antineoplastic effects of cannabis have been known since 1975. Since the identification of the components of the endogenous cannabinoid system (ECS) in the 1990s, research into the potential of cannabinoids as medicine has exploded, including in anti-cancer research. However, nearly all of this research has been on adults. Physicians and governing bodies remain cautious in recommending the use of cannabis in children, since the ECS develops early in life and data about cannabis exposure in utero show negative outcomes. However, there exist many published cases of use of cannabis in children to treat pediatric epilepsy and chemotherapy-induced nausea and vomiting (CINV) that show both the safety and efficacy of cannabis in pediatric populations. Additionally, promising preclinical evidence showing that cannabis has anti-cancer effects on pediatric cancer warrants further investigation of cannabis' use in pediatric cancer patients, as well as other populations of pediatric patients. This review aims to examine the evidence regarding the potential clinical utility of cannabis as an anti-cancer treatment in children by summarizing what is currently known about uses of medical cannabis in children, particularly regarding its anti-cancer potential.
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15030359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cannabinoids and terpenes for diabetes mellitus and its complications: from mechanisms to new therapies.

    Ghasemi-Gojani, Esmaeel / Kovalchuk, Igor / Kovalchuk, Olga

    Trends in endocrinology and metabolism: TEM

    2022  Volume 33, Issue 12, Page(s) 828–849

    Abstract: The number of people diagnosed with diabetes mellitus and its complications is markedly increasing worldwide, leading to a worldwide epidemic across all age groups, from children to older adults. Diabetes is associated with premature aging. In recent ... ...

    Abstract The number of people diagnosed with diabetes mellitus and its complications is markedly increasing worldwide, leading to a worldwide epidemic across all age groups, from children to older adults. Diabetes is associated with premature aging. In recent years, it has been found that peripheral overactivation of the endocannabinoid system (ECS), and in particular cannabinoid receptor 1 (CB1R) signaling, plays a crucial role in the progression of insulin resistance, diabetes (especially type 2), and its aging-related comorbidities such as atherosclerosis, nephropathy, neuropathy, and retinopathy. Therefore, it is suggested that peripheral blockade of CB1R may ameliorate diabetes and diabetes-related comorbidities. The use of synthetic CB1R antagonists such as rimonabant has been prohibited because of their psychiatric side effects. In contrast, phytocannabinoids such as cannabidiol (CBD) and tetrahydrocannabivarin (THCV), produced by cannabis, exhibit antagonistic activity on CB1R signaling and do not show any adverse side effects such as psychoactive effects, depression, or anxiety, thereby serving as potential candidates for the treatment of diabetes and its complications. In addition to these phytocannabinoids, cannabis also produces a substantial number of other phytocannabinoids, terpenes, and flavonoids with therapeutic potential against insulin resistance, diabetes, and its complications. In this review, the pathogenesis of diabetes, its complications, and the potential to use cannabinoids, terpenes, and flavonoids for its treatment are discussed.
    MeSH term(s) Child ; Humans ; Aged ; Cannabinoids/therapeutic use ; Terpenes/therapeutic use ; Insulin Resistance ; Cannabis ; Cannabinoid Receptor Agonists/pharmacology ; Diabetes Mellitus/drug therapy ; Flavonoids
    Chemical Substances Cannabinoids ; Terpenes ; Cannabinoid Receptor Agonists ; Flavonoids
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2022.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Cannabinoids as anticancer therapeutic agents.

    Kovalchuk, Olga / Kovalchuk, Igor

    Cell cycle (Georgetown, Tex.)

    2020  Volume 19, Issue 9, Page(s) 961–989

    Abstract: The recent announcement of marijuana legalization in Canada spiked many discussions about potential health benefits ... ...

    Abstract The recent announcement of marijuana legalization in Canada spiked many discussions about potential health benefits of
    MeSH term(s) Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Cannabinoids/metabolism ; Cannabinoids/therapeutic use ; Cannabis/chemistry ; Humans ; Neoplasms/drug therapy ; Phytotherapy/methods ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism
    Chemical Substances Antineoplastic Agents ; Cannabinoids ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2020-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2020.1742952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Cannabinol inhibits cell growth and triggers cell cycle arrest and apoptosis in cancer cells

    Zhong, Nuanying / Li, Dongping / Wang, Bo / Kovalchuk, Olga / Kovalchuk, Igor

    Biocatalysis and Agricultural Biotechnology. 2023 Mar., v. 48 p.102627-

    2023  

    Abstract: Cannabinol (CBN) is a weak-psychoactive cannabinoid and has been shown to exert several bio-logical activities. At the same time, not much is known about the anti-cancer activities of CBN. In this report, we characterized the anti-tumor effects of CBN on ...

    Abstract Cannabinol (CBN) is a weak-psychoactive cannabinoid and has been shown to exert several bio-logical activities. At the same time, not much is known about the anti-cancer activities of CBN. In this report, we characterized the anti-tumor effects of CBN on the glioma A172, liver cancer HepG2 and breast cancer HCC1806 cell lines. We found that CBN reduces the proliferation of the analyzed cancer cells and modulates the level of cannabinoid receptors, including GPR18, CB2 and GPR55. Furthermore, CBN inhibits the ERK1/2 pathway in A172 and HepG2 cells, while suppressing the AKT pathway in HCC1086 cells. Moreover, CBN may cause apoptosis through downregulation of p21 and p27 as well as a cell cycle arrest at G1 or S-phase via decreasing the CDK1, CDK2, and cyclin E1 levels. Taken together, these results offer new insights into the anti-cancer properties of CBN.
    Keywords agricultural biotechnology ; apoptosis ; biocatalysis ; breast neoplasms ; cannabinoids ; cell cycle checkpoints ; cell growth ; cyclin-dependent kinase ; cyclins ; glioma ; liver neoplasms ; Cannabinol ; Cell cycle arrest ; Cancer ; AKT pathway ; ERK pathway ; CDKs
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2642052-1
    ISSN 1878-8181
    ISSN 1878-8181
    DOI 10.1016/j.bcab.2023.102627
    Database NAL-Catalogue (AGRICOLA)

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