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  1. Article ; Online: Resolution by diastereomeric salts: Access to both enantiomers of racemic acid using the same enantiomer of resolving base.

    Kovalenko, Vitaly / Císařová, Ivana

    Chirality

    2023  Volume 35, Issue 12, Page(s) 1012–1018

    Abstract: Racemic carboxylic acid, a Diels-Alder cycloadduct derived from 5-bromo-3-phenyl-α-pyrone and acrylate dienophile, was resolved into enantiomers by diastereomeric salt crystallization. Quinidine was used as a sole resolving base. The salt of (+)-acid ... ...

    Abstract Racemic carboxylic acid, a Diels-Alder cycloadduct derived from 5-bromo-3-phenyl-α-pyrone and acrylate dienophile, was resolved into enantiomers by diastereomeric salt crystallization. Quinidine was used as a sole resolving base. The salt of (+)-acid crystallized from aqueous acetonitrile solution. Once this salt was separated by filtration, quinidine salt with (-)-acid crystallized from mother liquor. As a result, both enantiomers of Diels-Alder cycloadduct were isolated in high enantiomeric purity.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1011639-4
    ISSN 1520-636X ; 0899-0042
    ISSN (online) 1520-636X
    ISSN 0899-0042
    DOI 10.1002/chir.23615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: FEATURES OF EJACULATE MICROBIOCENOSIS IN MEN WITH IMPAIRED FERTILITY, DEPENDING ON THE TYPE OF CONSUMED ALCOHOLIC BEVERAGES.

    Vorontsova, L / Kozachuk, A / Kovalenko, V

    Georgian medical news

    2021  , Issue 320, Page(s) 27–32

    Abstract: Due to the lack of both common conception concerning etiology of male infertility and data about disorders of immune homeostasis concomitant with dysbiosis of urogenital tract in men with damages of reproductive function depending on features of ... ...

    Abstract Due to the lack of both common conception concerning etiology of male infertility and data about disorders of immune homeostasis concomitant with dysbiosis of urogenital tract in men with damages of reproductive function depending on features of alcoholic anamnesis, the aim of our research is studying influence of microbiocenoses in ejaculate on nonspecific immune factors in males suffering from fertile function damages depending on kind and amount of alcohol used. This article deals with findings concerning condition of semen analysis, cellular agents in innate immunity, bacteriological investigation of ejaculate in 73 males divided in 5 groups, depending on amount and kind of alcohol. According to data obtained it was established that all patients in groups under research suffered from incomplete phagocytosis in neutrophils links secondary to retaining functional and metabolic reserve in using strong alcoholic drinks and in its exhaustion in drinking excess bear and mixed alcohol. Studying microflora in ejaculate has shown presence only G+ flora (Staphylococcus haemolyticus, Staphylococcus epidermidis, Enterococcus faecalis) in drinking excess strong alcohol but in drinking excess bear and mixed alcohol both G+ microflora (Staphylococcus epidermidis, Enterococcus faecalis) and G- microflora (Escherichia coli, Klebsiella pneumoniae) have been observed. Associations of microorganisms have been revealed in males of all groups under research, in this case the most number of them has been revealed in drinking excess bear. In turn, the semen analysis showed that the most evident changes in ejaculate fertile properties were being observed at middle and high risk in consumption of beer and alcohol mixed, as astenoteratozoospermia. Proceeding from the data obtained one may suppose that drinking alcohol mixed is the factor causing development of incompetence for nonspecific protection, because it might lead to damages of microbiocenoses in ejaculate and male fertility reduced consequently.
    MeSH term(s) Alcohol Drinking/adverse effects ; Alcoholic Beverages ; Ethanol ; Fertility ; Humans ; Immunity, Innate ; Male
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-12-12
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
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  3. Article ; Online: Scalable Synthesis of All Stereoisomers of 2-Aminocyclopentanecarboxylic Acid─A Toolbox for Peptide Foldamer Chemistry.

    Kovalenko, Vitaly / Rudzińska-Szostak, Ewa / Ślepokura, Katarzyna / Berlicki, Łukasz

    The Journal of organic chemistry

    2024  Volume 89, Issue 7, Page(s) 4760–4767

    Abstract: Although the construction of peptides with well-defined three-dimensional structures and predictable functions, including biological activity, using conformationally constrained β-amino acids has been shown to be a very successful strategy, their broad ... ...

    Abstract Although the construction of peptides with well-defined three-dimensional structures and predictable functions, including biological activity, using conformationally constrained β-amino acids has been shown to be a very successful strategy, their broad application is limited by access to the appropriate building blocks. In particular,
    MeSH term(s) Stereoisomerism ; Peptides/chemistry ; Amino Acids/chemistry ; Magnetic Resonance Spectroscopy
    Chemical Substances Peptides ; Amino Acids
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02991
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Paired acoustic recordings and point count surveys reveal Clark's nutcracker and whitebark pine associations across Glacier National Park.

    Kovalenko, Vladimir / Doser, Jeffrey W / Bate, Lisa J / Six, Diana L

    Ecology and evolution

    2024  Volume 14, Issue 1, Page(s) e10867

    Abstract: Global declines in tree populations have led to dramatic shifts in forest ecosystem composition, biodiversity, and functioning. These changes have consequences for both forest plant and wildlife communities, particularly when declining species are ... ...

    Abstract Global declines in tree populations have led to dramatic shifts in forest ecosystem composition, biodiversity, and functioning. These changes have consequences for both forest plant and wildlife communities, particularly when declining species are involved in coevolved mutualisms. Whitebark pine (
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10867
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  5. Article ; Online: Layered Double Hydroxides as the Unique Product of Target Ionic Construction for Energy, Chemical, Foods, Cosmetics, Medicine and Ecology Applications.

    Kovalenko, Vadym / Kotok, Valerii / Murashevych, Bohdan

    Chemical record (New York, N.Y.)

    2023  Volume 24, Issue 2, Page(s) e202300260

    Abstract: Layered Double Hydroxide (LDH) is an α-modification of the M-host ( ... ...

    Abstract Layered Double Hydroxide (LDH) is an α-modification of the M-host (M
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2044646-9
    ISSN 1528-0691 ; 1527-8999
    ISSN (online) 1528-0691
    ISSN 1527-8999
    DOI 10.1002/tcr.202300260
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  6. Article: [MENTAL DERANGEMENT AS A MANDATORY MEDICAL CRITERION OF LIMITED SANTY].

    Akimov, M / Politova, A / Pekarskyi, S / Kovalenko, V / Telefanko, B

    Georgian medical news

    2021  , Issue 313, Page(s) 113–117

    Abstract: The aim of the article is scientific conceptualization of the problem of mental derangement as a mandatory medical criterion of limited sanity according to criminal legislation by experience of Ukraine and some foreign countries and development of new ... ...

    Abstract The aim of the article is scientific conceptualization of the problem of mental derangement as a mandatory medical criterion of limited sanity according to criminal legislation by experience of Ukraine and some foreign countries and development of new approaches to such status assessment. Empirical study base of the problem consists of judgments of conviction taken from Unified State Register of Court Rulings of Ukraine and carried out on persons who commit crimes in the state of limited sanity from March 1st, 2014, till August 1st, 2020. Results of some foreign researchers' studies of the problem in question have been used as well. A combination of general and special scientific methods (comparative method, system structural method, method of statistical analysis, method of legal phenomenon system analysis etc.) has been applied to reach the aim in view. In conclusion: medical criterion of limited sanity ("mental derangement") used by lawmaker does not allow defining clearly types of illnesses, represent all possible types of psychiatric pathology and also causes complications in law enforcement practice. It has been proved that increase of quantity of people having mental derangements and quantity of crimes committed by such people shows that non-application of compulsory measures of medical care, correlational programs leads to repeated crimes commitment. Taking into account absence of duration of compulsory measures of medical care application, it has been suggested to stipulate this by Ukrainian legislation and to develop classification of mental derangements and criteria of their division into severe and non-severe.
    MeSH term(s) Crime ; Criminals ; Humans ; Law Enforcement ; Research Design ; Ukraine
    Language Russian
    Publishing date 2021-06-08
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: TestSpark

    Sapozhnikov, Arkadii / Olsthoorn, Mitchell / Panichella, Annibale / Kovalenko, Vladimir / Derakhshanfar, Pouria

    IntelliJ IDEA's Ultimate Test Generation Companion

    2024  

    Abstract: Writing software tests is laborious and time-consuming. To address this, prior studies introduced various automated test-generation techniques. A well-explored research direction in this field is unit test generation, wherein artificial intelligence (AI) ...

    Abstract Writing software tests is laborious and time-consuming. To address this, prior studies introduced various automated test-generation techniques. A well-explored research direction in this field is unit test generation, wherein artificial intelligence (AI) techniques create tests for a method/class under test. While many of these techniques have primarily found applications in a research context, existing tools (e.g., EvoSuite, Randoop, and AthenaTest) are not user-friendly and are tailored to a single technique. This paper introduces TestSpark, a plugin for IntelliJ IDEA that enables users to generate unit tests with only a few clicks directly within their Integrated Development Environment (IDE). Furthermore, TestSpark also allows users to easily modify and run each generated test and integrate them into the project workflow. TestSpark leverages the advances of search-based test generation tools, and it introduces a technique to generate unit tests using Large Language Models (LLMs) by creating a feedback cycle between the IDE and the LLM. Since TestSpark is an open-source (https://github.com/JetBrains-Research/TestSpark), extendable, and well-documented tool, it is possible to add new test generation methods into the plugin with the minimum effort. This paper also explains our future studies related to TestSpark and our preliminary results. Demo video: https://youtu.be/0F4PrxWfiXo
    Keywords Computer Science - Software Engineering
    Subject code 000
    Publishing date 2024-01-12
    Publishing country us
    Document type Book ; Online
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  8. Article: [PREVENTION OF CORRUPTION OFFENCES IN THE HEALTHСARE: THE EXPERIENCE OF UKRAINE AND GEORGIA].

    Didkivska, G / Kovalenko, V / Fialka, M / Samotiievych, V / Sabadash, I

    Georgian medical news

    2020  , Issue 308, Page(s) 185–191

    Abstract: The aim of the article is a comparative and legal study of corruption and measures to combat corruption in health care in Ukraine, using the experience of Georgia and the European Union. The materials of the research are the legislation of the European ... ...

    Abstract The aim of the article is a comparative and legal study of corruption and measures to combat corruption in health care in Ukraine, using the experience of Georgia and the European Union. The materials of the research are the legislation of the European Union, Georgia, Ukraine, statistical information. The authors of the research have used the systematization method, comparative and legal method, analysis and generalization of statistical data. Corruption and corruption offences in the health system may lead to unpredictable consequences impacting accessibility, equity and health outcomes. Fighting against corruption in the health sector consists of the identification of specific forms of corruption and the implementation of effective anti-corruption measures, which must be designed to fit the context of a country's health system. A study of the experience of Georgia and the EU countries shows that, changes in the organization and management of the health system, financing of health care, provision of health services, increase access to medical services, reducing inequalities, financial risks reduction regarding expenditures on medical services, changing public opinion of the perception of corruption, transparency and accountability in the funding of medicine, the anti-corruption examination of legislative acts regulating the activity of healthcare in Ukraine, the formation of anti-corruption behaviour in society, active cooperation with civil society institutions are therefore of primary importance for Ukraine during the period of medical reform. Elimination of the reasons and conditions promoting the commission of corruption offences in the health system and the introduction of an effective anti-corruption strategy based on good governance, transparency and zero tolerance are among the priority areas for improving the current legislation of Ukraine in fighting against corruption in the field of healthcare.
    MeSH term(s) Delivery of Health Care ; European Union ; Georgia (Republic) ; Ukraine
    Language Russian
    Publishing date 2020-12-27
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
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  9. Book ; Online: Constructing Temporal Networks of OSS Programming Language Ecosystems

    Agroskin, Alexander / Lyulina, Elena / Titov, Sergey / Kovalenko, Vladimir

    2023  

    Abstract: One of the primary factors that encourage developers to contribute to open source software (OSS) projects is the collaborative nature of OSS development. However, the collaborative structure of these communities largely remains unclear, partly due to the ...

    Abstract One of the primary factors that encourage developers to contribute to open source software (OSS) projects is the collaborative nature of OSS development. However, the collaborative structure of these communities largely remains unclear, partly due to the enormous scale of data to be gathered, processed, and analyzed. In this work, we utilize the World Of Code dataset, which contains commit activity data for millions of OSS projects, to build collaboration networks for ten popular programming language ecosystems, containing in total over 290M commits across over 18M projects. We build a collaboration graph representation for each language ecosystem, having authors and projects as nodes, which enables various forms of social network analysis on the scale of language ecosystems. Moreover, we capture the information on the ecosystems' evolution by slicing each network into 30 historical snapshots. Additionally, we calculate multiple collaboration metrics that characterize the ecosystems' states. We make the resulting dataset publicly available, including the constructed graphs and the pipeline enabling the analysis of more ecosystems.

    Comment: Accepted to SANER 2023
    Keywords Computer Science - Software Engineering ; Computer Science - Social and Information Networks
    Subject code 000
    Publishing date 2023-04-21
    Publishing country us
    Document type Book ; Online
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  10. Book ; Online: Assessing the Impact of File Ordering Strategies on Code Review Process

    Bagirov, Farid / Derakhshanfar, Pouria / Kalina, Alexey / Kartysheva, Elena / Kovalenko, Vladimir

    2023  

    Abstract: Popular modern code review tools (e.g. Gerrit and GitHub) sort files in a code review in alphabetical order. A prior study (on open-source projects) shows that the changed files' positions in the code review affect the review process. Their results show ... ...

    Abstract Popular modern code review tools (e.g. Gerrit and GitHub) sort files in a code review in alphabetical order. A prior study (on open-source projects) shows that the changed files' positions in the code review affect the review process. Their results show that files placed lower in the order have less chance of receiving reviewing efforts than the other files. Hence, there is a higher chance of missing defects in these files. This paper explores the impact of file order in the code review of the well-known industrial project IntelliJ IDEA. First, we verify the results of the prior study on a big proprietary software project. Then, we explore an alternative to the default Alphabetical order: ordering changed files according to their code diff. Our results confirm the observations of the previous study. We discover that reviewers leave more comments on the files shown higher in the code review. Moreover, these results show that, even with the data skewed toward Alphabetical order, ordering changed files according to their code diff performs better than standard Alphabetical order regarding placing problematic files, which needs more reviewing effort, in the code review. These results confirm that exploring various ordering strategies for code review needs more exploration.
    Keywords Computer Science - Software Engineering
    Subject code 005
    Publishing date 2023-06-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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