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  1. Book ; Thesis: Rückbildungsstadien psychotischer Erkrankungen: eine empirische Untersuchung zur Rückbildung psychotischer Symptome bei schizophrenen Psychosen unter stationärer Behandlung

    Kowalik, Agnieszka

    2018  

    Author's details von Agnieszka Kowalik
    Language German ; English
    Size vi, 112 Blätter, Illustrationen, 31 cm
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, 2019
    HBZ-ID HT020189997
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Dietary Treatment from Birth to Pregnancy in a Woman with Methylmalonic Aciduria.

    Kowalik, Agnieszka / MacDonald, Anita / Sykut-Cegielska, Jolanta

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 2

    Abstract: Methylmalonic aciduria is treated with a natural protein-restricted diet with adequate energy intake to sustain metabolic balance. Natural protein is a source of methylmalonic acid precursors, and intake is individually modified according to the severity ...

    Abstract Methylmalonic aciduria is treated with a natural protein-restricted diet with adequate energy intake to sustain metabolic balance. Natural protein is a source of methylmalonic acid precursors, and intake is individually modified according to the severity and clinical course of the disease. The experience and approach to MMA treatment in European centers is variable with different amounts of natural protein and precursor-free l-amino acids being prescribed, although the outcome appears independent of the use of precursor-free l-amino acids. Further long-term outcome data is necessary for early treated patients with MMA. This case study, a woman with MMA followed from birth to the age of 35 years, including pregnancy, illustrates the long-term course of the disease and lifetime changes in dietary treatment. A low natural protein diet (1.5 g-1.0 g/kg/day) was the foundation of treatment, but temporary supplementation with precursor-free l-amino acids, vitamin-mineral mixture, and energy supplements were necessary at different timepoints (in childhood, adolescence, adulthood and pregnancy). Childhood psychomotor development was slightly delayed but within the normal range in adulthood. There were few episodes of metabolic decompensation requiring IV glucose, but at age 27 years, she required intensive care following steroid treatment. In pregnancy, she remained stable but received intensive biochemical and medical follow-up. This successful long-term follow-up of a patient with MMA from childhood, throughout pregnancy, delivery, and postpartum confirms that careful clinical, biochemical, and dietetic monitoring is crucial to ensure a favourable outcomes in MMA. Personalized treatment is necessary according to the individual clinical course. Knowledge about long-term treatment and clinical outcome is important information to influence future MMA clinical guidelines.
    MeSH term(s) Adolescent ; Adult ; Amino Acid Metabolism, Inborn Errors/drug therapy ; Diet ; Dietary Supplements ; Female ; Humans ; Methylmalonic Acid ; Pregnancy
    Chemical Substances Methylmalonic Acid (8LL8S712J7)
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57020128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Objective assessment of the functional status of stroke patients

    Nowak Karina / Sobota Grzegorz / Sarzyńska-Długosz Iwona / Łukowicz Małgorzata / Nitera-Kowalik Agnieszka / Owsiński Robert / Bujalski Wiesław / Malec Agnieszka / Syczewska Małgorzata

    Biomedical Human Kinetics, Vol 14, Iss 1, Pp 183-

    Can comprehensive rehabilitation treatment improve their functional efficiency?

    2022  Volume 190

    Abstract: Study aim: To check if the short rehabilitation treatment (3 weeks) complemented by complex rehabilitation on advanced equipment improves the functional status of chronic stroke patients; and which clinical and objective parameters can be used to assess ... ...

    Abstract Study aim: To check if the short rehabilitation treatment (3 weeks) complemented by complex rehabilitation on advanced equipment improves the functional status of chronic stroke patients; and which clinical and objective parameters can be used to assess the efficacy of such treatment.
    Keywords stroke ; rehabilitation ; efficacy ; advanced technologically equipment ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations.

    Krukiewicz, Katarzyna / Kowalik, Agnieszka / Turczyn, Roman / Biggs, Manus J P

    Bioelectrochemistry (Amsterdam, Netherlands)

    2020  Volume 134, Page(s) 107528

    Abstract: Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen (IBU), being one of the most ... ...

    Abstract Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen (IBU), being one of the most commonly used non-steroidal anti-inflammatory drugs, is known to possess neuroprotective activity and serve as a promising therapeutic for the treatment of neuroinflammation. In this study, the potential of an IBU-loaded poly(3,4-ethylenedioxypyrrole) (PEDOP) matrix has been assessed as a neural interface material with an aim to control astrocyte activation and suppress neuroinflammation in vitro. Three types of drug immobilization protocols were investigated, leading to the fabrication of IBU-loaded PEDOP matrices exhibiting a broad spectrum of electrical characteristics, drug release profiles, as well as biological responses. Among all investigated PEDOP formulations, PEDOP matrices formed through a three-step immobilization protocol exhibited the highest charge storage capacity (30 ± 1 mC/cm
    MeSH term(s) Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Astrocytes/drug effects ; Astrocytes/pathology ; Drug Compounding ; Drug Liberation ; Ibuprofen/chemistry ; Ibuprofen/pharmacology ; Pyrroles/chemistry
    Chemical Substances Anti-Inflammatory Agents ; Pyrroles ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2020-04-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010650-6
    ISSN 1878-562X ; 0302-4598 ; 1567-5394
    ISSN (online) 1878-562X
    ISSN 0302-4598 ; 1567-5394
    DOI 10.1016/j.bioelechem.2020.107528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Difficulties in the dietary management of a girl with two diseases requiring a special diet.

    Kowalik, Agnieszka / Gajewska, Danuta / Sykut-Cegielska, Jolanta

    Developmental period medicine

    2018  Volume 22, Issue 3, Page(s) 225–228

    Abstract: 3-Methylcrotonylglycinuria (3-MCG) is an autosomal recessive inborn error of leucine metabolism caused by the deficiency of 3-methylocrotonyl-CoA carboxylase (3-MCC deficiency). It is the most commonly detected organic aciduria in newborn screening ... ...

    Abstract 3-Methylcrotonylglycinuria (3-MCG) is an autosomal recessive inborn error of leucine metabolism caused by the deficiency of 3-methylocrotonyl-CoA carboxylase (3-MCC deficiency). It is the most commonly detected organic aciduria in newborn screening conducted by tandem mass spectrometry (MS/MS) [1, 2]. The clinical phenotype is heterogeneous, ranging from asymptomatic to acute metabolic decompensations [3, 4]. Although at least in severe cases and in acute life threatening episodes limiting natural protein intake (particularly leucine) together with high caloric intake during catabolic periods is required, the need for specific dietary management often seems questionable [2]. In contrast with the 3-MCC deficiency, in diabetes mellitus type 1 (DM1) a diet based on carbohydrate and protein-fat exchangers is beyond dispute. However, as DM1 is quite a common disease, it may occur in a single patient with a rare disease, such as 3-MCC deficiency.
    MeSH term(s) Carbon-Carbon Ligases/deficiency ; Child, Preschool ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diet therapy ; Diet ; Diet, Diabetic ; Disease Management ; Female ; Humans ; Urea Cycle Disorders, Inborn/complications ; Urea Cycle Disorders, Inborn/diet therapy
    Chemical Substances Carbon-Carbon Ligases (EC 6.4.-)
    Language English
    Publishing date 2018-09-18
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 2576573-5
    ISSN 1428-345X
    ISSN 1428-345X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Why science cannot be value-free: understanding the rationality and responsibility of science.

    Lekka-Kowalik, Agnieszka

    Science and engineering ethics

    2009  Volume 16, Issue 1, Page(s) 33–41

    Abstract: Against the ideal of value-free science I argue that science is not--and cannot be--value-free and that relevant values are both cognitive and moral. I develop an argument by indicating various aspects of the value-ladenness of science. The recognition ... ...

    Abstract Against the ideal of value-free science I argue that science is not--and cannot be--value-free and that relevant values are both cognitive and moral. I develop an argument by indicating various aspects of the value-ladenness of science. The recognition of the value-ladenness of science requires rethinking our understanding of the rationality and responsibility of science. Its rationality cannot be seen as merely instrumental--as it was seen by the ideal of value-free science--for this would result in limiting the autonomy of science and reducing scientists to "minds to hire". The scientific rationality must be seen as practical rationality which takes into account the full horizon of values. The scientific responsibility must also be broaden in scope and type. On this basis I draw three practical conclusions concerning the organization of research and training of young scientists, appealing to Plato's claim that those most capable of healing are also those most capable of harming.
    MeSH term(s) Beneficence ; Bioethics ; Double Effect Principle ; Ethical Theory ; Ethics, Research ; Goals ; Humans ; Intention ; Judgment/ethics ; Knowledge ; Logic ; Philosophy, Medical ; Politics ; Power, Psychological ; Research Support as Topic/ethics ; Risk Assessment/ethics ; Science/ethics ; Social Responsibility ; Social Values ; Technology Assessment, Biomedical/ethics
    Language English
    Publishing date 2009-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2136491-6
    ISSN 1471-5546 ; 1353-3452
    ISSN (online) 1471-5546
    ISSN 1353-3452
    DOI 10.1007/s11948-009-9128-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Deviations in Peripheral Blood Cell Populations are Associated with the Stage of Primary Biliary Cholangitis and Presence of Itching.

    Cichoż-Lach, Halina / Grywalska, Ewelina / Michalak, Agata / Kowalik, Agnieszka / Mielnik, Michał / Roliński, Jacek

    Archivum immunologiae et therapiae experimentalis

    2018  Volume 66, Issue 6, Page(s) 443–452

    Abstract: To evaluate the role of Th17, Treg cells, activated T ... ...

    Abstract To evaluate the role of Th17, Treg cells, activated T CD3
    MeSH term(s) Adult ; Aged ; B-Lymphocytes/immunology ; Blood Cells/immunology ; Disease Progression ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Liver Cirrhosis, Biliary/immunology ; Lymphocyte Activation ; Middle Aged ; Pruritus/immunology ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology
    Language English
    Publishing date 2018-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-018-0515-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Parametry gospodarki zelazem w przewlekłych chorobach watroby.

    Wójtowicz-Chomicz, Katarzyna / Cichoz-Lach, Halina / Lis, Emilia / Kowalik, Agnieszka / Słomka, Maria / Celiński, Krzysztof

    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

    2013  Volume 35, Issue 206, Page(s) 77–81

    Abstract: Unlabelled: Iron is an essential micronutrient of almost all organisms, which is involved in many metabolic processes. Disorders of serum iron balance that relate mainly to its deficiency are frequently observed in patients with liver diseases. The aim ... ...

    Title translation Serum iron parameters in chronic liver diseses.
    Abstract Unlabelled: Iron is an essential micronutrient of almost all organisms, which is involved in many metabolic processes. Disorders of serum iron balance that relate mainly to its deficiency are frequently observed in patients with liver diseases. The aim of the study was the evaluation of serum iron parameters in patients with different chronic liver diseases and analysis of the relationships between serum level of iron, ferritin and transferrin in women and men in groups examined.
    Material and methods: The study includes 424 patients: 151 with alcoholic liver cirrhosis (ALC), 53 with nonalcoholic fatty liver disease (NAFLD), 54 with autoimmune hepatitis (AIH), 19 patients with hepatocellulare cancer (HOC), 34 with primary biliaris cirrhosis (PBC), 39 with chronic HCV hepatitis, 48 with chronic HBV hepatitis, 15 with primary sclerosans cholangitis (PSC) and 11 patients with hemochromatosis. Forty two healthy volunteers were the control group.
    Results: The highest mean serum level of iron was observed in patients with hemochromatosis and was 278.56 +/- 25.04 mg/dl. The mean level of iron was statistically significant different in patients with HCC in comparison to the patients with ALC (p = 0.0000), with AIH (p = 0.0108) and NAFLD (p = 0.00768). The mean level of ferritin was statistically significantly higher among patients with hemochromatosis (p = 0.0000), with ALC (p = 0.0037) and NAFLD (p = 0.0442) than in the controls. Patients with AIH, HCC, HCV infection, PSC and hemochromatosis showed higher serum level of transferin than the controls (p = 0.0000). The mean level of iron and ferritin was lowerin women than in men in the patients with ALC (p = 0.0088, p = 0.0018 respectively). The mean level of ferritin was significantly lower in men than in women among patients with NAFLD. (p = 0.0065). There were no statistically significant differences in the mean level of examined parameters between the sexes.
    Conclusion: Reduced serum level of iron is observed in chronic liver diseases. Elevated ferritin level is typical for patients with ALC and NAFLD. Differences in the level of iron, ferritin and transferin between men and women concemrn the patients with ALC while among patients with NAFLD only ferritin level differences are found.
    MeSH term(s) Adult ; Aged ; Chronic Disease ; Female ; Ferritins/blood ; Hemochromatosis/blood ; Hemochromatosis/complications ; Humans ; Iron/blood ; Liver Diseases/blood ; Liver Diseases/classification ; Male ; Middle Aged ; Transferrin/metabolism ; Young Adult
    Chemical Substances Transferrin ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language Polish
    Publishing date 2013-08
    Publishing country Poland
    Document type English Abstract ; Journal Article
    ZDB-ID 1388406-2
    ISSN 1426-9686
    ISSN 1426-9686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Realizacja diety z ograniczeniem leucyny, izoleucyny i waliny u dzieci z choroba syropu klonowego (MSUD).

    Kowalik, Agnieszka / Narojek, Lucyna / Sykut-Cegielska, Jolanta

    Roczniki Panstwowego Zakladu Higieny

    2007  Volume 58, Issue 1, Page(s) 95–101

    Abstract: The aim of this study was to evaluate the compliance of the diet with limited branched-chain amino acids (BCAA) content in long-term observation of patients with maple syrup urine disease (MSUD). The study group consisted of 7 children at age of 1.5-18 ... ...

    Title translation Compliance of the diet restricted with leucine, isoleucine and valine in maple syrup urine disease (MSUD) children.
    Abstract The aim of this study was to evaluate the compliance of the diet with limited branched-chain amino acids (BCAA) content in long-term observation of patients with maple syrup urine disease (MSUD). The study group consisted of 7 children at age of 1.5-18 years. Nutrition evaluation was based on current diet records from 3-4 days, every 3-4 months. Energy and nutrition values of proposed daily products lists and diet records was compared with adequate references and recommendations. Energy and content of most of the nutrients in proposed daily products lists were in agreement with RDI except calcium. Diet analysis at MSUD children revealed insufficient contents of: iron, zinc, copper, vitamin B1, B2, niacin and vitamin C (often below 90% RDI).
    MeSH term(s) Adolescent ; Calcium/deficiency ; Child ; Child, Preschool ; Copper/deficiency ; Diet Records ; Dietary Proteins/metabolism ; Energy Intake ; Female ; Humans ; Infant ; Iron/deficiency ; Isoleucine/administration & dosage ; Isoleucine/metabolism ; Leucine/administration & dosage ; Leucine/metabolism ; Longitudinal Studies ; Male ; Maple Syrup Urine Disease/diet therapy ; Maple Syrup Urine Disease/metabolism ; Nutritional Requirements ; Patient Compliance/statistics & numerical data ; Valine/administration & dosage ; Valine/metabolism ; Vitamins/administration & dosage ; Zinc/deficiency
    Chemical Substances Dietary Proteins ; Vitamins ; Isoleucine (04Y7590D77) ; Copper (789U1901C5) ; Iron (E1UOL152H7) ; Leucine (GMW67QNF9C) ; Valine (HG18B9YRS7) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
    Language Polish
    Publishing date 2007
    Publishing country Poland
    Document type English Abstract ; Journal Article
    ZDB-ID 421739-1
    ISSN 0035-7715
    ISSN 0035-7715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: QT Interval Prolongation and QRS Voltage Reduction in Patients with Liver Cirrhosis.

    Cichoż-Lach, Halina / Tomaszewski, Michał / Kowalik, Agnieszka / Lis, Emilia / Tomaszewski, Andrzej / Lach, Tomasz / Boczkowska, Sylwia / Celiński, Krzysztof

    Advances in clinical and experimental medicine : official organ Wroclaw Medical University

    2015  Volume 24, Issue 4, Page(s) 615–622

    Abstract: Background: Liver cirrhosis is associated with functional abnormalities of the cardiovascular system with co-existing electrocardiographic (ECG) abnormalities.: Objectives: The aim was to analyze ECG changes in patients with cirrhosis, to evaluate ... ...

    Abstract Background: Liver cirrhosis is associated with functional abnormalities of the cardiovascular system with co-existing electrocardiographic (ECG) abnormalities.
    Objectives: The aim was to analyze ECG changes in patients with cirrhosis, to evaluate whether alcoholic etiology of cirrhosis and ascites has an impact on ECG changes.
    Material and methods: The study involved 81 patients with previously untreated alcoholic cirrhosis (64 patients with ascites, classes B and C according to the Child-Pugh classification; and 17 without ascites, categorized as class A); 41 patients with previously untreated cirrhosis due to chronic hepatitis C (HCV--30 patients with ascites, classes B and C; and 11 without ascites, class A); 42 with alcoholic steatohepatitis and 46 with alcoholic steatosis. The control group consisted of 32 healthy volunteers. Twelve-lead ECG recordings were performed and selected parameters were measured.
    Results: Significantly longer QT and QTc intervals and lower QRS voltage were found in patients with alcoholic and HCV cirrhosis compared to the controls. Significantly lower QRS voltage was found in subjects with ascites than in those without ascites. Removal of ascites significantly increased QRS voltage.
    Conclusions: In cirrhosis, irrespective of etiology, ECG changes involved prolonged QT and QTc intervals and reduced QRS voltage. Prolonged QT and QTc intervals were not related to the severity of cirrhosis or to the presence of ascites. However, low QRS voltage was associated with the presence of ascites. Removal of ascites reverses low QRS voltage.
    MeSH term(s) Action Potentials ; Adult ; Aged ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/prevention & control ; Ascites/etiology ; Ascites/therapy ; Electrocardiography ; Female ; Heart Conduction System/physiopathology ; Hepatitis, Chronic/complications ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Cirrhosis/therapy ; Liver Cirrhosis/virology ; Liver Cirrhosis, Alcoholic/diagnosis ; Liver Cirrhosis, Alcoholic/etiology ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Severity of Illness Index ; Time Factors
    Language English
    Publishing date 2015-07
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2270257-X
    ISSN 1899-5276 ; 1230-025X
    ISSN 1899-5276 ; 1230-025X
    DOI 10.17219/acem/28681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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