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  1. Book ; Thesis: Zentrale Effekte von Candesartan, einem selektiven AT1-Rezeptorantagonisten

    Kox, Thomas

    2002  

    Author's details vorgelegt von Thomas Kox
    Language German
    Size 53 S., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 2002
    HBZ-ID HT013513338
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 76 order for loan Magazin

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  2. Article: Successful transseptal puncture and cryoballoon ablation of symptomatic paroxysmal atrial fibrillation via jugular access in a patient with bilateral thrombotic femoral vein occlusion.

    Kox, Thomas / Laubenthal, Florin / Imnadze, Guram

    HeartRhythm case reports

    2019  Volume 5, Issue 6, Page(s) 347–350

    Language English
    Publishing date 2019-02-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2019.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Perception and use of uncertainty in severe weather warnings

    Kox, Thomas [Verfasser] / Thieken, Annegret Henriette [Akademischer Betreuer]

    2018  

    Author's details Thomas Kox ; Betreuer: Annegret Henriette Thieken
    Keywords Geowissenschaften ; Earth Sciences
    Subject code sg550
    Language English
    Publisher Universität Potsdam
    Publishing place Potsdam
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article: Perception and use of uncertainty in severe weather warnings by emergency services in Germany

    Kox, Thomas / Lars Gerhold / Uwe Ulbrich

    Atmospheric research. 2015 May 01, v. 158-159

    2015  

    Abstract: In the course of the WEXICOM project at the Hans-Ertel-Centre for Weather Research of the Deutscher Wetterdienst (DWD), a survey was conducted in autumn 2012 to question how weather warnings are communicated to professional end-users in the emergency ... ...

    Abstract In the course of the WEXICOM project at the Hans-Ertel-Centre for Weather Research of the Deutscher Wetterdienst (DWD), a survey was conducted in autumn 2012 to question how weather warnings are communicated to professional end-users in the emergency community and how the warnings are converted into mitigation measures.161 members of emergency services (e.g. fire fighters, police officers and civil servants) across Germany answered an online questionnaire. Questions included user's confidence in forecasts, their understanding of probabilistic information and their perception and use of uncertainty in forecasts and warnings. A large number of open questions were selected to identify new topics of interest, unknown problems, and research gaps in the field of communicating weather information in Germany.Results show that the emergency service personnel who participated in this survey generally have a good appreciation of the uncertainty of weather forecasts. Although no single probability threshold could be identified for organisations to start with preparatory mitigation measures, it became clear that emergency services tend to avoid forecast based on low probabilities as basis for their decisions.This paper suggests that when trying to enhance weather communication by reducing the uncertainty in forecasts, the focus should not only be on improving computer models and observation tools, but also on the communication aspect, as uncertainty also arises from linguistic origins. Here, improvements are also possible and thus uncertainty might be reducible.
    Keywords autumn ; computer simulation ; fire fighters ; human resources ; meteorological data ; police ; questionnaires ; surveys ; uncertainty ; Germany
    Language English
    Dates of publication 2015-0501
    Size p. 292-301.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0169-8095
    DOI 10.1016/j.atmosres.2014.02.024
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats.

    Gohlke, Peter / Von Kügelgen, Sebastian / Jürgensen, Thomas / Kox, Thomas / Rascher, Wolfgang / Culman, Juraj / Unger, Thomas

    Journal of hypertension

    2002  Volume 20, Issue 5, Page(s) 909–918

    Abstract: Objective: In the present study, we investigated the ability of the peripherally administered angiotensin II type 1 (AT1) receptor antagonist, candesartan cilexetil, to block central effects of angiotensin II (Ang II) in conscious rats.: Design and ... ...

    Abstract Objective: In the present study, we investigated the ability of the peripherally administered angiotensin II type 1 (AT1) receptor antagonist, candesartan cilexetil, to block central effects of angiotensin II (Ang II) in conscious rats.
    Design and methods: Candesartan cilexetil was administered orally by gavage at doses of 0.1, 1, 10 and 30 mg/kg. Drinking response, pressor response and release of vasopressin into the circulation following intracerebroventricular (i.c.v.) Ang II (10 or 100 ng) were measured at 0.5, 2, 4 and 24 h following the drug application. The same parameters were measured after chronic treatment with candesartan cilexetil for 1 week. In a separate experiment, the release of vasopressin induced by microinjection of Ang II (100 ng) into the paraventricular nucleus (PVN) was determined 4 h after oral administration of candesartan cilexetil (1 mg/kg) or vehicle.
    Results: Oral treatment with candesartan cilexetil inhibited all central responses to i.c.v. Ang II in a dose- and time-dependent manner. The Ang II-induced responses were inhibited 4 h after acute or chronic treatment with 0.1 mg/kg candesartan cilexetil, but had returned to control levels 24 h after drug application. In contrast, the highest dose of candesartan cilexetil (30 mg/kg) nearly abolished the central responses to Ang II for 24 h. Candesartan cilexetil completely blocked vasopressin release into the circulation induced by Ang II microinjection into the PVN.
    Conclusions: Our results demonstrate that the AT1 receptor antagonist, candesartan cilexetil, very effectively inhibits the centrally mediated effects of Ang II upon peripheral application.
    MeSH term(s) Administration, Oral ; Angiotensin II/administration & dosage ; Angiotensin II/antagonists & inhibitors ; Angiotensin II/pharmacology ; Angiotensin Receptor Antagonists ; Animals ; Arginine Vasopressin/metabolism ; Benzimidazoles/administration & dosage ; Benzimidazoles/pharmacology ; Biphenyl Compounds/administration & dosage ; Biphenyl Compounds/pharmacology ; Blood Pressure/drug effects ; Brain/drug effects ; Dose-Response Relationship, Drug ; Injections, Intraventricular ; Male ; Microinjections ; Paraventricular Hypothalamic Nucleus/drug effects ; Paraventricular Hypothalamic Nucleus/physiology ; Rats ; Rats, Wistar ; Receptor, Angiotensin, Type 1 ; Tetrazoles
    Chemical Substances Angiotensin Receptor Antagonists ; Benzimidazoles ; Biphenyl Compounds ; Receptor, Angiotensin, Type 1 ; Tetrazoles ; Angiotensin II (11128-99-7) ; Arginine Vasopressin (113-79-1) ; candesartan cilexetil (R85M2X0D68)
    Language English
    Publishing date 2002-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/00004872-200205000-00026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 614: Show issues

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  6. Article: The relationship between urotensin II plasma immunoreactivity and left ventricular filling pressures in coronary artery disease.

    Heringlake, Matthias / Kox, Thomas / Uzun, Orhan / Will, Barbara / Bahlmann, Ludger / Klaus, Stephan / Eleftheriadis, Sawas / Armbruster, Franz Paul / Franz, Norbert / Kraatz, Ernst

    Regulatory peptides

    2004  Volume 121, Issue 1-3, Page(s) 129–136

    Abstract: The role of urotensin II (U-II)--a vasoactive, mitogenic, and inotropic, peptide--in the pathophysiology of heart failure is controversial. The present study explores the relationship between plasma U-II immunoreactivity (U-IIIR) and hemodynamics in ... ...

    Abstract The role of urotensin II (U-II)--a vasoactive, mitogenic, and inotropic, peptide--in the pathophysiology of heart failure is controversial. The present study explores the relationship between plasma U-II immunoreactivity (U-IIIR) and hemodynamics in patients with coronary artery disease (CAD). Thirty-six patients with CAD-3 undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and 36 medical patients (MED group) with CAD-1 to CAD-3 during right heart catheterization were studied. Significant correlations were observed between pulmonary capillary wedge pressure (PCWP) and U-IIIR--determined by enzyme immunoassay (EIA)--before (rho = 0.83) and after (rho = 0.6) cardiopulmonary bypass in the CABG group. With the exception of the CPB period, CABG patients with increased PCWP before CPB had higher U-II(IR) concentrations throughout the procedure. Significant correlations were observed between U-IIIR, proANP, proBNP, and mean right ventricular pressure (RVPM) in MED patients. No correlation was detectable between U-IIIR and PCWP. However, MED patients with CAD-3 (n = 13) had higher levels of U-IIIR, NTproANPIR (RIA), NTproBNPIR (EIA) and higher cardiac filling pressures than patients with CAD-1 (n = 13). These findings support an association between plasma U-IIIR levels and diastolic myocardial dysfunction in ischemic heart failure. The discrepancies regarding left and right cardiac filling pressures and U-IIIR levels in CABG and MED patients require further evaluation.
    MeSH term(s) Aged ; Cardiac Catheterization ; Case-Control Studies ; Coronary Artery Bypass ; Coronary Artery Disease/blood ; Coronary Artery Disease/physiopathology ; Female ; Heart Ventricles/physiopathology ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Urotensins/blood ; Urotensins/immunology ; Ventricular Pressure/physiology
    Chemical Substances Urotensins ; urotensin II (9047-55-6)
    Language English
    Publishing date 2004-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 225685-x
    ISSN 1873-1686 ; 0167-0115
    ISSN (online) 1873-1686
    ISSN 0167-0115
    DOI 10.1016/j.regpep.2004.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1593: Show issues Location:
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