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Article ; Online: Pathology of Ketoacidosis in Emergency of Diabetic Ketoacidosis and Alcoholic Ketoacidosis: A Retrospective Study.

Koyama, Katsumasa / Anno, Takatoshi / Kimura, Yukiko / Kawasaki, Fumiko / Kaku, Kohei / Tomoda, Koichi / Kaneto, Hideaki

Journal of diabetes research

2024 Volume 2024, Page(s) 8889415

Abstract: This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical ... ...

Abstract	This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical Center from April 2015 to March 2021. Almost all patients in this study were brought to the emergency room in a coma and hospitalized. All patients underwent blood gas aspiration and laboratory tests. We evaluated the difference in diagnosis markers in emergencies between DKA and alcoholic ketoacidosis AKA. Compared to AKA patients, DKA patients had statistically higher values of serum acetoacetic acid and lower values of serum lactate, arterial blood pH, and base excess. In contrast, total ketone bodies,
MeSH term(s)	Humans ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Diabetic Ketoacidosis/therapy ; Retrospective Studies ; 3-Hydroxybutyric Acid ; Dehydration/complications ; Ketosis/diagnosis ; Ketosis/etiology ; Ketosis/metabolism ; Diabetes Mellitus ; Acetoacetates
Chemical Substances	acetoacetic acid (4ZI204Y1MC) ; 3-Hydroxybutyric Acid (TZP1275679) ; Acetoacetates
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2024/8889415
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Case Report: Repeated esophageal obstruction in a patient with type 3C diabetes mellitus.

Koyama, Katsumasa / Anno, Takatoshi / Takenouchi, Haruka / Kimura, Tomohiko / Kaku, Kohei / Kaneto, Hideaki

Frontiers in endocrinology

2023 Volume 14, Page(s) 1225385

Abstract: Although diabetic neuropathy is a well-known cause of gastrointestinal motility disorders, it is rare that diabetic neuropathy brings about esophageal obstruction. Here, we report a case with Type 3C diabetes mellitus (DM) lasting over 15 years and ... ...

Abstract	Although diabetic neuropathy is a well-known cause of gastrointestinal motility disorders, it is rare that diabetic neuropathy brings about esophageal obstruction. Here, we report a case with Type 3C diabetes mellitus (DM) lasting over 15 years and repeated esophageal obstruction resulting in chicken-meat-induced esophageal obstruction and candidiasis. This case highlights the importance of management of DM to prevent the development of complications such as diabetic neuropathy and associated symptoms.
MeSH term(s)	Humans ; Diabetic Neuropathies/diagnosis ; Gastrointestinal Diseases ; Candidiasis ; Diabetes Mellitus
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1225385
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Article ; Online: Case report: Acute submandibular sialadenitis in poorly controlled diabetes mellitus patient fed twenty days by enteral tube.

Iwamoto, Yuichiro / Anno, Takatoshi / Koyama, Katsumasa / Tomoda, Koichi / Kimura, Tomohiko / Kaneto, Hideaki

Medicine

2023 Volume 102, Issue 27, Page(s) e34193

Abstract: Introduction: Enteral tube feeding is an effective method of providing nutrients for patients who are unable to meet their nutritional requirements, and patients with parenteral nutrition are at an increased risk of infection. The submandibular gland is ...

Abstract	Introduction: Enteral tube feeding is an effective method of providing nutrients for patients who are unable to meet their nutritional requirements, and patients with parenteral nutrition are at an increased risk of infection. The submandibular gland is one of the major salivary glands and sialadenitis are often caused by obstruction of the salivary outflow tract. Patient concerns: A 91-year-old woman had parenteral nutrition with nasogastric tube feeding. Her history includes angina pectoris, myocardial infarction, type 2 diabetes mellitus (T2DM), heart failure, atrial fibrillation, sick sinus syndrome, and she recently had a pacemaker implanted. She was continued parenteral nutrition with nasogastric tube feeding for 20 days, and her fasting blood glucose ranged from 200 to 400 mg/dL. In the midst of poor glycemic control, she suddenly had high fever and elevated infection markers under poorly glycemic control. Diagnoses: She had neck swelling with a feeling of heat. We performed cervical computed tomography, and it revealed swelling of the bilateral submandibular glands and fluffing of surrounding tissue. She was diagnosed with acute submandibular glanditis. Interventions: We treated her with antibiotics therapy, extubation, daily massage of the submandibular gland and strict glycemic control. Outcomes: Her neck swelling disappeared about 11 days after such treatment. Lessons: We reported acute submandibular glanditis induced by nasogastric tube feeding under poorly controlled diabetes mellitus. We have to keep good oral hygiene and also pay attention to glycemic control in subjects under parenteral nutrition with tube feeding management.
MeSH term(s)	Humans ; Female ; Aged, 80 and over ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Intubation, Gastrointestinal ; Enteral Nutrition/methods ; Autoimmune Diseases ; Sialadenitis/etiology ; Sialadenitis/therapy
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034193
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Article: Obstructive pneumonia with bronchial foreign body: A case report.

Tanaka, Hitomi / Anno, Takatoshi / Takenouchi, Haruka / Koyama, Katsumasa / Kaneto, Hideaki / Okimoto, Niro / Tomoda, Koichi

Heliyon

2023 Volume 9, Issue 11, Page(s) e21362

Abstract: The age of predilection for foreign body aspiration into the lower airway shows a bimodal distribution, with the majority of cases occurring in children or infants and in the elderly. Although several pediatric airway foreign bodies have been summarized, ...

Abstract	The age of predilection for foreign body aspiration into the lower airway shows a bimodal distribution, with the majority of cases occurring in children or infants and in the elderly. Although several pediatric airway foreign bodies have been summarized, in adults, bronchial foreign bodies are relatively uncommon. There are a variety of symptoms induced by airway foreign bodies, although the typical symptoms of some bronchial foreign bodies are cough. Bronchial foreign bodies, especially in the elderly, may have few symptoms and it is necessary for careful identification. Therefore, it is very important to carefully perform medical consultations about current and past medical history. Herein, we report a case of an elderly Japanese with obstructive pneumonia with a bronchial foreign body of fish bone with a long history of cough. It is known that people in some countries such as Japan have a habit of eating fish. Therefore, it is necessary to more carefully explore the possibility of some bronchial foreign body such as a fish bone, when we observe symptoms of persistent cough in such countries.
Language	English
Publishing date	2023-10-21
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21362
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Article ; Online: Edematous wall thickening of the gallbladder induced by hyperthyroidism: A case report.

Koyama, Katsumasa / Anno, Takatoshi / Kawasaki, Fumiko / Nishino, Ken / Kawamoto, Hirofumi / Kaneto, Hideaki / Tomoda, Koichi

Medicine

2022 Volume 101, Issue 4, Page(s) e28720

Abstract: Rationale: Hyperthyroidism, such as Basedow disease, causes fluid retention, although the common cause is volume overload due to congestive heart failure. In addition, hyperthyroidism and Basedow disease are known to cause pulmonary hypertension. ... ...

Abstract	Rationale: Hyperthyroidism, such as Basedow disease, causes fluid retention, although the common cause is volume overload due to congestive heart failure. In addition, hyperthyroidism and Basedow disease are known to cause pulmonary hypertension. Edematous thickening of the gallbladder wall is caused by venous blood congestion. The feature of edematous wall thickening of the gallbladder on abdominal computed tomography (CT) is subserosal edema and is often accompanied by a periportal collar sign. Patient concerns: A 30-year-old woman was referred to our hospital because of liver dysfunction, edematous gallbladder wall thickening, and fluid retention. In addition, the patient developed hyperthyroidism and heart failure. Enhanced abdominal CT revealed edematous wall thickening of the gallbladder and a periportal collar sign. Diagnosis: We suspected that fluid retention and congestion were caused by hyperthyroidism and Basedow disease. Interventions: On admission, we started thiamazole therapy for Basedow disease, and her thyroid hormone levels normalized. Outcomes: Abdominal CT revealed disappearance of edematous wall thickening of the gallbladder, which was likely associated with an improvement in thyroid function. The patient was discharged 10 days after admission. Lessons: We encountered a case of hyperthyroidism and Basedow disease accompanied by edematous wall thickening of the gallbladder and various fluid retentions as the first symptoms. Such edematous wall thickening of the gallbladder and various fluid retentions were reduced, together with the improvement of hyperthyroidism.
MeSH term(s)	Adult ; Edema/etiology ; Female ; Gallbladder/diagnostic imaging ; Graves Disease/complications ; Graves Disease/drug therapy ; Heart Failure/complications ; Humans ; Hyperthyroidism/complications ; Hyperthyroidism/drug therapy ; Methimazole/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome ; Ultrasonography/methods
Chemical Substances	Methimazole (554Z48XN5E)
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028720
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Article: Case Report: Use of endobronchial Watanabe spigot and coagulation factor XIII supplementation in the treatment of persistent pneumothorax due to pneumocystis pneumonia with human immunodeficiency virus infection.

Koyama, Katsumasa / Minami, Daisuke / Isobe, Hayato / Shirai, Ryo / Okimoto, Niro / Tomoda, Koichi

Frontiers in medicine

2022 Volume 9, Page(s) 956333

Abstract: Pneumocystis ... ...

Abstract	Pneumocystis jiroveceii
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.956333
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Article: Case Report: Massive Hemoptysis From a Spontaneously Regression Inflammatory Bronchial Polyp.

Iwamoto, Yuichiro / Takenouchi, Haruka / Koyama, Katsumasa / Shirai, Ryo / Kaneto, Hideaki / Tomoda, Koichi

Frontiers in medicine

2022 Volume 9, Page(s) 875311

Abstract: Background: Bronchial inflammatory polyps are usually treated by surgical operation or with steroids and/or antibiotics, and it is quite rare that such polys spontaneously disappear without any treatment. This report shows a rare case with a bronchial ... ...

Abstract	Background: Bronchial inflammatory polyps are usually treated by surgical operation or with steroids and/or antibiotics, and it is quite rare that such polys spontaneously disappear without any treatment. This report shows a rare case with a bronchial inflammatory polyp which caused massive hemoptysis but spontaneously disappeared without any treatment. Case presentation: A 66-year-old man with type 2 diabetes mellitus and a history of cough and asthma suddenly developed massive hemoptysis while smoking and was brought to an emergency room in our institution. In bronchoscopy on admission, a polypoidal elevated lesion was observed in the left upper lobe bifurcation. Pulsatile hemorrhage from a polypoidal elevated lesion was observed upon stimulation of passage of the bronchoscope. Bronchoscopy performed 25 days after discharge showed no evidence of active bleeding and a tendency toward reduction of the elevated lesion. In bronchoscopy performed 106 days after the initial hospitalization, the bronchial inflammatory polyp completely disappeared. Conclusions: We should bear in mind the possibility of spontaneous disappearance of bronchial inflammatory polyps causing some serious symptoms such as massive hemoptysis and repeated bloody sputum. Finally, we should select the best therapy for bronchial inflammatory polys based on each patient's background and conditions in clinical practice.
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.875311
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Article ; Online: Acute respiratory distress syndrome triggered by marked cytokine storm in a subject with diabetic ketoacidosis: A case report.

Horiya, Megumi / Anno, Takatoshi / Shigemoto, Ryo / Koyama, Katsumasa / Kawasaki, Fumiko / Tomoda, Koichi / Kaku, Kohei / Kaneto, Hideaki

Medicine

2022 Volume 101, Issue 12, Page(s) e29119

Abstract: Rationale: Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury. Many causes of acute direct and indirect lung injury have been described as possible initiators of ARDS. According to the literature data, ARDS could be ... ...

Abstract	Rationale: Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury. Many causes of acute direct and indirect lung injury have been described as possible initiators of ARDS. According to the literature data, ARDS could be a rare complication associated with the acute onset of diabetic ketoacidosis (DKA). Moreover, it has been suggested that cytokine release during DKA is involved in the above-mentioned acute clinical complications of DKA. Patientconcerns: A 48-year-old Japanese woman with a 4-year history of type 1 diabetes mellitus was brought to an emergency room with symptoms of deteriorated consciousness. Three days before, she was diagnosed with influenza A infection. Diagnosis: Inflammation markers were markedly elevated and she was under DKA condition. Since her respiratory conditions were suddenly and markedly aggravated 2 days later, we diagnosed her as ARDS and continued systemic management with the ventilator.Interleukin-6 (IL-6) level was markedly elevated at the onset of ARDS, although IL-6 level was high at the onset of DKA. ARDS was suggested to be caused by marked cytokine storm and DKA. Interventions: We continued to treat her hyperglycemic crises. Moreover, we continued systemic management with the ventilator. Outcomes: Approximately three weeks later, her general conditions were stabilized and ventilator management was stopped. We successfully treated her ARDS and hyperglycemic crises. Lessons: This case is very important because it shows that DKA can induce cytokine storm, which leads to the onset of ARDS. Therefore, monitoring various cytokines such as IL-6, which are associated with ARDS during the period of treatment of DKA is beneficial.
MeSH term(s)	Cytokine Release Syndrome ; Cytokines ; Diabetes Mellitus, Type 1/complications ; Diabetic Ketoacidosis/diagnosis ; Female ; Humans ; Middle Aged ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy
Chemical Substances	Cytokines
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029119
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Article ; Online: IgG4-related lung disease with multifocal pulmonary consolidations near the pleura: A case report.

Tanaka, Hitomi / Anno, Takatoshi / Takenouchi, Haruka / Koyama, Katsumasa / Kaneto, Hideaki / Oga, Toru / Monobe, Yasumasa / Tomoda, Koichi

Medicine

2022 Volume 101, Issue 34, Page(s) e30285

Abstract: Rationale: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic immune-mediated condition that can cause fibroinflammatory lesions in multiple organs. Approximately 35% of IgG4-RD patients have some symptoms in the chest and IgG4-related ... ...

Abstract	Rationale: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic immune-mediated condition that can cause fibroinflammatory lesions in multiple organs. Approximately 35% of IgG4-RD patients have some symptoms in the chest and IgG4-related lung disease (IgG4-RLD) is observed in about 10% of IgG4-RD cases. In addition, it is thought that glucocorticoid therapy is effective for IgG4-RD and IgG4-RLD. It is difficult to diagnose IgG4-RLD complicated with another lung disease. Patient concerns: An 85-year-old Japanese man was hospitalized due to pulmonary consolidations just below the pleura in chest computed tomography while being treated with antibiotics. Previously, an upper lobectomy of the right lung was performed for an upper lung mucinous adenocarcinoma, and he was diagnosed with chronic obstructive pulmonary disease. Although he took antibiotics before admission, C-reactive protein levels were elevated. Diagnosis: IgG4 levels were also elevated (IgG4; 733 mg/dL), and lung biopsy histology showed an abundance of IgG4-positive plasma cell infiltration; about 40% of the affected area was occupied by such infiltration. Based on such findings, we finally diagnosed him as IgG4-RLD. Interventions: We administered 20 mg/d prednisolone. Outcomes: About 2 weeks after administration of prednisolone by intravenous injection, his multifocal pulmonary consolidations just below the pleura were markedly improved and his pulmonary symptoms disappeared. Four weeks after glucocorticoid therapy, IgG4 levels decreased from 831 mg/dL (peak) to 547 mg/dL. Lessons: We should consider IgG4-RLD, a rare disease, when lesions are detected as pulmonary consolidations near the pleura and are unresponsive to antibiotic therapy. Glucocorticoid therapy, however, is very effective for such IgG4-RLD.
MeSH term(s)	Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/drug therapy ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases/complications ; Lung Diseases/diagnosis ; Lung Diseases/drug therapy ; Male ; Pleura/pathology ; Prednisolone/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Glucocorticoids ; Immunoglobulin G ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030285
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Article ; Online: Case Report: Appearance of Various Disease-Specific Antibodies After the Onset of Dipeptidyl Peptidase-4 Inhibitor-Associated Bullous Pemphigoid.

Iwamoto, Yuichiro / Anno, Takatoshi / Koyama, Katsumasa / Kawasaki, Fumiko / Kaku, Kohei / Tomoda, Koichi / Sugiyama, Seiko / Aoyama, Yumi / Kaneto, Hideaki

Frontiers in immunology

2022 Volume 13, Page(s) 843480

Abstract: Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can ...

Abstract	Bullous pemphigoid (BP) is a rare autoimmune blistering disease, and the prevalence of type 2 diabetes mellitus (T2DM) is relatively high in subjects with BP. It is known that dipeptidyl peptidase-4 inhibitor (DPP-4i), one kind of antidiabetic drugs, can cause BP, although precise mechanism of DPP-4i-related BP remains unclear. In this report, we showed a case with appearance of various disease-specific antibodies after the onset of DPP-4i-related BP. Furthermore, various disease-specific antibodies became positive and showed high titers two years after the onset of DPP-4i-related BP and discontinuation of DPP-4i. These data showed that it is possible for immune tolerance to be broken after the onset of DPP-4i-related BP, and it may be important to check autoimmune antibodies in DPP-4i-related BP subjects even when BP symptoms are improved.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Humans ; Hypoglycemic Agents ; Pemphigoid, Bullous/chemically induced ; Pemphigoid, Bullous/diagnosis ; Pemphigoid, Bullous/epidemiology
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-)
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.843480
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