LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: The role of the environment in transmission of vancomycin-resistant

    Tan, Charlie / Linkenheld-Struk, Amber / Williams, Victoria / Kozak, Rob / Dhabaan, Ghulam / Maze Dit Mieusement, Lorraine / Salt, Natasha / Maguire, Finlay / Chan, Adrienne K / Leis, Jerome A

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e178

    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.318
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Screening Large Population Health Databases for Potential Coronavirus Disease 2019 Therapeutics: A Pharmacopeia-Wide Association Study of Commonly Prescribed Medications.

    MacFadden, Derek R / Brown, Kevin / Buchan, Sarah A / Chung, Hannah / Kozak, Rob / Kwong, Jeffrey C / Manuel, Doug / Mubareka, Samira / Daneman, Nick

    Open forum infectious diseases

    2022  Volume 9, Issue 5, Page(s) ofac156

    Abstract: Background: For both the current and future pandemics, there is a need for high-throughput drug screening methods to identify existing drugs with potential preventive and/or therapeutic activity. Epidemiologic studies could complement laboratory-focused ...

    Abstract Background: For both the current and future pandemics, there is a need for high-throughput drug screening methods to identify existing drugs with potential preventive and/or therapeutic activity. Epidemiologic studies could complement laboratory-focused efforts to identify possible therapeutic agents.
    Methods: We performed a pharmacopeia-wide association study (PWAS) to identify commonly prescribed medications and medication classes that are associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older individuals (≥65 years) in long-term care homes (LTCHs) and the community, between 15 January 2020 and 31 December 2020, across the province of Ontario, Canada.
    Results: A total of 26 121 cases and 2 369 020 controls from LTCHs and the community were included in this analysis. Many of the drugs and drug classes evaluated did not yield significant associations with SARS-CoV-2 detection. However, some drugs and drug classes appeared to be significantly associated with reduced SARS-CoV-2 detection, including cardioprotective drug classes such as statins (weighted odds ratio [OR], 0.91; standard
    Conclusions: Using this epidemiologic approach, which can be applied to current and future pandemics, we have identified a variety of target drugs and drug classes that could offer therapeutic benefit in coronavirus disease 2019 (COVID-19) and may warrant further validation. Some of these agents (eg, fluoxetine) have already been identified for their therapeutic potential.
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac156
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Diagnosis and Management of First Case of COVID-19 in Canada: Lessons Applied From SARS-CoV-1.

    Marchand-Senécal, Xavier / Kozak, Rob / Mubareka, Samira / Salt, Natasha / Gubbay, Jonathan B / Eshaghi, Alireza / Allen, Vanessa / Li, Yan / Bastien, Natalie / Gilmour, Matthew / Ozaldin, Omar / Leis, Jerome A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 16, Page(s) 2207–2210

    Abstract: We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest ... ...

    Abstract We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest sustainable and scalable control measures developed based on lessons learned from severe acute respiratory syndrome.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Canada ; Clinical Laboratory Techniques ; Coronavirus ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-02-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa227
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: A policy nexus approach to forests and the SDGs: tradeoffs and synergies

    Timko, Joleen / de la Roche, Ian / Gaston, Chris / Honey-Rosés, Jordi / Kozak, Rob A / Le Billon, Philippe / Sunderland, Terry CH / Zerriffi, Hisham

    Current opinion in environmental sustainability. 2018 Oct., v. 34

    2018  

    Abstract: The transformational potential of Agenda 2030 lies in the synergies to be found among the Sustainable Development Goals (SDGs). The SDGs were designed to be interdependent, requiring enhanced policy coherence for sustainable development, and forests have ...

    Abstract The transformational potential of Agenda 2030 lies in the synergies to be found among the Sustainable Development Goals (SDGs). The SDGs were designed to be interdependent, requiring enhanced policy coherence for sustainable development, and forests have a prominent role to play in their success. To support SDGs integration and highlight challenges to, and opportunities for, policy coherence among sectors that affect forests, we identify three policy clusters that are each defined by a set of closely related SDGs: ecosystem services and livelihoods; the green economy; and rights, justice, equality and inclusion. We illustrate how enhanced policy coherence within each cluster can support integrated approaches that both benefit from, and provide support for, forests.
    Keywords ecosystem services ; forests ; issues and policy ; livelihood ; sustainable development
    Language English
    Dates of publication 2018-10
    Size p. 7-12.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2514810-2
    ISSN 1877-3435
    ISSN 1877-3435
    DOI 10.1016/j.cosust.2018.06.004
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2.

    Cao, Huibi / Mai, Juntao / Zhou, Zhichang / Li, Zhijie / Duan, Rongqi / Watt, Jacqueline / Chen, Ziyan / Bandara, Ranmal Avinash / Li, Ming / Ahn, Sang Kyun / Poon, Betty / Christie-Holmes, Natasha / Gray-Owen, Scott D / Banerjee, Arinjay / Mossman, Karen / Kozak, Rob / Mubareka, Samira / Rini, James M / Hu, Jim /
    Liu, Jun

    Cell & bioscience

    2021  Volume 11, Issue 1, Page(s) 202

    Abstract: Background: The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However, all the ... ...

    Abstract Background: The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However, all the approved vaccines are administered by intramuscular injection and this may not prevent upper airway infection or viral transmission.
    Results: Here, we describe a novel, intranasally delivered COVID-19 vaccine based on a helper-dependent adenoviral (HD-Ad) vector. The vaccine (HD-Ad_RBD) produces a soluble secreted form of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and we show it induced robust mucosal and systemic immunity. Moreover, intranasal immunization of K18-hACE2 mice with HD-Ad_RBD using a prime-boost regimen, resulted in complete protection of the upper respiratory tract against SARS-CoV-2 infection.
    Conclusion: Our approaches provide a powerful platform for constructing highly effective vaccines targeting SARS-CoV-2 and its emerging variants.
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-021-00723-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Diagnosis and Management of First Case of COVID-19 in Canada: Lessons applied from SARS

    Marchand-Senécal, Xavier / Kozak, Rob / Mubareka, Samira / Salt, Natasha / Gubbay, Jonathan B / Eshaghi, Alireza / Allen, Vanessa / Li, Yan / Bastien, Natalie / Gilmour, Matthew / Ozaldin, Omar / Leis, Jerome A

    Clin. infect. dis

    Abstract: We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest ... ...

    Abstract We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest sustainable and scalable control measures developed based on lessons learned from SARS.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32147731
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Diagnosis and management of first case of COVID-19 in Canada

    Marchand-Senécal, Xavier / Kozak, Rob / Mubareka, Samira / Salt, Natasha / Gubbay, Jonathan B / Eshaghi, Alireza / Allen, Vanessa / Li, Yan / Bastien, Natalie / Gilmour, Matthew / Ozaldin, Omar / Leis, Jerome A

    Lessons applied from SARS-CoV-1

    2020  

    Abstract: We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest ... ...

    Abstract We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest sustainable and scalable control measures developed based on lessons learned from SARS.
    Keywords covid19
    Language English
    Publishing date 2020-03-09
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Diagnosis and Management of First Case of COVID-19 in Canada

    Marchand-Senécal, Xavier / Kozak, Rob / Mubareka, Samira / Salt, Natasha / Gubbay, Jonathan B / Eshaghi, Alireza / Allen, Vanessa / Li, Yan / Bastien, Natalie / Gilmour, Matthew / Ozaldin, Omar / Leis, Jerome A

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    Lessons Applied From SARS-CoV-1

    2020  

    Abstract: Abstract We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we ...

    Abstract Abstract We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. No healthcare-associated transmission occurred. In the face of a potential pandemic of COVID-19, we suggest sustainable and scalable control measures developed based on lessons learned from severe acute respiratory syndrome.
    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa227
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Intranasal HD-Ad Vaccine Protects the Upper and Lower Respiratory Tracts of hACE2 Mice against SARS-CoV-2

    Cao, Huibi / Mai, Juntao / Zhou, Zhichang / Li, Zhijie / Duan, Rongqi / Watt, Jacqueline / Chen, Ziyan / Bandara, Ranmal Avinash / Li, Ming / Ahn, Sang Kyun / Boon, Betty / Christie, Natasha / Gray-Owen, Scott / Kozak, Rob / Mubareka, Samira / Rini, James M / Hu, Jim / Liu, Jun

    bioRxiv

    Abstract: The COVID-19 pandemic has affected more than 120 million people and resulted in over 2.8 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However, all of the approved ...

    Abstract The COVID-19 pandemic has affected more than 120 million people and resulted in over 2.8 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However, all of the approved vaccines are administered by intramuscular injection and this may not prevent upper airway infection or viral transmission. Here, we describe intranasal immunization of a COVID-19 vaccine delivered by a novel platform, the helper-dependent adenoviral (HD-Ad) vector. Since HD-Ad vectors are devoid of adenoviral coding sequences, they have a superior safety profile and a large cloning capacity for transgenes. The vaccine (HD-Ad_RBD) codes for the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and intranasal immunization induced robust mucosal and systemic immunity. Moreover, intranasal immunization of K18-hACE2 mice with HD-Ad_RBD using a prime-boost regimen, resulted in complete protection of the upper respiratory tract against SARS-CoV-2 infection. As such, intranasal immunization based on the HD-Ad vector promises to provide a powerful platform for constructing highly effective vaccines targeting SARS-CoV-2 and its emerging variants.
    Keywords covid19
    Language English
    Publishing date 2021-04-09
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.04.08.439006
    Database COVID19

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top