Article ; Online: Multicenter study of serotype distribution of Streptococcus pneumoniae nasopharyngeal isolates from healthy children in the Russian Federation after introduction of PCV13 into the National Vaccination Calendar.
Diagnostic microbiology and infectious disease
2019 Volume 96, Issue 1, Page(s) 114914
Abstract: Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and ... ...
| Abstract | Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose course of PCV13, while 25.6% had received 1 or 2 doses. Pneumococcal DNA detection by PCR demonstrated S. pneumoniae in 37.2% of samples with regional variation between sites (27.3 to 56.9%). There was little difference between vaccinated, partially vaccinated and un-vaccinated children. Children who had received at least 1 dose of PCV13 had lower carriage rates of vaccine serotypes than their unvaccinated peers (49.9 vs. 61.4%; p < 0.001). Children who had received at least 1 dose of PCV13 showed increased carriage rates of non-vaccine serotypes (50 vs 38.6%; P < 0.001). Especially serogroup 15AF was more prevalent among fully immunized children than among their peers (12.5 vs 2.7%; P < 0.05). |
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| MeSH term(s) | Carrier State/epidemiology ; Carrier State/microbiology ; Child ; Child, Preschool ; Healthy Volunteers ; Humans ; Immunization Programs ; Infant ; Infant, Newborn ; Nasopharynx/microbiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Prevalence ; Russia/epidemiology ; Serogroup ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics | |||||
| Chemical Substances | 13-valent pneumococcal vaccine ; Pneumococcal Vaccines | |||||
| Language | English | |||||
| Publishing date | 2019-11-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Multicenter Study | |||||
| ZDB-ID | 604920-5 | |||||
| ISSN | 1879-0070 ; 0732-8893 | |||||
| ISSN (online) | 1879-0070 | |||||
| ISSN | 0732-8893 | |||||
| DOI | 10.1016/j.diagmicrobio.2019.114914 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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