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  1. Article ; Online: Chronic exposure to low-dose arsenic modulates lipogenic gene expression in mice.

    Adebayo, Adeola O / Zandbergen, Fokko / Kozul-Horvath, Courtney D / Gruppuso, Philip A / Hamilton, Joshua W

    Journal of biochemical and molecular toxicology

    2014  Volume 29, Issue 1, Page(s) 1–9

    Abstract: Arsenic, a ubiquitous environmental toxicant, can affect lipid metabolism through mechanisms that are not well understood. We studied the effect of arsenic on serum lipids, lipid-regulating genes, and transcriptional regulator sterol regulatory element ... ...

    Abstract Arsenic, a ubiquitous environmental toxicant, can affect lipid metabolism through mechanisms that are not well understood. We studied the effect of arsenic on serum lipids, lipid-regulating genes, and transcriptional regulator sterol regulatory element binding protein 1c (SREBP-1c). C57BL/6 mice were administered 0 or 100 ppb sodium arsenite in drinking water for 5 weeks. Arsenic exposure was associated with decreased liver weight but no change in body weight. Serum triglycerides level fell in arsenic-exposed animals, but not in fed animals, after short-term fasting. Hepatic expression of SREBP-1c was reduced in arsenic-exposed fed animals, with a 16-fold change in reduction. Similar effects were seen for SREBP-1c in white adipose tissue. However, fasting resulted in dissociation of the expression of SREBP-1c and its targets, and SREBP-1c protein content could not be shown to correlate with its mRNA expression. We conclude that arsenic modulates hepatic expression of genes involved in lipid regulation through mechanisms that are independent of SREBP-1c expression.
    MeSH term(s) Adipose Tissue, White/metabolism ; Animals ; Arsenic/pharmacology ; Arsenites/pharmacology ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation/drug effects ; Lipogenesis/drug effects ; Liver/metabolism ; Male ; Mice ; Sodium Compounds/pharmacology ; Sterol Regulatory Element Binding Protein 1/biosynthesis ; Triglycerides/biosynthesis
    Chemical Substances Arsenites ; Enzyme Inhibitors ; Sodium Compounds ; Srebf1 protein, mouse ; Sterol Regulatory Element Binding Protein 1 ; Triglycerides ; sodium arsenite (48OVY2OC72) ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2014-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.21600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development.

    Kozul-Horvath, Courtney D / Zandbergen, Fokko / Jackson, Brian P / Enelow, Richard I / Hamilton, Joshua W

    PloS one

    2012  Volume 7, Issue 5, Page(s) e38249

    Abstract: Background: Arsenic (As) exposure is a significant worldwide environmental health concern. Chronic exposure via contaminated drinking water has been associated with an increased incidence of a number of diseases, including reproductive and developmental ...

    Abstract Background: Arsenic (As) exposure is a significant worldwide environmental health concern. Chronic exposure via contaminated drinking water has been associated with an increased incidence of a number of diseases, including reproductive and developmental effects. The goal of this study was to identify adverse outcomes in a mouse model of early life exposure to low-dose drinking water As (10 ppb, current U.S. EPA Maximum Contaminant Level).
    Methodology and findings: C57B6/J pups were exposed to 10 ppb As, via the dam in her drinking water, either in utero and/or during the postnatal period. Birth outcomes, the growth of the F1 offspring, and health of the dams were assessed by a variety of measurements. Birth outcomes including litter weight, number of pups, and gestational length were unaffected. However, exposure during the in utero and postnatal period resulted in significant growth deficits in the offspring after birth, which was principally a result of decreased nutrients in the dam's breast milk. Cross-fostering of the pups reversed the growth deficit. Arsenic exposed dams displayed altered liver and breast milk triglyceride levels and serum profiles during pregnancy and lactation. The growth deficits in the F1 offspring resolved following separation from the dam and cessation of exposure in male mice, but did not resolve in female mice up to six weeks of age.
    Conclusions/significance: Exposure to As at the current U.S. drinking water standard during critical windows of development induces a number of adverse health outcomes for both the dam and offspring. Such effects may contribute to the increased disease risks observed in human populations.
    MeSH term(s) Animal Husbandry ; Animals ; Arsenic/metabolism ; Arsenic/pharmacology ; Dose-Response Relationship, Drug ; Drinking Water/chemistry ; Female ; Fetus/drug effects ; Growth and Development/drug effects ; Lactation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Milk, Human/drug effects ; Milk, Human/metabolism ; Pregnancy ; Triglycerides/metabolism ; Water Pollutants, Chemical/pharmacology
    Chemical Substances Drinking Water ; Triglycerides ; Water Pollutants, Chemical ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2012-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0038249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development

    Kozul-Horvath, Courtney D. / Zandbergen, Fokko / Jackson, Brian P. / Enelow, Richard I. / Hamilton, Joshua W.

    Abstract: This work was supported by National Institute of Environmental Health Sciences at the National Institutes of Health grants 1F32 ES019070 (CDK-H) and P42 ES007373 (BPJ, JWH, RIE and CDK-H, Dartmouth Superfund Research Program Project Grant, Project 2 and ... ...

    Abstract This work was supported by National Institute of Environmental Health Sciences at the National Institutes of Health grants 1F32 ES019070 (CDK-H) and P42 ES007373 (BPJ, JWH, RIE and CDK-H, Dartmouth Superfund Research Program Project Grant, Project 2 and Pilot Project).
    Language en_us
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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