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Article ; Online: Dynamics of Zeeman and dipolar states in the spin locking in a liquid entrapped in nano-cavities: Application to study of biological systems.

Furman, Gregory / Kozyrev, Andrey / Meerovich, Victor / Sokolovsky, Vladimir / Xia, Yang

Journal of magnetic resonance (San Diego, Calif. : 1997)

2021 Volume 325, Page(s) 106933

Abstract: We analyze the application of the spin locking method to study the spin dynamics and spin-lattice relaxation of nuclear spins-1/2 in liquids or gases enclosed in a nano-cavity. Two cases are considered: when the amplitude of the radio-frequency field is ... ...

Abstract	We analyze the application of the spin locking method to study the spin dynamics and spin-lattice relaxation of nuclear spins-1/2 in liquids or gases enclosed in a nano-cavity. Two cases are considered: when the amplitude of the radio-frequency field is much greater than the local field acting the nucleus and when the amplitude of the radio-frequency field is comparable or even less than the local field. In these cases, temperatures of two spin reservoirs, the Zeeman and dipole ones, change in different ways: in the first case, temperatures of the Zeeman and dipolar reservoirs reach the common value relatively quickly, and then turn to the lattice temperature; in the second case, at the beginning of the process, these temperatures are equal, and then turn to the lattice temperature with different relaxation times. Good agreement between the obtained theoretical results and the experimental data is achieved by fitting the parameters of the distribution of the orientation of nanocavities. The parameters of this distribution can be used to characterize the fine structure of biological samples, potentially enabling the detection of degradative changes in connective tissues.
MeSH term(s)	Connective Tissue/chemistry ; Electron Spin Resonance Spectroscopy/methods ; Models, Chemical ; Models, Statistical ; Nanostructures/chemistry
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2021.106933
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of genes AMPD1, CNB and COL1A1 in the propensity to employment rowing.

Kozyrev A.V.

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, Vol 4, Pp 77-

2011 Volume 79

Abstract: The question of the frequency distribution of polymorphic alleles of genes AMPD1, CNB and COL1A1. In the experiment, was attended by athletes, rowers qualifications at the age of 21 to 28 years, and people without experience of regular sport at the age ... ...

Abstract	The question of the frequency distribution of polymorphic alleles of genes AMPD1, CNB and COL1A1. In the experiment, was attended by athletes, rowers qualifications at the age of 21 to 28 years, and people without experience of regular sport at the age of 20 to 22 years. Established that certain combinations of alleles can be recommended as a diagnostic complex genetic markers to assess the propensity to develop and display of strength, endurance and speed. It is shown that upon receipt of positive results may conduct a successful selection in rowing, the implementation of the individualization of the training process and improve its efficiency.
Keywords	enes ; polymorphism ; sports ; selection ; rowing ; Special aspects of education ; LC8-6691 ; Education ; L ; DOAJ:Education ; DOAJ:Social Sciences ; Sports ; GV557-1198.995 ; Recreation. Leisure ; GV1-1860 ; Geography. Anthropology. Recreation ; G ; DOAJ:Sports Science
Language	Ukrainian
Publishing date	2011-04-01T00:00:00Z
Publisher	Kharkov Regional Branch of the National Olympic Committee of Ukraine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prunus cerasifera Ehrh. fruits are a source of biologically active substances and high-quality feedstock for Food for Specific Health Use

Dunaevskaya E.V. / Gorina V.M. / Melkozerova E.A. / Кhеtagurov Kh.M. / Kozyrev A.Kh.

E3S Web of Conferences, Vol 282, p

2021 Volume 04008

Abstract: From the Southern Coast collection of Prunus cerasifera Ehrh. the fruits cultivars of the Nikitsky Gardens’ breeding Medovaya, Olenka, Rumyanaya Zorka and Idilliya were distinguished by their high taste qualities and the content of BAS. According to the ... ...

Abstract	From the Southern Coast collection of Prunus cerasifera Ehrh. the fruits cultivars of the Nikitsky Gardens’ breeding Medovaya, Olenka, Rumyanaya Zorka and Idilliya were distinguished by their high taste qualities and the content of BAS. According to the norms of the Russian Federation, the fruits of these cultivars belong to the group of products with a high content of potassium and cuprum; satisfactory content of magnesium and ferrum, pastilles and jams from them belong to the group of products with a satisfactory content of potassium and cuprum. Cherry plum fruits, especially dark-colored ones, are a natural complex source of antioxidants, characterized by a high content of phenolic compounds and cuprum, and a satisfactory content of ascorbic acid and zinc. The content of pectin substances in the studied cultivars is comparable to that in apples. The fruits of the Idyllia cultivar with dark-colored pulp are distinguished by the maximum accumulation of pectins - 1.14%, ascorbic acid - 9.3, phenolic compounds – 441 mg/100 g, potassium – 11239, magnesium - 464, ferrum -10.81, zinc - 10.23, cuprum - 4.17, manganese - 0.228 mg/kg. Cherry plum fruits are characterized by a high content of BAS and are suitable for use in health nutrition both in fresh form and as raw materials for Food for Specific Health Use.
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Label-Free Protein Detection by Micro-Acoustic Biosensor Coupled with Electrical Field Sorting. Theoretical Study in Urine Models.

Mukhin, Nikolay / Konoplev, Georgii / Oseev, Aleksandr / Schmidt, Marc-Peter / Stepanova, Oksana / Kozyrev, Andrey / Dmitriev, Alexander / Hirsch, Soeren

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 7

Abstract: Diagnostic devices for point-of-care (POC) urine analysis (urinalysis) based on microfluidic technology have been actively developing for several decades as an alternative to laboratory based biochemical assays. Urine proteins (albumin, immunoglobulins, ... ...

Abstract	Diagnostic devices for point-of-care (POC) urine analysis (urinalysis) based on microfluidic technology have been actively developing for several decades as an alternative to laboratory based biochemical assays. Urine proteins (albumin, immunoglobulins, uromodulin, haemoglobin etc.) are important biomarkers of various pathological conditions and should be selectively detected by urinalysis sensors. The challenge is a determination of different oligomeric forms of the same protein, e.g., uromodulin, which have similar bio-chemical affinity but different physical properties. For the selective detection of different types of proteins, we propose to use a shear bulk acoustic resonator sensor with an additional electrode on the upper part of the bioliquid-filled channel for protein electric field manipulation. It causes modulation of the protein concentration over time in the near-surface region of the acoustic sensor, that allows to distinguish proteins based on their differences in diffusion coefficients (or sizes) and zeta-potentials. Moreover, in order to improve the sensitivity to density, we propose to use structured sensor interface. A numerical study of this approach for the detection of proteins was carried out using the example of albumin, immunoglobulin, and oligomeric forms of uromodulin in model urine solutions. In this contribution we prove the proposed concept with numerical studies for the detection of albumin, immunoglobulin, and oligomeric forms of uromodulin in urine models.
MeSH term(s)	Acoustics ; Biosensing Techniques ; Electrodes ; Models, Theoretical ; Proteins
Chemical Substances	Proteins
Language	English
Publishing date	2021-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21072555
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Article: Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures.

Konoplev, Georgii / Agafonova, Darina / Bakhchova, Liubov / Mukhin, Nikolay / Kurachkina, Marharyta / Schmidt, Marc-Peter / Verlov, Nikolay / Sidorov, Alexander / Oseev, Aleksandr / Stepanova, Oksana / Kozyrev, Andrey / Dmitriev, Alexander / Hirsch, Soeren

Biomedicines

2022 Volume 10, Issue 2

Abstract: Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. ... ...

Abstract	Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.
Language	English
Publishing date	2022-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10020207
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Article ; Online: Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022.

Life sciences in space research

2023 Volume 39, Page(s) 106–118

Abstract: The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, ... ...

Abstract	The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, dose rates and estimation of dose equivalent rates at ExoMars TGO Mars science orbit, provided by Liulin-MO from May 2018 to June 2022. The period of measurements covers the declining and minimum phases of the solar activity in 24th solar cycle and the rising phase of the 25th cycle. Compared are the radiation values of the galactic cosmic rays (GCR) obtained during the different phases of the solar activity. The highest values of the dose rate and flux from GCR are registered from March to August 2020. At the minimum of 24th and transition to 25th solar cycle the dose rate from GCR is 15.9 ± 1.6 µGy h
MeSH term(s)	Solar Activity ; Space Flight ; Orbit ; Radiation Monitoring/methods ; Cosmic Radiation
Language	English
Publishing date	2023-03-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2214-5532
ISSN (online)	2214-5532
DOI	10.1016/j.lssr.2023.03.006
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Article: Efficacy of Arbidol in the prevention of virus-induced exacerbations of bronchial asthma and chronic obstructive pulmonary disease.

Titova, O N / Petrova, M A / Shklyarevich, N A / Kuzubova, N A / Aleksandrov, A L / Kovaleva, L F / Kozyrev, A G / Kulikov, V D

Terapevticheskii arkhiv

2019 Volume 90, Issue 8, Page(s) 48–52

Abstract: Aim: To assess the efficacy and safety of Arbidol in the influenza and ARVI preventing in patients with asthma and chronic obstructive pulmonary disease (COPD).: Materials and methods: This study was an open label and prospective during epidemic ... ...

Abstract	Aim: To assess the efficacy and safety of Arbidol in the influenza and ARVI preventing in patients with asthma and chronic obstructive pulmonary disease (COPD). Materials and methods: This study was an open label and prospective during epidemic period of 2016-2017 years. 100 outpatients aged 18 to 80 years with verified asthma and/or COPD, were enrolled to therapy group, and received oral umifenovir 200 mg once daily for 14 days and then 200 mg twice a week for 3 weeks.The medical records data for the same epidemic period of 2016-2017 seasons of the same patients during witch they received no prophylaxis was taken as a control. The data analysis was made by applying parametric and nonparametric statistical methods. Results: Seasonal and post-exposure prophylaxis using umifenovir was associated with 2.6-times reduction in influenza and ARVI morbidity compared to control. In diseased patients (ARVI) of the therapy group the number of patients with mild illness prevailed (62.2%) and was significantly differed from control (37.1%). Severity of catarrhal symptoms and intoxication, was reduced with umifenovir prophylaxis course and were mild in 67.6% and 67.6% respectively of therapy group compared with 43.3% and 46.4% of control. Influenza and ARVI complications were only detected in control group (4 cases). The percentage of patients with incidents of underlying disease exacerbation was 42% in therapy group and 93% in control group. Also, exacerbation in the therapy group were mild in 59.5% and 34.4% in control group, while moderate exacerbation prevailed in control group and was in 59.1% of cases with was significantly higher then in therapy group (39.3%). Results in more frequent use of adjuvant in the control group compared with the therapy group (81.7% and 59.5% respectively). Patients of control group had a higher risk of hospitalizations due to underlying disease aggravation (11.8%), compared with therapy group (9.5%) but these differences were not significant. Conclusion: Seasonal and post-exposure prophylaxis with Arbidol reduce influenza and ARVI morbidity in patients with asthma and COPD during epidemic period, frequency and severity of chronic obstructive pulmonary disease aggravations resulting in decrease in the number of hospitalizations. Also, prophylaxis with Arbidol reduced the severity of catarrhal symptoms and intoxication.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Asthma/prevention & control ; Asthma/virology ; Disease Progression ; Humans ; Indoles/administration & dosage ; Indoles/therapeutic use ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/prevention & control ; Pulmonary Disease, Chronic Obstructive/virology ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/virology ; Young Adult
Chemical Substances	Antiviral Agents ; Indoles ; umifenovir (93M09WW4RU)
Language	English
Publishing date	2019-04-03
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/terarkh201890848-52
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Book: Poisk korotkich gamma-vspleskov po dannym ėksperimentov APEX i LILAS na bortu mežplanetnogo kosmičeskogo apparata "Fobos-2"

Kozyrev, A. S

(Pr / Rossijskaja Akademija Nauk, Institut Kosmičeskich Issledovanij ; 2092)

2003

Title variant	Search for short cosmic gamma-ray bursts in data bases of instruments APEX and LILAS onboard interplanetary spacecraft "Phobos-2"
Author's details	A. S. Kozyrev
Series title	Pr / Rossijskaja Akademija Nauk, Institut Kosmičeskich Issledovanij ; 2092
Language	Russian
Size	28 S.
Publishing place	Moskva
Document type	Book
Note	In kyrill. Schr. ; Engl. Zsfassung u.d.T.: Search for short cosmic gamma-ray bursts in data bases of instruments APEX and LILAS onboard interplanetary spacecraft "Phobos-2"
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: A bright γ-ray flare interpreted as a giant magnetar flare in NGC 253.

Svinkin, D / Frederiks, D / Hurley, K / Aptekar, R / Golenetskii, S / Lysenko, A / Ridnaia, A V / Tsvetkova, A / Ulanov, M / Cline, T L / Mitrofanov, I / Golovin, D / Kozyrev, A / Litvak, M / Sanin, A / Goldstein, A / Briggs, M S / Wilson-Hodge, C / von Kienlin, A /

Zhang, X-L / Rau, A / Savchenko, V / Bozzo, E / Ferrigno, C / Ubertini, P / Bazzano, A / Rodi, J C / Barthelmy, S / Cummings, J / Krimm, H / Palmer, D M / Boynton, W / Fellows, C W / Harshman, K P / Enos, H / Starr, R

Nature

2021 Volume 589, Issue 7841, Page(s) 211–213

Abstract: Soft γ-ray repeaters exhibit bursting emission in hard X-rays and soft γ-rays. During the active phase, they emit random short (milliseconds to several seconds long), hard-X-ray bursts, with peak ... ...

Abstract	Soft γ-ray repeaters exhibit bursting emission in hard X-rays and soft γ-rays. During the active phase, they emit random short (milliseconds to several seconds long), hard-X-ray bursts, with peak luminosities
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-020-03076-9
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Zs.MO 244: Show issues

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Article: The early Upper Palaeolithic of the Tunka rift valley, Lake Baikal region, Siberia

Kozyrev, Artem / Alexander Shchetnikov / Alexey Klement'ev / Andrei Fedorenko / Dustin White / Ivan A. Filinov

Quaternary international. 2014 Oct. 20, v. 348

2014

Abstract: This paper presents recent results of geological and archaeological research at Late Pleistocene sites in the Tunka rift valley (Lake Baikal region, southern Siberia), including new radiocarbon dating of the Palaeolithic layers at Bol'shoi Zangisan, ... ...

Abstract	This paper presents recent results of geological and archaeological research at Late Pleistocene sites in the Tunka rift valley (Lake Baikal region, southern Siberia), including new radiocarbon dating of the Palaeolithic layers at Bol'shoi Zangisan, Slavin Yar and Tuyana. The sites range in age from ∼26 to 45 ka 14C BP and represent the earliest evidence of human habitation in the area. Numerous faunal remains have also been identified in the archaeological horizons from which palaeoenvironmental conditions can be reconstructed. These data also provide important new information about the age, context, and development of an early microlithic industry in the Tunka-Pribaikal'e region during the late Karginskii interstadial, attributed to Marine Isotope Stage 3 (MIS3). Although further research is needed to verify the reconstructed site age models, archaeological evidence recovered at Tuyana and Bol'shoi Zangisan represent among the oldest known occurrences of microcore-microblade technology in North Asia.
Keywords	fauna ; humans ; industry ; models ; paleoclimatology ; paleoecology ; radiocarbon dating ; Lake Baikal ; Siberia
Language	English
Dates of publication	2014-1020
Size	p. 4-13.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1040-6182
DOI	10.1016/j.quaint.2014.06.012
Database	NAL-Catalogue (AGRICOLA)

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