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  1. Book ; Thesis: Untersuchung von Parametern der Gefäßfunktion bei Lebendnierenspendern und Lebendnierentransplantatempfängern

    Mang, Johannes / Krämer, Bernhard

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Johannes Felix Mang ; Referent: Prof. Dr. med. Bernhard Krämer
    Subject code 617.46 ; 610
    Language German
    Size 59 Blätter, Diagramme, Illustrationen
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030358747
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Patienten- und Transplantatüberleben nach Doppelnierentransplantation im Vergleich zu einer gematchten Kontrollgruppe

    Marinez, Julian / Krämer, Bernhard

    „Ergebnisse des Mannheimer Transplantationszentrums in der aktuellen Spendersituation mit zunehmender Zahl marginaler Organe“

    2021  

    Title variant Patientenüberleben
    Institution Universität Heidelberg
    Author's details vorgelegt von Julian Marinez ; Referent: Herr Prof. Dr. med. B. Krämer
    Language German
    Size 55 Blätter, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021410254
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Effekt von Omega-3-Fettsäuren auf die Expression der endothelialen und thrombozytären Aktivitäts- und Progressionsmarker

    Michaeli, Christoph T. / Krämer, Bernhard

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Christoph Thomas Michaeli ; Referent: Prof. Dr. med. Bernhard Krämer
    Language German
    Size 100 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2023
    HBZ-ID HT030043566
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Thesis: Der Einsatz von Minoxidil zur Behandlung der therapieresistenten Hypertonie bei chronischer Niereninsuffizienz

    Matenaer, Matthias / Krämer, Bernhard

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von Matthias Matenaer ; Referent: Prof. Dr. med. Bernhard Krämer
    Language German
    Size 46 Blätter, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2020
    HBZ-ID HT020893723
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Does the Expanded Controlled Evidence Now Mandate the Routine Use of Machine Perfusion in Kidney Transplantation?

    Schnuelle, Peter / Krämer, Bernhard K

    Mayo Clinic proceedings

    2023  Volume 99, Issue 1, Page(s) 22–25

    MeSH term(s) Humans ; Kidney Transplantation ; Kidney ; Perfusion ; Graft Survival
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erhöhen Antihypertensiva das Krebsrisiko?

    Krämer, Bernhard K

    MMW Fortschritte der Medizin

    2019  Volume 161, Issue 13, Page(s) 63–64

    Title translation Hypertension therapy - what is the risk of getting cancer from antihypertensive drugs?
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/drug therapy ; Neoplasms/chemically induced
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
    Language German
    Publishing date 2019-07-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-019-0717-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 72: Show issues

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  7. Article ; Conference proceedings: Abstracts / International Meeting on Cyclooxygenase-2 and Renal Function

    Krämer, Bernhard K.

    May 26 - 27, 2000, Regensburg, Germany

    2000  

    Event/congress International Meeting on Cyclooxygenase-2 and Renal Function (2000, Regensburg)
    Author's details ed. Bernhard Krämer
    Language English
    Publishing country Switzerland
    Document type Article ; Conference proceedings
    Note In: Kidney & blood pressure research. - ISSN 1420-4096. - 23 (2000),6, S. 405 - 413
    HBZ-ID HT012856743
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1458 -23- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Clinical and genetic diagnosis of familial hypercholesterolaemia in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study.

    Molnar, Stefan / Scharnagl, Hubert / Delgado, Graciela E / Krämer, Bernhard K / Laufs, Ulrich / März, Winfried / Kleber, Marcus E / Katzmann, Julius L

    European heart journal. Quality of care & clinical outcomes

    2024  

    Abstract: Aims: To investigate the prevalence of familial hypercholesterolaemia (FH) and compare the performance of clinical criteria and genetic testing in patients undergoing coronary angiography.: Methods: The prevalence of FH was determined with the Dutch ... ...

    Abstract Aims: To investigate the prevalence of familial hypercholesterolaemia (FH) and compare the performance of clinical criteria and genetic testing in patients undergoing coronary angiography.
    Methods: The prevalence of FH was determined with the Dutch Lipid Clinical Network (DLCN), US-MEDPED, Simon Broome (SB) criteria, the 'Familial Hypercholesterolaemia Case Ascertainment Tool' (FAMCAT), and a clinical algorithm. Genetic screening was conducted with a custom array from Affymetrix (CARRENAL array) harboring 944 FH mutations.
    Results: The study cohort consisted of 3267 patients (78.6% with coronary artery disease [CAD]). FH was diagnosed in 2.8%, 2.2%, 3.9%, and 7.9% using the DLCN, US-MEDPED, SB criteria, and the FAMCAT. The clinical algorithm identified the same patients as the SB criteria. Pathogenic FH mutations were found in 1.2% (1.2% in patients with CAD, 1.0% in patients without CAD). FH was more frequently diagnosed in younger patients. With genetic testing as reference, the clinical criteria achieved areas under the ROC curve (AUCs) in the range of 0.56-0.68. Using only LDL-C corrected for statin intake, an AUC of 0.68 was achieved.
    Conclusion: FH is up to fourfold more prevalent in patients undergoing coronary angiography than in contemporary cohorts representing the general population. Different clinical criteria yield substantially different diagnosis rates, overestimating the prevalence of FH compared to genetic testing. LDL-C testing alone may be sufficient to raise the suspicion of FH, which then needs to be corroborated by genetic testing.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcad075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench.

    Chen, Xin / Hocher, Carl-Friedrich / Shen, Linghong / Krämer, Bernhard K / Hocher, Berthold

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 3, Page(s) C661–C681

    Abstract: Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular events in a glucose-independent manner, thereby ultimately reducing mortality ... ...

    Abstract Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular events in a glucose-independent manner, thereby ultimately reducing mortality in patients with chronic kidney disease (CKD) and/or heart failure. These existing clinical data stimulated preclinical studies aiming to understand the observed clinical effects. In animal models, it was shown that the beneficial effect of SGLT2i on the tubuloglomerular feedback (TGF) improves glomerular pressure and reduces tubular workload by improving renal hemodynamics, which appears to be dependent on salt intake. High salt intake might blunt the SGLT2i effects on the TGF. Beyond the salt-dependent effects of SGLT2i on renal hemodynamics, SGLT2i inhibited several key aspects of macrophage-mediated renal inflammation and fibrosis, including inhibiting the differentiation of monocytes to macrophages, promoting the polarization of macrophages from a proinflammatory M1 phenotype to an anti-inflammatory M2 phenotype, and suppressing the activation of inflammasomes and major proinflammatory factors. As macrophages are also important cells mediating atherosclerosis and myocardial remodeling after injury, the inhibitory effects of SGLT2i on macrophage differentiation and inflammatory responses may also play a role in stabilizing atherosclerotic plaques and ameliorating myocardial inflammation and fibrosis. Recent studies suggest that SGLT2i may also act directly on the Na
    MeSH term(s) Animals ; Fibrosis ; Inflammation/drug therapy ; Kidney/metabolism ; Renal Insufficiency, Chronic ; Sodium Chloride, Dietary ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium Chloride, Dietary ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00177.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  10. Article ; Online: Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

    Yazdani, Babak / Lutz, Niklas / Krämer, Bernhard K

    The New England journal of medicine

    2020  Volume 382, Issue 12, Page(s) 1181–1182

    MeSH term(s) Aminobutyrates ; Angiotensins ; Heart Failure ; Humans ; Neprilysin ; Stroke Volume
    Chemical Substances Aminobutyrates ; Angiotensins ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2000284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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