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  1. Book ; Online ; Thesis: Fraktionsbindungen in den deutschen Volksvertretungen 1819 - 1849.

    Kramer, Helmut [Verfasser]

    2023  

    Author's details Helmut Kramer
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Duncker & Humblot
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    ISBN 978-3-428-42013-1 ; 3-428-42013-6
    Database Digital theses on the web

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  2. Book ; Online ; Thesis: Spektrum der Zuversicht

    Krämer, Helmut [Verfasser]

    Zur Kontingenzbewältigung im politischen Denken der Schottischen Aufklärung

    2021  

    Author's details Helmut Krämer
    Keywords Philosophie ; Philosophy
    Subject code sg100
    Language German
    Publisher Böhlau Verlag Köln
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    ISBN 978-3-412-52294-0 ; 3-412-52294-5 ; 3-412-52294-5 ; 978-3-412-52294-0
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  3. Article: Visual impairment cell non-autonomously dysregulates brain-wide proteostasis.

    Shekhar, Shashank / Wert, Katherine J / Krämer, Helmut

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Loss of hearing or vision has been identified as a significant risk factor for dementia but underlying molecular mechanisms are unknown. In different Drosophila models of blindness, we observe non-autonomous induction of stress granules in the brain and ... ...

    Abstract Loss of hearing or vision has been identified as a significant risk factor for dementia but underlying molecular mechanisms are unknown. In different Drosophila models of blindness, we observe non-autonomous induction of stress granules in the brain and their reversal upon restoration of vision. Stress granules include cytosolic condensates of p62, ATF4 and XRP1. This cytosolic restraint of the ATF4 and XRP1 transcription factors dampens expression of their downstream targets during cellular stress. Cytosolic condensates of p62 and ATF4 were also evident in the thalamus and hippocampus of mouse models of congenital or degenerative blindness. These data indicate conservation of the link between loss of sensory input and dysregulation of stress responses critical for protein quality control in the brain.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.19.563166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A phosphoswitch at acinus-serine

    Nandi, Nilay / Zaidi, Zuhair / Tracy, Charles / Krämer, Helmut

    eLife

    2022  Volume 11

    Abstract: Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that ... ...

    Abstract Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in
    MeSH term(s) Animals ; Autophagy/drug effects ; Autophagy/genetics ; Autophagy/physiology ; Cadmium/metabolism ; Cadmium/toxicity ; Cadmium Poisoning ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/enzymology ; Drosophila melanogaster/physiology ; Female ; Male ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/metabolism ; Serine/genetics ; Serine/metabolism ; Stress, Physiological/drug effects
    Chemical Substances Cadmium (00BH33GNGH) ; Serine (452VLY9402) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.72169
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  5. Article ; Online: In situ

    Nandi, Nilay / Tracy, Charles / Krämer, Helmut

    Bio-protocol

    2022  Volume 12, Issue 18

    Abstract: The activity of numerous autophagy-related proteins depends on their phosphorylation status, which places importance on understanding the responsible kinases and phosphatases. Great progress has been made in identifying kinases regulating autophagy, but ... ...

    Abstract The activity of numerous autophagy-related proteins depends on their phosphorylation status, which places importance on understanding the responsible kinases and phosphatases. Great progress has been made in identifying kinases regulating autophagy, but much less is known about the phosphatases counteracting their function. Genetic screens and modern proteomic approaches provide powerful tools to identify candidate phosphatases, but further experiments are required to assign direct roles for candidates. We have devised a novel protocol to test the role of purified phosphatases in dephosphorylating specific targets
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Route to destruction: autophagosomes SNARE lysosomes.

    Krämer, Helmut

    The Journal of cell biology

    2013  Volume 201, Issue 4, Page(s) 495–497

    Abstract: Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradation. Three recent papers, including one by Takáts et al. ...

    Abstract Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradation. Three recent papers, including one by Takáts et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201211160), have taken different routes to discover a role for Syntaxin 17 in the maturation of autophagosomes.
    MeSH term(s) Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Lysosomes/metabolism ; Neurons/metabolism ; Phagosomes/physiology ; Qa-SNARE Proteins/metabolism ; R-SNARE Proteins/metabolism ; SNARE Proteins/metabolism
    Chemical Substances Drosophila Proteins ; Qa-SNARE Proteins ; R-SNARE Proteins ; SNARE Proteins ; Snap29 protein, Drosophila ; VAMP7 protein, Drosophila
    Language English
    Publishing date 2013-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201304065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Autophagy Keeps the Balance in Tissue Homeostasis.

    Buszczak, Michael / Krämer, Helmut

    Developmental cell

    2019  Volume 49, Issue 4, Page(s) 499–500

    Abstract: Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of Developmental Cell, Zhang and colleagues (2019) show autophagy-mediated regulation of EGFR ... ...

    Abstract Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of Developmental Cell, Zhang and colleagues (2019) show autophagy-mediated regulation of EGFR signaling cell autonomously controls intestinal stem cell proliferation, with implications for human colorectal cancer development.
    MeSH term(s) Autophagy ; Cell Differentiation ; Cell Proliferation ; ErbB Receptors ; Homeostasis ; Humans ; Stem Cells
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2019-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2019.05.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
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  8. Article ; Online: Cdk5-mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress.

    Nandi, Nilay / Krämer, Helmut

    Autophagy

    2018  Volume 14, Issue 7, Page(s) 1271–1272

    Abstract: In neurons, autophagy counteracts consequences of aging. It is therefore of interest how basal rates of macroautophagy/autophagy can be controlled independently of metabolic stress. We recently investigated the regulation of basal, starvation-independent ...

    Abstract In neurons, autophagy counteracts consequences of aging. It is therefore of interest how basal rates of macroautophagy/autophagy can be controlled independently of metabolic stress. We recently investigated the regulation of basal, starvation-independent autophagy by Acn/Acinus, a multifunctional nuclear protein with proposed roles in apoptosis, alternative RNA splicing, and basal autophagy. We found that Acn is stabilized by phosphorylation of the conserved serine 437. The phosphomimetic Acn
    MeSH term(s) Animals ; Autophagy ; Cyclin-Dependent Kinase 5 ; Drosophila Proteins ; Drosophila melanogaster ; Longevity ; Phosphorylation ; Stress, Physiological ; Transcription Factors
    Chemical Substances Acn protein, Drosophila ; Drosophila Proteins ; Transcription Factors ; Cyclin-Dependent Kinase 5 (EC 2.7.11.1) ; Cdk5 protein, Drosophila (EC 2.7.11.22)
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2018.1441472
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    Zs.A 6741: Show issues Location:
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  9. Article ; Online: Acinus: a nuclear regulator of autophagy and endocytic trafficking.

    Krämer, Helmut

    Autophagy

    2010  Volume 6, Issue 7, Page(s) 974–975

    Abstract: Fusion with lysosomes is the common last step of endocytic trafficking and autophagy. Accordingly, several proteins are required in both pathways for cargoes to reach their destinations. Among these proteins, Drosophila Acinus stands out, as it exerts ... ...

    Abstract Fusion with lysosomes is the common last step of endocytic trafficking and autophagy. Accordingly, several proteins are required in both pathways for cargoes to reach their destinations. Among these proteins, Drosophila Acinus stands out, as it exerts opposite effects on these two pathways, and thus establishes a new paradigm. Loss of Acinus function destabilizes early endosomes, thereby promoting the delivery of their cargo to lysosomes. By contrast, the maturation of autophagosomes to autolysosomes is inhibited in acn mutant cells. The increase in autophagy upon Acinus overexpression and its location to the nucleus are consistent with Acinus being a novel regulator of autophagy.
    MeSH term(s) Autophagy/physiology ; Cell Nucleus/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Endocytosis/physiology ; Endosomes/metabolism ; Lysosomes/metabolism ; Mutation ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Acn protein, Drosophila ; Drosophila Proteins ; Transcription Factors
    Language English
    Publishing date 2010-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.4161/auto.6.7.13100
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    Zs.A 6741: Show issues Location:
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  10. Article: Reformbedarf der Nationalökonomie

    Kramer, Helmut

    Monatsberichte // WIFO, Österreichisches Institut für Wirtschaftsforschung Vol. 87, No. 12 , p. 823-833

    2014  Volume 87, Issue 12, Page(s) 823–833

    Abstract: This time is different" - so lautet der Titel des umstrittenen Buches von Carmen M. Reinhart und Kenneth S. Rogoff (2011). Eine Häufung von retardierenden Einflüssen lähmt nun schon sieben Jahre die internationale Wirtschaft, die Gesellschaft und die ... ...

    Author's details Helmut Kramer
    Abstract "This time is different" - so lautet der Titel des umstrittenen Buches von Carmen M. Reinhart und Kenneth S. Rogoff (2011). Eine Häufung von retardierenden Einflüssen lähmt nun schon sieben Jahre die internationale Wirtschaft, die Gesellschaft und die Politik vieler Länder, vor allem Europas. Einiges von den fatalen Abläufen und ihren Ursachen wird heute besser verstanden als vor Ausbruch der Krise, viele Zusammenhänge sind jedoch umstritten und wohl noch lange nicht abschließend geklärt. Die komplexe Zusammenballung von Problemen beschränkt sich nicht auf die ökonomische Ebene. Daher versprechen Versuche, die Hintergründe mit den herkömmlichen, zumal regelmäßig meist widersprüchlichen ökonomischen Ansätzen auszuleuchten, wenig Erfolg. Grundlegende Veränderungen auf Gebieten, deren Ursache nur indirekt mit der Wirtschaft zu tun hat, sind schwierig zu analysierende Komplikationen für die Nationalökonomie und die einschlägigen Wissenschaften.
    Keywords Wirtschaftswissenschaft ; Wirtschaftswissenschaftliche Methoden ; Geschichte des ökonomischen Denkens ; Heterodoxe Ansätze ; Reform
    Language German
    Publisher WIFO
    Publishing place Wien
    Document type Article
    Note Zsfassung in engl. Sprache
    ZDB-ID 206451-0 ; 1494217-3
    ISSN 0029-9898
    ISSN 0029-9898
    Database ECONomics Information System

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