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  1. Article ; Online: Characterizing follicular dendritic cells: A progress report.

    Aguzzi, Adriano / Krautler, Nike J

    European journal of immunology

    2010  Volume 40, Issue 8, Page(s) 2134–2138

    Abstract: In 1965, Mitchell and Abbot (Mitchell, J. and Abbot A, Nature 1965. 30: 500-502) discovered peculiar cells with filiform processes, which were capable of capturing and retaining antigens within secondary lymphoid organs. Yet half a century since the ... ...

    Abstract In 1965, Mitchell and Abbot (Mitchell, J. and Abbot A, Nature 1965. 30: 500-502) discovered peculiar cells with filiform processes, which were capable of capturing and retaining antigens within secondary lymphoid organs. Yet half a century since the first description of follicular dendritic cells (FDC), their function and their histogenesis remain largely mysterious. FDC are thought to help with organization of the lymphoid follicles, to facilitate the germinal center reaction by presenting antigen to B cells, and to legislate the engulfment of apoptotic bodies, but it has proved difficult to stringently verify any of these functions. One reason for such slow progress is a dearth of markers specific to FDC and their precursors, which limits our ability to isolate, target, and follow FDC. Here we review the current state of FDC science with specific reference to a study in this issue of the European Journal of Immunology and its efforts in discovering new FDC markers.
    MeSH term(s) Animals ; Antigen Presentation ; Antigens, Differentiation/metabolism ; B-Lymphocytes/immunology ; Cell Differentiation ; Cell Lineage ; Dendritic Cells, Follicular/immunology ; Dendritic Cells, Follicular/metabolism ; Dendritic Cells, Follicular/pathology ; Germinal Center/pathology ; Humans ; Mice
    Chemical Substances Antigens, Differentiation
    Language English
    Publishing date 2010-08
    Publishing country Germany
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201040765
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    Zs.A 489: Show issues Location:
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  2. Article ; Online: LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular.

    Greczmiel, Ute / Kräutler, Nike J / Borsa, Mariana / Pedrioli, Alessandro / Bartsch, Ilka / Richter, Kirsten / Agnellini, Paola / Bedenikovic, Gregor / Oxenius, Annette

    European journal of immunology

    2019  Volume 50, Issue 3, Page(s) 396–403

    Abstract: Persistent virus infections with non- or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus-unspecific antibodies. These seemingly unspecific ... ...

    Abstract Persistent virus infections with non- or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus-unspecific antibodies. These seemingly unspecific antibody responses interfere with the virus-specific humoral immunity and contribute to delayed virus control. Whether these virus-unspecific antibodies are induced in the B cell follicle or at extrafollicular sites and whether one specific CD4 T cell subset is involved in the polyclonal B cell activation is unclear. Here we studied virus-unrelated IgG antibody responses against self or foreign antigens in the context of persistent lymphocytic choriomeningitis virus (LCMV) infection. We found that the LCMV-unspecific antibody response is short-lived and induced predominantly at extrafollicular sites and depends on the presence of LCMV-specific CD4 T cells. Our data support a scenario in which activated, virus-specific CD4 T cells provide help to non-specific B cells at extrafollicular sites, supporting the production of virus unspecific IgG antibodies during persistent viral infection.
    MeSH term(s) Animals ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; Immunoglobulin G/immunology ; Lymphocyte Activation/immunology ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic choriomeningitis virus/immunology ; Mice, Inbred C57BL
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2019-11-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201948286
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  3. Article ; Online: Positive selection of IgG

    Sundling, Christopher / Lau, Angelica W Y / Bourne, Katherine / Young, Clara / Laurianto, Candy / Hermes, Jana R / Menzies, Rosemary J / Butt, Danyal / Kräutler, Nike J / Zahra, David / Suan, Dan / Brink, Robert

    Immunity

    2021  Volume 54, Issue 5, Page(s) 988–1001.e5

    Abstract: Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs contained mostly ... ...

    Abstract Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs contained mostly unswitched IgM
    MeSH term(s) Animals ; Antibody Formation/immunology ; Antigens/immunology ; B-Lymphocytes/immunology ; Female ; Germinal Center/immunology ; Immunoglobulin Class Switching/immunology ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Immunoglobulin Variable Region/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Sheep/immunology ; Somatic Hypermutation, Immunoglobulin/immunology
    Chemical Substances Antigens ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin Variable Region
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness.

    Isringhausen, Stephan / Mun, YeVin / Kovtonyuk, Larisa / Kräutler, Nike J / Suessbier, Ute / Gomariz, Alvaro / Spaltro, Gianluca / Helbling, Patrick M / Wong, Hui Chyn / Nagasawa, Takashi / Manz, Markus G / Oxenius, Annette / Nombela-Arrieta, César

    The Journal of experimental medicine

    2021  Volume 218, Issue 12

    Abstract: Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM) failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral challenge and inflammatory responses target BM tissues and perturb hematopoietic ...

    Abstract Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM) failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral challenge and inflammatory responses target BM tissues and perturb hematopoietic competence remains poorly understood. Here, we combine functional analyses with advanced 3D microscopy to demonstrate that chronic infection with lymphocytic choriomeningitis virus leads to (1) long-lasting decimation of the BM stromal network of mesenchymal CXCL12-abundant reticular cells, (2) proinflammatory transcriptional remodeling of remaining components of this key niche subset, and (3) durable functional defects and decreased competitive fitness in HSCs. Mechanistically, BM immunopathology is elicited by virus-specific, activated CD8 T cells, which accumulate in the BM via interferon-dependent mechanisms. Combined antibody-mediated inhibition of type I and II IFN pathways completely preempts degeneration of CARc and protects HSCs from chronic dysfunction. Hence, viral infections and ensuing immune reactions durably impact BM homeostasis by persistently decreasing the competitive fitness of HSCs and disrupting essential stromal-derived, hematopoietic-supporting cues.
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Bone Marrow/virology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism ; Chronic Disease ; Gene Expression Regulation ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/pathology ; Hematopoietic Stem Cells/virology ; Interferons/metabolism ; Lymphocytic Choriomeningitis/metabolism ; Lymphocytic Choriomeningitis/pathology ; Lymphocytic Choriomeningitis/virology ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/immunology ; Receptor, Interferon alpha-beta/metabolism ; Mice
    Chemical Substances Chemokine CXCL12 ; Cxcl12 protein, mouse ; Receptor, Interferon alpha-beta (156986-95-7) ; Interferons (9008-11-1)
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20192070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Characterizing follicular dendritic cells: A progress report

    Aguzzi, Adriano / Krautler, Nike J

    European journal of immunology. 2010 Aug., v. 40, no. 8

    2010  

    Abstract: In 1965, Mitchell and Abbot (Mitchell, J. and Abbot A, Nature 1965. 30: 500-502) discovered peculiar cells with filiform processes, which were capable of capturing and retaining antigens within secondary lymphoid organs. Yet half a century since the ... ...

    Abstract In 1965, Mitchell and Abbot (Mitchell, J. and Abbot A, Nature 1965. 30: 500-502) discovered peculiar cells with filiform processes, which were capable of capturing and retaining antigens within secondary lymphoid organs. Yet half a century since the first description of follicular dendritic cells (FDC), their function and their histogenesis remain largely mysterious. FDC are thought to help with organization of the lymphoid follicles, to facilitate the germinal center reaction by presenting antigen to B cells, and to legislate the engulfment of apoptotic bodies, but it has proved difficult to stringently verify any of these functions. One reason for such slow progress is a dearth of markers specific to FDC and their precursors, which limits our ability to isolate, target, and follow FDC. Here we review the current state of FDC science with specific reference to a study in this issue of the European Journal of Immunology and its efforts in discovering new FDC markers.
    Language English
    Dates of publication 2010-08
    Size p. 2134-2138.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201040765
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner.

    Barnstorf, Isabel / Borsa, Mariana / Baumann, Nicolas / Pallmer, Katharina / Yermanos, Alexander / Joller, Nicole / Spörri, Roman / Welten, Suzanne P M / Kräutler, Nike J / Oxenius, Annette

    The Journal of experimental medicine

    2019  Volume 216, Issue 3, Page(s) 571–586

    Abstract: Chronic viral infections are widespread among humans, with ∼8-12 chronic viral infections per individual, and there is epidemiological proof that these impair heterologous immunity. We studied the impact of chronic LCMV infection on the phenotype and ... ...

    Abstract Chronic viral infections are widespread among humans, with ∼8-12 chronic viral infections per individual, and there is epidemiological proof that these impair heterologous immunity. We studied the impact of chronic LCMV infection on the phenotype and function of memory bystander CD8
    MeSH term(s) Animals ; Bystander Effect ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; Chronic Disease ; Female ; Host-Pathogen Interactions/immunology ; Immunologic Memory ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Lectins, C-Type/genetics ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/metabolism ; Lymphocytic choriomeningitis virus/pathogenicity ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Perforin/immunology ; Perforin/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; STAT1 Transcription Factor/immunology ; STAT1 Transcription Factor/metabolism
    Chemical Substances Interleukin-6 ; Klrg1 protein, mouse ; Lectins, C-Type ; Receptors, Immunologic ; STAT1 Transcription Factor ; Stat1 protein, mouse ; interleukin-6, mouse ; Perforin (126465-35-8)
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20181589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

    Suan, Dan / Kräutler, Nike J / Maag, Jesper L V / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Avery, Danielle T / Young, Clara / Statham, Aaron / Elliott, Michael / Dinger, Marcel E / Basten, Antony / Tangye, Stuart G / Brink, Robert

    Immunity

    2017  Volume 47, Issue 6, Page(s) 1142–1153.e4

    Abstract: Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC ...

    Abstract Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6
    MeSH term(s) Animals ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Immunophenotyping ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype ; Plasma Cells/cytology ; Plasma Cells/immunology ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/immunology ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/immunology ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology ; Receptors, CXCR4/genetics ; Receptors, CXCR4/immunology ; Signal Transduction
    Chemical Substances B7-2 Antigen ; CCR6 protein, mouse ; CXCR4 protein, mouse ; Cd86 protein, mouse ; Prdm1 protein, mouse ; Receptors, CCR6 ; Receptors, CXCR4 ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
    Language English
    Publishing date 2017--19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2017.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

    Kräutler, Nike J / Suan, Dan / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Chan, Tyani D / Sundling, Christopher / Kaplan, Warren / Schofield, Peter / Jackson, Jennifer / Basten, Antony / Christ, Daniel / Brink, Robert

    The Journal of experimental medicine

    2017  Volume 214, Issue 5, Page(s) 1259–1267

    Abstract: Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying ... ...

    Abstract Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of the GC. Initiation of differentiation required signals delivered upon engagement with intact antigen. Signals delivered by T follicular helper cells were not required to initiate differentiation but were essential to complete the differentiation process and drive migration of maturing PCs through the dark zone and out of the GC. This bipartite or two-signal mechanism has likely evolved to both sustain protective immunity and avoid autoantibody production.
    MeSH term(s) Animals ; Antigens, Differentiation, B-Lymphocyte/physiology ; B-Lymphocytes/physiology ; Cell Differentiation/physiology ; Germinal Center/physiology ; Mice ; Mice, Inbred C57BL ; Plasma Cells/physiology ; T-Lymphocytes, Helper-Inducer/physiology
    Chemical Substances Antigens, Differentiation, B-Lymphocyte
    Language English
    Publishing date 2017-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20161533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bacterial colitis increases susceptibility to oral prion disease.

    Sigurdson, Christina J / Heikenwalder, Mathias / Manco, Giuseppe / Barthel, Manja / Schwarz, Petra / Stecher, Bärbel / Krautler, Nike J / Hardt, Wolf-Dietrich / Seifert, Burkhardt / MacPherson, Andrew J S / Corthesy, Irène / Aguzzi, Adriano

    The Journal of infectious diseases

    2006  Volume 199, Issue 2, Page(s) 243–252

    Abstract: Dietary exposure to prion-contaminated materials has caused kuru and variant Creutzfeldt-Jakob disease in humans and transmissible spongiform encephalopathies (TSEs) in cattle, mink, and felines. The epidemiology of dietary prion infections suggests that ...

    Abstract Dietary exposure to prion-contaminated materials has caused kuru and variant Creutzfeldt-Jakob disease in humans and transmissible spongiform encephalopathies (TSEs) in cattle, mink, and felines. The epidemiology of dietary prion infections suggests that host genetic modifiers and possibly exogenous cofactors may play a decisive role in determining disease susceptibility. However, few cofactors influencing susceptibility to prion infection have been identified. In the present study, we investigated whether colitis might represent one such cofactor. We report that moderate colitis caused by an attenuated Salmonella strain more than doubles the susceptibility of mice to oral prion infection and modestly accelerates the development of disease after prion challenge. The prion protein was up-regulated in intestines and mesenteric lymph nodes of mice with colitis, providing a possible mechanism for the effect of colitis on the pathogenesis of prion disease. Therefore, moderate intestinal inflammation at the time of prion exposure may constitute one of the elusive risk factors underlying the development of TSE.
    MeSH term(s) Animals ; Cecum/metabolism ; Disease Susceptibility ; Enterocolitis/complications ; Enterocolitis/microbiology ; Mice ; Mice, Inbred C57BL ; Mouth Diseases/complications ; Mouth Diseases/metabolism ; PrPC Proteins/metabolism ; PrPSc Proteins/metabolism ; Prion Diseases/complications ; Prion Diseases/metabolism ; Prions/metabolism ; Prions/pathogenicity ; Risk Factors ; Salmonella Infections/complications ; Salmonella Infections/microbiology ; Salmonella typhimurium/genetics ; Salmonella typhimurium/pathogenicity ; Scrapie/complications ; Scrapie/metabolism ; Specific Pathogen-Free Organisms
    Chemical Substances PrPC Proteins ; PrPSc Proteins ; Prions
    Language English
    Publishing date 2006-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1086/595791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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