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Article ; Online: Self-assembly and percolation in two dimensional binary magnetic colloids.

Carstensen, Hauke / Krämer, Anne / Kapaklis, Vassilios / Wolff, Max

2022 Volume 18, Issue 33, Page(s) 6222–6228

Abstract: We study the self-assembly of branching-chain networks and crystals in a binary colloidal system with tunable interactions. The particle positions are extracted from microscopy images and order parameters are extracted by image processing and statistical ...

Abstract	We study the self-assembly of branching-chain networks and crystals in a binary colloidal system with tunable interactions. The particle positions are extracted from microscopy images and order parameters are extracted by image processing and statistical analysis. With these, we construct phase diagrams with respect to particle density, ratio and interaction. In order to draw a more complete picture, we complement the experiments with computer simulations. We establish a region in the phase diagram, where bead ratios and interactions are symmetric, promoting percolated structures.
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d2sm00661h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism.

Krämer, Anne I / Handschin, Christoph

International journal of molecular sciences

2019 Volume 20, Issue 21

Abstract: Epigenetic changes are a hallmark of short- and long-term transcriptional regulation, and hence instrumental in the control of cellular identity and plasticity. Epigenetic mechanisms leading to changes in chromatin structure, accessibility for ... ...

Abstract	Epigenetic changes are a hallmark of short- and long-term transcriptional regulation, and hence instrumental in the control of cellular identity and plasticity. Epigenetic mechanisms leading to changes in chromatin structure, accessibility for recruitment of transcriptional complexes, and interaction of enhancers and promoters all contribute to acute and chronic adaptations of cells, tissues and organs to internal and external perturbations. Similarly, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is activated by stimuli that alter the cellular energetic demand, and subsequently controls complex transcriptional networks responsible for cellular plasticity. It thus is of no surprise that PGC-1α is under the control of epigenetic mechanisms, and constitutes a mediator of epigenetic changes in various tissues and contexts. In this review, we summarize the current knowledge of the link between epigenetics and PGC-1α in health and disease.
MeSH term(s)	Adipose Tissue, Brown/metabolism ; Animals ; DNA Methylation ; Energy Metabolism/genetics ; Epigenesis, Genetic ; Gene Expression Regulation ; Humans ; Obesity/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics
Chemical Substances	PPARGC1A protein, human ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Language	English
Publishing date	2019-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20215449
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Article ; Online: LeerstandsOFFENSIVE

Krämer, Anne-Karin

Nimm's sportlich : Planung als Hindernislauf ; 16. Junges Forum der ARL, 29. bis 31. Mai 2013 in Kaiserslautern , p. 110-124

ein interkommunales Projekt zur Leerstandsbewältigung

2014 , Page(s) 110–124

Abstract: 2011 starteten elf Gemeinden in peripherer Lage in der Oberpfalz die LeerstandsOFFENSIVE, um auf öffentlichkeitswirksame Weise ein unpopuläres Thema zu bearbeiten. Zunehmendem Leerstand, insbesondere in Ortskernen, kann nur in Zusammenarbeit mit ... ...

Author's details	Anne-Karin Krämer
Abstract	2011 starteten elf Gemeinden in peripherer Lage in der Oberpfalz die LeerstandsOFFENSIVE, um auf öffentlichkeitswirksame Weise ein unpopuläres Thema zu bearbeiten. Zunehmendem Leerstand, insbesondere in Ortskernen, kann nur in Zusammenarbeit mit Eigentümern und lokalen Akteuren begegnet werden, so der Konsens. Neben der Kartierung der Leerstände und der Ideenentwicklung sind vor allem Bewusstseinsbildung sowie die Beteiligung wesentlicher Akteure die Projektaufgaben. Erste Konzeptideen greifen fehlende Angebote der Kommunen auf. Die Umsetzung eines genossenschaftlichen Dorfladens wird ebenso in die Wege geleitet wie die Umnutzung leerstehender Gebäude zu barrierefreien Wohnungen. Eine Umsetzung wird zuerst in Bestandsgebäuden und erst nachrangig im Neubau gesucht. Aufgrund teilweise schwieriger Rahmenbedingungen werden die Projekte nur langsam zur Durchführung gebracht. Den Projektinitiatoren und Akteuren begegnen Vorbehalte gegenüber den für ländliche Räume neuen Ansätzen. In 2011 eleven municipalities located in peripheral regions of the Upper Palatinate started a project named LeerstandsOFFENSIVE. Measures with an effect on the public are used to deal with the unpopular issue of vacancy. The consensus: The problem of increasing vacancy rates, mainly in the centers of municipalities, can only be solved in cooperation with owners and local actors. Essential project tasks are the mapping of vacancies, increasing the awareness of all stakeholders, participation, brainstorming, information and networking. First concepts include missing offers in the municipalities. Currently, the most successful projects are a cooperative village shop and the conversion of vacant buildings to barrier-free apartments. An implementation is mainly aimed for existing buildings, and only subordinated to new construction. Due to difficult conditions, the realisation of the projects runs slowly. The initiators and actors of the projects are confronted with reservations about new approaches for rural areas.
Keywords	Innenentwicklung ; Leerstand ; interkommunale Zusammenarbeit ; Daseinsvorsorge ; Strukturwandel ; demographischer Wandel
Language	German
Size	Online-Ressource, Ill., graph. Darst., Kt.
Publisher	Akademie für Raumforschung und Landesplanung
Publishing place	Hannover
Document type	Article ; Online
Note	Zsfassung in engl. Sprache
ISBN	978-3-88838-389-2 ; 3-88838-389-7
Database	ECONomics Information System

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Article ; Online: LeerstandsOFFENSIVE

Krämer, Anne-Karin

Ein interkommunales Projekt zur Leerstandsbewältigung

2014

Abstract	2011 starteten elf Gemeinden in peripherer Lage in der Oberpfalz die LeerstandsOFFENSIVE, um auf öffentlichkeitswirksame Weise ein unpopuläres Thema zu bearbeiten. Zunehmendem Leerstand, insbesondere in Ortskernen, kann nur in Zusammenarbeit mit Eigentümern und lokalen Akteuren begegnet werden, so der Konsens. Neben der Kartierung der Leerstände und der Ideenentwicklung sind vor allem Bewusstseinsbildung sowie die Beteiligung wesentlicher Akteure die Projektaufgaben. Erste Konzeptideen greifen fehlende Angebote der Kommunen auf. Die Umsetzung eines genossenschaftlichen Dorfladens wird ebenso in die Wege geleitet wie die Umnutzung leerstehender Gebäude zu barrierefreien Wohnungen. Eine Umsetzung wird zuerst in Bestandsgebäuden und erst nachrangig im Neubau gesucht. Aufgrund teilweise schwieriger Rahmenbedingungen werden die Projekte nur langsam zur Durchführung gebracht. Den Projektinitiatoren und Akteuren begegnen Vorbehalte gegenüber den für ländliche Räume neuen Ansätzen. In 2011 eleven municipalities located in peripheral regions of the Upper Palatinate started a project named LeerstandsOFFENSIVE. Measures with an effect on the public are used to deal with the unpopular issue of vacancy. The consensus: The problem of increasing vacancy rates, mainly in the centers of municipalities, can only be solved in cooperation with owners and local actors. Essential project tasks are the mapping of vacancies, increasing the awareness of all stakeholders, participation, brainstorming, information and networking. First concepts include missing offers in the municipalities. Currently, the most successful projects are a cooperative village shop and the conversion of vacant buildings to barrier-free apartments. An implementation is mainly aimed for existing buildings, and only subordinated to new construction. Due to difficult conditions, the realisation of the projects runs slowly. The initiators and actors of the projects are confronted with reservations about new approaches for rural areas.
Keywords	ddc:710 ; Innenentwicklung ; Leerstand ; interkommunale Zusammenarbeit ; Daseinsvorsorge ; Strukturwandel ; demographischer Wandel
Subject code	801
Language	German
Publisher	Hannover: Verlag der ARL - Akademie für Raumforschung und Landesplanung
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia.

Kraemer, Bjoern F / Hennis, Irina / Karge, Anne / Kraemer, Anne Katrin / Dreyer, Tobias F / Kiechle, Marion / Kuschel, Bettina / Bronger, Holger

Molecular medicine (Cambridge, Mass.)

2022 Volume 28, Issue 1, Page(s) 51

Abstract: Background: Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly understood and only few ... ...

Abstract	Background: Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly understood and only few platelet-based markers have been investigated. In sepsis, platelet mitochondrial membrane depolarization, a sensitive and early indicator of mitochondrial dysfunction and platelet cell death, correlates with disease severity and outcome as shown in previous studies. The aim of this study was to investigate platelet mitochondrial membrane potential (Mmp-Index) by flow-cytometry in patients with preeclampsia compared to controls and to assess its value in correlation with disease severity of PE and during follow-up after delivery. Methods: In this prospective translational case-control study, platelet Mmp-Index was measured in PE (n = 16) by flow cytometry in living platelets in simultaneous comparison to healthy pregnant (n = 32) and non-pregnant controls (n = 16) and was individually reassessed after delivery to investigate recovery of platelet mitochondrial function. Subgroup analysis of patients with severe and non-severe PE was performed. Six patients with isolated gestational hypertension were also included for comparative analysis. Results: Platelet Mmp-Index in patients with symptomatic preeclampsia (Mmp-Index non-severe PE 0.72 ([0.591; 0.861]; p = 0.002) was significantly reduced compared to healthy pregnant controls (Mmp-Index 0.97 [0.795; 1.117]) and even more pronounced in patients with severe PE (n = 6) (Mmp-Index severe PE 0.542 [0.361; 0.623]; p = 0.03). In the severe PE group, complementary measurements of platelet Annexin V- and CD62 (P-Selectin) surface expression showed apoptosis of platelet populations in the majority of patients. Platelet Mmp normalized after delivery within few days. Patients with isolated gestational hypertension showed normal Mmp-Index values. Conclusions: This study shows for the first time that platelet Mmp-Index is a quantifiable, easy-to-measure intracellular marker of platelet mitochondrial function in vital cells that reflects disease severity of preeclampsia. For future investigations, platelet Mmp may serve as a prognostic marker that may aid clinical risk stratification and adds novel information on potential mechanisms for thrombocytopenia in preeclampsia.
MeSH term(s)	Biomarkers ; Blood Platelets/physiology ; Case-Control Studies ; Female ; Humans ; Hypertension, Pregnancy-Induced ; Matrix Metalloproteinases ; Mitochondrial Membranes ; Pre-Eclampsia ; Pregnancy ; Prospective Studies ; Severity of Illness Index ; Thrombocytopenia
Chemical Substances	Biomarkers ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-022-00472-x
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Article ; Online: Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides.

Ferreira, Humberto J / Stevenson, Brian J / Pak, HuiSong / Yu, Fengchao / Almeida Oliveira, Jessica / Huber, Florian / Taillandier-Coindard, Marie / Michaux, Justine / Ricart-Altimiras, Emma / Kraemer, Anne I / Kandalaft, Lana E / Speiser, Daniel E / Nesvizhskii, Alexey I / Müller, Markus / Bassani-Sternberg, Michal

Nature communications

2024 Volume 15, Issue 1, Page(s) 2357

Abstract: Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5' cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in human cancers ... ...

Abstract	Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5' cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in human cancers could be an unexplored source of tumor-specific antigens, potentially mediating anti-tumor T cell responses. This study presents an immunopeptidomics workflow with a specific focus on generating a circRNA-specific protein fasta reference. The main goal of this workflow is to streamline the process of identifying and validating human leukocyte antigen (HLA) bound peptides potentially originating from circRNAs. We increase the analytical stringency of our workflow by retaining peptides identified independently by two mass spectrometry search engines and/or by applying a group-specific FDR for canonical-derived and circRNA-derived peptides. A subset of circRNA-derived peptides specifically encoded by the region spanning the back-splice junction (BSJ) are validated with targeted MS, and with direct Sanger sequencing of the respective source transcripts. Our workflow identifies 54 unique BSJ-spanning circRNA-derived peptides in the immunopeptidome of melanoma and lung cancer samples. Our approach enlarges the catalog of source proteins that can be explored for immunotherapy.
MeSH term(s)	Humans ; RNA, Circular/metabolism ; RNA, Messenger ; Peptides ; Histocompatibility Antigens Class I
Chemical Substances	RNA, Circular ; RNA, Messenger ; Peptides ; Histocompatibility Antigens Class I
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46408-3
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Book ; Thesis: Getaktete Transportnetzwerke

Krämer, Anne K

eine betriebswirtschaftliche und strategische Analyse

(Schriftenreihe Logistik-Management in Forschung und Praxis ; 40)

2011

Author's details	Anne K. Krämer
Series title	Schriftenreihe Logistik-Management in Forschung und Praxis ; 40
Keywords	Lean Management ; Taktfrequenz ; Transportplanung ; Logistikunternehmen ; Kundenorientierung ; Taktfahrplan ; Logistikdienstleister ; Netzwerk ; Spieltheorie
Language	German
Size	XII, 226 S., graph. Darst., 210 mm x 148 mm, 307 g
Publisher	Kovač
Publishing place	Hamburg
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Inst. für Technologie, Diss.--Karlsruhe, 2011
ISBN	3830061080 ; 9783830061083
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Getaktete Transportnetzwerke

Krämer, Anne K

eine betriebswirtschaftliche und strategische Analyse

(Schriftenreihe Logistik-Management in Forschung und Praxis ; 40)

2011

Author's details	Anne K. Krämer
Series title	Schriftenreihe Logistik-Management in Forschung und Praxis ; 40
Keywords	Lean Management ; Taktfrequenz ; Transportplanung ; Logistikunternehmen ; Kundenorientierung ; Taktfahrplan ; Logistikdienstleister ; Netzwerk ; Spieltheorie
Language	German
Size	XII, 226 S., graph. Darst., 210 mm x 148 mm, 307 g
Publisher	Kovač
Publishing place	Hamburg
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Inst. für Technologie, Diss.--Karlsruhe, 2011
ISBN	3830061080 ; 9783830061083
Database	ECONomics Information System

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Article ; Online: The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer.

Kraemer, Anne I / Chong, Chloe / Huber, Florian / Pak, HuiSong / Stevenson, Brian J / Müller, Markus / Michaux, Justine / Altimiras, Emma Ricart / Rusakiewicz, Sylvie / Simó-Riudalbas, Laia / Planet, Evarist / Wiznerowicz, Maciej / Dagher, Julien / Trono, Didier / Coukos, George / Tissot, Stephanie / Bassani-Sternberg, Michal

Nature cancer

2023 Volume 4, Issue 5, Page(s) 608–628

Abstract: One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with ... ...

Abstract	One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3
MeSH term(s)	Humans ; Lung Neoplasms/therapy ; Lung Neoplasms/pathology ; Antigens, Neoplasm/metabolism ; Immunotherapy ; Inflammation ; Tumor Microenvironment
Chemical Substances	Antigens, Neoplasm
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00548-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction.

Müller, Markus / Huber, Florian / Arnaud, Marion / Kraemer, Anne I / Altimiras, Emma Ricart / Michaux, Justine / Taillandier-Coindard, Marie / Chiffelle, Johanna / Murgues, Baptiste / Gehret, Talita / Auger, Aymeric / Stevenson, Brian J / Coukos, George / Harari, Alexandre / Bassani-Sternberg, Michal

Immunity

2023 Volume 56, Issue 11, Page(s) 2650–2663.e6

Abstract: The accurate selection of neoantigens that bind to class I human leukocyte antigen (HLA) and are recognized by autologous T cells is a crucial step in many cancer immunotherapy pipelines. We reprocessed whole-exome sequencing and RNA sequencing (RNA-seq) ...

Abstract	The accurate selection of neoantigens that bind to class I human leukocyte antigen (HLA) and are recognized by autologous T cells is a crucial step in many cancer immunotherapy pipelines. We reprocessed whole-exome sequencing and RNA sequencing (RNA-seq) data from 120 cancer patients from two external large-scale neoantigen immunogenicity screening assays combined with an in-house dataset of 11 patients and identified 46,017 somatic single-nucleotide variant mutations and 1,781,445 neo-peptides, of which 212 mutations and 178 neo-peptides were immunogenic. Beyond features commonly used for neoantigen prioritization, factors such as the location of neo-peptides within protein HLA presentation hotspots, binding promiscuity, and the role of the mutated gene in oncogenicity were predictive for immunogenicity. The classifiers accurately predicted neoantigen immunogenicity across datasets and improved their ranking by up to 30%. Besides insights into machine learning methods for neoantigen ranking, we have provided homogenized datasets valuable for developing and benchmarking companion algorithms for neoantigen-based immunotherapies.
MeSH term(s)	Humans ; Antigens, Neoplasm/genetics ; Neoplasms/genetics ; Neoplasms/therapy ; Histocompatibility Antigens Class I ; Machine Learning ; Peptides ; Immunotherapy/methods
Chemical Substances	Antigens, Neoplasm ; Histocompatibility Antigens Class I ; Peptides
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.09.002
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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