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Article ; Online: Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Wang, Zhe / Emmerich, Andrew / Pillon, Nicolas J / Moore, Tim / Hemerich, Daiane / Cornelis, Marilyn C / Mazzaferro, Eugenia / Broos, Siacia / Ahluwalia, Tarunveer S / Bartz, Traci M / Bentley, Amy R / Bielak, Lawrence F / Chong, Mike / Chu, Audrey Y / Berry, Diane / Dorajoo, Rajkumar / Dueker, Nicole D / Kasbohm, Elisa / Feenstra, Bjarke /
Feitosa, Mary F / Gieger, Christian / Graff, Mariaelisa / Hall, Leanne M / Haller, Toomas / Hartwig, Fernando P / Hillis, David A / Huikari, Ville / Heard-Costa, Nancy / Holzapfel, Christina / Jackson, Anne U / Johansson, Åsa / Jørgensen, Anja Moltke / Kaakinen, Marika A / Karlsson, Robert / Kerr, Kathleen F / Kim, Boram / Koolhaas, Chantal M / Kutalik, Zoltan / Lagou, Vasiliki / Lind, Penelope A / Lorentzon, Mattias / Lyytikäinen, Leo-Pekka / Mangino, Massimo / Metzendorf, Christoph / Monroe, Kristine R / Pacolet, Alexander / Pérusse, Louis / Pool, Rene / Richmond, Rebecca C / Rivera, Natalia V / Robiou-du-Pont, Sebastien / Schraut, Katharina E / Schulz, Christina-Alexandra / Stringham, Heather M / Tanaka, Toshiko / Teumer, Alexander / Turman, Constance / van der Most, Peter J / Vanmunster, Mathias / van Rooij, Frank J A / van Vliet-Ostaptchouk, Jana V / Zhang, Xiaoshuai / Zhao, Jing-Hua / Zhao, Wei / Balkhiyarova, Zhanna / Balslev-Harder, Marie N / Baumeister, Sebastian E / Beilby, John / Blangero, John / Boomsma, Dorret I / Brage, Soren / Braund, Peter S / Brody, Jennifer A / Bruinenberg, Marcel / Ekelund, Ulf / Liu, Ching-Ti / Cole, John W / Collins, Francis S / Cupples, L Adrienne / Esko, Tõnu / Enroth, Stefan / Faul, Jessica D / Fernandez-Rhodes, Lindsay / Fohner, Alison E / Franco, Oscar H / Galesloot, Tessel E / Gordon, Scott D / Grarup, Niels / Hartman, Catharina A / Heiss, Gerardo / Hui, Jennie / Illig, Thomas / Jago, Russell / James, Alan / Joshi, Peter K / Jung, Taeyeong / Kähönen, Mika / Kilpeläinen, Tuomas O / Koh, Woon-Puay / Kolcic, Ivana / Kraft, Peter P / Kuusisto, Johanna / Launer, Lenore J / Li, Aihua / Linneberg, Allan / Luan, Jian'an / Vidal, Pedro Marques / Medland, Sarah E / Milaneschi, Yuri / Moscati, Arden / Musk, Bill / Nelson, Christopher P / Nolte, Ilja M / Pedersen, Nancy L / Peters, Annette / Peyser, Patricia A / Power, Christine / Raitakari, Olli T / Reedik, Mägi / Reiner, Alex P / Ridker, Paul M / Rudan, Igor / Ryan, Kathy / Sarzynski, Mark A / Scott, Laura J / Scott, Robert A / Sidney, Stephen / Siggeirsdottir, Kristin / Smith, Albert V / Smith, Jennifer A / Sonestedt, Emily / Strøm, Marin / Tai, E Shyong / Teo, Koon K / Thorand, Barbara / Tönjes, Anke / Tremblay, Angelo / Uitterlinden, Andre G / Vangipurapu, Jagadish / van Schoor, Natasja / Völker, Uwe / Willemsen, Gonneke / Williams, Kayleen / Wong, Quenna / Xu, Huichun / Young, Kristin L / Yuan, Jian Min / Zillikens, M Carola / Zonderman, Alan B / Ameur, Adam / Bandinelli, Stefania / Bis, Joshua C / Boehnke, Michael / Bouchard, Claude / Chasman, Daniel I / Smith, George Davey / de Geus, Eco J C / Deldicque, Louise / Dörr, Marcus / Evans, Michele K / Ferrucci, Luigi / Fornage, Myriam / Fox, Caroline / Garland, Theodore / Gudnason, Vilmundur / Gyllensten, Ulf / Hansen, Torben / Hayward, Caroline / Horta, Bernardo L / Hyppönen, Elina / Jarvelin, Marjo-Riitta / Johnson, W Craig / Kardia, Sharon L R / Kiemeney, Lambertus A / Laakso, Markku / Langenberg, Claudia / Lehtimäki, Terho / Marchand, Loic Le / Magnusson, Patrik K E / Martin, Nicholas G / Melbye, Mads / Metspalu, Andres / Meyre, David / North, Kari E / Ohlsson, Claes / Oldehinkel, Albertine J / Orho-Melander, Marju / Pare, Guillaume / Park, Taesung / Pedersen, Oluf / Penninx, Brenda W J H / Pers, Tune H / Polasek, Ozren / Prokopenko, Inga / Rotimi, Charles N / Samani, Nilesh J / Sim, Xueling / Snieder, Harold / Sørensen, Thorkild I A / Spector, Tim D / Timpson, Nicholas J / van Dam, Rob M / van der Velde, Nathalie / van Duijn, Cornelia M / Vollenweider, Peter / Völzke, Henry / Voortman, Trudy / Waeber, Gérard / Wareham, Nicholas J / Weir, David R / Wichmann, Heinz-Erich / Wilson, James F / Hevener, Andrea L / Krook, Anna / Zierath, Juleen R / Thomis, Martine A I / Loos, Ruth J F / Hoed, Marcel den

Nature genetics

2022  Volume 54, Issue 9, Page(s) 1332–1344

Abstract: Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide ... ...

Abstract Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II
MeSH term(s) Actinin/genetics ; Cross-Sectional Studies ; Exercise/physiology ; Genome-Wide Association Study ; Humans ; Leisure Activities ; Sedentary Behavior
Chemical Substances ACTN3 protein, human ; Actinin (11003-00-2)
Language English
Publishing date 2022-09-07
Publishing country United States
Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID 1108734-1
ISSN 1546-1718 ; 1061-4036
ISSN (online) 1546-1718
ISSN 1061-4036
DOI 10.1038/s41588-022-01165-1
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Zs.A 3613: Show issues Location:
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