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  1. Article ; Online: Adherence to dietary guidelines and dental caries among children: a longitudinal cohort study.

    van Meijeren-van Lunteren, Agatha W / Voortman, Trudy / Wolvius, Eppo B / Kragt, Lea

    European journal of public health

    2023  Volume 33, Issue 4, Page(s) 653–658

    Abstract: Background: Even though dietary sugars are the most important nutrient for caries development, the disease process is dependent on other dietary practices. The intake of individual nutrient components cannot be evaluated separately from the overall diet ...

    Abstract Background: Even though dietary sugars are the most important nutrient for caries development, the disease process is dependent on other dietary practices. The intake of individual nutrient components cannot be evaluated separately from the overall diet which includes other nutrients, foods and habits. Therefore, the aim of this study was to investigate the association between adherence to dietary guidelines and dental caries.
    Methods: This study was embedded in the Generation R Study, conducted in Rotterdam, the Netherlands. In total, 2911 children were included in the present analyses. Dietary intake at the age of 8 years was assessed using food-frequency questionnaires. Diet quality scores were estimated, reflecting adherence to Dutch dietary guidelines. Dental caries was assessed at the age of 13 years using intra-oral photographs. Associations were estimated using multinomial logistic regression analyses, adjusted for sociodemographic characteristics and oral hygiene practices.
    Results: The prevalence of dental caries at the age of 13 years was 33% (n = 969). Better diet quality was associated with a lower occurrence of severe dental caries after adjustments for sociodemographic factors [e.g. highest vs. lowest quartile of diet quality: odds ratio (OR) 0.62, 95% confidence interval (CI) 0.39-0.98]. After additional adjustments for oral hygiene practices, this association was not statistically significant (OR 0.65, 95% CI 0.41-1.03).
    Conclusion: Adherence to dietary guidelines has the potential to reduce dental caries in children; however, with proper oral hygiene practices, this relationship might be attenuated. To understand the role of dietary patterns and dental caries, the contributing role of daily eating occasions needs to be studied further.
    MeSH term(s) Humans ; Child ; Adolescent ; Longitudinal Studies ; Dental Caries/epidemiology ; Dental Caries/prevention & control ; Feeding Behavior ; Cohort Studies ; Nutrition Policy
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckad097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oral microbiota of adolescents with dental caries: A systematic review.

    Veenman, Francien / van Dijk, Anne / Arredondo, Alexandre / Medina-Gomez, Carolina / Wolvius, Eppo / Rivadeneira, Fernando / Àlvarez, Gerard / Blanc, Vanessa / Kragt, Lea

    Archives of oral biology

    2024  Volume 161, Page(s) 105933

    Abstract: Objective: This systematic review summarizes the current knowledge on the association between the oral microbiota and dental caries in adolescents.: Design: An electronic search was carried out across five databases. Studies were included if they ... ...

    Abstract Objective: This systematic review summarizes the current knowledge on the association between the oral microbiota and dental caries in adolescents.
    Design: An electronic search was carried out across five databases. Studies were included if they conducted research on generally healthy adolescents, applied molecular-based microbiological analyses and assessed caries status. Data extraction was performed by two reviewers and the Newcastle-Ottawa Scale was applied for quality assessment.
    Results: In total, 3935 records were reviewed which resulted in a selection of 20 cross-sectional studies (published 2005-2022) with a sample size ranging from 11 to 614 participants including adolescents between 11 and 19 years. The studies analyzed saliva, dental biofilm or tongue swabs with Checkerboard DNA-DNA hybridization, (q)PCR or Next-Generation Sequencing methods. Prevotella denticola, Scardoviae Wiggsiae, Streptococcus sobrinus and Streptococcus mutans were the most frequently reported species presenting higher abundance in adolescents with caries. The majority of the studies reported that the microbial diversity was similar between participants with and without dental caries.
    Conclusion: This systematic review is the first that shows how the oral microbiota composition in adolescents appears to differ between those with and without dental caries, suggesting certain taxa may be associated with increased caries risk. However, there is a need to replicate and expand these findings in larger, longitudinal studies that also focus on caries severity and take adolescent-specific factors into account.
    MeSH term(s) Humans ; Adolescent ; Dental Caries/microbiology ; Cross-Sectional Studies ; Streptococcus mutans ; Saliva/microbiology ; Microbiota ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2024.105933
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  3. Article ; Online: Neighbourhood characteristics and children's oral health: a multilevel population-based cohort study.

    van Meijeren-van Lunteren, Agatha W / Oude Groeniger, Joost / Wolvius, Eppo B / Kragt, Lea

    European journal of public health

    2021  Volume 31, Issue 4, Page(s) 742–748

    Abstract: Background: To understand determinants of oral health inequalities, multilevel modelling is a useful manner to study contextual factors in relation to individual oral health. Several studies outside Europe have been performed so far, however, contextual ...

    Abstract Background: To understand determinants of oral health inequalities, multilevel modelling is a useful manner to study contextual factors in relation to individual oral health. Several studies outside Europe have been performed so far, however, contextual variables used are diverse and results conflicting. Therefore, this study investigated whether neighbourhood level differences in oral health exist, and whether any of the neighbourhood characteristics used were associated with oral health.
    Methods: This study is embedded in The Generation R Study, a prospective cohort study conducted in The Netherlands. In total, 5 960 6-year-old children, representing 158 neighbourhoods in the area of Rotterdam, were included. Data on individual and neighbourhood characteristics were derived from questionnaires, and via open data resources. Caries was assessed via intraoral photographs, and defined as decayed, missing and filled teeth (dmft).
    Results: Differences between neighbourhoods explained 13.3% of the risk of getting severe caries, and 2% of the chance of visiting the dentist yearly. After adjustments for neighbourhood and individual characteristics, neighbourhood deprivation was significantly associated with severe dental caries (OR: 1.48, 95% CI: 1.02-2.15), and suggestive of a low odds of visiting the dentist yearly (OR: 0.81, 95% CI: 0.56-1.18).
    Conclusions: Childhood caries and use of dental services differs between neighbourhoods and living in a deprived neighbourhood is associated with increased dental caries and decreased yearly use of dental services. This highlights the importance of neighbourhoods for understanding differences in children's oral health, and for targeted policies and interventions to improve the oral health of children living in deprived neighbourhoods.
    MeSH term(s) Child ; Cohort Studies ; Dental Caries/epidemiology ; Humans ; Oral Health ; Prospective Studies ; Residence Characteristics ; Socioeconomic Factors
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckab013
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  4. Article ; Online: Effectiveness of the new mandatory mouthguard use and orodental injuries in Dutch field hockey.

    Cicek, Tevfik / Dhamo, Brunilda / Wolvius, Eppo B / Wesselink, Paul R / Kragt, Lea

    The Physician and sportsmedicine

    2020  Volume 49, Issue 4, Page(s) 455–462

    Abstract: ... ...

    Abstract Objectives
    MeSH term(s) Athletic Injuries/epidemiology ; Athletic Injuries/prevention & control ; Female ; Hockey/injuries ; Humans ; Male ; Mouth Protectors ; Surveys and Questionnaires ; Tooth Injuries/epidemiology ; Tooth Injuries/prevention & control
    Language English
    Publishing date 2020-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 753046-8
    ISSN 2326-3660 ; 0091-3847
    ISSN (online) 2326-3660
    ISSN 0091-3847
    DOI 10.1080/00913847.2020.1853487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of orthodontic treatment need and deviant occlusal traits on oral health-related quality of life in children: A cross-sectional study in the Generation R cohort.

    Nguee, Amanda-Mae A M / Ongkosuwito, Edwin M / Jaddoe, Vincent W V / Wolvius, Eppo B / Kragt, Lea

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2020  Volume 157, Issue 6, Page(s) 764–772.e4

    Abstract: Introduction: Many studies have investigated the impact of orthodontic treatment need (OTN) on children's oral health-related quality of life (OHRQOL). However, few studies have explored the impact of deviant occlusal traits on OHRQOL regarding the ... ...

    Abstract Introduction: Many studies have investigated the impact of orthodontic treatment need (OTN) on children's oral health-related quality of life (OHRQOL). However, few studies have explored the impact of deviant occlusal traits on OHRQOL regarding the severity of OTN. This cross-sectional study aims to address this gap in the literature.
    Methods: This study was conducted within the Generation R Study, a population-based prospective cohort study. We assessed OTN with the Index of Orthodontic Treatment Need and OHRQOL with a parental short-form of the Child Oral Health Impact Profile in 3048 children at a median age of 9.74 years (9.5-10.0). We also further assessed individual malocclusion traits in a subsample of 2714 children. We investigated the association between OTN, malocclusion traits, and OHRQOL using multiple regression analysis with weighted least squares.
    Results: Children with definite (adjusted effect estimate = -0.81; 95% confidence interval -1.12 to -0.50) or borderline (adjusted effect estimate = -0.34; 95% confidence interval -0.61 to -0.08) OTN experienced significant decreases in their OHRQOL than those with no need. An impacted tooth, increased overjet, or crowding had significant negative impacts on children's OHRQOL. Children with an overjet experienced negative impacts on OHRQOL even when orthodontic treatment was not necessary.
    Conclusions: Progressively greater OTN has increasingly negative impacts on parent's perception of children's OHRQOL. In particular, children presenting with large overjets and impacted teeth have lower OHRQOL. These perspectives add to better patient-clinician communication and understanding of patient expectations around OTN, which may potentially lead to improvements in quality of care from the patient perspective.
    MeSH term(s) Child ; Cross-Sectional Studies ; Humans ; Index of Orthodontic Treatment Need ; Malocclusion ; Oral Health ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2019.06.015
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  6. Article ; Online: Oral and craniofacial research in the Generation R study: an executive summary.

    van Meijeren-van Lunteren, Agatha W / Liu, Xianjing / Veenman, Francien C H / Grgic, Olja / Dhamo, Brunilda / van der Tas, Justin T / Prijatelj, Vid / Roshchupkin, Gennady V / Rivadeneira, Fernando / Wolvius, Eppo B / Kragt, Lea

    Clinical oral investigations

    2023  Volume 27, Issue 7, Page(s) 3379–3392

    Abstract: Objectives: Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve ( ... ...

    Abstract Objectives: Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve (equal access to) oral health care systems, and to develop effective oral health promotion programs. Longitudinal population-based (birth-)cohort studies are very suitable to study risk factors on common oral diseases and have the potential to emphasize the importance of a healthy start for oral health. In this paper, we provide an overview of the comprehensive oral and craniofacial dataset that has been collected in the Generation R study: a population-based prospective birth cohort in the Netherlands that was designed to identify causes of health from fetal life until adulthood.
    Methods: Within the multidisciplinary context of the Generation R study, oral and craniofacial data has been collected from the age of 3 years onwards, and continued at the age of six, nine, and thirteen. Data collection is continuing in 17-year-old participants.
    Research outcomes: In total, the cohort population comprised 9749 children at birth, and 7405 eligible participants at the age of seventeen. Based on questionnaires, the dataset contains information on oral hygiene, dental visits, oral habits, oral health-related quality of life, orthodontic treatment, and obstructive sleep apnea. Based on direct measurements, the dataset contains information on dental caries, developmental defects of enamel, objective orthodontic treatment need, dental development, craniofacial characteristics, mandibular cortical thickness, and 3D facial measurements.
    Conclusions: Several research lines have been set up using the oral and craniofacial data linked with the extensive data collection that exists within the Generation R study.
    Clinical relevance: Being embedded in a multidisciplinary and longitudinal birth cohort study allows researchers to study several determinants of oral and craniofacial health, and to provide answers and insight into unknown etiologies and oral health problems in the general population.
    MeSH term(s) Child ; Infant, Newborn ; Humans ; Adult ; Child, Preschool ; Adolescent ; Dental Caries/epidemiology ; Cohort Studies ; Quality of Life ; Prospective Studies ; Oral Health ; Mouth Diseases
    Language English
    Publishing date 2023-06-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-023-05076-1
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  7. Article ; Online: The association of subjective orthodontic treatment need with oral health-related quality of life.

    Kragt, Lea / Jaddoe, Vincent / Wolvius, Eppo / Ongkosuwito, Edwin

    Community dentistry and oral epidemiology

    2017  Volume 45, Issue 4, Page(s) 365–371

    Abstract: Objectives: The existing body of evidence reports an inconsistent association between subjective and objective orthodontic treatment need. The concept of oral health-related quality of life (OHRQoL) might help to explain the differences in subjective ... ...

    Abstract Objectives: The existing body of evidence reports an inconsistent association between subjective and objective orthodontic treatment need. The concept of oral health-related quality of life (OHRQoL) might help to explain the differences in subjective and objective orthodontic treatment need. Our aim was to investigate the association of subjective orthodontic treatment with OHRQoL in children.
    Methods: This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort study. OHRQoL and subjective orthodontic treatment need were assessed by parental questionnaires. Questionnaire items were individually compared among children with no, borderline and definite subjective orthodontic need. The association between subjective orthodontic treatment need and OHRQoL was investigated in multivariate regression analysis with weighted least squares. Differences by sex and levels of objective orthodontic treatment need were evaluated.
    Results: In total, 3774 children were included in the analysis. Children with borderline subjective orthodontic treatment need and those with definite subjective orthodontic treatment need had significantly poorer OHRQoL based on the fully adjusted model (adjusted regression coefficient (aβ)=-0.49, 95% CI: -0.75, -0.30; (aβ)=-1.58, 95% CI: -1.81, -1.58, respectively). The association between subjective orthodontic treatment need and OHRQoL was stronger in girls than in boys and stronger in children with objective orthodontic treatment need than in those with none.
    Conclusions: Oral health-related quality of life is poorer in children with subjective orthodontic treatment need. This has not been investigated before in such a large-population-based study and clearly offers an explanation for the lack of concurrence between objective and subjective orthodontic treatment need.
    MeSH term(s) Child ; Cross-Sectional Studies ; Female ; Health Services Needs and Demand/statistics & numerical data ; Humans ; Male ; Malocclusion/epidemiology ; Malocclusion/therapy ; Netherlands/epidemiology ; Oral Health/statistics & numerical data ; Orthodontics, Corrective/statistics & numerical data ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2017-03-31
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189172-8
    ISSN 1600-0528 ; 0301-5661
    ISSN (online) 1600-0528
    ISSN 0301-5661
    DOI 10.1111/cdoe.12299
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  8. Article ; Online: Associations Between Prenatal, Perinatal, and Early Childhood Vitamin D Status and Risk of Dental Caries at 6 Years.

    Navarro, Constanza L Andaur / Grgic, Olja / Trajanoska, Katerina / van der Tas, Justin T / Rivadeneira, Fernando / Wolvius, Eppo B / Voortman, Trudy / Kragt, Lea

    The Journal of nutrition

    2021  Volume 151, Issue 7, Page(s) 1993–2000

    Abstract: Background: Previous studies have suggested that insufficient concentrations of vitamin D are associated with dental caries in primary teeth, but evidence remains inconclusive.: Objectives: We assessed the longitudinal associations between prenatal, ... ...

    Abstract Background: Previous studies have suggested that insufficient concentrations of vitamin D are associated with dental caries in primary teeth, but evidence remains inconclusive.
    Objectives: We assessed the longitudinal associations between prenatal, perinatal, and early childhood serum 25-hydroxyvitamin D concentrations [25(OH)D] and the risk of dental caries in 6-year-old children.
    Methods: This research was conducted within the Generation R Study, a large, multi-ethnic, prospective cohort study located in Rotterdam, the Netherlands. Dental caries were assessed in children using the decayed-missing-filled-primary teeth index at a mean age of 6.1 years (90% range, 4.8-9.1). We measured serum total 25(OH)D concentrations at 3 time points: prenatally (at 18-24 weeks of gestation), perinatally (at birth), and during early childhood (at age 6 years). We performed logistic regression analyses to determine the longitudinal association of serum 25(OH)D concentrations with caries risks in 5257 children. Additionally, we constructed a Genetic Risk Score (GRS) for the genetic predispositions to serum total 25(OH)D concentrations based on 6 vitamin D-related single nucleotide polymorphisms in a subsample of 3385 children.
    Results: Children with severe prenatal and early childhood serum 25(OH)D deficiencies (<25 nmol/L) were more likely to be diagnosed with caries [OR, 1.56 (95% CI, 1.18-2.06) and 1.58 (95% CI, 1.10-2.25), respectively] than children with optimal concentrations (≥75 nmol/L). After adjustment for residuals of serum 25(OH)D concentrations at other time points, only the early childhood serum 25(OH)D concentration was inversely associated with the caries risk at 6 years (OR, 0.97; 95% CI, 0.95-0.98). However, our GRS analysis showed that children who are genetically predisposed to have lower serum 25(OH)D concentrations do not have a higher risk of developing caries in primary teeth.
    Conclusions: Our study suggests a weak association between serum 25(OH)D concentrations and risks of caries in primary teeth. Based on our results, we do not recommend vitamin D supplementation for the prevention of dental caries in children.
    MeSH term(s) Child ; Child, Preschool ; Dental Caries/epidemiology ; Dental Caries/etiology ; Female ; Humans ; Infant, Newborn ; Longitudinal Studies ; Netherlands/epidemiology ; Pregnancy ; Prospective Studies ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxab075
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  9. Article ; Online: Breastfeeding and Childhood Dental Caries: Results from a Socially Diverse Birth Cohort Study.

    van Meijeren-van Lunteren, Agatha W / Voortman, Trudy / Elfrink, Marlies E C / Wolvius, Eppo B / Kragt, Lea

    Caries research

    2021  Volume 55, Issue 2, Page(s) 153–161

    Abstract: Previous studies showed that prolonged breastfeeding increases the risk of caries. However, the observed associations were mainly based on non-European populations, and important confounding and mediating factors like socioeconomic position (SEP) and ... ...

    Abstract Previous studies showed that prolonged breastfeeding increases the risk of caries. However, the observed associations were mainly based on non-European populations, and important confounding and mediating factors like socioeconomic position (SEP) and diet were often neglected. The aim of this study was to investigate the role of breastfeeding and bottle-feeding practices on dental caries during childhood while accounting for SEP, ethnic background, and sugar intake. This study was part of the Generation R Study, a prospective multiethnic cohort study conducted in Rotterdam, The Netherlands. In total, 4,146 children were included in the analyses. Information about feeding practices was derived from delivery reports and questionnaires during infancy. Caries was measured via intraoral photographs at the age of 6 years and defined as decayed, missing, and filled teeth (dmft). Negative binomial hurdle regression analyses were used to study the associations between several infant feeding practices and childhood caries. The prevalence of dental caries at the age of 6 years was 27.9% (n = 1,158). Prolonged breastfeeding (for >12 months) was associated with dental caries (OR 1.35, 95% CI 1.04-1.74) and the number of teeth affected by dental caries (RR 1.27, 95% CI 1.03-1.56). Furthermore, nocturnal bottle-feeding was associated with dental caries (OR 1.52, 95% CI 1.20-1.93). All associations were independent of family SEP, ethnic background, and sugar intake. Results from this Dutch cohort study confirmed the previously observed associations between prolonged breastfeeding and nocturnal bottle-feeding and the increased risk of childhood dental caries, even after proper adjustments for indicators of SEP, ethnic background, and sugar intake. Future studies are encouraged to elaborate further on possible explanations for the observed relationships. Healthcare professionals should be aware and advise caregivers about the potential risk of prolonged breastfeeding on caries development by applying the current recommendations on breastfeeding, oral hygiene, and feeding frequency.
    MeSH term(s) Breast Feeding ; Child ; Cohort Studies ; Cross-Sectional Studies ; DMF Index ; Dental Caries/epidemiology ; Dental Caries/etiology ; Female ; Humans ; Infant ; Netherlands/epidemiology ; Prevalence ; Prospective Studies
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390575-5
    ISSN 1421-976X ; 0008-6568
    ISSN (online) 1421-976X
    ISSN 0008-6568
    DOI 10.1159/000514502
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  10. Article ; Online: Caries experience among children born after a complicated pregnancy.

    van der Tas, Justin T / Wolvius, Eppo B / Kragt, Lea / Rivadeneira, Fernando / Moll, Henriëtte A / Steegers, Eric A P / Schalekamp-Timmermans, Sarah

    Community dentistry and oral epidemiology

    2020  Volume 49, Issue 3, Page(s) 225–231

    Abstract: Objectives: Behavioural and lifestyle factors, as oral hygiene and diet, are well-established risk factors in the pathogenesis of dental caries, though displaying large differences in susceptibility across individuals. Since enamel formation already ... ...

    Abstract Objectives: Behavioural and lifestyle factors, as oral hygiene and diet, are well-established risk factors in the pathogenesis of dental caries, though displaying large differences in susceptibility across individuals. Since enamel formation already starts in utero, pregnancy course and outcome may eventually play a role in enamel strength and caries susceptibility. Therefore, we studied the association between history of pregnancy complications and the caries experience in their six-year-old children. The pregnancy complications included small for gestational age (SGA), spontaneous preterm birth (sPTB), gestational hypertension (GH), pre-eclampsia (PE), individually, and a combination of those, designated as placental syndrome.
    Methods: This study was embedded in Generation R, a prospective longitudinal Dutch multiethnic pregnancy cohort study. Information about pregnancy complications was obtained from questionnaires completed by midwives and obstetricians with cross-validation in medical records. These included SGA, sPTB, GH and PE. Caries experience was assessed with the decayed, missing and filled teeth (dmft) index at a mean age of six years. The association between dental caries experience and a history of pregnancy complications was studied by using hurdle negative binomial (HNB) models.
    Results: We were able to assess the dmft index in 5323 six-year-old children (mean age 6.2 years, SD 0.5). We did not find an association between the different pregnancy complications and dental caries experience in childhood, whether for SGA, sPTB, GH, PE, or for the combined outcome placental syndrome (HNB estimates: OR 1.02, 95%CI 0.87 - 1.19; RR 0.90, 95%CI 0.78 - 1.04). Further adjustment of the models with different confounders did not alter the outcome.
    Conclusions: Although it is expected that prenatal stress can be a risk factor for caries development later in life, our findings do not support this hypothesis. Therefore, we believe disparities in caries experience between children are probably not explained by early life events during a critical intrauterine period of development.
    MeSH term(s) Child ; Cohort Studies ; Cross-Sectional Studies ; DMF Index ; Dental Caries/epidemiology ; Dental Caries/etiology ; Dental Caries Susceptibility ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth/epidemiology ; Premature Birth/etiology ; Prospective Studies
    Language English
    Publishing date 2020-11-20
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189172-8
    ISSN 1600-0528 ; 0301-5661
    ISSN (online) 1600-0528
    ISSN 0301-5661
    DOI 10.1111/cdoe.12593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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