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  1. Book: Irritability in pediatric psychopathology

    Roy, Amy Krain / Brotman, Melissa A. / Leibenluft, Ellen

    2019  

    Author's details edited by Amy Krain Roy, Melissa A. Brotman and Ellen Leibenluft
    Keywords Irritable Mood ; Affective Symptoms / psychology ; Child Behavior Disorders / diagnosis ; Child ; Adolescent
    Language English
    Size 311 Seiten, Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020132260
    ISBN 978-0-19-084680-0 ; 9780190846824 ; 9780190846831 ; 0-19-084680-1 ; 0190846828 ; 0190846836
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Evidence of Altered Habenular Intrinsic Functional Connectivity in Pediatric ADHD.

    Arfuso, Melissa / Salas, Ramiro / Castellanos, F Xavier / Krain Roy, Amy

    Journal of attention disorders

    2019  Volume 25, Issue 5, Page(s) 749–757

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Brain ; Brain Mapping ; Child ; Child, Preschool ; Habenula ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/1087054719843177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity.

    Henderson, Sarah E / Vallejo, Ana I / Ely, Benjamin A / Kang, Guoxin / Krain Roy, Amy / Pine, Daniel S / Stern, Emily R / Gabbay, Vilma

    Psychiatry research

    2014  Volume 224, Issue 3, Page(s) 234–241

    Abstract: Deficits in emotion processing, a known clinical feature of major depressive disorder (MDD), have been widely investigated using emotional face paradigms and neuroimaging. However, most studies have not accounted for the high inter-subject variability of ...

    Abstract Deficits in emotion processing, a known clinical feature of major depressive disorder (MDD), have been widely investigated using emotional face paradigms and neuroimaging. However, most studies have not accounted for the high inter-subject variability of symptom severity. Similarly, only sparse research has focused on MDD in adolescence, early in the course of the illness. Here we sought to investigate neural responses to emotional faces using both categorical and dimensional analyses with a focus on anhedonia, a core symptom of MDD associated with poor outcomes. Nineteen medication-free depressed adolescents and 18 healthy controls (HC) were scanned during presentation of happy, sad, fearful, and neutral faces. ANCOVAs and regressions assessed group differences and relationships with illness and anhedonia severity, respectively. Findings included a group by valence interaction with depressed adolescents exhibiting decreased activity in the superior temporal gyrus (STG), putamen and premotor cortex. Post-hoc analyses confirmed decreased STG activity in MDD adolescents. Dimensional analyses revealed associations between illness severity and altered responses to negative faces in prefrontal, cingulate, striatal, and limbic regions. However, anhedonia severity was uniquely correlated with responses to happy faces in the prefrontal, cingulate, and insular regions. Our work highlights the need for studying specific symptoms dimensionally in psychiatric research.
    MeSH term(s) Adolescent ; Adult ; Anhedonia/physiology ; Cerebral Cortex/physiopathology ; Child ; Depressive Disorder, Major/physiopathology ; Emotions/physiology ; Facial Expression ; Female ; Functional Neuroimaging/methods ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Severity of Illness Index ; Young Adult
    Language English
    Publishing date 2014-12-30
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.pscychresns.2014.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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