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  1. AU="Kramer, Alexander G"
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  1. Article ; Online: Fipronil Affects Craniofacial and Heart Development in Zebrafish Embryos (

    Cooper, Kasey L / Krut, Zoe G / Franz, Bennet D / Walker, Benjamin S / Kramer, Alexander G / Morgan, Jonathan R / Lassiter, Christopher S

    Zebrafish

    2024  Volume 21, Issue 2, Page(s) 181–190

    Abstract: Fipronil is a broad-spectrum insecticide that has off-target effects in developing vertebrate embryos. In this study, we investigate treatment of zebrafish embryos with fipronil over the course of 5 days and examine the effects on body length, the ... ...

    Abstract Fipronil is a broad-spectrum insecticide that has off-target effects in developing vertebrate embryos. In this study, we investigate treatment of zebrafish embryos with fipronil over the course of 5 days and examine the effects on body length, the cardiovascular system, and craniofacial morphology. We found the insecticide caused shorter body length and a decrease in eye size. By examining specific heart chamber morphology, as well as jaw angle and length, we quantified defects including enlargement of the heart and increases in jaw length and width. Further studies are needed to assess the mechanisms of fipronil's effect on vertebrate development for both environmental and human health concerns.
    MeSH term(s) Animals ; Humans ; Zebrafish ; Insecticides/toxicity ; Embryo, Nonmammalian ; Pyrazoles/toxicity ; Water Pollutants, Chemical
    Chemical Substances Insecticides ; fipronil (QGH063955F) ; Pyrazoles ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2156020-1
    ISSN 1557-8542 ; 1545-8547
    ISSN (online) 1557-8542
    ISSN 1545-8547
    DOI 10.1089/zeb.2023.0055
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  2. Article: Evaluation of growth, sex (male proportion; sexual dimorphism), and color segregation in four cross combinations of different strains of XX female and YY male Nile Tilapia

    Novelo, Noel D / Gomelsky, Boris / Coyle, Shawn D / Kramer, Alexander G

    Journal of the World Aquaculture Society. 2021 Apr., v. 52, no. 2

    2021  

    Abstract: Four cross combinations of different YY male and female Nile Tilapia Oreochromis niloticus strains were evaluated for growth, sex, and color segregation. Red color parental strains included blotched phenotypes. The Genetically Improved Farmed Tilapia ( ... ...

    Abstract Four cross combinations of different YY male and female Nile Tilapia Oreochromis niloticus strains were evaluated for growth, sex, and color segregation. Red color parental strains included blotched phenotypes. The Genetically Improved Farmed Tilapia (GIFT) was the only dark (wild‐type) color parental strain. Fish of the same age and cross were stocked in three replicate tanks for four crosses in one recirculating system for 167 days. Data recorded included feed consumed, body weight, total length, color, sex, and fillet weight. YY males crossed with GIFT females (Cross 2) exhibited superior growth that was significantly different (p < .05) to other three crosses. Male proportions were 79–100%. Only YY males crossed with the LSA female strain (Cross 4) yielded 100% males, but, Cross 4's productivity was inferior to that of Cross 2. Body weight advantage of males over females was 28.7–84.2%. Color segregation indicated that red color trait in Nile Tilapia is autosomal dominant, and black patch coverage was variable. This study showed that different parental strain combinations clearly impact productivity traits, and that YY male technology combined with crossbreeding provide the opportunity for genetic improvement and development of commercially beneficial superior traits in Nile Tilapia.
    Keywords Oreochromis niloticus ; aquaculture ; body weight ; color ; females ; fillets ; genetic improvement ; males ; sexual dimorphism
    Language English
    Dates of publication 2021-04
    Size p. 445-456.
    Publishing place Wiley Subscription Services, Inc.
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 2233509-2
    ISSN 1749-7345 ; 0893-8849
    ISSN (online) 1749-7345
    ISSN 0893-8849
    DOI 10.1111/jwas.12742
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  3. Article ; Online: Atrazine affects craniofacial chondrogenesis and axial skeleton mineralization in zebrafish ( Danio rerio).

    Walker, Benjamin S / Kramer, Alexander G / Lassiter, Christopher S

    Toxicology and industrial health

    2018  Volume 34, Issue 5, Page(s) 329–338

    Abstract: Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in ... ...

    Abstract Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects similar to other endocrine disruptors, zebrafish embryos were treated with a range of atrazine concentrations. Atrazine treatment at a low concentration of 0.1 µM resulted in significant differences in craniofacial cartilage elements, while concentrations ≥1 µM led to decreased survival and increased heart rates. Fish treated with ≥1 µM atrazine also developed with delayed vertebrae mineralization. Higher concentrations of atrazine caused gross craniofacial defects and decreased hatching rates. Further studies into the molecular pathways disrupted in these developmental processes could shed light on a link between endocrine-disrupting compounds and developmental abnormalities.
    MeSH term(s) Animals ; Atrazine/toxicity ; Chondrogenesis/drug effects ; Craniofacial Abnormalities/chemically induced ; Craniofacial Abnormalities/diagnosis ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Embryo, Nonmammalian/drug effects ; Endocrine Disruptors/toxicity ; Heart Rate/drug effects ; Herbicides/toxicity ; Larva/drug effects ; Water Pollutants, Chemical/toxicity ; Zebrafish/embryology ; Zebrafish/growth & development
    Chemical Substances Endocrine Disruptors ; Herbicides ; Water Pollutants, Chemical ; Atrazine (QJA9M5H4IM)
    Language English
    Publishing date 2018-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/0748233718760419
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2268: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Gonad Development and Reproductive Ability of Aneuploid Ornamental Koi Carp Obtained by Crossing Triploid Females with Diploid Males

    Gomelsky, Boris / Warner, Jeffrey L. / Delomas, Thomas A. / Novelo, Noel D. / Kramer, Alexander G.

    North American journal of aquaculture. 2019 July, v. 81, no. 3

    2019  

    Abstract: It was described earlier that triploid female koi (ornamental variant of the Common Carp Cyprinus carpio) from heat‐shocked progeny developed large ovaries and produced mass aneuploid progeny when crossed with normal diploid koi males. This study ... ...

    Abstract It was described earlier that triploid female koi (ornamental variant of the Common Carp Cyprinus carpio) from heat‐shocked progeny developed large ovaries and produced mass aneuploid progeny when crossed with normal diploid koi males. This study presents data on gonad development and reproductive ability of aneuploid koi obtained from triploid females. Aneuploid koi had low viability when raised in indoor recirculating systems; only 12–19% of fish survived up to 25–28 months of age. The 28‐month‐old aneuploid fish with a ploidy range of 2.31–2.78n obtained in 2013 (n = 30) did not release sperm or eggs after hormonal injection. Dissection of fish showed that similar to triploid males, aneuploid males had pinkish testes that did not contain sperm; the gonadosomatic index (GSI) of aneuploid males varied from 0.3% to 3.5%, with a mean value of 1.2%. More than 50% of aneuploid females had ovaries that were severely reduced in development, with GSI values less than 2%; about 40% of females had ovaries at the maturing stage, with GSIs ranging from 2.5% to 5.6%. One aneuploid female had mature ovaries filled with fully grown oocytes (GSI = 9.6%). The aneuploid fish obtained in 2015 (n = 165) did not produce sperm at 25 months of age; all fish from this group died during subsequent overwintering in an earthen pond. Our results show that aneuploid koi males are functionally sterile, whereas some potentially fertile aneuploid females can be found. However, because aneuploid koi have very low viability, the chance of survival for fertile aneuploid females is low, especially under natural conditions. Fertile aneuploid females, even if they survive, would likely produce aneuploid eggs, and fertilization of those eggs would again result in aneuploid progeny with low viability and fertility.
    Keywords Cyprinus carpio ; aneuploidy ; aquaculture ; diploidy ; dissection ; females ; gonadosomatic index ; koi ; oocytes ; overwintering ; progeny ; reproductive performance ; spermatozoa ; triploidy ; viability
    Language English
    Dates of publication 2019-07
    Size p. 211-214.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1482260-x
    ISSN 1548-8454 ; 1522-2055
    ISSN (online) 1548-8454
    ISSN 1522-2055
    DOI 10.1002/naaq.10088
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    In stock of ZB MED Bonn / Germany

    Z 3629: Show issues

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  5. Article ; Online: Bis-GMA affects craniofacial development in zebrafish embryos (Danio rerio).

    Kramer, Alexander G / Vuthiganon, Jompobe / Lassiter, Christopher S

    Environmental toxicology and pharmacology

    2016  Volume 43, Page(s) 159–165

    Abstract: Estrogen is a steroid hormone that is vital in vertebrate development and plays a role in a variety of developmental processes including cartilage and craniofacial formation. The effects of estrogen can be mimicked by other compounds found in the ... ...

    Abstract Estrogen is a steroid hormone that is vital in vertebrate development and plays a role in a variety of developmental processes including cartilage and craniofacial formation. The effects of estrogen can be mimicked by other compounds found in the environment known as xenoestrogens. Bisphenol-A (BPA) is a known xenoestrogen and is combined with glycidyl methacrylate to make Bisphenol A glycidyl methacrylate (Bis-GMA), a major component in dental resin based composites (RBCs). Bis-GMA based RBCs can release their components into the saliva and bloodstream. Exposure to 1μM and 10μM Bis-GMA in Danio rerio embryos results in increased mortality of approximately 30% and 45% respectively. Changes to gross morphology, specifically craniofacial abnormalities, were seen at concentrations as low as 10nM. While the molecular pathways of Bis-GMA effects have not been studied extensively, more is known about one of the components, BPA. Further research of Bis-GMA could lead to a better understanding of xenoestrogenic activity resulting in improved public and environmental health.
    MeSH term(s) Acrylic Resins/toxicity ; Animals ; Bisphenol A-Glycidyl Methacrylate/toxicity ; Composite Resins/toxicity ; Embryo, Nonmammalian ; Polyurethanes/toxicity ; Zebrafish/embryology
    Chemical Substances Acrylic Resins ; Composite Dental Resin ; Composite Resins ; Polyurethanes ; Bisphenol A-Glycidyl Methacrylate (454I75YXY0)
    Language English
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2015938-9
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2016.02.018
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  6. Article: Reproductive ability of second generation ornamental (koi) carp (Cyprinus carpio L.) × goldfish (Carassius auratus L.) hybrids and characteristics of their offspring

    Warner, Jeffrey L / Delomas, Thomas A / Gomelsky, Boris / Kramer, Alexander G / Novelo, Noel D

    Aquaculture research. 2018 June, v. 49, no. 6

    2018  

    Abstract: The purpose of this study was to investigate the reproductive ability of second generation (F2) koi (Cyprinus carpio L.) × goldfish (Carassius auratus L.) hybrids. Only diploid F2 males and females were fertile and used in crosses. A significant increase ...

    Abstract The purpose of this study was to investigate the reproductive ability of second generation (F2) koi (Cyprinus carpio L.) × goldfish (Carassius auratus L.) hybrids. Only diploid F2 males and females were fertile and used in crosses. A significant increase was recorded in male fertility in F2 versus F1. In contrast with an earlier study in which only one fertile F1 male was found, about 20% of F2 males produced sperm. The observed reproductive ability of F2 hybrids was similar to that demonstrated by the only fertile F1 male and F1 females. F2 males produced diploid spermatozoa and generated triploids when crossed with koi females. All triploid fish in these progenies were males indicating that F2 males had a sex chromosome constitution of XY. F2 females produced diploid eggs and generated mostly triploids when crossed with koi males. In progenies obtained by crosses of F2 males with F1 and F2 females, most of the surviving juveniles (63%–100%) were diploid; a minority of juveniles were aneuploid (ploidy ranged from 2.1n to 3.6n). Diploid fish in these progenies were presumably the result of spontaneous androgenesis and gynogenesis, by the same mechanisms observed earlier in progenies obtained by crossing the F1 male with F1 females.
    Keywords androgenesis ; aneuploidy ; Carassius auratus ; crossing ; Cyprinus carpio ; diploidy ; eggs ; females ; goldfish ; gynogenesis ; hybrids ; juveniles ; koi ; male fertility ; males ; progeny ; reproductive performance ; sex chromosomes ; spermatozoa ; triploidy
    Language English
    Dates of publication 2018-06
    Size p. 2317-2321.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1227359-4
    ISSN 1355-557X
    ISSN 1355-557X
    DOI 10.1111/are.13694
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    In stock of ZB MED Bonn / Germany

    Z 4230: Show issues

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