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  1. Book: Rettet die Liebe!

    Čajkovac, Vladimir / Kramer-Tunçludemir, Kristina

    internationale Plakate gegen AIDS

    2020  

    Institution Museum Folkwang
    Deutsches Plakat Museum
    Author's details Museum Folkwang, Deutsches Plakat Museum ; Beiträge: Vladimir Čajkovac und Kristina Kramer-Tunçludemir
    Keywords AIDS ; HIV ; Prävention ; Plakate
    Subject code 700
    Language German
    Size 143 Seiten
    Edition Erste Auflage
    Publisher Edition Folkwang / Steidl
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    Note "'Rettet die Liebe! Internationale Plakate gegen AIDS', 21. August-29. November 2020, Museum Folkwang, eine Ausstellung des Deutschen Plakat Museums im Museum Folkwang." - Impressum
    HBZ-ID HT020620130
    ISBN 978-3-95829-871-2 ; 3-95829-871-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 1446 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Characterization of the Gateway Decarboxylase for Psilocybin Biosynthesis.

    Schäfer, Tim / Kramer, Kristina / Werten, Sebastiaan / Rupp, Bernhard / Hoffmeister, Dirk

    Chembiochem : a European journal of chemical biology

    2022  Volume 23, Issue 24, Page(s) e202200551

    Abstract: The l-tryptophan decarboxylase PsiD catalyzes the initial step of the metabolic cascade to psilocybin, the major indoleethylamine natural product of the "magic" mushrooms and a candidate drug against major depressive disorder. Unlike numerous pyridoxal ... ...

    Abstract The l-tryptophan decarboxylase PsiD catalyzes the initial step of the metabolic cascade to psilocybin, the major indoleethylamine natural product of the "magic" mushrooms and a candidate drug against major depressive disorder. Unlike numerous pyridoxal phosphate (PLP)-dependent decarboxylases for natural product biosyntheses, PsiD is PLP-independent and resembles type II phosphatidylserine decarboxylases. Here, we report on the in vitro biochemical characterization of Psilocybe cubensis PsiD along with in silico modeling of the PsiD structure. A non-canonical serine protease triad for autocatalytic cleavage of the pro-protein was predicted and experimentally verified by site-directed mutagenesis.
    MeSH term(s) Humans ; Psilocybin ; Depressive Disorder, Major ; Carboxy-Lyases/genetics ; Biological Products ; Pyridoxal Phosphate
    Chemical Substances Psilocybin (2RV7212BP0) ; Carboxy-Lyases (EC 4.1.1.-) ; Biological Products ; Pyridoxal Phosphate (5V5IOJ8338)
    Language English
    Publishing date 2022-11-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202200551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Quantitativer Vergleich der Harnausscheidung gesunder Versuchspersonen bei Spontanatmung und assistierender Beatmung

    Kramer, Kristina

    1983  

    Author's details vorgelegt von: Kristina Kramer
    Size 93, [13] Bl. : graph. Darst.
    Publishing country XA-DDDE
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 1983
    HBZ-ID HT003776959
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    91 E 1367 order for loan Magazin

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  4. Article: A Western Massachusetts hospital system's response to the COVID-19 pandemic.

    Ramanathan, Nikita / Alouidor, Reginald / Kramer, Kristina / Putnam, Tyler

    American journal of disaster medicine

    2020  Volume 16, Issue 1, Page(s) 13–24

    Abstract: Objective: The objective of this paper was to outline a novel model created for the management of the critical care surge due to coronavirus disease 2019 (COVID-19) in a Western Massachusetts hospital.: Setting: This model was created and implemented ...

    Abstract Objective: The objective of this paper was to outline a novel model created for the management of the critical care surge due to coronavirus disease 2019 (COVID-19) in a Western Massachusetts hospital.
    Setting: This model was created and implemented at a Western Massachusetts Level 1 Trauma and tertiary referral center.
    Conclusions: This article outlines a model devised by an interdisciplinary team for rapid expansion of critical care services by increasing allocated space, staffing, and supplies via modifications of existing systems of care to accommodate a predicted large critical care patient surge due to the COVID-19 pandemic. We predict that this model can be utilized and adapted for future critical care surges in times of similar pandemic situations.
    MeSH term(s) COVID-19 ; Critical Care ; Humans ; Massachusetts/epidemiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2020-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 1932-149X
    ISSN 1932-149X
    DOI 10.5055/ajdm.2021.0382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of Telemedicine on Extended Focused Assessment With Sonography for Trauma Performance and Workload by Critical Care Transport Personnel.

    Siu, Margaret / Dan, Jeffrey / Cohen, Jason / Carey, Yamuna / Alouidor, Reginald / Kramer, Kristina / Kamine, Tovy Haber

    Air medical journal

    2023  Volume 42, Issue 2, Page(s) 105–109

    Abstract: Introduction: There are currently no reports on whether telementoring for extended focused assessment with sonography for trauma (eFAST) improves critical care transport providers' performance in prehospital settings. Our objective was to determine the ... ...

    Abstract Introduction: There are currently no reports on whether telementoring for extended focused assessment with sonography for trauma (eFAST) improves critical care transport providers' performance in prehospital settings. Our objective was to determine the impact of teleguidance on eFAST performance and quantify workload experience.
    Methods: Eight trauma injury modules were selected on simulated patients. Critical care transport (CCT) providers were tasked to complete one independent and one emergency physician-telementored eFAST. The time to completion and the percent of correct findings were obtained. Participants completed the NASA Task Load Index after each iteration to assess workload.
    Results: Eight independent and 8 telementored eFASTs were completed. The mean times to complete the independent and telementored eFAST were 5 minutes 16 seconds (95% confidence interval [CI], 3 minutes 32 seconds, 6 minutes 59 seconds) and 8 minutes 27 seconds (95% CI, 5 minutes 14 seconds, 11 minutes 39 seconds), respectively (P = .06). The percentage of correctly identified injuries for the independent versus the teleguided eFAST was 65% versus 92.5% (P = .01). The CCT providers experienced higher mental (P = .004), temporal (P = .01), and effort (P = .004) demands; greater frustration (P = .001); and subjective lower performance (P = .003) during independent trials. The emergency physician experienced higher mental (P = .001), temporal (P = .02), effort (P = .005), and frustration (P = .001) demands than the CCT members.
    Conclusion: The teleguided eFAST yielded higher accuracy than the independent eFAST. The CCT providers relied on teleguidance of the remote physician when performing the eFAST. Teleguidance may improve the accuracy of ultrasounds performed by prehospital personnel in real-life scenarios.
    MeSH term(s) Humans ; Focused Assessment with Sonography for Trauma ; Workload ; Telemedicine ; Ultrasonography
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2072853-0
    ISSN 1532-6497 ; 1067-991X
    ISSN (online) 1532-6497
    ISSN 1067-991X
    DOI 10.1016/j.amj.2022.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5623: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Spatial Volume Necessary to Perform Open Appendectomy in a Spacecraft.

    Kamine, Tovy H / Siu, Margaret / Kramer, Kristina / Kelly, Edward / Alouidor, Reginald / Fernandez, Gladys / Levin, Dana

    Aerospace medicine and human performance

    2022  Volume 93, Issue 10, Page(s) 760–763

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Appendectomy/methods ; Appendicitis/surgery ; Humans ; Space Flight ; Spacecraft ; Weightlessness
    Language English
    Publishing date 2022-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809085-8
    ISSN 2375-6322 ; 2375-6314
    ISSN (online) 2375-6322
    ISSN 2375-6314
    DOI 10.3357/AMHP.6062.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 57: Show issues Location:
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  7. Article ; Online: From LUVs to GUVs─How to Cover Micrometer-Sized Pores with Membranes.

    Kramer, Kristina / Sari, Merve / Schulze, Kathrin / Flegel, Hendrik / Stehr, Miriam / Mey, Ingo / Janshoff, Andreas / Steinem, Claudia

    The journal of physical chemistry. B

    2022  Volume 126, Issue 41, Page(s) 8233–8244

    Abstract: Pore-spanning membranes (PSMs) are a versatile tool to investigate membrane-confined processes in a bottom-up approach. Pore sizes in the micrometer range are most suited to visualize PSMs using fluorescence microscopy. However, the preparation of these ... ...

    Abstract Pore-spanning membranes (PSMs) are a versatile tool to investigate membrane-confined processes in a bottom-up approach. Pore sizes in the micrometer range are most suited to visualize PSMs using fluorescence microscopy. However, the preparation of these PSMs relies on the spreading of giant unilamellar vesicles (GUVs). GUV production faces several limitations. Thus, alternative ways to generate PSMs starting from large or small unilamellar vesicles that are more reproducibly prepared are highly desirable. Here we describe a method to produce PSMs obtained from large unilamellar vesicles, making use of droplet-stabilized GUVs generated in a microfluidic device. We analyzed the lipid diffusion in the free-standing and supported parts of the PSMs using
    MeSH term(s) Unilamellar Liposomes/chemistry ; Syntaxin 1 ; Membranes ; Solvents ; Lipids/chemistry
    Chemical Substances Unilamellar Liposomes ; Syntaxin 1 ; Solvents ; Lipids
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c05685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Time Cost of Provider Skill: A Pilot Study of Medical Officer Occupied Time By Knowledge, Skill, and Ability Level.

    Levin, Dana R / Siu, Margaret / Kramer, Kristina / Kelly, Edward / Alouidor, Reginald / Fernandez, Gladys / Kamine, Tovy

    Aerospace medicine and human performance

    2022  Volume 93, Issue 11, Page(s) 816–821

    Abstract: INTRODUCTION: ...

    Abstract INTRODUCTION:
    MeSH term(s) Humans ; Internship and Residency ; Pilot Projects ; Clinical Competence ; Surgeons ; Computer Simulation
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809085-8
    ISSN 2375-6322 ; 2375-6314
    ISSN (online) 2375-6322
    ISSN 2375-6314
    DOI 10.3357/AMHP.6093.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 57: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online ; Thesis: Droplet-based giant unilamellar vesicles as a tool for pore-spanning membrane preparation and transmembrane protein reconstitution

    Kramer, Kristina [Verfasser] / Steinem, Claudia [Akademischer Betreuer] / Steinem, Claudia [Gutachter] / Grubmüller, Helmut [Gutachter] / Brose, Nils [Gutachter]

    2022  

    Author's details Kristina Kramer ; Gutachter: Claudia Steinem, Helmut Grubmüller, Nils Brose ; Betreuer: Claudia Steinem
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Cost-Effectiveness Analysis of 177Lu-PSMA-617 Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.

    Mehrens, Dirk / Kramer, Kristina K M / Unterrainer, Lena M / Beyer, Leonie / Bartenstein, Peter / Froelich, Matthias F / Tollens, Fabian / Ricke, Jens / Rübenthaler, Johannes / Schmidt-Hegemann, Nina-Sophie / Herlemann, Annika / Unterrainer, Marcus / Kunz, Wolfgang G

    Journal of the National Comprehensive Cancer Network : JNCCN

    2023  Volume 21, Issue 1, Page(s) 43–50.e2

    Abstract: Background: Metastatic castration-resistant prostate cancer poses a therapeutic challenge with poor prognosis. The VISION trial showed prolonged progression-free and overall survival in patients treated with lutetium Lu 177 vipivotide tetraxetan (177Lu- ... ...

    Abstract Background: Metastatic castration-resistant prostate cancer poses a therapeutic challenge with poor prognosis. The VISION trial showed prolonged progression-free and overall survival in patients treated with lutetium Lu 177 vipivotide tetraxetan (177Lu-PSMA-617) radioligand therapy compared with using the standard of care (SoC) alone. The objective of this study was to determine the cost-effectiveness of 177Lu-PSMA-617 treatment compared with SoC therapy.
    Methods: A partitioned survival model was developed using data from the VISION trial, which included overall and progression-free survival and treatment regimens for 177Lu-PSMA-617 and SoC. Treatment costs, utilities for health states, and adverse events were derived from public databases and the literature. Because 177Lu-PSMA-617 was only recently approved, costs for treatment were extrapolated from 177Lu-DOTATATE. Outcome measurements included the incremental cost, effectiveness, and cost-effectiveness ratio. The analysis was performed in a US setting from a healthcare system perspective over the lifetime horizon of 60 months. The willingness-to-pay threshold was set to $50,000, $100,000, and $200,000 per quality-adjusted life years (QALYs).
    Results: The 177Lu-PSMA-617 group was estimated to gain 0.42 incremental QALYs. Treatment using 177Lu-PSMA-617 led to an increase in costs compared with SoC ($169,110 vs $85,398). The incremental cost, effectiveness, and cost-effectiveness ratio for 177Lu-PSMA-617 therapy was $200,708/QALYs. Sensitivity analysis showed robustness of the model regarding various parameters, which remained cost-effective at all lower and upper parameter bounds. In probabilistic sensitivity analysis using Monte Carlo simulation with 10,000 iterations, therapy using 177Lu-PSMA-617 was determined as the cost-effective strategy in 37.14% of all iterations at a willingness-to-pay threshold of $200,000/QALYs.
    Conclusions: Treatment using 177Lu-PSMA-617 was estimated to add a notable clinical benefit over SoC alone. Based on the model results, radioligand therapy represents a treatment strategy for patients with metastatic castration-resistant prostate cancer with cost-effectiveness in certain scenarios.
    MeSH term(s) Male ; Humans ; Lutetium/therapeutic use ; Lutetium/adverse effects ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Cost-Effectiveness Analysis ; Dipeptides/therapeutic use ; Dipeptides/adverse effects ; Prostate-Specific Antigen ; Treatment Outcome ; Cost-Benefit Analysis
    Chemical Substances 177Lu-PSMA-617 ; Lutetium (5H0DOZ21UJ) ; Dipeptides ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2022.7070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6365: Show issues Location:
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