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Artikel ; Online: Endobronchial aspergilloma: Benign appearance of potentially fatal consequences.

Izhakian, Shimon / Kramer, Mordechai R

Indian journal of pathology & microbiology

2022 Band 65, Heft 4, Seite(n) 944–945

Mesh-Begriff(e)	Humans ; Pulmonary Aspergillosis/diagnosis ; Bronchoscopy
Sprache	Englisch
Erscheinungsdatum	2022-10-19
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_116_21
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The acute effect of inhaled nitric oxide on the exercise capacity of patients with advanced interstitial lung disease: a randomized controlled trial.

Freidkin, Lev / Kramer, Mordechai R / Rosengarten, Dror / Izhakian, Shimon / Taieb, Shani / Pertzov, Barak

BMC pulmonary medicine

2024 Band 24, Heft 1, Seite(n) 226

Abstract: Background: Inhaled nitric oxide (iNO) selectively acts on the pulmonary vasculature of ventilated lung tissue by reducing pulmonary vascular resistance and intrapulmonary shunt. This effect may reduce ventilation/perfusion mismatch and decrease ... ...

Abstract	Background: Inhaled nitric oxide (iNO) selectively acts on the pulmonary vasculature of ventilated lung tissue by reducing pulmonary vascular resistance and intrapulmonary shunt. This effect may reduce ventilation/perfusion mismatch and decrease pulmonary hypertension in patients with interstitial lung disease. Methods: In a prospective, single-blinded, randomized, placebo-controlled trial, participants with advanced interstitial lung disease, underwent two separate six-minute walk tests (6MWT): one with iNO and the other with a placebo. The primary outcome measured the difference in meters between the distances covered in the two tests. Secondary outcomes included oxygen saturation levels, distance-saturation product, and Borg dyspnea score. A predefined subgroup analysis was conducted for patients with pulmonary hypertension. Results: Overall, 44 patients were included in the final analysis. The 6MWT distance was similar for iNO treatment and placebo, median 362 m (IQR 265-409) vs 371 m (IQR 250-407), respectively (p = 0.29). Subgroup analysis for patients with pulmonary hypertension showed no difference in 6MWT distance with iNO and placebo, median 339 (256-402) vs 332 (238-403) for the iNO and placebo tests respectively (P=0.50). No correlation was observed between mean pulmonary artery pressure values and the change in 6MWT distance with iNO versus placebo (spearman correlation Coefficient 0.24, P=0.33). Conclusion: In patients with advanced interstitial lung disease, both with and without concurrent pulmonary hypertension, the administration of inhaled nitric oxide failed to elicit beneficial effects on the six-minute walk distance and oxygen saturation. The use of inhaled NO was found to be safe and did not lead to any serious side effects. Trial registration: (NCT03873298, MOH_2018-04-24_002331).
Mesh-Begriff(e)	Humans ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/physiopathology ; Nitric Oxide/administration & dosage ; Male ; Female ; Administration, Inhalation ; Middle Aged ; Aged ; Walk Test ; Prospective Studies ; Exercise Tolerance/drug effects ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Single-Blind Method ; Oxygen Saturation
Chemische Substanzen	Nitric Oxide (31C4KY9ESH)
Sprache	Englisch
Erscheinungsdatum	2024-05-10
Erscheinungsland	England
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-03051-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Successful treatment of acute relapse of chronic eosinophilic pneumonia with benralizumab and without corticosteroids: A case report.

Izhakian, Shimon / Pertzov, Barak / Rosengarten, Dror / Kramer, Mordechai R

World journal of clinical cases

2022 Band 10, Heft 18, Seite(n) 6105–6109

Abstract: Background: Currently, the mainstay of chronic eosinophilic pneumonia (CEP) treatment is corticosteroids, usually with a favorable response and good prognosis. However, relapse is common, requiring long-term use of corticosteroids, with risk of ... ...

Abstract	Background: Currently, the mainstay of chronic eosinophilic pneumonia (CEP) treatment is corticosteroids, usually with a favorable response and good prognosis. However, relapse is common, requiring long-term use of corticosteroids, with risk of significant treatment-related complications. The dire need to develop new treatments for patients with CEP, who are dependent on, or resistant to corticosteroids has led to exploring novel therapies. We herein describe a patient with acute relapse of CEP, who was successfully treated with benralizumab, an IL-5Rα antagonist that has demonstrated rapid anti-eosinophil action in patients with asthma. Currently, only three recent patient reports on CEP relapse, also demonstrated successful treatment with benralizumab alone, without corticosteroids. Case summary: A 31-year-old non-smoking woman presented in our hospital with a 3 wk history of shortness of breath, dry cough and fever up to 38.3 °C. Laboratory examination revealed leukocytosis 10240 K/µL, eosinophilia 900 K/µL and normal values of hemoglobin, platelets, creatinine and liver enzymes. Computed tomography of the chest showed a mediastinal lymphadenopathy and consolidations in the right upper and left lower lobes. CEP was diagnosed, and the patient was treated with hydrocortisone intravenously, followed by oral prednisone, with prompt improvement. Three months later, she presented with relapse of CEP: aggravation of dyspnea, rising of eosinophilia and extension of pulmonary infiltrates on chest X-ray. She was treated with benralizumab only, with clinical improvement within 2 wk, and complete resolution of lung infiltrates following 5 wk. Conclusion: Due to Benralizumab's dual mechanism of action, it both neutralizes IL-5Rα pro-eosinophil functions and triggers apoptosis of eosinophils. We therefore maintain benralizumab can serve as a reasonable therapy choice for every patient with chronic eosinophilic pneumonia and a good alternative for corticosteroids.
Sprache	Englisch
Erscheinungsdatum	2022-07-15
Erscheinungsland	United States
Dokumenttyp	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i18.6105
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transbronchial Cryobiopsy Success With "Gentle Ice".

Gershman, Evgeni / Kramer, Mordechai R

Journal of bronchology & interventional pulmonology

2019 Band 26, Heft 4, Seite(n) e44

Mesh-Begriff(e)	Bronchoscopy ; Humans ; Ice ; Lung Diseases, Interstitial
Chemische Substanzen	Ice
Sprache	Englisch
Erscheinungsdatum	2019-10-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Comment
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000604
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Endobronchial closure of broncho-biliary fistula using Amplatzer device: Case report.

Freidkin, Lev / Azem, Karam / Pertzov, Barak / Izhakian, Shimon / Rosengarten, Dror / Kramer, Mordechai R

Respiratory medicine case reports

2023 Band 46, Seite(n) 101943

Abstract: Broncho-biliary fistula (BBF) is an extremely rare but serious medical condition resulting from pathological communication between the biliary system and the bronchial tree. Treatment options include both surgical and non-surgical approaches. Several ... ...

Abstract	Broncho-biliary fistula (BBF) is an extremely rare but serious medical condition resulting from pathological communication between the biliary system and the bronchial tree. Treatment options include both surgical and non-surgical approaches. Several endobronchial techniques, such as the spigot and glue, can be used for this purpose. This report discusses a patient who developed a broncho-biliary fistula following a liver biopsy. The BBF was diagnosed during bronchoscopy and successfully treated with an endobronchial Amplatzer device. To the best of our knowledge, this is the first report of the use of the Amplatzer device to manage BBF.
Sprache	Englisch
Erscheinungsdatum	2023-11-04
Erscheinungsland	England
Dokumenttyp	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2023.101943
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [INTUBATION RELATED TRACHEAL RUPTURE: EXPECTING THE UNEXPECTED].

Neuman, Ido / Krasula, Boris / Kramer, Mordechai R / Peysakhovich, Yury / Eidelman, Leonid

Harefuah

2023 Band 162, Heft 2, Seite(n) 82–85

Abstract: Introduction: This case involved a 67-year-old female who was admitted for general anesthesia for a mitral clip procedure. Following anesthesia induction, the patient underwent an uneventful orotracheal intubation. Shortly afterwards she developed an ... ...

Abstract	Introduction: This case involved a 67-year-old female who was admitted for general anesthesia for a mitral clip procedure. Following anesthesia induction, the patient underwent an uneventful orotracheal intubation. Shortly afterwards she developed an ongoing respiratory failure, accompanied by neck and chest subcutaneous emphysema. Upon workup, she was found to have a 6 cm long tracheal laceration on the posterior side. Emergency repair surgery was performed using an extracorporeal membrane oxygenator (ECMO). The patient passed away 11 days later from sepsis. The aim of this case report is to increase awareness of this rare intubation complication, and explore the best approach to prevent, diagnose and treat tracheal injuries during endotracheal intubation.
Mesh-Begriff(e)	Female ; Humans ; Aged ; Trachea/injuries ; Trachea/surgery ; Rupture/etiology ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Lacerations/complications ; Respiratory Insufficiency/complications
Sprache	Hebräisch
Erscheinungsdatum	2023-03-01
Erscheinungsland	Israel
Dokumenttyp	Case Reports ; English Abstract ; Journal Article
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [THE SYNDROME OF COMBINED PULMONARY FIBROSIS AND EMPHYSEMA - CPFE].

Wand, Ori / Kramer, Mordechai R

Harefuah

2018 Band 157, Heft 1, Seite(n) 28–33

Abstract: Introduction: There is an increasing recognition of patients with radiologic features of both pulmonary fibrosis and emphysema. This association has enabled the description of a syndrome termed combined pulmonary fibrosis and emphysema (CPFE) with ... ...

Abstract	Introduction: There is an increasing recognition of patients with radiologic features of both pulmonary fibrosis and emphysema. This association has enabled the description of a syndrome termed combined pulmonary fibrosis and emphysema (CPFE) with unique features. Patients are mostly male smokers who suffer from effort dyspnea and hypoxemia, with near-normal spirometric and lung volumes measurements, and abnormalities of gas exchange. On the computerized tomography there is upper-lobe emphysema and lower-lobe interstitial fibrosis. CPFE is frequently complicated by pulmonary hypertension, lung cancer, acute lung injury and coronary artery disease. Mortality is significant, especially in the presence of pulmonary hypertension. In this article we will review the CPFE syndrome.
Mesh-Begriff(e)	Humans ; Lung ; Male ; Pulmonary Emphysema/diagnosis ; Pulmonary Fibrosis/diagnosis ; Smoking/adverse effects ; Tomography, X-Ray Computed
Sprache	Hebräisch
Erscheinungsdatum	2018-01
Erscheinungsland	Israel
Dokumenttyp	Journal Article ; Review
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature.

Bigman-Peer, Noa / Peer, Eyal / Pertzov, Barak / Kramer, Mordechai / Segal, Gad / Eliakim-Raz, Noa

European journal of case reports in internal medicine

2022 Band 9, Heft 8, Seite(n) 3502

Abstract: We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after ... ...

Abstract	We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomatic infection. Possible explanations are discussed. Learning points: Four cases of COVID-19 infection in anti-CD20 treated patients are described.These cases display a unique biphasic course that was previously undescribed: respiratory deterioration weeks after convalescence.Awareness of such a course and rapid utilisation of bronchoalveolar lavage will lead to quicker diagnosis and more timely, appropriate treatment.
Sprache	Englisch
Erscheinungsdatum	2022-08-31
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2022_003502
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Marked safety and high diagnostic yield of freehand ultrasound-guided core-needle biopsies performed by pulmonologists.

Gershman, Evgeni / Vaynshteyn, Ilya / Freidkin, Lev / Pertzov, Barak / Rosengarten, Dror / Kramer, Mordechai Reuven

Thoracic cancer

2022 Band 13, Heft 11, Seite(n) 1577–1582

Abstract: Background: Adequate tissue sampling is fundamental for establishing a definitive diagnosis, assessing prognosis and tailoring therapy. Each of the methods for obtaining tissue (e.g., endoscopic, image guidance and surgical biopsies) results in a ... ...

Abstract	Background: Adequate tissue sampling is fundamental for establishing a definitive diagnosis, assessing prognosis and tailoring therapy. Each of the methods for obtaining tissue (e.g., endoscopic, image guidance and surgical biopsies) results in a different diagnostic yield and complication rate profile. Objectives: Present feasibility, and assess safety and efficacy of freehand transthoracic ultrasound-guided core-needle biopsies (USGNB) of thoracic lesions performed by pulmonologist. Methods: A retrospective analysis study of ultrasound-guided core-needle biopsies of thoracic lesions performed at the Pulmonary Institute of Rabin Medical Center was conducted from September 2020 to October 2021. All core-needle biopsies were performed under local anesthesia with guidance of Mindray TE7 2019 US system. Procedural variables including complications and pathological diagnostic yield were the primary end point. IRB 0671-21-RMC. Results: In total 91 biopsy procedures were analyzed in38 females and 53 males, average age 71.1 years. Twenty-three (25.3%) cases were lung lesions, 7 (7.7%) - mediastinal, 13 (14.3%) - chest wall, 27 (29.7%) - pleural, and 21 (23.1%) supraclavicular lesions. Average lesion size was 51.6 mm, the largest in the mediastinum and the smallest in supraclavicular locations (97.7mm and 28.0 mm, respectively). Overall pathological diagnostic yield was 90%, highest success in chest wall (100%) and lowest in mediastinal biopsies (71.4%). We had only one complication -hemothorax resolved by chest tube drainage- accounting for only 1.1% complication rate. Conclusion: Safety and efficacy were demonstrated in freehand US-guided core-needle biopsy of thoracic lesions performed by pulmonologists. We suggest thoracic ultrasound and USG-CNB be part of training and clinical practice in interventional pulmonology.
Mesh-Begriff(e)	Aged ; Biopsy, Large-Core Needle/adverse effects ; Biopsy, Large-Core Needle/methods ; Female ; Humans ; Image-Guided Biopsy ; Male ; Pulmonologists ; Retrospective Studies ; Ultrasonography, Interventional
Sprache	Englisch
Erscheinungsdatum	2022-04-26
Erscheinungsland	Singapore
Dokumenttyp	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14413
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mediastinal "deep freeze"-transcarinal lymph node cryobiopsy.

Gershman, Evgeni / Amram Ikan, Alon / Pertzov, Barak / Rosengarten, Dror / Kramer, Mordechai Reuven

Thoracic cancer

2022 Band 13, Heft 11, Seite(n) 1592–1596

Abstract: Background: The diagnostic yield of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) from mediastinal lymph nodes ranges from 66%-89%. However, in many cases cytologic material is not sufficient for full molecular evaluation. A ... ...

Abstract	Background: The diagnostic yield of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) from mediastinal lymph nodes ranges from 66%-89%. However, in many cases cytologic material is not sufficient for full molecular evaluation. A novel method of transcarinal cryobiopsy aims to provide bronchoscopically obtained, larger specimen samples from mediastinal lymph nodes. We aimed to assess the efficacy and safety of transcarinal EBUS-guided lymph node cryobiopsy. Methods: Patients referred for EBUS-TBNA, based on abnormal mediastinal clinical and radiographic findings, were enrolled into this prospective interventional study between July 2020 and August 2021. All EBUS-TBNA procedures were performed using ProCore 22G needle (Cook Medical) to create, both a transcarinal tract for the cryoprobe and to obtain TBNA samples. For EBUS guided transcarinal cryobiopsy, we used flexible 1.1 mm or 1.7 mm cryoprobe inserted into the working channel of the EBUS scope and into the target subcarinal lymph node. Results: Twenty-four patients with male predominance 2:1 and mean age of 60.12 ± 10.16 years were enrolled. All target lymph nodes had hypoechoic, homogenic consistency with demarcated borders, without central structures. Cryobiopsy provided pathological diagnosis in 20 cases (83.33%), with 1.1 mm cryoprobe in 14 and with 1.7 mm cryoprobe in 6 cases. In one case each, pathology was provided by TBNA or by cryoprobe alone. No immediate or late complications were encountered during the procedures. Conclusion: Transcarinal EBUS guided lymph node cryobiopsy following EBUS-TBNA proved to be efficient with a high diagnostic yield and can be considered safe, because no immediate or late complications occurred.
Mesh-Begriff(e)	Aged ; Bronchoscopy/methods ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Female ; Humans ; Lung Neoplasms/pathology ; Lymph Nodes/pathology ; Male ; Mediastinum/pathology ; Middle Aged ; Prospective Studies
Sprache	Englisch
Erscheinungsdatum	2022-04-26
Erscheinungsland	Singapore
Dokumenttyp	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14422
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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