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  1. Article ; Online: PET Standardized Uptake Value May Influence Surgical Planning for Clinical Stage IA Non-Small Cell Lung Cancer.

    Murillo, Alyssa D / Kratz, Johannes Ruediger

    The Annals of thoracic surgery

    2023  Volume 117, Issue 5, Page(s) 1024

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Lung Neoplasms/diagnostic imaging ; Neoplasm Staging ; Positron-Emission Tomography/methods ; Fluorodeoxyglucose F18 ; Pneumonectomy/methods ; Male
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-06-25
    Publishing country Netherlands
    Document type Letter ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2023.05.041
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  2. Article ; Online: Commentary: Cardiothoracic surgery training: Global challenges without universal solutions.

    Kratz, Johannes R / Nguyen, Tom C

    The Journal of thoracic and cardiovascular surgery

    2021  Volume 163, Issue 1, Page(s) 177–178

    MeSH term(s) Curriculum ; Education, Medical, Graduate ; Humans ; Internship and Residency ; Thoracic Surgery/education
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2021.01.048
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  3. Article: Overlapping multiple object assignments

    Kratz, Jörgen

    Economic theory Vol. 63, No. 3 , p. 723-753

    2017  Volume 63, Issue 3, Page(s) 723–753

    Author's details Jörgen Kratz
    Keywords Overlapping assignments ; Sharable goods ; Sequential dictatorship ; Compatibility
    Language English
    Publisher Springer
    Publishing place Berlin
    Document type Article
    ZDB-ID 1059110-2 ; 1398355-6
    ISSN 1432-0479 ; 0938-2259
    ISSN (online) 1432-0479
    ISSN 0938-2259
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  4. Article: Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models.

    Li, P Jonathan / Roose, Jeroen P / Jablons, David M / Kratz, Johannes R

    Cancers

    2021  Volume 13, Issue 4

    Abstract: 3D models of cancer have the potential to improve basic, translational, and clinical studies. Patient-derived xenografts, spheroids, and organoids are broad categories of 3D models of cancer, and to date, these 3D models of cancer have been established ... ...

    Abstract 3D models of cancer have the potential to improve basic, translational, and clinical studies. Patient-derived xenografts, spheroids, and organoids are broad categories of 3D models of cancer, and to date, these 3D models of cancer have been established for a variety of cancer types. In lung cancer, for example, 3D models offer a promising new avenue to gain novel insights into lung tumor biology and improve outcomes for patients afflicted with the number one cancer killer worldwide. However, the adoption and utility of these 3D models of cancer vary, and demonstrating the fidelity of these models is a critical first step before seeking meaningful applications. Here, we review use cases of current 3D lung cancer models and bioinformatic approaches to assessing model fidelity. Bioinformatics approaches play a key role in both validating 3D lung cancer models and high dimensional functional analyses to support downstream applications.
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040701
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  5. Book ; Online: Overlapping multiple assignments

    Kratz, Jörgen

    (Working paper / Department of Economics, Lund University ; 2014,44)

    2014  

    Author's details Jörgen Kratz
    Series title Working paper / Department of Economics, Lund University ; 2014,44
    Keywords Soziale Wohlfahrtsfunktion ; Allokationseffizienz ; Modellierung ; Theorie
    Language English
    Size Online-Ressource (31 S.)
    Publisher Dep. of Economics, Lund University
    Publishing place Lund
    Document type Book ; Online
    Database ECONomics Information System

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  6. Article ; Online: Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas.

    Woodard, Gavitt A / Ding, Vivianne / Cho, Christina / Brand, Nathan R / Kratz, Johannes R / Jones, Kirk D / Jablons, David M

    Lung cancer (Amsterdam, Netherlands)

    2023  Volume 180, Page(s) 107211

    Abstract: Background: Genetic changes that drive the transition from lepidic to invasive cancer development within a radiographic ground glass or semi-solid lung lesion (SSL) are not well understood. Biomarkers to predict the transition to solid, invasive cancer ... ...

    Abstract Background: Genetic changes that drive the transition from lepidic to invasive cancer development within a radiographic ground glass or semi-solid lung lesion (SSL) are not well understood. Biomarkers to predict the transition to solid, invasive cancer within SSL are needed.
    Methods: Patients with surgically resected SSL were identified retrospectively from a surgical database. Clinical characteristics and survival were compared between stage I SSL (n = 65) and solid adenocarcinomas (n = 120) resected during the same time period. Areas of normal lung, in situ lepidic, and invasive solid tumor were microdissected from within the same SSL specimens and next generation sequencing (NGS) and Affymetrix microarray of gene expression were performed.
    Results: There were more never smokers, Asian patients, and sub-lobar resections among SSL but no difference in 5-year survival between SSL and solid adenocarcinoma. Driver mutations found in both lepidic and solid invasive portion were EGFR (43%), KRAS (21%), and DNMT3A (5%). CEACAM5 was the most upregulated gene found in solid, invasive portions of SSL. Lepidic and invasive solid areas had many similarities in gene expression, however there were some significant differences with the gene SPP1 being a unique biomarker for the invasive component of a SSL.
    Conclusions: Common lung cancer driver mutations are present in in situ lepidic as well as invasive solid portions of a SSL, suggesting early development of driver mutations. CEACAM5 and SPP1 emerged as promising biomarkers of invasive potential in semi-solid lesions. Other studies have shown both genes to correlate with poor prognosis in lung cancer and their role in evolution of semi-solid lung lesions warrants further study.
    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Retrospective Studies ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma/pathology ; Genomics
    Language English
    Publishing date 2023-04-21
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.107211
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    Zs.A 2135: Show issues Location:
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    Zs.MO 423: Show issues

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  7. Article ; Online: Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development.

    Lancaster, Elizabeth M / Jablons, David / Kratz, Johannes R

    Genetic testing and molecular biomarkers

    2019  Volume 24, Issue 2, Page(s) 59–66

    Abstract: Next-generation sequencing has changed the face of cancer immunotherapy research by making tumor-specific cancer vaccines a reality. Whole exome sequencing and RNA sequencing combined with bioinformatic pipelines allow the prediction of neoantigen ... ...

    Abstract Next-generation sequencing has changed the face of cancer immunotherapy research by making tumor-specific cancer vaccines a reality. Whole exome sequencing and RNA sequencing combined with bioinformatic pipelines allow the prediction of neoantigen targets for cancer vaccines. In this review, we discuss the preclinical and early clinical evidence for cancer vaccines; describe methods and challenges in neoantigen prediction; and summarize emerging new technologies that will improve neoantigen cancer vaccine development.
    MeSH term(s) Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Cancer Vaccines/genetics ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Whole Exome Sequencing
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2018.0211
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    Zs.A 5195: Show issues Location:
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  8. Article ; Online: Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay.

    Gupta, Alexander R / Woodard, Gavitt A / Jablons, David M / Mann, Michael J / Kratz, Johannes R

    Future oncology (London, England)

    2021  Volume 17, Issue 34, Page(s) 4785–4795

    Abstract: There remains a critical need for improved staging of non-small-cell lung cancer, as recurrence and mortality due to undetectable metastases at the time of surgery remain high even after complete resection of tumors currently categorized as 'early stage.' ...

    Abstract There remains a critical need for improved staging of non-small-cell lung cancer, as recurrence and mortality due to undetectable metastases at the time of surgery remain high even after complete resection of tumors currently categorized as 'early stage.' A 14-gene quantitative PCR-based expression profile has been extensively validated to better identify patients at high-risk of 5-year mortality after surgical resection than conventional staging - mortality that almost always results from previously undetectable metastases. Furthermore, prospective studies now suggest a predictive benefit in disease-free survival when the assay is used to guide adjuvant chemotherapy decisions in early-stage non-small-cell lung cancer patients.
    MeSH term(s) Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemotherapy, Adjuvant/statistics & numerical data ; Clinical Decision-Making ; Datasets as Topic ; Disease-Free Survival ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/therapy ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/statistics & numerical data ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging/methods ; Pneumonectomy/statistics & numerical data ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Risk Assessment/methods
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Validation Study
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2021-0517
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    Zs.A 6478: Show issues Location:
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  9. Article ; Online: Giant right coronary artery aneurysm presenting as cardiac tamponade.

    Ramirez, Joel L / Kratz, Johannes R / Wieselthaler, Georg M

    Interactive cardiovascular and thoracic surgery

    2018  Volume 27, Issue 5, Page(s) 787–789

    Abstract: Giant coronary artery aneurysms are rare and have variable presentations, which range from an incidental finding to sudden death. We report a case of a female presenting with chest pain and signs of cardiac tamponade who underwent a computed tomography ( ... ...

    Abstract Giant coronary artery aneurysms are rare and have variable presentations, which range from an incidental finding to sudden death. We report a case of a female presenting with chest pain and signs of cardiac tamponade who underwent a computed tomography (CT) pulmonary embolus protocol and was found to have haemopericardium with accumulation of contrast adjacent to the aorta. She underwent emergent sternotomy and was found to have a ruptured giant right coronary artery aneurysm, which was ligated and bypassed. This report highlights the difficulty of diagnosing a ruptured giant coronary artery aneurysm via CT and provides valuable information on an atypical presentation.
    MeSH term(s) Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnosis ; Aneurysm, Ruptured/surgery ; Cardiac Tamponade/diagnosis ; Cardiac Tamponade/etiology ; Coronary Aneurysm/complications ; Coronary Aneurysm/diagnosis ; Coronary Aneurysm/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Diagnosis, Differential ; Female ; Humans ; Incidental Findings ; Male ; Middle Aged ; Tomography, X-Ray Computed ; Transgender Persons ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2018-05-15
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivy166
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  10. Article ; Online: Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer.

    Hu, Kenneth H / Kuhn, Nicholas F / Courau, Tristan / Tsui, Jessica / Samad, Bushra / Ha, Patrick / Kratz, Johannes R / Combes, Alexis J / Krummel, Matthew F

    Cell stem cell

    2023  Volume 30, Issue 6, Page(s) 885–903.e10

    Abstract: Tissue repair responses in metazoans are highly coordinated by different cell types over space and time. However, comprehensive single-cell-based characterization covering this coordination is lacking. Here, we captured transcriptional states of single ... ...

    Abstract Tissue repair responses in metazoans are highly coordinated by different cell types over space and time. However, comprehensive single-cell-based characterization covering this coordination is lacking. Here, we captured transcriptional states of single cells over space and time during skin wound closure, revealing choreographed gene-expression profiles. We identified shared space-time patterns of cellular and gene program enrichment, which we call multicellular "movements" spanning multiple cell types. We validated some of the discovered space-time movements using large-volume imaging of cleared wounds and demonstrated the value of this analysis to predict "sender" and "receiver" gene programs in macrophages and fibroblasts. Finally, we tested the hypothesis that tumors are like "wounds that never heal" and found conserved wound healing movements in mouse melanoma and colorectal tumor models, as well as human tumor samples, revealing fundamental multicellular units of tissue biology for integrative studies.
    MeSH term(s) Mice ; Animals ; Humans ; Wound Healing/genetics ; Skin/pathology ; Neoplasms/pathology ; Macrophages/metabolism ; Fibroblasts/physiology ; Stromal Cells
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2023.05.001
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