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  1. Article ; Online: Hyperoxia and Acute Kidney Injury: A Tale of Oxygen and the Kidney.

    Kraus, Abigayle C / De Miguel, Carmen

    Seminars in nephrology

    2022  Volume 42, Issue 3, Page(s) 151282

    Abstract: Although oxygen supplementation is beneficial to support life in the clinic, excessive oxygen therapy also has been linked to damage to organs such as the lung or the eye. However, there is a lack of understanding of whether high oxygen therapy directly ... ...

    Abstract Although oxygen supplementation is beneficial to support life in the clinic, excessive oxygen therapy also has been linked to damage to organs such as the lung or the eye. However, there is a lack of understanding of whether high oxygen therapy directly affects the kidney, leading to acute kidney injury, and what molecular mechanisms may be involved in this process. In this review, we revise our current understanding of the mechanisms by which hyperoxia leads to organ damage and highlight possible areas of investigation for the scientific community interested in novel mechanisms of kidney disease. Overall, we found a significant need for both animal and clinical studies evaluating the role of hyperoxia in inducing kidney damage. Thus, we urge the research community to further investigate oxygen therapy and its impact on kidney health with the goal of optimizing oxygen therapy guidelines and improving patient care.
    MeSH term(s) Animals ; Humans ; Oxygen ; Hyperoxia/complications ; Oxidative Stress ; Kidney ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2022.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Prospective Evaluation of Automated Contouring for CT-Based Brachytherapy for Gynecologic Malignancies.

    Kraus, Abigayle C / Iqbal, Zohaib / Cardan, Rex A / Popple, Richard A / Stanley, Dennis N / Shen, Sui / Pogue, Joel A / Wu, Xingen / Lee, Kevin / Marcrom, Samuel / Cardenas, Carlos E

    Advances in radiation oncology

    2023  Volume 9, Issue 4, Page(s) 101417

    Abstract: Purpose: The use of deep learning to auto-contour organs at risk (OARs) in gynecologic radiation treatment is well established. Yet, there is limited data investigating the prospective use of auto-contouring in clinical practice. In this study, we ... ...

    Abstract Purpose: The use of deep learning to auto-contour organs at risk (OARs) in gynecologic radiation treatment is well established. Yet, there is limited data investigating the prospective use of auto-contouring in clinical practice. In this study, we assess the accuracy and efficiency of auto-contouring OARs for computed tomography-based brachytherapy treatment planning of gynecologic malignancies.
    Methods and materials: An inhouse contouring tool automatically delineated 5 OARs in gynecologic radiation treatment planning: the bladder, small bowel, sigmoid, rectum, and urethra. Accuracy of each auto-contour was evaluated using a 5-point Likert scale: a score of 5 indicated the contour could be used without edits, while a score of 1 indicated the contour was unusable. During scoring, automated contours were edited and subsequently used for treatment planning. Dice similarity coefficient, mean surface distance, 95% Hausdorff distance, Hausdorff distance, and dosimetric changes between original and edited contours were calculated. Contour approval time and total planning time of a prospective auto-contoured (AC) cohort were compared with times from a retrospective manually contoured (MC) cohort.
    Results: Thirty AC cases from January 2022 to July 2022 and 31 MC cases from July 2021 to January 2022 were included. The mean (±SD) Likert score for each OAR was the following: bladder 4.77 (±0.58), small bowel 3.96 (±0.91), sigmoid colon 3.92 (±0.81), rectum 4.6 (±0.71), and urethra 4.27 (±0.78). No ACs required major edits. All OARs had a mean Dice similarity coefficient > 0.86, mean surface distance < 0.48 mm, 95% Hausdorff distance < 3.2 mm, and Hausdorff distance < 10.32 mm between original and edited contours. There was no significant difference in dose-volume histogram metrics (D2.0 cc/D0.1 cc) between original and edited contours (
    Conclusions: Automated contouring is useful and accurate in clinical practice. Auto-contouring OARs streamlines radiation treatment workflows and decreases time required to design and approve gynecologic brachytherapy plans.
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The University of Alabama at Birmingham Surgery Community Network: Tackling the Challenges of Rural Surgery.

    Kraus, Abigayle C / Gunnells, Drew J / Chu, Daniel I / Kennedy, Alexis E / Hughes, Tyler G / Chen, Herb / Hollis, Robert H / Porterfield, John R / Stahl, Richard D / Kennedy, Gregory D

    The American surgeon

    2022  Volume 89, Issue 6, Page(s) 2194–2199

    Abstract: Over the past 5 years, The University of Alabama at Birmingham (UAB) Department of Surgery has taken a keen interest in the practice of surgery in rural Alabama and has established the UAB surgery community network. Our goal is to improve the delivery of ...

    Abstract Over the past 5 years, The University of Alabama at Birmingham (UAB) Department of Surgery has taken a keen interest in the practice of surgery in rural Alabama and has established the UAB surgery community network. Our goal is to improve the delivery of surgical care in rural areas through active recruitment of rural surgeons, the development of research around rural surgery practice, and the expansion of a surgery network throughout the state. Here, we will present the challenges faced by rural surgery, our early work to address these challenges, and offer a plan for moving forward.
    MeSH term(s) Humans ; Community Networks ; Alabama ; Surgeons ; Rural Population
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348221109471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.106: Show issues Location:
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  4. Article ; Online: ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction.

    De Miguel, Carmen / Kraus, Abigayle C / Saludes, Mitchell A / Konkalmatt, Prasad / Ruiz Domínguez, Almudena / Asico, Laureano D / Latham, Patricia S / Offen, Daniel / Jose, Pedro A / Cuevas, Santiago

    International journal of molecular sciences

    2020  Volume 21, Issue 19

    Abstract: DJ-1 is a redox-sensitive chaperone with reported antioxidant and anti-inflammatory properties in the kidney. The 20 amino acid (aa) peptide ND-13 consists of 13 highly conserved aas from the DJ-1 sequence and a TAT-derived 7 aa sequence that helps in ... ...

    Abstract DJ-1 is a redox-sensitive chaperone with reported antioxidant and anti-inflammatory properties in the kidney. The 20 amino acid (aa) peptide ND-13 consists of 13 highly conserved aas from the DJ-1 sequence and a TAT-derived 7 aa sequence that helps in cell penetration. This study aimed to determine if ND-13 treatment prevents the renal damage and inflammation associated with unilateral ureter obstruction (UUO). Male C57Bl/6 and
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Biomarkers/metabolism ; Collagen Type I/metabolism ; Collagen Type I, alpha 1 Chain ; Inflammation/drug therapy ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Peptide Fragments/therapeutic use ; Protective Agents/therapeutic use ; Protein Deglycase DJ-1/therapeutic use ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Ureteral Obstruction/drug therapy
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Biomarkers ; Collagen Type I ; Collagen Type I, alpha 1 Chain ; DJ-1 based peptide, ND-13 ; Interleukin-6 ; Peptide Fragments ; Protective Agents ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; interleukin-6, mouse ; Protein Deglycase DJ-1 (EC 3.1.2.-)
    Language English
    Publishing date 2020-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21197048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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