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  1. Book ; Thesis: Diagnostische Wertigkeit von Plasmafibronectin in der Neonatalperiode

    Kraus, Günter

    1990  

    Author's details vorgelegt von Günter Kraus
    Size 100 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1990
    HBZ-ID HT003809541
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    91 D 2393 order for loan Magazin

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  2. Book: Biochemie (physiologische Chemie)

    Kraus, Günter / Spachmüller, Brigitte / Raithel, Martin

    Orig.-Fragen mit bes. ausführl. Kommentaren zu schwierigen Fragen, sowie e. Anh. mit d. Orig.-Fragen 1987 u. Frühjahr 1988, kommentiert vom Fachverb. Medizin e.V

    (Exa-med : Prüfungsfragen ; 6 : GK 1)

    1988  

    Author's details bearb. von Günter Kraus, Brigitte Spachmüller u. Martin Raithel
    Series title Exa-med : Prüfungsfragen ; 6 : GK 1
    Exa-med
    Exa-med ; Prüfungsfragen
    Collection Exa-med
    Exa-med ; Prüfungsfragen
    Keywords Biochemistry / examination questions ; Biochemie
    Subject Biologische Chemie
    Language German
    Size VII, 382 S. : graph. Darst.
    Edition 7., neubearb. Aufl.
    Publisher Jungjohann
    Publishing place Neckarsulm u.a.
    Document type Book
    Old title 6. Aufl. u.d.T. Spachmüller, Brigitte: Prüfungsfragen Biochemie (physiologische Chemie)
    HBZ-ID HT003238404
    ISBN 3-8243-1010-4 ; 978-3-8243-1010-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 375 order for loan Magazin

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  3. Book ; Online: 100 Fragen zum Mac: kurz und einfach beantwortet. Mit Tipps zu OS X 10.8 Mountain Lion

    Weber, Mario / Cronenberg, Ulf / Kraus, Günter

    2012  

    Abstract: Dieses Buch beantwortet 100 grundlegende Fragen, die sich dem Apple-Nutzer beim täglichen Umgang mit dem Mac und dessen Betriebssystem stellen. Wie schließe ich einen Drucker an, welche Vorteile bringt mir die Mitteilungszentrale oder was ist eigentlich ... ...

    Abstract Dieses Buch beantwortet 100 grundlegende Fragen, die sich dem Apple-Nutzer beim täglichen Umgang mit dem Mac und dessen Betriebssystem stellen. Wie schließe ich einen Drucker an, welche Vorteile bringt mir die Mitteilungszentrale oder was ist eigentlich die iCloud? All diese Kleinigkeiten, die manchmal zu unüberwindbaren Hürden werden, erklärt dieses leicht und verständlich geschriebene Buch. Das Buch ist im Frage-Antwort-Muster aufgebaut. Damit finden Sie die Lösung zu einem Problem besonders schnell und lernen weitere Fähigkeiten von Mac OS X kennen. Mit Tipps zu OS X 10.8 Mountain Lion.
    Keywords Computer Betriebssysteme ; Computer Mac
    Language German
    Size Online-Ressource
    Edition 1. Aufl.
    Publisher SmartBooks
    Publishing place s.l.
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 3908498120 ; 9783908498124
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book: Mac OS X 10.6 Snow Leopard

    Cronenberg, Ulf / Kraus, Günter / Weber, Mario

    Workbook für Ein- und Umsteiger

    2009  

    Title variant Einsteiger
    Author's details Ulf Cronenberg; Günter Kraus; Mario Weber
    Keywords MacOS X 10.6
    Language German
    Size 380 S., durchg. farb. Ill
    Edition 1. Aufl.
    Publisher Smart Books
    Publishing place Pfäffikon SZ
    Document type Book
    ISBN 9783908497950 ; 3908497957
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book: Mac OS X 10.5 Leopard

    Weber, Mario / Cronenberg, Ulf / Kraus, Günter

    einfach nützlich für Einsteiger, Umsteiger und Aufsteiger

    2008  

    Abstract: Mac OS X 10.5 Leopard ist die neueste Version des UNIX-angeglichenen Betriebssystems für den Macintosh von Apple. Die Unterschiede zur vorangegangenen Version OS X 10.4 Tiger sind beträchtlich. Eine Beschaffung von Literatur für die Version 10.5 Leopard ... ...

    Author's details [Weber; Kraus; Cronenberg]
    Abstract Mac OS X 10.5 Leopard ist die neueste Version des UNIX-angeglichenen Betriebssystems für den Macintosh von Apple. Die Unterschiede zur vorangegangenen Version OS X 10.4 Tiger sind beträchtlich. Eine Beschaffung von Literatur für die Version 10.5 Leopard ist auf jeden Fall zu empfehlen, auch wenn Literatur zur Version 10.4 Tiger ausreichend vorhanden ist. Eine Einführung in die Version Leopard hat bereits A. Cherif gegeben (BA 2/08). Er setzt den Schwerpunkt bei Power-Usern und bei Umsteigern aus der Windows-Welt. Das vorliegende Buch setzt auf einem einfacheren Niveau an. Angesprochen werden in erster Linie Einsteiger ohne allzu große Vorkenntnisse und Aufsteiger von früheren Versionen des Mac-Betriebssystems. Im Mittelpunkt steht das sichere und komfortable Arbeiten mit der Version Leopard. Hierzu zahlreiche Tipps und Tricks und Hinweise zum Trouble-Shooting. Neu ist auch ein umfangreiches Kapitel über Free- und Sharewareprogramme, die die Version Leopard gut ergänzen. Ein empfehlenswertes Buch; eine Parallelbeschaffung zu A. Cherif ist aber nicht unbedingt nötig. (2)
    Keywords MacOS X 10.5
    Language German
    Size 217 S, Ill, 24 cm
    Edition 2. Aufl.
    Publisher Smart Books
    Publishing place Baar
    Document type Book
    ISBN 3908497701 ; 9783908497707
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Mac OS X 10.5 Leopard

    Weber, Mario / Cronenberg, Ulf / Kraus, Günter

    einfach nützlich für Einsteiger, Umsteiger und Aufsteiger

    2008  

    Abstract: Mac OS X 10.5 Leopard ist die neueste Version des UNIX-angeglichenen Betriebssystems für den Macintosh von Apple. Die Unterschiede zur vorangegangenen Version OS X 10.4 Tiger sind beträchtlich. Eine Beschaffung von Literatur für die Version 10.5 Leopard ... ...

    Author's details [Weber; Kraus; Cronenberg]
    Abstract Mac OS X 10.5 Leopard ist die neueste Version des UNIX-angeglichenen Betriebssystems für den Macintosh von Apple. Die Unterschiede zur vorangegangenen Version OS X 10.4 Tiger sind beträchtlich. Eine Beschaffung von Literatur für die Version 10.5 Leopard ist auf jeden Fall zu empfehlen, auch wenn Literatur zur Version 10.4 Tiger ausreichend vorhanden ist. Eine Einführung in die Version Leopard hat bereits A. Cherif gegeben (BA 2/08). Er setzt den Schwerpunkt bei Power-Usern und bei Umsteigern aus der Windows-Welt. Das vorliegende Buch setzt auf einem einfacheren Niveau an. Angesprochen werden in erster Linie Einsteiger ohne allzu große Vorkenntnisse und Aufsteiger von früheren Versionen des Mac-Betriebssystems. Im Mittelpunkt steht das sichere und komfortable Arbeiten mit der Version Leopard. Hierzu zahlreiche Tipps und Tricks und Hinweise zum Trouble-Shooting. Neu ist auch ein umfangreiches Kapitel über Free- und Sharewareprogramme, die die Version Leopard gut ergänzen. Ein empfehlenswertes Buch; eine Parallelbeschaffung zu A. Cherif ist aber nicht unbedingt nötig. (2)
    Keywords MacOS X 10.5
    Language German
    Size 217 S, Ill, 24 cm
    Edition 2. Aufl.
    Document type Book
    ISBN 3908497701 ; 9783908497707
    Database Johann Heinrich von Thünen-Institut, Federal Research Institute for Rural Areas, Forestry and Fisheries

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  7. Article: Hide-and-seek: the challenge of viral persistence in HIV-1 infection.

    Geeraert, Luc / Kraus, Günter / Pomerantz, Roger J

    Annual review of medicine

    2008  Volume 59, Page(s) 487–501

    Abstract: The success of highly active antiretroviral therapy (HAART) for HIV-1 infection has sparked interest in mechanisms by which the virus can persist despite effectively suppressive therapy. Latent HIV-1 reservoirs established early during infection not only ...

    Abstract The success of highly active antiretroviral therapy (HAART) for HIV-1 infection has sparked interest in mechanisms by which the virus can persist despite effectively suppressive therapy. Latent HIV-1 reservoirs established early during infection not only prevent sterilizing immunity but also represent a major obstacle to virus eradication. When HIV-1 gains a foothold in the immunologic memory or in certain inaccessible compartments of the human body, it cannot be easily purged by HAART and is able to replenish systemic infection on treatment interruption. Because latently infected cells are indistinguishable from uninfected cells, deliberate activation of latent infection combined with intensified HAART seems to be the best strategy to combat latent infection. Initial hypothesis-driven clinical trials did not achieve their ultimate goal, although they provided valuable insight for the design of future eradication protocols. A more detailed understanding of the basic mechanisms underlying the establishment and long-term maintenance of HIV-1 reservoirs will be critical in developing new eradication approaches.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; HIV Infections/drug therapy ; HIV-1/physiology ; Humans ; Treatment Failure ; Virus Activation ; Virus Latency
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 0066-4219
    ISSN 0066-4219
    DOI 10.1146/annurev.med.59.062806.123001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.321: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Thesis: Diagnostische Wertigkeit von Plasmafibronectin in der Neonatalperiode

    Kraus, Günter

    1990  

    Author's details Günter Kraus
    Language Undetermined
    Size 100 S, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Erlangen, Nürnberg, Univ., Diss. : 1990
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats.

    Hiller, Karl-Heinz / Ruile, Philipp / Kraus, Günter / Bauer, Wolfgang R / Waller, Christiane

    Microvascular research

    2010  Volume 80, Issue 3, Page(s) 484–490

    Abstract: ACE inhibition has been shown to improve left ventricular (LV) and myocardial blood flow. Previous data regarding changes in capillary density and angiogenesis during ACE inhibition are controversial. The aim of the following study was to determine ... ...

    Abstract ACE inhibition has been shown to improve left ventricular (LV) and myocardial blood flow. Previous data regarding changes in capillary density and angiogenesis during ACE inhibition are controversial. The aim of the following study was to determine myocardial microcirculation and heart function in the rat after coronary stenosis using non invasive MR imaging techniques. MR spin labeling and cine techniques have been performed in female Wistar rats 2weeks after coronary artery stenosis. In one group, animals were treated with quinapril in a dose of 6mg/kg/day. Perfusion, relative blood volume (RBV), LV mass and function were determined non-invasively 2weeks after treatment. Finally, fibrosis and capillary density were analyzed histologically. Additionally, hemodynamic measurements were realized in a further group in order to calculate systemic vascular resistance (SVR). Quinapril resulted in a significant increase in perfusion at rest in the remote and the poststenotic myocardium with improved systolic function and a decrease in SVR compared to the non treated control group. Additionally, maximum perfusion and RBV were slightly elevated whereas capillary density was unchanged among the groups. MRI allows for non-invasive quantification of functional microcirculation and heart function. In addition to the well known effect of ACE inhibition on systolic function, treatment with the tissue specific ACE inhibitor quinapril revealed an important microvascular improvement, especially at arteriolar level. These findings may support the use of tissue ACE inhibitors to improve cardiac microcirculation after ischemia.
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Coronary Circulation ; Coronary Stenosis/drug therapy ; Coronary Stenosis/pathology ; Coronary Stenosis/physiopathology ; Disease Models, Animal ; Female ; Fibrosis ; Hemodynamics/drug effects ; Magnetic Resonance Imaging, Cine ; Microcirculation/drug effects ; Myocardial Perfusion Imaging/methods ; Myocardium/enzymology ; Myocardium/pathology ; Peptidyl-Dipeptidase A/blood ; Rats ; Rats, Wistar ; Recovery of Function ; Tetrahydroisoquinolines/pharmacology ; Time Factors ; Ventricular Function, Left/drug effects
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Tetrahydroisoquinolines ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; quinapril (RJ84Y44811)
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2010.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 746: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease

    Smeulders Liesbeth / Keuleers Inge / Anders Maria / Jochmans Dirk / Kräusslich Hans-Georg / Kraus Günter / Müller Barbara

    Retrovirology, Vol 7, Iss 1, p

    2010  Volume 89

    Abstract: Abstract Background Current antiretroviral therapy against human immunodeficiency virus (HIV-1) reduces viral load and thereby prevents viral spread, but it cannot eradicate proviral genomes from infected cells. Cells in immunological sanctuaries as well ...

    Abstract Abstract Background Current antiretroviral therapy against human immunodeficiency virus (HIV-1) reduces viral load and thereby prevents viral spread, but it cannot eradicate proviral genomes from infected cells. Cells in immunological sanctuaries as well as cells producing low levels of virus apparently contribute to a reservoir that maintains HIV persistence in the presence of highly active antiretroviral therapy. Thus, accelerated elimination of virus producing cells may represent a complementary strategy to control HIV infection. Here we sought to exploit HIV protease (PR) related cytotoxicity in order to develop a strategy for drug induced killing of HIV producing cells. PR processes the viral Gag and Gag-Pol polyproteins during virus maturation, but is also implicated in killing of virus producing cells through off-target cleavage of host proteins. It has been observed previously that micromolar concentrations of certain non-nucleoside reverse transcriptase inhibitors (NNRTIs) can stimulate intracellular PR activity, presumably by enhancing Gag-Pol dimerization. Results Using a newly developed cell-based assay we compared the degree of PR activation displayed by various NNRTIs. We identified inhibitors showing higher potency with respect to PR activation than previously described for NNRTIs, with the most potent compounds resulting in ~2-fold increase of the Gag processing signal at 250 nM. The degree of enhancement of intracellular Gag processing correlated with the compound's ability to enhance RT dimerization in a mammalian two-hybrid assay. Compounds were analyzed for their potential to mediate specific killing of chronically infected MT-4 cells. Levels of cytotoxicity on HIV infected cells determined for the different NNRTIs corresponded to the relative degree of drug induced intracellular PR activation, with CC 50 values ranging from ~0.3 μM to above the tested concentration range (10 μM). Specific cytotoxicity was reverted by addition of PR inhibitors. Two of the most active compounds, VRX-480773 and GW-678248, were also tested in primary human cells and mediated cytotoxicity on HIV-1 infected peripheral blood mononuclear cells. Conclusion These data present proof of concept for targeted drug induced elimination of HIV producing cells. While NNRTIs themselves may not be sufficiently potent for therapeutic application, the results provide a basis for the development of drugs exploiting this mechanism of action.
    Keywords Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 570
    Language English
    Publishing date 2010-10-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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