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  1. Article ; Online: Evading eviction: leukemic stem cell squatters.

    Krause, Daniela S

    Blood

    2021  Volume 138, Issue 12, Page(s) 1007–1008

    MeSH term(s) Humans ; Stem Cells ; Transients and Migrants
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021012623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  2. Article ; Online: The Fox(o) and the HDAC.

    Krause, Daniela S

    Blood

    2020  Volume 135, Issue 17, Page(s) 1416–1417

    MeSH term(s) Forkhead Transcription Factors ; Histone Deacetylases ; Leukemia, Myeloid, Acute ; Maintenance ; Tumor Suppressor Protein p53
    Chemical Substances Forkhead Transcription Factors ; Tumor Suppressor Protein p53 ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis.

    Krause, Daniela S / Dikic, Ivan

    Molecular cell

    2022  Volume 82, Issue 24, Page(s) 4588–4590

    Abstract: Chai et al. ...

    Abstract Chai et al.
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.11.020
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  4. Article ; Online: Killing the minotaur in its amazing maze.

    Krause, Daniela S

    Blood

    2019  Volume 134, Issue 22, Page(s) 1884–1885

    MeSH term(s) Stem Cells
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019003431
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  5. Article ; Online: Et tu, E2F1? The assassins of CML stem cells.

    Krause, Daniela S

    Blood

    2018  Volume 131, Issue 14, Page(s) 1499–1500

    MeSH term(s) Cell Survival ; E2F1 Transcription Factor ; Early Growth Response Protein 1 ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Stem Cells
    Chemical Substances E2F1 Transcription Factor ; E2F1 protein, human ; EGR1 protein, human ; Early Growth Response Protein 1
    Language English
    Publishing date 2018-04-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-02-833699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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  6. Article ; Online: Recent advances in understanding chronic myeloid leukemia: where do we stand?

    Kumar, Rahul / Krause, Daniela S

    Faculty reviews

    2021  Volume 10, Page(s) 35

    Abstract: While the need for complete eradication of leukemic stem cells (LSCs) in chronic myeloid leukemia may be controversial, it is agreed that remaining LSCs are the cause of relapse and disease progression. Current efforts are focused on the understanding of ...

    Abstract While the need for complete eradication of leukemic stem cells (LSCs) in chronic myeloid leukemia may be controversial, it is agreed that remaining LSCs are the cause of relapse and disease progression. Current efforts are focused on the understanding of the persistence of immunophenotypically defined LSCs, which feature abnormalities in signaling pathways relating to autophagy, metabolism, epigenetics, and others and are influenced by leukemia cell-extrinsic factors such as the immune and bone marrow microenvironments. In sum, these elements modulate response and resistance to therapies and the clinical condition of treatment-free remission (TFR), the newly established goal in CML treatment, once the patient has achieved a durable molecular remission after treatment with tyrosine kinase inhibitors. Novel combination therapies based on these identified vulnerabilities of LSCs, aimed at the induction or maintenance of TFR, are being developed, while other research is directed at the elucidation of factors mediating progression to blast crisis.
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/10-35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: "Caught in the net": the extracellular matrix of the bone marrow in normal hematopoiesis and leukemia.

    Zanetti, Costanza / Krause, Daniela S

    Experimental hematology

    2020  Volume 89, Page(s) 13–25

    Abstract: The influence of the bone marrow microenvironment on normal hematopoiesis, but also leukemia, has largely been accepted. However, the focus has been predominantly on the role of various cell types or cytokines maintaining hematopoietic stem cells or ... ...

    Abstract The influence of the bone marrow microenvironment on normal hematopoiesis, but also leukemia, has largely been accepted. However, the focus has been predominantly on the role of various cell types or cytokines maintaining hematopoietic stem cells or protecting leukemia stem cells from different therapies. A frequently overlooked component of the bone marrow microenvironment is the extracellular matrix, which not only provides a mechanical scaffold, but also serves as a source of growth factors. We discuss here how extracellular matrix proteins directly or indirectly modulate hematopoietic stem cell physiology and influence leukemia progression. It is hoped that existing and future studies on this topic may propel forward the possibility of augmenting normal hematopoiesis and improving therapies for leukemia, for instance, by targeting of the extracellular matrix in the bone marrow.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Disease Progression ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Gene Expression Regulation, Leukemic ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Leukemia/drug therapy ; Leukemia/genetics ; Leukemia/metabolism ; Leukemia/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
    Chemical Substances Antineoplastic Agents ; Extracellular Matrix Proteins ; Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2020-08-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2020.07.010
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    Zs.A 922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future.

    Minciacchi, Valentina R / Kumar, Rahul / Krause, Daniela S

    Cells

    2021  Volume 10, Issue 1

    Abstract: Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after ... ...

    Abstract Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
    MeSH term(s) Epigenesis, Genetic ; History, 20th Century ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/history ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Models, Biological ; Molecular Targeted Therapy ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2021-01-10
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10010117
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  9. Book ; Online ; Thesis: The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukaemia progression via CXCR5-CXCL13

    Zanetti, Costanza [Verfasser] / Maschalek, Rolf [Gutachter] / Krause, Daniela S. [Gutachter]

    2022  

    Author's details Costanza Zanetti ; Gutachter: Rolf Maschalek, Daniela S. Krause
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
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  10. Book ; Online ; Thesis: The vascular bone marrow niche influences outcome in chronic myeloid leukaemia via the E-selectin - SCL/TAL1 - CD44 axis

    Godavarthy, Parimala Sonika [Verfasser] / Krause, Daniela S. [Akademischer Betreuer] / Rolf, Marschalek [Gutachter] / Krause, Daniela S. [Gutachter]

    2020  

    Author's details Parimala Sonika Godavarthy ; Gutachter: Marschalek Rolf, Daniela S. Krause ; Betreuer: Daniela S. Krause
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
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