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  1. Book ; Thesis: Einflüsse einer Musikintervention auf perioperative Streßfaktoren bei ambulanten Operationen von Naevuszellnaevi in Lokalanästhesie

    Krause, Maren

    1999  

    Author's details vorgelegt von Maren Krause
    Language German
    Size 57, [25] Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1999 (Nur beschränkt für den Austausch)
    HBZ-ID HT013238121
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 249 order for loan Magazin

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  2. Article: "War dit schön!" - Wandertag der Region Berlin / Brandenburg / Mecklenburg-Vorpommern

    Krause, Maren / Rasch, Sylvia

    Gesprächspsychotherapie und personzentrierte Beratung

    2021  Volume 52, Issue 3, Page(s) 33

    Language German
    Document type Article
    ZDB-ID 1377384-7
    ISSN 0932-934X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Isoelectronic Pt(II) complexes of cyclometalating C^N^N ligands with phenyl/(benzo)thiophenyl and pyridyl/(benzo)thiazolyl moieties.

    Krause, Maren / Friedel, Joshua / Buss, Stefan / Brünink, Dana / Berger, Annemarie / Strassert, Cristian A / Doltsinis, Nikos L / Klein, Axel

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 42, Page(s) 16181–16194

    Abstract: A series of cyclometalated Pt(II) complexes [Pt(C^N^N)X] (X = Cl, CCPh, C ... ...

    Abstract A series of cyclometalated Pt(II) complexes [Pt(C^N^N)X] (X = Cl, CCPh, CCC
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt02688k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Triplet Emitting C^N^C Cyclometalated Dibenzo[c,h]Acridine Pt(II) Complexes.

    Friedel, Joshua / Krause, Maren / Jordan, Rose / Maisuls, Iván / Brünink, Dana / Schwab, Dominik / Doltsinis, Nikos L / Strassert, Cristian A / Klein, Axel

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 22

    Abstract: In a series of Pt(II) complexes [Pt(dba)(L)] containing the very rigid, dianionic, bis-cyclometalating, tridentate C^N^C2− heterocyclic ligand dba2− (H2dba = dibenzo[c,h]acridine), the coligand (ancillary ligand) L = dmso, PPh3, CNtBu and Me2Imd (N,N’- ... ...

    Abstract In a series of Pt(II) complexes [Pt(dba)(L)] containing the very rigid, dianionic, bis-cyclometalating, tridentate C^N^C2− heterocyclic ligand dba2− (H2dba = dibenzo[c,h]acridine), the coligand (ancillary ligand) L = dmso, PPh3, CNtBu and Me2Imd (N,N’-dimethylimidazolydene) was varied in order to improve its luminescence properties. Beginning with the previously reported dmso complex, we synthesized the PPh3, CNtBu and Me2Imd derivatives and characterized them by elemental analysis, 1H (and 31P) NMR spectroscopy and MS. Cyclic voltammetry showed partially reversible reduction waves ranging between −1.89 and −2.10 V and increasing along the series Me2Imd < dmso ≈ PPh3 < CNtBu. With irreversible oxidation waves ranging between 0.55 (L = Me2Imd) and 1.00 V (dmso), the electrochemical gaps range between 2.65 and 2.91 eV while increasing along the series Me2Imd < CNtBu < PPh3 < dmso. All four complexes show in part vibrationally structured long-wavelength absorption bands peaking at around 530 nm. TD-DFT calculated spectra agree quite well with the experimental spectra, with only a slight redshift. The photoluminescence spectra of all four compounds are very similar. In fluid solution at 298 K, they show broad, only partially structured bands, with maxima at around 590 nm, while in frozen glassy matrices at 77 K, slightly blue-shifted (~580 nm) bands with clear vibronic progressions were found. The photoluminescence quantum yields ΦL ranged between 0.04 and 0.24, at 298 K, and between 0.80 and 0.90 at 77 K. The lifetimes τ at 298 K ranged between 60 and 14040 ns in Ar-purged solutions and increased from 17 to 43 µs at 77 K. The TD-DFT calculated emission spectra are in excellent agreement with the experimental findings. In terms of high ΦL and long τ, the dmso and PPh3 complexes outperform the CNtBu and Me2Imd derivatives. This is remarkable in view of the higher ligand strength of Me2Imd, compared with all other coligands, as concluded from the electrochemical data.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27228054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Reactions of the organoplatinum complex [Pt(cod) (neoSi)Cl] (neoSi = trimethylsilylmethyl) with the non-coordinating anions SbF6– and BPh4–

    Neugebauer Michael / Schmitz Simon / Krause Maren / L. Doltsinis Nikos / Klein Axel

    Open Chemistry, Vol 16, Iss 1, Pp 1214-

    2018  Volume 1226

    Keywords neosilyl ligand ; non-coordinating anions ; transmetalation ; fluorine ; dft calculations ; Chemistry ; QD1-999
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice.

    Steigerwald, Hanna / Blanco-Pérez, Frank / Macías-Camero, Andrea / Albrecht, Melanie / Huch, Melanie / Bender, Caroline / Schülke, Stefan / Keller, Judith / Krause, Maren / Barbas, Coral / Gonzalez-Menendez, Irene / Quintanilla-Martinez, Leticia / Toda, Masako / Barber, Domingo / Kulling, Sabine / Bunzel, Mirko / Vieths, Stefan / Villaseñor, Alma / Stoll, Dominic /
    Scheurer, Stephan

    Carbohydrate polymers

    2024  Volume 334, Page(s) 122007

    Abstract: Pectins are dietary fibers that are attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low methoxyl pectin (LMP). The aim of this study ... ...

    Abstract Pectins are dietary fibers that are attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low methoxyl pectin (LMP). The aim of this study was to investigate the effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice. Supplementation of the diet with LMP or HMP induced changes in the composition of the intestinal microbiota in mice toward Bacteroides, which was mainly promoted by HMP. Metabolome analysis of stool samples from pectin-fed mice showed a different effect of the two types of pectin on the levels of short-chain fatty acids and bile acids, which was consistent with highly efficient in vivo fermentation of LMP. Analysis of serum antibody levels showed a significant increase in IgG and IgA levels by both pectins, while FACS analysis revealed a decrease of infiltrating inflammatory cells in the intestinal lamina propria by HMP. Our study revealed that the structural properties of the investigated pectins determine fermentability, effects on microbial composition, metabolite production, and modulation of immune responses. Consumption of HMP preferentially altered the gut microbiota and suppressed pro-inflammatory immune responses, suggesting a beneficial role in inflammatory diseases.
    MeSH term(s) Mice ; Animals ; Pectins/chemistry ; Gastrointestinal Microbiome ; Esterification ; Dietary Fiber/pharmacology ; Dietary Fiber/metabolism ; Fermentation
    Chemical Substances Pectins (89NA02M4RX) ; Dietary Fiber
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2024.122007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy.

    Zimmermann, Jennifer / Goretzki, Alexandra / Meier, Clara / Wolfheimer, Sonja / Lin, Yen-Ju / Rainer, Hannah / Krause, Maren / Wedel, Saskia / Spies, Gerd / Führer, Frank / Vieths, Stefan / Scheurer, Stephan / Schülke, Stefan

    Frontiers in immunology

    2022  Volume 13, Page(s) 916491

    Abstract: Background: Recently, bacterial components were shown to enhance immune responses by shifting immune cell metabolism towards glycolysis and lactic acid production, also known as the Warburg Effect. Currently, the effect of allergen products for ... ...

    Abstract Background: Recently, bacterial components were shown to enhance immune responses by shifting immune cell metabolism towards glycolysis and lactic acid production, also known as the Warburg Effect. Currently, the effect of allergen products for immunotherapy (AIT) and commercial vaccines on immune cell metabolism is mostly unknown.
    Objective: To investigate the effect of AIT products (adjuvanted with either MPLA or Alum) on myeloid dendritic cell (mDC) metabolism and activation.
    Methods: Bone marrow-derived mDCs were stimulated with five allergoid-based AIT products (one adjuvanted with MPLA, four adjuvanted with Alum) and two MPLA-adjuvanted vaccines and analyzed for their metabolic activation, expression of cell surface markers, and cytokine secretion by ELISA. mDCs were pre-incubated with either immunological or metabolic inhibitors or cultured in glucose- or glutamine-free culture media and subsequently stimulated with the MPLA-containing AIT product (AIT product 1). mDCs were co-cultured with allergen-specific CD4+ T cells to investigate the contribution of metabolic pathways to the T cell priming capacity of mDCs stimulated with AIT product 1.
    Results: Both the MPLA-containing AIT product 1 and commercial vaccines, but not the Alum-adjuvanted AIT products, activated Warburg metabolism and TNF-α secretion in mDCs. Further experiments focused on AIT product 1. Metabolic analysis showed that AIT product 1 increased glycolytic activity while also inducing the secretion of IL-1β, IL-10, IL-12, and TNF-α. Both rapamycin (mTOR-inhibitor) and SP600125 (SAP/JNK MAPK-inhibitor) dose-dependently suppressed the AIT product 1-induced Warburg Effect, glucose consumption, IL-10-, and TNF-α secretion. Moreover, both glucose- and glutamine deficiency suppressed secretion of all investigated cytokines (IL-1β, IL-10, and TNF-α). Glucose metabolism in mDCs was also critical for the (Th1-biased) T cell priming capacity of AIT product 1-stimulated mDCs, as inhibition of mTOR signaling abrogated their ability to induce Th1-responses.
    Conclusion: The AIT product and commercial vaccines containing the adjuvant MPLA were shown to modulate the induction of immune responses by changing the metabolic state of mDCs. Better understanding the mechanisms underlying the interactions between cell metabolism and immune responses will allow us to further improve vaccine development and AIT.
    MeSH term(s) Adjuvants, Immunologic/pharmacology ; Adjuvants, Pharmaceutic/metabolism ; Adjuvants, Pharmaceutic/pharmacology ; Allergens ; Dendritic Cells ; Glucose/metabolism ; Immunologic Factors/pharmacology ; Immunotherapy ; Interleukin-10 ; TOR Serine-Threonine Kinases/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Vaccines/pharmacology
    Chemical Substances Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Allergens ; Immunologic Factors ; Tumor Necrosis Factor-alpha ; Vaccines ; Interleukin-10 (130068-27-8) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.916491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Photophysical Study on the Rigid Pt(II) Complex [Pt(naphen)(Cl)] (Hnaphen = Naphtho[1,2-

    Krause, Maren / Maisuls, Iván / Buss, Stefan / Strassert, Cristian A / Winter, Andreas / Schubert, Ulrich S / Nair, Shruthi S / Dietzek-Ivanšić, Benjamin / Klein, Axel

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: The electrochemistry and photophysics of the Pt(II) complexes [Pt(naphen)(X)] (Hnaphen = naphtho[1,2- ...

    Abstract The electrochemistry and photophysics of the Pt(II) complexes [Pt(naphen)(X)] (Hnaphen = naphtho[1,2-
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27207022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms.

    Krause, Maren / Crauwels, Peter / Blanco-Pérez, Frank / Globisch, Martin / Wangorsch, Andrea / Henle, Thomas / Lidholm, Jonas / van Zandbergen, Ger / Vieths, Stefan / Scheurer, Stephan / Toda, Masako

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 10141

    Abstract: Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin), a C-type lectin receptor, and contributes to ... ...

    Abstract Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin), a C-type lectin receptor, and contributes to development of peanut allergy. Since macrophages, as well as DCs, play a crucial role in innate immunity, we investigated whether natural Ara h 1 (nAra h 1) activates two different subsets of macrophages, human monocyte derived macrophage type 1 (hMDM1: pro-inflammatory model) and type 2 (hMDM2: anti-inflammatory model). hMDM1 and hMDM2 predominantly produced pro-inflammatory cytokines (IL-6 and TNF-α) and an anti-inflammatory cytokine (IL-10) in response to nAra h 1, respectively. hMDM2 took up nAra h 1 and expressed DC-SIGN at higher levels than hMDM1. However, small interfering RNA knockdown of DC-SIGN did not suppress nAra h 1 uptake and nAra h 1-mediated cytokine production in hMDM2. Inhibitors of scavenger receptor class A type I (SR-AI) suppressed the response of hMDM2, but not of hMDM1, suggesting that SR-AI is a major receptor in hMDM2 for nAra h 1 recognition and internalization. nAra h 1 appears to exert stimulatory capacity on DC and macrophages via different receptors. This study advances our understanding how a major peanut allergen interacts with innate immunity.
    MeSH term(s) Allergens/immunology ; Antigens, Plant/immunology ; Arachis/immunology ; Biomarkers ; Cell Plasticity/immunology ; Disease Susceptibility ; Humans ; Immunophenotyping ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Membrane Proteins/immunology ; Monocytes/immunology ; Monocytes/metabolism ; Peanut Hypersensitivity/diagnosis ; Peanut Hypersensitivity/immunology ; Peanut Hypersensitivity/metabolism ; Plant Proteins/immunology
    Chemical Substances Allergens ; Antigens, Plant ; Ara h 1 protein, Arachis hypogaea ; Biomarkers ; Membrane Proteins ; Plant Proteins
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-89402-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Photophysics and Excited State Dynamics of Cyclometalated [M(Phbpy)(CN)] (M = Ni, Pd, Pt) Complexes: A Theoretical and Experimental Study.

    Eskelinen, Toni / Buss, Stefan / Petrovskii, Stanislav K / Grachova, Elena V / Krause, Maren / Kletsch, Lukas / Klein, Axel / Strassert, Cristian A / Koshevoy, Igor O / Hirva, Pipsa

    Inorganic chemistry

    2021  Volume 60, Issue 12, Page(s) 8777–8789

    Abstract: Cyclometalated complexes [M(Phbpy)(CN)] (HPhbpy = 6-phenyl-2,2'-bipyridine) of the group 10 metals (Ni, Pd, and Pt) bearing a ... ...

    Abstract Cyclometalated complexes [M(Phbpy)(CN)] (HPhbpy = 6-phenyl-2,2'-bipyridine) of the group 10 metals (Ni, Pd, and Pt) bearing a carbanionic
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c00680
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