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Article ; Online: A late sharp increase in influenza detections and low interim vaccine effectiveness against the circulating A(H3N2) strain, Denmark, 2021/22 influenza season up to 25 March 2022.

Emborg, Hanne-Dorthe / Vestergaard, Lasse S / Botnen, Amanda Bolt / Nielsen, Jens / Krause, Tyra G / Trebbien, Ramona

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2022 Volume 27, Issue 15

Abstract: We estimated interim influenza A vaccine effectiveness (VE) following a late sharp rise in cases during an influenza A(H3N2)-dominated 2021/22 season, after lifting COVID-19 restrictions. In children aged 2-6 years offered a live attenuated influenza ... ...

Abstract	We estimated interim influenza A vaccine effectiveness (VE) following a late sharp rise in cases during an influenza A(H3N2)-dominated 2021/22 season, after lifting COVID-19 restrictions. In children aged 2-6 years offered a live attenuated influenza vaccine, adjusted VE was 62.7% (95% CI: 10.9-84.4) in hospitalised and 64.2% (95% CI: 50.5-74.1) in non-hospitalised children. In non-hospitalised patients aged 7-44 years, VE was 24.8% (95% CI: 12.8-35.2); VE was non-significant in remaining age groups and hospital/non-hospital settings.
MeSH term(s)	COVID-19 ; Case-Control Studies ; Child ; Denmark/epidemiology ; Humans ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza B virus ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Seasons ; Vaccination ; Vaccine Efficacy
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2022-04-15
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2022.27.15.2200278
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Article ; Online: COVID-19 mortality attenuated during widespread Omicron transmission, Denmark, 2020 to 2022.

Friis, Nikolaj U / Martin-Bertelsen, Tomas / Pedersen, Rasmus K / Nielsen, Jens / Krause, Tyra G / Andreasen, Viggo / Vestergaard, Lasse S

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 28, Issue 3

Abstract: BackgroundIt sparked considerable attention from international media when Denmark lifted restrictions against COVID-19 in February 2022 amidst widespread transmission of the new SARS-CoV-2 Omicron variant and a steep rise in reported COVID-19 mortality ... ...

Abstract	BackgroundIt sparked considerable attention from international media when Denmark lifted restrictions against COVID-19 in February 2022 amidst widespread transmission of the new SARS-CoV-2 Omicron variant and a steep rise in reported COVID-19 mortality based on the 30-day COVID-19 death count.AimOur aim was to investigate how coincidental infections affected COVID-19 mortality estimates following the introduction of the Omicron variant in late 2021.MethodsWe compared the 30-day COVID-19 death count with the observed mortality using three alternative mortality estimation methods; (i) a mathematical model to correct the 30-day COVID-19 death count for coincidental deaths, (ii) the Causes of Death Registry (CDR) and (iii) all-cause excess mortality.ResultsThere was a substantial peak in the 30-day COVID-19 death count following the emergence of the Omicron variant in late 2021. However, there was also a substantial change in the proportion of coincidental deaths, increasing from 10-20% to around 40% of the recorded COVID-19 deaths. The high number of 30-day COVID-19 deaths was not reflected in the number of COVID-19 deaths in the CDR and the all-cause excess mortality surveillance.ConclusionOur analysis showed a distinct change in the mortality pattern following the introduction of Omicron in late 2021 with a markedly higher proportion of people estimated to have died
MeSH term(s)	Humans ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Denmark/epidemiology
Language	English
Publishing date	2023-01-12
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2023.28.3.2200547
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Article ; Online: Authors' response: Excess all-cause mortality during second wave of COVID-19 - the Polish perspective.

Vestergaard, Lasse S / Nørgaard, Sarah K / Nielsen, Jens / Krause, Tyra G / Mølbak, Kåre

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 7

MeSH term(s)	COVID-19 ; Cause of Death ; Humans ; Influenza, Human ; Poland/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-02-18
Publishing country	Sweden
Document type	Letter ; Comment
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.7.2100191
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Article ; Online: Excess all-cause mortality in the USA and Europe during the COVID-19 pandemic, 2020 and 2021.

Rossen, Lauren M / Nørgaard, Sarah K / Sutton, Paul D / Krause, Tyra G / Ahmad, Farida B / Vestergaard, Lasse S / Mølbak, Kåre / Anderson, Robert N / Nielsen, Jens

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18559

Abstract: Both the USA and Europe experienced substantial excess mortality in 2020 and 2021 related to the COVID-19 pandemic. Methods used to estimate excess mortality vary, making comparisons difficult. This retrospective observational study included data on ... ...

Abstract	Both the USA and Europe experienced substantial excess mortality in 2020 and 2021 related to the COVID-19 pandemic. Methods used to estimate excess mortality vary, making comparisons difficult. This retrospective observational study included data on deaths from all causes occurring in the USA and 25 European countries or subnational areas participating in the network for European monitoring of excess mortality for public health action (EuroMOMO). We applied the EuroMOMO algorithm to estimate excess all-cause mortality in the USA and Europe during the first two years of the COVID-19 pandemic, 2020-2021, and compared excess mortality by age group and time periods reflecting three primary waves. During 2020-2021, the USA experienced 154.5 (95% Uncertainty Interval [UI]: 154.2-154.9) cumulative age-standardized excess all-cause deaths per 100,000 person years, compared with 110.4 (95% UI: 109.9-111.0) for the European countries. Excess all-cause mortality in the USA was higher than in Europe for nearly all age groups, with an additional 44.1 excess deaths per 100,000 person years overall from 2020-2021. If the USA had experienced an excess mortality rate similar to Europe, there would have been approximately 391 thousand (36%) fewer excess deaths in the USA.
MeSH term(s)	Humans ; United States/epidemiology ; COVID-19/epidemiology ; Pandemics ; Europe/epidemiology ; Public Health ; Algorithms ; Mortality
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21844-7
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Article ; Online: All-cause versus cause-specific excess deaths for estimating influenza-associated mortality in Denmark, Spain, and the United States.

Schmidt, Sebastian S S / Iuliano, Angela Danielle / Vestergaard, Lasse S / Mazagatos-Ateca, Clara / Larrauri, Amparo / Brauner, Jan M / Olsen, Sonja J / Nielsen, Jens / Salomon, Joshua A / Krause, Tyra G

Influenza and other respiratory viruses

2022 Volume 16, Issue 4, Page(s) 707–716

Abstract: Background: Seasonal influenza-associated excess mortality estimates can be timely and provide useful information on the severity of an epidemic. This methodology can be leveraged during an emergency response or pandemic.: Method: For Denmark, Spain, ...

Abstract	Background: Seasonal influenza-associated excess mortality estimates can be timely and provide useful information on the severity of an epidemic. This methodology can be leveraged during an emergency response or pandemic. Method: For Denmark, Spain, and the United States, we estimated age-stratified excess mortality for (i) all-cause, (ii) respiratory and circulatory, (iii) circulatory, (iv) respiratory, and (v) pneumonia, and influenza causes of death for the 2015/2016 and 2016/2017 influenza seasons. We quantified differences between the countries and seasonal excess mortality estimates and the death categories. We used a time-series linear regression model accounting for time and seasonal trends using mortality data from 2010 through 2017. Results: The respective periods of weekly excess mortality for all-cause and cause-specific deaths were similar in their chronological patterns. Seasonal all-cause excess mortality rates for the 2015/2016 and 2016/2017 influenza seasons were 4.7 (3.3-6.1) and 14.3 (13.0-15.6) per 100,000 population, for the United States; 20.3 (15.8-25.0) and 24.0 (19.3-28.7) per 100,000 population for Denmark; and 22.9 (18.9-26.9) and 52.9 (49.1-56.8) per 100,000 population for Spain. Seasonal respiratory and circulatory excess mortality estimates were two to three times lower than the all-cause estimates. Discussion: We observed fewer influenza-associated deaths when we examined cause-specific death categories compared with all-cause deaths and observed the same trends in peaks in deaths with all death causes. Because all-cause deaths are more available, these models can be used to monitor virus activity in near real time. This approach may contribute to the development of timely mortality monitoring systems during public health emergencies.
MeSH term(s)	Denmark/epidemiology ; Humans ; Influenza, Human ; Mortality ; Pandemics ; Seasons ; Spain/epidemiology ; United States/epidemiology
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.12966
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Article ; Online: Virus isolation and neutralisation of SARS-CoV-2 variants BA.2.86 and EG.5.1.

Lassaunière, Ria / Polacek, Charlotta / Utko, Magdalena / Sørensen, Karina M / Baig, Sharmin / Ellegaard, Kirsten / Escobar-Herrera, Leandro A / Fomsgaard, Anders / Spiess, Katja / Gunalan, Vithiagaran / Bennedbæk, Marc / Fonager, Jannik / Schwartz, Olivier / Planas, Delphine / Simon-Lorière, Etienne / Schneider, Uffe V / Sieber, Raphael N / Stegger, Marc / Nielsen, Lene /

Hoppe, Morten / Krause, Tyra G / Ullum, Henrik / Jokelainen, Pikka / Rasmussen, Morten

The Lancet. Infectious diseases

2023 Volume 23, Issue 12, Page(s) e509–e510

MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19 ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Letter
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00682-5
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Zs.A 5743: Show issues

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Article ; Online: Reassortant Influenza A(H1N1)pdm09 Virus in Elderly Woman, Denmark, January 2021.

Nissen, Jakob N / George, Sophie J / Hjulsager, Charlotte K / Krog, Jesper S / Nielsen, Xiaohui C / Madsen, Tina V / Andersen, Klara M / Krause, Tyra G / Vestergaard, Lasse S / Larsen, Lars E / Trebbien, Ramona

Emerging infectious diseases

2021 Volume 27, Issue 12, Page(s) 3202–3205

Abstract: A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark in January 2021. We describe the clinical case and report testing results ...

Abstract	A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark in January 2021. We describe the clinical case and report testing results of the genetic and antigenic characterizations of the virus.
MeSH term(s)	Aged ; Animals ; Denmark/epidemiology ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Orthomyxoviridae Infections ; Reassortant Viruses/genetics ; Swine ; Swine Diseases
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2712.211361
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Article ; Online: Simultaneous vaccination with MMR and DTaP-IPV-Hib and rate of hospital admissions with any infections: A nationwide register based cohort study.

Sørup, Signe / Benn, Christine S / Poulsen, Anja / Krause, Tyra G / Aaby, Peter / Ravn, Henrik

Vaccine

2016 Volume 34, Issue 50, Page(s) 6172–6180

Abstract: Background: In Denmark, live measles, mumps, and rubella vaccine (MMR) is associated with a reduced risk of infectious disease admissions, particularly for lower respiratory tract infections. In low-income countries, simultaneous vaccination (i.e. ... ...

Abstract	Background: In Denmark, live measles, mumps, and rubella vaccine (MMR) is associated with a reduced risk of infectious disease admissions, particularly for lower respiratory tract infections. In low-income countries, simultaneous vaccination (i.e. vaccination at the same visit) with live and inactivated vaccines may increase child mortality compared with the live vaccine alone. We examined the hypothesis that simultaneous administration of MMR and the inactivated DTaP-IPV-Hib vaccine compared with MMR alone is associated with higher incidence of infectious disease admissions. Methods: Nationwide, retrospective, register based cohort study of 520,859 children born in Denmark 1997-2006, who were followed from 15months to 4years of age. Incidence rate ratios (IRRs) of hospital admissions were estimated by Cox regression and adjusted for background factors including exact age. Results: By 2years of age, 4965 children had simultaneous MMR and DTaP-IPV-Hib as their most recent vaccination. Compared with MMR alone, simultaneous administration was associated with a higher rate of lower respiratory tract infections (adjusted incidence rate ratio (IRR), 1.27; 95% confidence interval (CI), 1.13-1.42). There was no effect on other infections. Overall, simultaneous administration was associated with a 7% (95% CI, 0-15%) increase in infectious disease admissions. Conclusions: Simultaneous administration of MMR and DTaP-IPV-Hib compared with MMR alone may increase the rate of hospital admissions related to lower respiratory tract infections. These findings require replication in other high-income settings.
Language	English
Publishing date	2016-12-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2016.11.005
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: How are children who are delayed in the Childhood Vaccination Programme vaccinated: A nationwide register-based cohort study of Danish children aged 15-24 months and semi-structured interviews with vaccination providers.

Pedersen, Kenneth B / Holck, Marie E / Jensen, Aksel K G / Suppli, Camilla H / Benn, Christine S / Krause, Tyra G / Sørup, Signe

Scandinavian journal of public health

2018 Volume 48, Issue 1, Page(s) 96–105

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Child, Preschool ; Cohort Studies ; Denmark ; Female ; Health Personnel/psychology ; Humans ; Immunization Programs ; Immunization Schedule ; Infant ; Male ; Practice Guidelines as Topic ; Qualitative Research ; Registries ; Vaccination/statistics & numerical data ; Vaccines/administration & dosage
Chemical Substances	Vaccines
Language	English
Publishing date	2018-07-19
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/1403494818786146
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Article: Oral Polio Vaccination and Hospital Admissions With Non-Polio Infections in Denmark: Nationwide Retrospective Cohort Study.

Sørup, Signe / Stensballe, Lone G / Krause, Tyra G / Aaby, Peter / Benn, Christine S / Ravn, Henrik

Open forum infectious diseases

2015 Volume 3, Issue 1, Page(s) ofv204

Abstract: Background. Live vaccines may have nonspecific beneficial effects on morbidity and mortality. This study examines whether children who had the live-attenuated oral polio vaccine (OPV) as the most recent vaccine had a different rate of admissions for ... ...

Abstract	Background. Live vaccines may have nonspecific beneficial effects on morbidity and mortality. This study examines whether children who had the live-attenuated oral polio vaccine (OPV) as the most recent vaccine had a different rate of admissions for infectious diseases than children with inactivated diphtheria-tetanus-pertussis-polio-Haemophilus influenzae type b vaccine (DTaP-IPV-Hib) or live measles-mumps-rubella vaccine (MMR) as their most recent vaccine. Methods. A nationwide, register-based, retrospective cohort study of 137 403 Danish children born 1997-1999, who had received 3 doses of DTaP-IPV-Hib, were observed from 24 months (first OPV dose) to 36 months of age. Results. Oral polio vaccine was associated with a lower rate of admissions with any type of non-polio infection compared with DTaP-IPV-Hib as most recent vaccine (adjusted incidence rate ratio [IRR], 0.85; 95% confidence interval [CI], .77-.95). The association was separately significant for admissions with lower respiratory infections (adjusted IRR, 0.73; 95% CI, .61-.87). The admission rates did not differ for OPV versus MMR. Conclusions. Like MMR, OPV was associated with fewer admissions for lower respiratory infections than having DTaP-IPV-Hib as the most recent vaccination. Because OPV is now being phased-out globally, further studies of the potential beneficial nonspecific effects of OPV are warranted.
Language	English
Publishing date	2015-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofv204
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