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  1. Article ; Online: Neutrophils Mediate Pulmonary Artery Thrombosis In Situ.

    Porembskaya, Olga / Zinserling, Vsevolod / Tomson, Vladimir / Toropova, Yana / Starikova, Eleonora A / Maslei, Vitaliy V / Bulavinova, Nika I / Kirik, Olga V / Syrtsova, Marina A / Laberko, Leonid / Galchenko, Maxim I / Kravchuk, Vyacheslav / Saiganov, Sergey / Brill, Alexander

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs) ...

    Abstract Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of the vessels in the lungs can develop without preceding deep vein thrombosis (DVT). In this work, we used an inferior vena cava (IVC) complete ligation model of DVT in Wistar rats to explore the possibility and mechanisms of PA thrombosis under the conditions where all routes of thrombotic mass migration from peripheral veins are blocked. We demonstrate that rats both with normal and reduced neutrophil counts developed thrombi in the IVC, although, neutropenia caused a substantial decrease in thrombus size and a shift from fresh fibrin toward mature fibrin and connective tissue inside the thrombus. Massive fibrin deposition was found in the PA branches in the majority of DVT rats with normal neutrophil counts, but in none of the neutropenic animals. Neutrophil ablation also abolished macroscopic signs of lung damage. Altogether, the results demonstrate that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the DVT setting.
    MeSH term(s) Animals ; Fibrin ; Lung ; Neutrophils ; Pulmonary Artery ; Rats ; Rats, Wistar ; Venous Thrombosis/etiology
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hospital and long-term results of carotid endarterectomy in patients with different severity of coronary artery lesion according to syntax score.

    Kazantsev, Anton N / Korotkikh, Alexander V / Wang, Showen / Nonye, Okenu Gloria / Artyukhov, Sergey V / Mukhtorov, Otabek Sh / Roshkovskaya, Lyudmila V / Unguryan, Vladimir M / Shmatov, Dmitry V / Urokov, Davron A / Choriev, Abdurazok A / Zabolotniy, Vadim N / Lebedev, Oleg V / Zarkua, Nona E / Kravchuk, Vyacheslav N / Koplik, Victoria O / Kudryavtsev, Mikhail E / Bagdavadze, Goderzi Sh / Chernyavin, Maxim P /
    Leader, Roman Yu / Kazantseva, Elizaveta G / Belov, Yuri V

    Current problems in cardiology

    2023  Volume 49, Issue 2, Page(s) 102244

    Abstract: Aim: Analysis of in-hospital and long-term results of carotid endarterectomy (CEE) in patients with different severity of coronary atherosclerosis.: Material and methods: This comparative, retrospective, open study for the period from January 2013 to ...

    Abstract Aim: Analysis of in-hospital and long-term results of carotid endarterectomy (CEE) in patients with different severity of coronary atherosclerosis.
    Material and methods: This comparative, retrospective, open study for the period from January 2013 to April 2020 included 1719 patients operated on for occlusive-stenotic lesions of the internal carotid arteries (ICA). Classical and eversion CEA were used as revascularization strategies. The criteria for inclusion in the study were: 1. Presence of coronary angiography within six months before the present CEE; 2. A history of myocardial revascularization in patients with severe coronary lesions. Depending on the severity of coronary atherosclerosis, all patients were divided into 3 groups: Group 1-871 (50.7 %) patients - with the presence of hemodynamically significant stenosis of the coronary arteries (CA) with a history of myocardial revascularization; Group 2-496 (28.8 %) patients - with the presence of hemodynamically insignificant lesions of the coronary artery (up to 70 %, not inclusive, and the trunk of the left coronary artery, up to 50 %, not inclusive); Group 3-352 (20.5 %) patients - without signs of atherosclerotic lesions of the coronary artery. In group 1, the observation period was 56.8±23.2 months, in group 2-62.0±15.6 months, in group 3-58.1±20.4 months.
    Results: During the hospital observation period, there were no significant intergroup differences in the number of complications. All cardiovascular events were detected in isolated cases. The most common injury was damage to the cranial nerves, diagnosed in every fifth patient in the total sample. The combined endpoint (CET), including death + myocardial infarction (MI) + acute cerebrovascular accident/transient ischemic attack (stroke/TIA), was 0.75 % (n=13). In the long-term follow-up period, when comparing survival curves, group 3 revealed the largest number of ischemic strokes (p = 0.007), myocardial infarction (p = 0.03), and CCT (p = 0.005). There were no intergroup differences in the number of deaths (p=0.62).
    Conclusion: The results of the study showed that there was no significant intergroup difference in the development of complications at the hospital postoperative stage. However, in the long-term follow-up period, a group of patients with isolated lesions of the ICA demonstrated a rapid increase in the number of MI, stroke/TIA, and a combined endpoint, which was apparently associated with low compliance and progression of atherosclerosis in previously unaffected arteries.
    MeSH term(s) Humans ; Endarterectomy, Carotid/adverse effects ; Endarterectomy, Carotid/methods ; Carotid Stenosis/complications ; Carotid Stenosis/surgery ; Carotid Stenosis/diagnosis ; Ischemic Attack, Transient/complications ; Coronary Artery Disease/surgery ; Retrospective Studies ; Treatment Outcome ; Stroke/etiology ; Atherosclerosis ; Myocardial Infarction/etiology ; Constriction, Pathologic/complications
    Language English
    Publishing date 2023-12-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.102244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of different types of carotid endarterectomy on the course of resistant arterial hypertension.

    Kazantsev, Anton N / Lider, Roman Yu / Korotkikh, Alexander V / Kazantseva, Elizaveta G / Bagdavadze, Goderzi Sh / Kravchuk, Vyacheslav N / Shmatov, Dmitriy V / Lebedev, Oleg V / Lutsenko, Victor A / Zakeryaev, Aslan B / Artyukhov, Sergey / Palagin, Petr D / Sirotkin, Alexey A / Sultanov, Roman V / Taits, Denis / Taits, Boris / Snopova, Elena V / Zharova, Alina S / Zarkua, Nona /
    Zakharova, Kristina / Belov, Yuriy

    Vascular

    2022  , Page(s) 17085381221140620

    Abstract: Objective: Analysis of the dynamics of systolic blood pressure (SBP) and the results of various types of carotid endarterectomy (СЕЕ) (classical with plasty of the reconstruction zone with a patch, eversion, formation of a new bifurcation, autoarterial ... ...

    Abstract Objective: Analysis of the dynamics of systolic blood pressure (SBP) and the results of various types of carotid endarterectomy (СЕЕ) (classical with plasty of the reconstruction zone with a patch, eversion, formation of a new bifurcation, autoarterial reconstruction, glomus-saving techniques) in patients with resistant arterial hypertension (RAH).
    Materials and methods: The actual cohort, comparative, retrospective, open research for the period from January 2013 to December 2021 includes 1577 patients with significant hemodynamic stenosis of the internal carotid artery Depending on revascularization strategy five groups were formed: Group 1: 18.3% (
    Results: In the postoperative period, no significant differences were obtained in the frequency of deaths, myocardial infarction, stroke, hemorrhagic transformation. However, according to the frequency of the combined endpoint (death + myocardial infarction + ischemic stroke + hemorrhagic transformation), the lowest rates were observed in the group of classical carotid endarterectomy with plasty of the reconstruction zone with a patch and glomus-sparing CEE (group 1: 1.03% (
    Conclusion: Classical CEE and glomus-sparing CEE techniques make it possible to achieve a stable target SBP level in patients with RAH as a result of CG preservation. Removal or traumatization of the latter during eversional CEE, the formation of a new bifurcation, autoarterial reconstruction is accompanied by the development of labile hypertension, an increase in the degree of hypertension and a high risk of hemorrhagic transformation in the brain. Thus, the most effective and safe types of CEE in the presence of RAH are classical CEE with plasty of the reconstruction zone with a patch and glomus-sparing CEE, accompanied by the lowest incidence of adverse cardiovascular events caused by postoperative hypertensive crisis and hyperperfusion syndrome.
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381221140620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Features of Carotid Endarterectomy in Russia. How do we Resolution Issues?

    Belov, Yuri V / Kazantsev, Anton N / Kravchuk, Vyacheslav N / Vinogradov, Roman A / Korotkikh, Alexander V / Shmatov, Dmitriy V / Chernykh, Konstantin P / Zakeryaev, Aslan B / Sukhoruchkin, Pavel V / Matusevich, Vyacheslav V / Yu Lider, Roman / Kazantseva, Elizaveta G / Zakharova, Christina L / Sh Bagdavadze, Goderzi / Zharova, Alina S / Artyukhov, Sergey V / Lutsenko, Victor A / Sultanov, Roman V

    Current problems in cardiology

    2022  Volume 47, Issue 9, Page(s) 101272

    Abstract: This review of the literature discusses the solution of unresolved issues related to carotid endarterectomy in Russia: (1) A program has been created for choosing the tactics of revascularization of patients with simultaneous atherosclerotic lesions of ... ...

    Abstract This review of the literature discusses the solution of unresolved issues related to carotid endarterectomy in Russia: (1) A program has been created for choosing the tactics of revascularization of patients with simultaneous atherosclerotic lesions of the coronary and carotid arteries; (2) Using the methods of computer modeling, studying the genetics and morphology of restenosis, it was found that the classic carotid endarterectomy with plasty of the reconstruction zone with a patch is an unsafe type of revascularization; (3) An eversion carotid endarterectomy with transposition of the internal carotid artery over the hypoglossal nerve has been developed, which makes it possible to prevent damage to the latter during repeated carotid endarterectomy for restenosis; (4) It has been established that carotid endarterectomy is associated with a high risk of complications in patients over 75 years of age; (5) It has been proven that emergency carotid endarterectomy in the first hours after the development of a stroke is not safe because. combined with the maximum number of all non-favorable cardiovascular events; (6) 3 new types of carotid endarterectomy with carotid glomus preservation have been developed.
    MeSH term(s) Carotid Arteries ; Carotid Artery, Internal/pathology ; Carotid Artery, Internal/surgery ; Carotid Stenosis/complications ; Carotid Stenosis/pathology ; Carotid Stenosis/surgery ; Endarterectomy, Carotid/adverse effects ; Endarterectomy, Carotid/methods ; Humans ; Stroke/etiology ; Treatment Outcome
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2022.101272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 505: Show issues Location:
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