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  1. Book ; Thesis: Der Einfluss von porcinem Surfactant auf die Expression von Aktivierungsmarkern auf T-Zellen und eosinophilen Granulozyten nach segmentaler Allergenprovokation bei Patienten mit alergischem Asthma bronchiale

    Krentel, Harald

    2006  

    Author's details vorgelegt von Harald Krentel
    Language German
    Size 70 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2006
    HBZ-ID HT014791807
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    2006 E 1196

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  2. Article ; Online: Robotic-assisted total hysterectomy with transilluminating uterine manipulator - The guiding green light of the firefly mode.

    Krentel, Harald / Naem, Antoine / Moawad, Gaby / De Wilde, Rudy Leon

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  3. Article ; Online: The incidental diagnosis of a rectal neuroendocrine tumor after a segmental rectal resection for endometriosis.

    Naem, Antoine / Andrikos, Dimitrios / Schimmack, Simon / Krentel, Harald

    Asian journal of surgery

    2023  Volume 46, Issue 12, Page(s) 5917–5919

    MeSH term(s) Female ; Humans ; Endometriosis/diagnosis ; Endometriosis/surgery ; Endometriosis/pathology ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/surgery ; Neuroendocrine Tumors/pathology ; Rectal Diseases/surgery ; Rectum/surgery ; Rectum/pathology ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Laparoscopy ; Postoperative Complications/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.08.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Modified Oxford technique of colpopexy for the treatment of uterine and vaginal vault prolapse: a retrospective pilot cohort study.

    Devassy, Rajesh / Naem, Antoine / Krentel, Harald / De Wilde, Rudy Leon

    Frontiers in surgery

    2023  Volume 10, Page(s) 1222950

    Abstract: Introduction: Pelvic organ prolapse is a common health issue that affects 30.8% of women. Laparoscopic sacrocolpopexy and colpopectopexy are two of the most common procedures to restore the pelvic anatomy. Mesh application on the other hand carries an ... ...

    Abstract Introduction: Pelvic organ prolapse is a common health issue that affects 30.8% of women. Laparoscopic sacrocolpopexy and colpopectopexy are two of the most common procedures to restore the pelvic anatomy. Mesh application on the other hand carries an increased complications risk over the short and long terms. The aim of this study is to provide a basis for meshless sacrocolpopexy and colpopectopexy.
    Methods: This study is a retrospective cohort pilot study that analyzed the data of patients with a pelvic organ prolapse according to the pelvic organ prolapse quantification system and underwent the modified technique for sacrocolpopexy and colpopectopexy. Descriptive statistics were used to express the different variables.
    Results: A total of 36 patients met the inclusion criteria and provided consent for the participation in this study. The majority of patients were postmenopausal. 22 out of 36 patients received a previous prolapse surgery. All patients presented with reducible vaginal lump. Dyspareunia and sexual dysfunction were the most commonly reported symptoms. The intraoperative complications rate was 0%. Only one patient had a postoperative persistent urinary retention that was managed medically.
    Discussion: Sacrocolpopexy and colpopectopexy seems to be a safe alternative to the mesh-based pelvic surgeries with a very low rate of intraoperative complications and favorable follow up outcomes.
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1222950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Large Ovarian Endometrioma Occupying the Abdominal Cavity in a Postmenopausal Patient: A Case Report.

    Zografou, Maria Themeli / Naem, Antoine / Laganà, Antonio Simone / Krentel, Harald

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 8

    Abstract: Endometriosis is defined by the presence of endometrial-like glands and/or stroma outside the uterus. The prevalence of endometriosis in postmenopausal women is reported to be 2.55%, which is much lower than that in reproductive-aged women. Ovarian ... ...

    Abstract Endometriosis is defined by the presence of endometrial-like glands and/or stroma outside the uterus. The prevalence of endometriosis in postmenopausal women is reported to be 2.55%, which is much lower than that in reproductive-aged women. Ovarian endometriomas are the most common form of endometriosis. However, these form only 4.3% of ovarian masses in patients in the sixth decade of life. In this manuscript, we report the case of a 60-year-old patient who was referred to our department with an external diagnosis of an abdominal mass. The patient was in good general condition and asymptomatic. A computed tomography scan revealed the presence of a cystic mass originating from the right adnexa and measuring 26 cm. No signs of malignancy were observed. Due to the cyst's size, a midline laparotomy and a bilateral salpingo-oophorectomy were performed successfully. A postoperative histopathologic examination confirmed the diagnosis of an ovarian endometrioma with no signs of hyperplasia or atypia. Cases of postmenopausal large ovarian endometriomas are few. However, due to the risk of malignant transformation, an oophorectomy could be considered the treatment of choice, even in asymptomatic patients.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Endometriosis/surgery ; Postmenopause ; Abdominal Cavity ; Pelvis ; Ovariectomy
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59081398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6270: Show issues Location:
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  6. Article: Prevalence of adenomyosis in women undergoing hysterectomy for abnormal uterine bleeding, pelvic pain or uterine prolapse - A retrospective cohort study.

    Krentel, Harald / De Wilde, Rudy Leon

    Annals of medicine and surgery (2012)

    2022  Volume 78, Page(s) 103809

    Abstract: Background: Adenomyosis can cause symptoms like dysmenorrhea, dyspareunia, pelvic pain and bleeding disorders and is related to subfertility and obstetrical complications. The disease is probably underestimated and underdiagnosed because of difficulties ...

    Abstract Background: Adenomyosis can cause symptoms like dysmenorrhea, dyspareunia, pelvic pain and bleeding disorders and is related to subfertility and obstetrical complications. The disease is probably underestimated and underdiagnosed because of difficulties in reliable clinical examination and imaging results. The age-related prevalence of adenomyosis still remains unclear. In this retrospective analysis we describe the rate of adenomyosis in two independent cohorts of patients undergoing hysterectomy for benign diseases (2011-2013 and 2015-2018) and its correlation to presurgical symptoms respectively indications for hysterectomy.
    Materials and methods: All surgeries have been performed in the same department of minimally invasive gynecological surgery by a total of two experienced surgeons following a surgical internal standard for the indication bleeding disorder, dysmenorrhea. We analyzed the overall rate of patients with adenomyosis in both cohorts and related the histological presence of adenomyosis to presurgical symptoms. We also analyzed a subgroup of postmenopausal patients with uterine prolapse.
    Results: In 307 patients we detected 42.0% of cases with histologically proven adenomyosis. In the group of patients with bleeding disorders and dysmenorrhea as indication for surgery we found the highest rate of adenomyosis (59.3%, cohort 1). 81,1% patients with adenomyosis (cohort 1) reported symptoms. In the subgroup of 42 postmenopausal patients, we found 23.8% of cases with adenomyosis.
    Conclusion: Our data shows that a positive anamnesis regarding the symptoms bleeding disorders and dysmenorrhea is suspicious for adenomyosis. In hysterectomy specimen adenomyosis can be found in more than 40%. The role of adenomyosis-related symptoms requires further investigation, especially in adolescent and postmenopausal patients.
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Laparoscopic Fluorescence Guided Detection of Uterine Niche-The Next Step in Surgical Diagnosis and Treatment.

    Krentel, Harald / Lauterbach, Lisa-Kathrin / Mavrogiannis, Georgios / De Wilde, Rudy Leon

    Journal of clinical medicine

    2022  Volume 11, Issue 9

    Abstract: 1) Background: Uterine niche is a frequent condition in patients with a history of cesarean section. Although the relation to uterotomy seems to be clear, the exact pathogenesis is not fully understood. Uterine niche can easily be diagnosed by ... ...

    Abstract (1) Background: Uterine niche is a frequent condition in patients with a history of cesarean section. Although the relation to uterotomy seems to be clear, the exact pathogenesis is not fully understood. Uterine niche can easily be diagnosed by transvaginal ultrasound. It can be related to symptoms like dysmenorrhea, bleeding disorders, dysuria and dyspareunia. Uterine niche can be the cause of scar pregnancy, a rare form of ectopic pregnancy which can be related to severe complications; (2) Methods: We present a series of nine cases with different uterine niche related findings and discuss the diagnostic and therapeutic options reviewing the current literature and introduce a novel intrauterine ICG use for laparoscopic niche detection in one case; (3) Results: Most of uterine niche related symptoms and complications can be treated by a minimally invasive approach. Laparoscopic fluorescence guided niche detection is feasible; (4) Conclusions: Hysteroscopic and laparoscopic techniques allow the treatment of uterine niche related symptoms and complications. Intrauterine ICG application during fluorescence guided laparoscopy may allow easy niche detection.
    Language English
    Publishing date 2022-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11092657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of complications, conversion rate, malignancy rate, and, surgeon's experience in laparoscopic assisted supracervical hysterectomy (LASH) of 1274 large uteri: A retrospective study.

    Tchartchian, Garri / Bojahr, Bernd / Krentel, Harald / De Wilde, Rudy L

    Acta obstetricia et gynecologica Scandinavica

    2022  Volume 101, Issue 12, Page(s) 1450–1457

    Abstract: Introduction: Hysterectomy now belongs to standard gynecological procedures. Moreover, a shift towards laparoscopic techniques is ever more apparent as they provide many advantages such as less traumatization and shorter convalescence. Large uteri are ... ...

    Abstract Introduction: Hysterectomy now belongs to standard gynecological procedures. Moreover, a shift towards laparoscopic techniques is ever more apparent as they provide many advantages such as less traumatization and shorter convalescence. Large uteri are still mentioned as contraindications for laparoscopic hysterectomy even though those patients might benefit from the lower morbidity associated with minimal invasive techniques. In this study, the largest reported so far, we analyzed intraoperative and postoperative complications as well as the surgeon's experience of laparoscopic assisted supracervical hysterectomy (LASH) in patients with a uterus weight over 500 g.
    Material and methods: The present retrospective study, between June 27, 1998 and August 31, 2019, evaluates 1274 patients with a uterus weight over 500 g who were treated with LASH for benign uterine diseases at the Clinic for Minimal Invasive Surgery (Berlin, Germany). All surgeries were performed by one of four in-house surgeons with experience in LASH: they had performed at least 500 LASH procedures before the study. Patients receiving surgical treatment for malignant tumors were not included in the study. Major and minor intraoperative and postoperative complications were recorded and evaluated. Additionally, medical files were evaluated for demographic data, American Society of Anesthesiologists score (I-IV), name of the surgeon, duration and indication for surgery, history of previous gynecological procedures and concomitant surgical interventions, weight of removed uterine tissue, duration of postoperative hospitalization in patients with complications, intraoperative conversion from laparoscopy to laparotomy, and malignancy rate.
    Results: The mean age was 47.0 ± 7.3 years and mean body mass index was 25.6 ± 7.1 kg/m
    Conclusions: The overall low complication and malignancy rates observed in this study allow us to present LASH as a safe and efficient alternative laparoscopic approach to remove uteri of any size in the hands of experienced surgeons.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Retrospective Studies ; Hysterectomy/methods ; Uterus/surgery ; Uterus/pathology ; Laparoscopy/methods ; Leiomyoma/surgery ; Leiomyoma/pathology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Surgeons
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Robotic surgery for deep-infiltrating endometriosis: is it time to take a step forward?

    Ferrari, Filippo Alberto / Youssef, Youssef / Naem, Antoine / Ferrari, Federico / Odicino, Franco / Krentel, Harald / Moawad, Gaby

    Frontiers in medicine

    2024  Volume 11, Page(s) 1387036

    Abstract: Endometriosis is a chronic debilitating disease that affects nearly 10% of women of the reproductive age. Although the treatment modalities of endometriosis are numerous, surgical excision of the endometriotic implants and nodules remains the sole ... ...

    Abstract Endometriosis is a chronic debilitating disease that affects nearly 10% of women of the reproductive age. Although the treatment modalities of endometriosis are numerous, surgical excision of the endometriotic implants and nodules remains the sole cytoreductive approach. Laparoscopic excision of endometriosis was proven to be beneficial in improving the postoperative pain and fertility. Moreover, it was also proved to be safe and efficient in treating the visceral localization of deep endometriosis, such as urinary and colorectal endometriosis. More recently, robotic-assisted surgery gained attention in the field of endometriosis surgery. Although the robotic technology provides a 3D vision of the surgical field and 7-degree of freedom motion, the safety, efficacy, and cost-effectiveness of this approach are yet to be determined. With this paper, we aim to review the available evidence regarding the role of robotic surgery in the management of endometriosis along with the current practices in the field.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1387036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: now and the future.

    Laganà, Antonio Simone / Myers, Samuel H / Forte, Gianpiero / Naem, Antoine / Krentel, Harald / Allahqoli, Leila / Alkatout, Ibrahim / Unfer, Vittorio

    Expert opinion on drug metabolism & toxicology

    2024  Volume 20, Issue 1-2, Page(s) 61–72

    Abstract: Introduction: This Expert Opinion covers recent updates in the use of Inositol in polycystic ovary syndrome (PCOS) and type II diabetes and gives support to researchers and clinicians.: Areas covered: This article discusses the role of Myo-Inositol ( ... ...

    Abstract Introduction: This Expert Opinion covers recent updates in the use of Inositol in polycystic ovary syndrome (PCOS) and type II diabetes and gives support to researchers and clinicians.
    Areas covered: This article discusses the role of Myo-Inositol (MI) and D-Chiro-Inositol (DCI) in physiological function, the use of MI in PCOS, the risks of using DCI in reproductive conditions, the 40:1 combination of MI/DCI in PCOS. Furthermore, we discuss the issues of insulin resistance and how α-lactalbumin may increase the intestinal bioavailability of MI. The paper then transitions to talk about the use of inositols in diabetes, including type II diabetes, Gestational Diabetes Mellitus (GDM), and double diabetes. Literature searches were performed with the use of PubMed, Google Scholar, and Web of Science between July and October 2023.
    Expert opinion: Inositol therapy has grown in the clinical field of PCOS, with it demonstrating an efficacy like that of metformin. The use of α-lactalbumin has further supported the use of MI, as issues with intestinal bioavailability have been largely overcome. In contrast, the effect of inositol treatment on the different PCOS phenotypes remains an outstanding question. The use of inositols in type II diabetes requires further study despite promising analogous data from GDM.
    MeSH term(s) Pregnancy ; Female ; Humans ; Inositol/pharmacology ; Inositol/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Lactalbumin/therapeutic use ; Insulin Resistance ; Diabetes, Gestational
    Chemical Substances Inositol (4L6452S749) ; Lactalbumin (9013-90-5)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2024.2306851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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