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  1. Book ; Thesis: Nachresektionen nach erfolgloser epilepsiechirurgischer Behandlung

    Pieper-Kretz, Madeleine

    Langzeitverlauf und Anfalls-Outcome

    2016  

    Author's details Madeleine Marie Laure Pieper-Kretz geb. Pieper
    Language German
    Size 60 Seiten, Illustrationen, 21 cm
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2016
    HBZ-ID HT019094814
    Database Catalogue ZB MED Medicine, Health

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    2016 D 969 order for loan Magazin

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  2. Article ; Online: The human long non-coding RNA LINC00941 and its modes of action in health and disease.

    Morgenstern, Eva / Kretz, Markus

    Biological chemistry

    2023  Volume 404, Issue 11-12, Page(s) 1025–1036

    Abstract: Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non- ... ...

    Abstract Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non-coding RNA LINC00941, which was recently found to be highly upregulated in various types of cancer influencing cell proliferation and metastasis. Initial studies could not elucidate the mode of action to understand the role and real impact of LINC00941 in tissue homeostasis and cancer development. However, recent analyses have demonstrated multiple potential modes of action of LINC00941 influencing the functionality of various cancer cell types. Correspondingly, LINC00941 was proposed to be involved in regulation of mRNA transcription and modulation of protein stability, respectively. In addition, several experimental approaches suggest a function of LINC00941 as competitive endogenous RNA, thus acting in a post-transcriptional regulatory fashion. This review summarizes our recent knowledge about the mechanisms of action of LINC00941 elucidated so far and discusses its putative role in miRNA sequestering processes. In addition, the functional role of LINC00941 in regulating human keratinocytes is discussed to also highlight its role in normal tissue homeostasis tissue aside from its involvement in cancer.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; MicroRNAs/genetics ; Gene Expression Regulation ; Neoplasms/genetics
    Chemical Substances RNA, Long Noncoding ; RNA, Messenger ; MicroRNAs
    Language English
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2023-0183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Regulatory noncoding RNAs help protect keratinocytes from ultraviolet-mediated damage in vitiligo.

    Cotter, C / Kretz, M / Rajan, N

    The British journal of dermatology

    2021  Volume 184, Issue 6, Page(s) 999–1000

    MeSH term(s) Humans ; Hypopigmentation ; Keratinocytes ; Melanocytes ; Vitiligo/genetics ; Vitiligo/prevention & control
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19827
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  4. Article ; Online: lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.

    Morgenstern, Eva / Molthof, Carolin / Schwartz, Uwe / Graf, Johannes / Bruckmann, Astrid / Hombach, Sonja / Kretz, Markus

    Life science alliance

    2024  Volume 7, Issue 7

    Abstract: Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 ... ...

    Abstract Numerous long non-coding RNAs (lncRNAs) were shown to have a functional impact on cellular processes such as human epidermal homeostasis. However, the mechanism of action for many lncRNAs remains unclear to date. Here, we report that lncRNA LINC00941 regulates keratinocyte differentiation on an epigenetic level through association with the NuRD complex, one of the major chromatin remodelers in cells. We find that LINC00941 interacts with NuRD-associated MTA2 and CHD4 in human primary keratinocytes. LINC00941 perturbation changes MTA2/NuRD occupancy at bivalent chromatin domains in close proximity to transcriptional regulator genes, including the
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Cell Differentiation/genetics ; Keratinocytes/metabolism ; Keratinocytes/cytology ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Epidermis/metabolism ; Histone Deacetylases/metabolism ; Histone Deacetylases/genetics ; Early Growth Response Protein 3/genetics ; Early Growth Response Protein 3/metabolism ; Epigenesis, Genetic ; Epidermal Cells/metabolism ; Epidermal Cells/cytology ; Chromatin/metabolism ; Chromatin/genetics ; Gene Expression Regulation ; Cells, Cultured
    Chemical Substances RNA, Long Noncoding ; Mi-2 Nucleosome Remodeling and Deacetylase Complex (EC 3.5.1.98) ; Repressor Proteins ; MTA2 protein, human (EC 3.5.1.-) ; Histone Deacetylases (EC 3.5.1.98) ; Early Growth Response Protein 3 (144516-98-3) ; EGR3 protein, human ; Chromatin
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: From structure to function: Route to understanding lncRNA mechanism.

    Graf, Johannes / Kretz, Markus

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2020  Volume 42, Issue 12, Page(s) e2000027

    Abstract: RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein-coding RNAs (ncRNAs) in particular display remarkable versatility. They can fold into complex structures and interact with proteins, DNA, and other ... ...

    Abstract RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein-coding RNAs (ncRNAs) in particular display remarkable versatility. They can fold into complex structures and interact with proteins, DNA, and other RNAs, thus modulating activity, localization, or interactome of multi-protein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of regulatory control. Interestingly, long noncoding RNAs (lncRNAs) tend to acquire complex secondary and tertiary structures and their function-in many cases-is dependent on structural conservation rather than primary sequence conservation. Whereas for many proteins, structure and its associated function are closely connected, for lncRNAs, the structural domains that determine functionality and its interactome are still not well understood. Numerous approaches for analyzing the structural configuration of lncRNAs have been developed recently. Here, will provide an overview of major experimental approaches used in the field, and discuss the potential benefit of using combinatorial strategies to analyze lncRNA modes of action based on structural information.
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202000027
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  6. Article ; Online: Neuer federführender Herausgeber für Der Urologe.

    Stratmann, V / Herrmann, P / Kretz, M

    Der Urologe. Ausg. A

    2018  Volume 57, Issue 5, Page(s) 529

    Title translation New Editor-in-Chief of Der Urologe.
    MeSH term(s) Editorial Policies ; Humans ; Periodicals as Topic ; Urology
    Language German
    Publishing date 2018-05-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-018-0664-9
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  7. Article ; Online: TINCR, staufen1, and cellular differentiation.

    Kretz, Markus

    RNA biology

    2013  Volume 10, Issue 10, Page(s) 1597–1601

    Abstract: The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction ... ...

    Abstract The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes mutated in human skin diseases characterized by disrupted epidermal barrier formation. High-throughput analyses of TINCR RNA- and protein-interactomes revealed TINCR interaction with differentiation mRNAs as well as the Staufen1 protein. TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for epidermal differentiation. Here, we discuss the emerging roles of Staufen1 and TINCR in the regulation of mammalian cell differentiation mediated by interaction with target mRNAs. We consider a role for TINCR as an epithelial-specific guide for targeting the Staufen1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue.
    MeSH term(s) Animals ; Cell Differentiation ; Cytoskeletal Proteins/metabolism ; Epidermal Cells ; Gene Expression Regulation ; Humans ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism
    Chemical Substances Cytoskeletal Proteins ; RNA, Long Noncoding ; RNA, Messenger ; RNA-Binding Proteins ; STAU1 protein, human
    Language English
    Publishing date 2013-08-27
    Publishing country United States
    Document type Journal Article
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.4161/rna.26249
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  8. Conference proceedings: Nebenwirkungsmanagement unter Checkpoint-Inhibitoren-Therapie an der Urologischen Abteilung des Salzkammergut-Klinikums

    Schwaiger, B. / Stoiber, F. / Kretz, M. / Dunzinger, M.

    2020  , Page(s) 20urobay028

    Event/congress 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie; Nürnberg; ; Österreichische Gesellschaft für Urologie und Andrologie; 2020
    Keywords Medizin, Gesundheit
    Publishing date 2020-07-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/20urobay028
    Database German Medical Science

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  9. Article ; Online: Profils et motivations des donneuses d'ovocytes en France en 2017–2018 : comparaison entre les nullipares et celles qui ont déjà procréé.

    Kretz, M / Ohl, J / Letur, H / Guivarch, A / Catteau-Jonard, S / De Mouzon, J

    Gynecologie, obstetrique, fertilite & senologie

    2020  Volume 48, Issue 10, Page(s) 736–745

    Abstract: Objectives: Since the authorization of French nulliparous women to donate oocytes, who are the new donors? What are the similar and differential points with the initial donors who have already procreated?: Methods: Retrospective multicenter cohort ... ...

    Title translation Comparative survey of French oocyte donor's profile and motivations between nulliparous and multiparous donors, 2017-2018.
    Abstract Objectives: Since the authorization of French nulliparous women to donate oocytes, who are the new donors? What are the similar and differential points with the initial donors who have already procreated?
    Methods: Retrospective multicenter cohort study using a questionnaire.
    Results: The return rate is 90.7% with 248 donor files from 5 French assisted reproductive technology (ART) centers, included between 1 January 2017 and 31 December 2018. The average age is 31,0 years. More than two thirds of women have a higher educational level than the license. Donation is spontaneous or relational in 69% and 25% of cases, respectively. Among nulliparous donors, 37% don't know the possibility of self-preservation but after information, 80% wish to benefit from it versus 32% of multiparous women if they were given the opportunity.
    Conclusions: This study by the Study Group for Egg Donation (GEDO) highlights the particularities of French oocytes donors. The 2015 decree allowed to diversify the origin of the donation, which remains mainly altruistic but the possibility of self-preservation for nulliparous donors also seems to motivate women. This link between donation and self-preservation poses an ethical problem that needs to be approached and resolved in the next Bioethics Law framing Assisted Reproductive Technologies (ART).
    MeSH term(s) Cohort Studies ; Female ; Humans ; Motivation ; Oocyte Donation ; Oocytes ; Retrospective Studies ; Surveys and Questionnaires
    Language French
    Publishing date 2020-04-11
    Publishing country France
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2887456-0
    ISSN 2468-7189
    ISSN (online) 2468-7189
    DOI 10.1016/j.gofs.2020.04.004
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  10. Article ; Online: Zum Herausgeberwechsel bei Der Urologe.

    Stratmann, V / Kretz, M / Herrmann, P

    Der Urologe. Ausg. A

    2017  Volume 57, Issue 1, Page(s) 1–2

    Title translation On the new Editor-in-Chief of Der Urologe.
    MeSH term(s) Editorial Policies ; Germany ; Humans ; Periodicals as Topic
    Language German
    Publishing date 2017-12-11
    Publishing country Germany
    Document type Editorial
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-017-0562-6
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