Article ; Online: Gene Therapy of the Peripheral Nervous System: Celiac Ganglia.
Methods in molecular biology (Clifton, N.J.)
2016 Volume 1382, Page(s) 275–283
Abstract: Gene therapy has played an integral role in advancing our understanding of the central nervous system. However, gene therapy techniques have yet to be widely utilized in the peripheral nervous system. Critical targets for gene therapy within the PNS are ... ...
| Abstract | Gene therapy has played an integral role in advancing our understanding of the central nervous system. However, gene therapy techniques have yet to be widely utilized in the peripheral nervous system. Critical targets for gene therapy within the PNS are the neurons in sympathetic ganglia, which are the final pathway to end organs. Thus they are the most specific targets for organ-specific neuron modification. This presents challenges because neurons are not viscerotopically organized within the ganglia and therefore cannot be targeted by their location. However, organ-specific neurons have been identified in sympathetic ganglia of some species and this offers an opportunity for targeting and transducing neurons by way of their target. In fact, alterations in sympathetic neurons have had pathological effects, and transducing organ-specific sympathetic neurons offer an exciting opportunity to selectively modify sympathetic pathology. In this chapter, we describe a method to virally transduce the celiac ganglion (CG), a prevertebral sympathetic ganglion that innervates abdominal organs, with AAV serotypes 1 and 6; thereby, providing a potential avenue to modulate specific subsets of neurons within the celiac ganglion. |
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| MeSH term(s) | Animals ; Dependovirus/genetics ; Ganglia, Sympathetic/pathology ; Ganglia, Sympathetic/virology ; Genetic Therapy ; Genetic Vectors/administration & dosage ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Injections ; Male ; Rats ; Transduction, Genetic |
| Chemical Substances | Green Fluorescent Proteins (147336-22-9) |
| Language | English |
| Publishing date | 2016 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1940-6029 |
| ISSN (online) | 1940-6029 |
| DOI | 10.1007/978-1-4939-3271-9_20 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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