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  1. Book: Progress in corticogenesis

    Kriegstein, Arnold

    Santorini, Greece, May 12 - 15, 2005

    (Cerebral cortex ; 16, Suppl. 1)

    2006  

    Author's details suppl. ed. Arnold Kriegstein
    Series title Cerebral cortex ; 16, Suppl. 1
    Collection
    Language English
    Size i167 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT014779708
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3235 -16,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Non-muscle myosins control the integrity of cortical radial glial endfeet.

    Wang, Li / Kriegstein, Arnold R

    PLoS biology

    2023  Volume 21, Issue 2, Page(s) e3002032

    Abstract: Radial glial cells, the stem cells of the cerebral cortex, extend a long basal fiber that ends in basal endfeet. A new study in PLOS Biology found that non-muscle myosins control basal endfoot integrity to regulate interneuron organization. ...

    Abstract Radial glial cells, the stem cells of the cerebral cortex, extend a long basal fiber that ends in basal endfeet. A new study in PLOS Biology found that non-muscle myosins control basal endfoot integrity to regulate interneuron organization.
    MeSH term(s) Ependymoglial Cells ; Cerebral Cortex ; Interneurons ; Stem Cells ; Myosins
    Chemical Substances Myosins (EC 3.6.4.1)
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002032
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  3. Article ; Online: Challenges of Organoid Research.

    Andrews, Madeline G / Kriegstein, Arnold R

    Annual review of neuroscience

    2022  Volume 45, Page(s) 23–39

    Abstract: Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect features of early tissue organization. Neural organoids are a particularly innovative scientific advance given the lack of ...

    Abstract Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect features of early tissue organization. Neural organoids are a particularly innovative scientific advance given the lack of accessibility of developing human brain tissue and intractability of neurological diseases. Neural organoids have become an invaluable approach to model features of human brain development that are not well reflected in animal models. Organoids also hold promise for the study of atypical cellular, molecular, and genetic features that underscore neurological diseases. Additionally, organoids may provide a platform for testing therapeutics in human cells and are a potential source for cell replacement approaches to brain injury or disease. Despite the promising features of organoids, their broad utility is tempered by a variety of limitations yet to be overcome, including lack of high-fidelity cell types, limited maturation, atypical physiology, and lack of arealization, features that may limit their reliability for certain applications.
    MeSH term(s) Animals ; Brain/physiology ; Induced Pluripotent Stem Cells ; Nervous System Diseases ; Organoids ; Reproducibility of Results
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-111020-090812
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  4. Article ; Online: Mitochondria Control Cortical Cell Fate after Mitosis.

    Wang, Li / Kriegstein, Arnold

    Developmental cell

    2020  Volume 55, Issue 2, Page(s) 120–122

    Abstract: During brain development, the daughter cells of neural stem cells have to make a choice - either to become new stem cells or to differentiate into neurons. In a recent issue of Science, Iwata et al. (2020) show that these fate decisions can be determined ...

    Abstract During brain development, the daughter cells of neural stem cells have to make a choice - either to become new stem cells or to differentiate into neurons. In a recent issue of Science, Iwata et al. (2020) show that these fate decisions can be determined after mitosis by mitochondrial remodeling.
    MeSH term(s) Mitochondria ; Mitochondrial Dynamics ; Mitosis ; Neural Stem Cells/metabolism ; Neurogenesis
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2020.09.028
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    Zs.A 5742: Show issues Location:
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  5. Article ; Online: How mechanisms of stem cell polarity shape the human cerebral cortex.

    Andrews, Madeline G / Subramanian, Lakshmi / Salma, Jahan / Kriegstein, Arnold R

    Nature reviews. Neuroscience

    2022  Volume 23, Issue 12, Page(s) 711–724

    Abstract: Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. The unique diversity of cortical stem cell populations and an expansion of progenitor population size in the human ... ...

    Abstract Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. The unique diversity of cortical stem cell populations and an expansion of progenitor population size in the human cortex have been mirrored by an increase in the complexity of cellular processes that regulate stem cell morphology and behaviour, including their polarity. The study of human cells in primary tissue samples and human stem cell-derived model systems (such as cortical organoids) has provided insight into these processes, revealing that protein complexes regulate progenitor polarity by controlling cell membrane adherence within appropriate cortical niches and are themselves regulated by cytoskeletal proteins, signalling molecules and receptors, and cellular organelles. Studies exploring how cortical stem cell polarity is established and maintained are key for understanding the features of human brain development and have implications for neurological dysfunction.
    MeSH term(s) Humans ; Cell Polarity ; Cerebral Cortex ; Stem Cells/physiology ; Organoids ; Cell Membrane
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-022-00631-3
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  6. Article ; Online: Yoshiki Sasai (1962–2014).

    Kriegstein, Arnold R

    Neuron

    2014  Volume 83, Issue 6, Page(s) 1237–1238

    MeSH term(s) Developmental Biology/history ; History, 20th Century ; History, 21st Century ; Japan ; Molecular Biology/history ; Pluripotent Stem Cells
    Language English
    Publishing date 2014-10-24
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2014.09.014
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    Zs.MG 92: Show issues

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  7. Article ; Online: mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex.

    Andrews, Madeline G / Subramanian, Lakshmi / Kriegstein, Arnold R

    eLife

    2020  Volume 9

    Abstract: Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion. The mammalian Target of Rapamycin (mTOR) signaling pathway is active in ... ...

    Abstract Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion. The mammalian Target of Rapamycin (mTOR) signaling pathway is active in human oRG cells. Mutations in mTOR pathway genes are linked to a variety of neurodevelopmental disorders and malformations of cortical development. We find that dysregulation of mTOR signaling specifically affects oRG cells, but not other progenitor types, by changing the actin cytoskeleton through the activity of the Rho-GTPase, CDC42. These effects change oRG cellular morphology, migration, and mitotic behavior, but do not affect proliferation or cell fate. Thus, mTOR signaling can regulate the architecture of the developing human cortex by maintaining the cytoskeletal organization of oRG cells and the radial glia scaffold. Our study provides insight into how mTOR dysregulation may contribute to neurodevelopmental disease.
    MeSH term(s) Cell Movement/physiology ; Cerebral Cortex/growth & development ; Cerebral Cortex/physiology ; Ependymoglial Cells/cytology ; Ependymoglial Cells/physiology ; Humans ; Neural Stem Cells/cytology ; Neural Stem Cells/physiology ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2020-09-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.58737
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  8. Article ; Online: Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain.

    Bhaduri, Aparna / Neumann, Elizabeth K / Kriegstein, Arnold R / Sweedler, Jonathan V

    JACS Au

    2021  Volume 1, Issue 12, Page(s) 2261–2270

    Abstract: The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid diversity because it is difficult to study the lipids within individual ...

    Abstract The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid diversity because it is difficult to study the lipids within individual cells. Here, we used single-cell mass spectrometry-based protocols to profile the lipidomes of 154 910 single cells across ten individuals consisting of five developmental ages and five brain regions, resulting in a unique lipid atlas available via a web browser of the developing human brain. From these data, we identify differentially expressed lipids across brain structures, cortical areas, and developmental ages. We inferred lipid profiles of several major cell types from this data set and additionally detected putative cell-type specific lipids. This data set will enable further interrogation of the developing human brain lipidome.
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.1c00393
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  9. Article ; Online: Yoshiki Sasai (1962–2014).

    Kriegstein, Arnold R

    Cell stem cell

    2013  Volume 15, Issue 3, Page(s) 265–266

    MeSH term(s) Animals ; History, 20th Century ; History, 21st Century ; Humans ; Japan ; Mice ; Stem Cell Research/history
    Language English
    Publishing date 2013-12-05
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2014.08.007
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  10. Article ; Online: Are Organoids Ready for Prime Time?

    Bhaduri, Aparna / Andrews, Madeline G / Kriegstein, Arnold R / Nowakowski, Tomasz J

    Cell stem cell

    2020  Volume 27, Issue 3, Page(s) 361–365

    Abstract: Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and disease. However, these models require systematic benchmarking against primary tissue to establish their value. We discuss ...

    Abstract Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and disease. However, these models require systematic benchmarking against primary tissue to establish their value. We discuss key parameters that impact the utility of organoid models, primarily focusing on cerebral organoids as examples.
    MeSH term(s) Humans ; Organoids
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2020.08.013
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