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Artikel ; Online: Chlorhexidine for the Treatment of Peri-Implantitis: Is it a Benison?

Krishnamoorthy, Gayathri / Narayana, Aparna / Balkrishanan, Dhanasekar

Journal of long-term effects of medical implants

2022 Band 32, Heft 1, Seite(n) 19–23

Abstract: Purpose: Chlorhexidine is the most favored and widely used antimicrobial agent for the treatment of peri-implantitis. But, not many clinicians are aware of its side effects on dental implants and its cytotoxic effects on osteoblasts. The objectives of ... ...

Abstract	Purpose: Chlorhexidine is the most favored and widely used antimicrobial agent for the treatment of peri-implantitis. But, not many clinicians are aware of its side effects on dental implants and its cytotoxic effects on osteoblasts. The objectives of this review are to study the effect of chlorhexidine on osteoblasts as well as on the surface topography of dental implants. Materials and methods: MEDLINE-PubMed (The National Library of Medicine, Washington DC) was used as a search engine. Databases were searched from 2010 to 2020 were explored using the following terms: "dental implant surface," "chlorhexidine mouthwash," "osteoblast cells," "osseointegration." From the total hits obtained, each article along with its cross-reference was manually read and filtered based on the focused question. The inclusion criteria included articles published only in English language involving human studies, randomized control trials, in vitro studies, and review articles. Exclusion criteria included studies published in languages other than English, orthodontic mini-implants, and pilot studies. The final process involved scrutinizing for any duplicate content of the hand searched articles. Following this, data was extracted from the compiled hand searched articles to obtain relevant information for the review. Results: Chlorhexidine alters the surface topography of dental implants and causes cell cytotoxicity. This, in turn, can hinder the re-osseointegration potential and hence cause dental implant failure. It is, therefore, recommended to discourage the use of chlorhexidine as a surface decontaminant for peri-implantitis cases and practice implementing other antimicrobial agents.
Mesh-Begriff(e)	Chlorhexidine/therapeutic use ; Dental Implants/adverse effects ; Humans ; Orthodontic Anchorage Procedures ; Osseointegration ; Peri-Implantitis/drug therapy ; Peri-Implantitis/etiology ; United States
Chemische Substanzen	Dental Implants ; Chlorhexidine (R4KO0DY52L)
Sprache	Englisch
Erscheinungsdatum	2022-04-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1073166-0
ISSN	1940-4379 ; 1050-6934
ISSN (online)	1940-4379
ISSN	1050-6934
DOI	10.1615/JLongTermEffMedImplants.2021039510
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Reinforcement Learning for Battery Energy Storage Dispatch augmented with Model-based Optimizer

Krishnamoorthy, Gayathri / Dubey, Anamika

2021

Abstract: Reinforcement learning has been found useful in solving optimal power flow (OPF) problems in electric power distribution systems. However, the use of largely model-free reinforcement learning algorithms that completely ignore the physics-based modeling ... ...

Abstract	Reinforcement learning has been found useful in solving optimal power flow (OPF) problems in electric power distribution systems. However, the use of largely model-free reinforcement learning algorithms that completely ignore the physics-based modeling of the power grid compromises the optimizer performance and poses scalability challenges. This paper proposes a novel approach to synergistically combine the physics-based models with learning-based algorithms using imitation learning to solve distribution-level OPF problems. Specifically, we propose imitation learning based improvements in deep reinforcement learning (DRL) methods to solve the OPF problem for a specific case of battery storage dispatch in the power distribution systems. The proposed imitation learning algorithm uses the approximate optimal solutions obtained from a linearized model-based OPF solver to provide a good initial policy for the DRL algorithms while improving the training efficiency. The effectiveness of the proposed approach is demonstrated using IEEE 34-bus and 123-bus distribution feeders with numerous distribution-level battery storage systems.
Schlagwörter	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Electrical Engineering and Systems Science - Systems and Control
Thema/Rubrik (Code)	006
Erscheinungsdatum	2021-09-02
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Buch ; Online: A Framework to Analyze Interactions between Transmission and Distribution Systems

Krishnamoorthy, Gayathri / Dubey, Anamika

2019

Abstract: Analyzing the interactions between the transmission and distribution (T&D) system is becoming imperative with the increased penetrations of distributed energy resources (DERs) on electric power distribution networks. An assessment of the impacts of ... ...

Abstract	Analyzing the interactions between the transmission and distribution (T&D) system is becoming imperative with the increased penetrations of distributed energy resources (DERs) on electric power distribution networks. An assessment of the impacts of distribution system connected DERs on the transmission system operations is required especially pertaining to system unbalance when modeling both T&D systems. In this paper, a coupled T&D analysis framework is developed through the co-simulation approach. The framework utilizes legacy software to separately solve the decoupled T&D models. The T&D interactions are captured by exchanging network solutions at the point of common coupling (PCC). The proposed co-simulation framework adopts an iterative coupling approach resulting in a co-simulation model close to a stand-alone T&D platform. The proposed framework is tested using the IEEE-9 bus transmission system model and EPRI's Ckt-24 test distribution feeder model. A case study in which the IEEE 9 bus model interfaced with three ckt24 models is also presented to demonstrate the scalability of the approach. The conditions of convergence by exchanging the boundary variables at the PCC are examined in detail using several case studies with varying levels of load unbalance.
Schlagwörter	Electrical Engineering and Systems Science - Systems and Control
Thema/Rubrik (Code)	006
Erscheinungsdatum	2019-12-16
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Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Buch ; Online: Hybrid Transmission Distribution Co-simulation

Krishnamoorthy, Gayathri / Dubey, Anamika

Frequency Regulation using Battery Energy Storage

2019

Abstract: Battery energy storage systems (BESS) are proving to be an effective solution in providing frequency regulation services to the bulk grid. However, there are several concerns for the transmission/distribution system operators (TSO/DSO) with the frequent ... ...

Abstract	Battery energy storage systems (BESS) are proving to be an effective solution in providing frequency regulation services to the bulk grid. However, there are several concerns for the transmission/distribution system operators (TSO/DSO) with the frequent dispatching of the distribution-connected fast-responding storage systems. Unfortunately, the existing decoupled models for transmission and distribution (T&D) simulations are unable to capture the complex interactions between the two systems especially concerning frequency regulation problems due to rapidly varying distribution-connected distributed energy resources (DERs). In this paper, an iteratively coupled T&D hybrid co-simulation framework is developed to facilitate the planning studies for the system operators to help integrate distribution-connected BESS in providing frequency regulation services in response to highly variable DERs such as photovoltaic generation (PVs). Specifically, the proposed framework helps evaluate: (1) the effects of distribution-connected DERs/PVs on the response of the system's automatic generation control (AGC) response, and (2) highlights the use of BESS in providing frequency regulation services using integrated T&D model. The proposed framework is demonstrated using the IEEE 9-bus transmission system model (operating in dynamics mode) coupled with multiple EPRI Ckt-24 distribution system models (operating in quasi-static mode). It is shown that the proposed co-simulation framework helps better visualize the system AGC response and frequency regulation especially in the presence of high-levels of DER generation variability requiring frequent dispatch of BESS.
Schlagwörter	Electrical Engineering and Systems Science - Systems and Control
Erscheinungsdatum	2019-12-16
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Buch ; Online: Transmission-Distribution Co-Simulation

Krishnamoorthy, Gayathri / Dubey, Anamika

Analytical Methods for Iterative Coupling

2019

Abstract: With the increased penetrations of distributed energy resources (DERs), the need for integrated transmission and distribution system analysis (T&D) is imperative. This paper presents an integrated unbalanced T&D analysis framework using an iteratively ... ...

Abstract	With the increased penetrations of distributed energy resources (DERs), the need for integrated transmission and distribution system analysis (T&D) is imperative. This paper presents an integrated unbalanced T&D analysis framework using an iteratively coupled co-simulation approach. The unbalanced T&D systems are solved separately using dedicated solvers. An iterative approach is developed for T&D interface coupling and to ensure convergence of the boundary variables. To do so, analytical expressions governing the T&D interface are obtained. First-order and second-order convergent methods using the Fixed-point iteration (FPI) method and Newton's method, respectively are proposed to solve the system of nonlinear T&D interface equations. The proposed framework is tested using an integrated T&D system model comprised of a 9-bus IEEE transmission test system integrated with a real-world 6000-bus distribution test system. The results show that the proposed framework can model the impacts of system unbalance and increased demand variability on integrated T&D systems and converges during stressed system conditions. As expected, Newton's method converges faster with a fewer number of iterations as compared to the FPI method and the improvements are more pronounced during high levels of system unbalance and high loading conditions.
Schlagwörter	Electrical Engineering and Systems Science - Systems and Control
Thema/Rubrik (Code)	531
Erscheinungsdatum	2019-12-15
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Mastication as a tool to prevent cognitive dysfunctions.

Krishnamoorthy, Gayathri / Narayana, Aparna I / Balkrishanan, Dhanasekar

The Japanese dental science review

2018 Band 54, Heft 4, Seite(n) 169–173

Abstract: Mastication as we all know has always been related to its primary function of digestion, but little do we know that it produces an enhancing effect on general health, especially the cognitive performance related aspects of memory. Recent studies have ... ...

Abstract	Mastication as we all know has always been related to its primary function of digestion, but little do we know that it produces an enhancing effect on general health, especially the cognitive performance related aspects of memory. Recent studies have shown its association with activation of various brain regions, however little is known about its effects on neuronal activity in these specified regions. According to the enormous evidences collected so far, mastication has proved to be effective in conducting huge amount of sensory information to the brain, and maintaining learning and memory functions of hippocampus. Therefore it is essential that we maintain normal occlusion and preserve the masticatory function as long as possible to prevent the attenuation of hippocampus, caused by occlusal disharmony and reduced mastication. We provide an overview on how mastication activates various cortical areas of the brain and how an increase in the cerebral blood oxygen level of hippocampus and prefrontal cortex (PFC) accentuates the learning and memory process. We also justify why maintaining and establishing a normal occlusion is important from neurological point of view.
Sprache	Englisch
Erscheinungsdatum	2018-08-31
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Review
ZDB-ID	2439945-0
ISSN	1882-7616
ISSN	1882-7616
DOI	10.1016/j.jdsr.2018.06.001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Distributed PV Penetration Impact Analysis on Transmission System Voltages using Co-Simulation

Krishnamoorthy, Gayathri / Sadnan, R. / Dubey, Anamika

2019

Abstract: With the growing penetrations of distributed energy resources (DERs), it is imperative to evaluate their impacts on transmission system operations. In this paper, an iteratively coupled transmission and distribution (T&D) co-simulation framework is ... ...

Abstract	With the growing penetrations of distributed energy resources (DERs), it is imperative to evaluate their impacts on transmission system operations. In this paper, an iteratively coupled transmission and distribution (T&D) co-simulation framework is employed to study the impacts of increasing penetrations of distribution-connected photovoltaic (PV) systems on transmission system voltages. The co-simulation framework introduces iterative coupling and unbalanced transmission system analysis that help accurately replicate the standalone T&D system results without resorting to the computational challenge of developing large-scale standalone T\&D models. The integrated T&D systems are evaluated for multiple PV deployment scenarios based on randomly generated PV locations and sizes. A test system is simulated using the IEEE-9 bus transmission system model integrated at each load point with three EPRI's Ckt-24 distribution feeder models. The results are thoroughly validated using a standalone T&D system model simulated in OpenDSS.
Schlagwörter	Electrical Engineering and Systems Science - Systems and Control
Thema/Rubrik (Code)	006
Erscheinungsdatum	2019-12-15
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: To study the effect of

Krishnamoorthy, Gayathri / Narayana, Aparna I / Peralam, Prakash Yegneswaran / Balkrishanan, Dhanasekar

Journal of Indian Prosthodontic Society

2018 Band 19, Heft 3, Seite(n) 225–232

Abstract: Aim: This study aims to test the tensile strength and growth of : Settings and design: Evaluative - : Materials and methods: Fifty dumbbell-shaped samples (: Statistical analysis used: Oneway ANOVA and : Results: 10% w/w CCO yielded a mean ... ...

Abstract	Aim: This study aims to test the tensile strength and growth of Settings and design: Evaluative - Materials and methods: Fifty dumbbell-shaped samples ( Statistical analysis used: Oneway ANOVA and Results: 10% w/w CCO yielded a mean tensile strength of 20.06 as compared to the plain tissue conditioner which showed a mean tensile strength of 17.81. Similarly, 10% w/w CCO incorporated into Viscogel tissue conditioner showed a significant reduction in the colonization of Conclusions: 10% w/w of CCO when mixed with Viscogel tissue conditioner showed a significant reduction in the growth of
Sprache	Englisch
Erscheinungsdatum	2018-07-23
Erscheinungsland	India
Dokumenttyp	Journal Article
ISSN	0972-4052
ISSN	0972-4052
DOI	10.4103/jips.jips_387_18
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ryanodine-induced vasoconstriction of the gerbil spiral modiolar artery depends on the Ca

Krishnamoorthy, Gayathri / Reimann, Katrin / Wangemann, Philine

BMC physiology

2016 Band 16, Heft 1, Seite(n) 6

Abstract: Background: In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca: Methods: SMAs were isolated from adult female gerbils, loaded with the Ca: Results: Ca: Conclusions: The results suggest that ... ...

Abstract	Background: In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca Methods: SMAs were isolated from adult female gerbils, loaded with the Ca Results: Ca Conclusions: The results suggest that Ca
Mesh-Begriff(e)	Animals ; Calcium Signaling/drug effects ; Cochlea/blood supply ; Cochlea/drug effects ; Cochlea/physiology ; Endothelin-1/administration & dosage ; Female ; Gerbillinae ; Large-Conductance Calcium-Activated Potassium Channels/physiology ; Muscle, Smooth, Vascular/blood supply ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiology ; Ryanodine/administration & dosage ; Vasoconstriction/drug effects
Chemische Substanzen	Endothelin-1 ; Large-Conductance Calcium-Activated Potassium Channels ; Ryanodine (15662-33-6)
Sprache	Englisch
Erscheinungsdatum	2016-11-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041340-3
ISSN	1472-6793 ; 1472-6793
ISSN (online)	1472-6793
ISSN	1472-6793
DOI	10.1186/s12899-016-0026-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: NOS inhibition enhances myogenic tone by increasing rho-kinase mediated Ca2+ sensitivity in the male but not the female gerbil spiral modiolar artery.

Reimann, Katrin / Krishnamoorthy, Gayathri / Wangemann, Philine

PloS one

2013 Band 8, Heft 1, Seite(n) e53655

Abstract: Cochlear blood flow regulation is important to prevent hearing loss caused by ischemia and oxidative stress. Cochlear blood supply is provided by the spiral modiolar artery (SMA). The myogenic tone of the SMA is enhanced by the nitric oxide synthase (NOS) ...

Abstract	Cochlear blood flow regulation is important to prevent hearing loss caused by ischemia and oxidative stress. Cochlear blood supply is provided by the spiral modiolar artery (SMA). The myogenic tone of the SMA is enhanced by the nitric oxide synthase (NOS) blocker L-N(G)-nitro-arginine (LNNA) in males, but not in females. Here, we investigated whether this gender difference is based on differences in the cytosolic Ca(2+) concentration and/or the Ca(2+) sensitivity of the myofilaments. Vascular diameter, myogenic tone, cytosolic Ca(2+), and Ca(2+) sensitivity were evaluated in pressurized SMA segments isolated from male and female gerbils using laser-scanning microscopy and microfluorometry. The gender difference of the LNNA-induced tone was compared, in the same vessel segments, to tone induced by 150 mM K(+) and endothelin-1, neither of which showed an apparent gender-difference. Interestingly, LNNA-induced tone in male SMAs was observed in protocols that included changes in intramural pressure, but not when the intramural pressure was held constant. LNNA in male SMAs did not increase the global Ca(2+) concentration in smooth muscle cells but increased the Ca(2+) sensitivity. This increase in the Ca(2+) sensitivity was abolished in the presence of the guanylyl cyclase inhibitor ODQ or by extrinsic application of either the nitric oxide (NO)-donor DEA-NONOate or the cGMP analog 8-pCPT-cGMP. The rho-kinase blocker Y27632 decreased the basal Ca(2+) sensitivity and abolished the LNNA-induced increase in Ca(2+) sensitivity in male SMAs. Neither LNNA nor Y27632 changed the Ca(2+) sensitivity in female SMAs. The data suggest that the gender difference in LNNA-induced tone is based on a gender difference in the regulation of rho-kinase mediated Ca(2+) sensitivity. Rho-kinase and NO thus emerge as critical factors in the regulation of cochlear blood flow. The larger role of NO-dependent mechanisms in male SMAs predicts greater restrictions on cochlear blood flow under conditions of impaired endothelial cell function.
Mesh-Begriff(e)	Animals ; Arteries/drug effects ; Arteries/physiopathology ; Calcium/metabolism ; Cytophotometry ; Cytosol/metabolism ; Female ; Gerbillinae/physiology ; Male ; Microscopy, Confocal ; Muscle Contraction ; Muscle Development/physiology ; Muscles/physiology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Nitroarginine/pharmacology ; Pressure ; Sex Factors ; rho-Associated Kinases/metabolism
Chemische Substanzen	Nitroarginine (2149-70-4) ; Nitric Oxide Synthase (EC 1.14.13.39) ; rho-Associated Kinases (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
Sprache	Englisch
Erscheinungsdatum	2013-01-03
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0053655
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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