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Article ; Online: Nutritional management of acute pancreatitis.

Krishnan, Kumar

2017 Volume 33, Issue 2, Page(s) 102–106

Abstract: Purpose of review: Acute pancreatitis is one of the most common causes for hospitalization related to a gastrointestinal disorder. It carries significant morbidity, and when severe, significant mortality. Multiple interventions have been studied to ... ...

Abstract	Purpose of review: Acute pancreatitis is one of the most common causes for hospitalization related to a gastrointestinal disorder. It carries significant morbidity, and when severe, significant mortality. Multiple interventions have been studied to treat pancreatitis. Of all these interventions, none is more important or impactful than nutrition. Recent findings: High-quality evidence along with society guidelines have recommended the use of enteral nutrition over parenteral nutrition in patients with pancreatitis. Recent systematic reviews and meta-analyses have been published and will be reviewed here. Summary: The use of enteral nutrition has been demonstrated to decrease mortality and infectious complications compared with parenteral nutrition. The ideal timing of initiating enteral nutrition is not clear, however, early nutrition (within 48 h) appears to be safe and tolerated. Most studies have utilized nasojejunal feeding tubes; however, some patients may tolerate nasogastric or even oral refeeding. Clinicians who manage patients with pancreatitis must be aware of the critical role of nutrition in preventing pancreatitis-related complications.
MeSH term(s)	Acute Disease ; Enteral Nutrition/methods ; Food, Formulated ; Humans ; Nutritional Support/methods ; Pancreatitis/diagnosis ; Pancreatitis/therapy ; Parenteral Nutrition
Language	English
Publishing date	2017-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632571-3
ISSN	1531-7056 ; 0267-1379
ISSN (online)	1531-7056
ISSN	0267-1379
DOI	10.1097/MOG.0000000000000340
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Utilizing mollusk soft tissue and shells as biomarkers for monitoring heavy metal pollution in mangrove forests.

Krishnan, Kumar / Saion, Elias / Halimah, M K / Yap, Chee Kong

MethodsX

2023 Volume 11, Page(s) 102281

Abstract: The primary objective of the study was to examine the distribution of various elements, namely Cadmium (Cd), Copper (Cu), Iron (Fe), Nickel (Ni), and Lead (Pb), in the soft tissues, shells, and associated surface sediments ... ...

Abstract	The primary objective of the study was to examine the distribution of various elements, namely Cadmium (Cd), Copper (Cu), Iron (Fe), Nickel (Ni), and Lead (Pb), in the soft tissues, shells, and associated surface sediments of
Language	English
Publishing date	2023-07-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2830212-6
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2023.102281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current status of newer generation endoscopic ultrasound core needles in the diagnostic evaluation of gastrointestinal lesions.

Soltani, Amin K / Krishnan, Kumar

Journal of the American Society of Cytopathology

2020 Volume 9, Issue 5, Page(s) 389–395

Abstract: Endoscopic ultrasound-guided tissue acquisition is now an imperative technique for the diagnosis of multiple diseases in the gastrointestinal tract and nearby structures. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and fine needle ... ...

Abstract	Endoscopic ultrasound-guided tissue acquisition is now an imperative technique for the diagnosis of multiple diseases in the gastrointestinal tract and nearby structures. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and fine needle biopsy via dedicated FNB needles (EUS-FNB) are two standard-essential tools for tissue acquisition. The choice of needle type is an important factor determining appropriate tissue acquisition. Multiple studies have compared EUS-FNA versus EUS-FNB on different lesions also there are several studies evaluated different needles in terms of sampling adequacy and cytological and histological accuracy. Prior studies comparing prior-generation FNB needles to FNA did not show an increased diagnostic yield with FNB. However, the newer-generation needles have demonstrated enhanced performance compared with their predecessors. As they may provide a large amount of tissue for the cytological and histological evaluation, rapid onsite specimen evaluation (ROSE), and immunohistochemical and molecular analyses, which may be very important for targeted therapy. In this review, we discuss current evidence and literature on the use of the newer generation needles for pancreatic and non-pancreatic lesions.
MeSH term(s)	Autoimmune Pancreatitis/diagnostic imaging ; Autoimmune Pancreatitis/pathology ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/instrumentation ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Gastrointestinal Neoplasms/diagnostic imaging ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Tract/pathology ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphoma/diagnostic imaging ; Lymphoma/pathology ; Needles/classification ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology
Keywords	covid19
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2213-2945
ISSN	2213-2945
DOI	10.1016/j.jasc.2020.05.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Utilizing mollusk soft tissue and shells as biomarkers for monitoring heavy metal pollution in mangrove forests

Krishnan, Kumar / Saion, Elias / Halimah, M.K. / Yap, Chee Kong

MethodsX. 2023 Dec., v. 11 p.102281-

2023

Abstract	The primary objective of the study was to examine the distribution of various elements, namely Cadmium (Cd), Copper (Cu), Iron (Fe), Nickel (Ni), and Lead (Pb), in the soft tissues, shells, and associated surface sediments of Cerithidea obtusa (C. obtusa) mangrove snails collected from Sungai Besar Sepang. To conduct the analysis, the preferred and most convenient methods employed were Instrumental Neutron Activation Analysis (INAA) and Atomic absorption spectrometry (AAS). The results showed that the mean concentration of elements in the sediments and soft tissues followed the order Fe > Cu > Ni > Pb > Cd, while for the shell of C. obtusa, it was Fe > Ni > Cu > Pb > Cd.•Iron (Fe) showed the highest concentration among all elements monitored in sediments, soft tissues, and shells of C. obtusa.•The PF results indicated higher incorporation of Pb and Ni into shells.•BSAF results showed that C. obtusa shells accumulated more Cu and Cd from sediments, making them effective biomonitors.
Keywords	Cerithidea ; atomic absorption spectrometry ; biomarkers ; cadmium ; heavy metals ; indicator species ; molluscs ; neutron activation analysis ; nickel ; pollution ; tissues ; Neutron activation ; Biota ; Toxic metals ; Mangrove snails ; Biomonitoring ; Biomarkers for Monitoring Heavy Metal Pollution
Language	English
Dates of publication	2023-12
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2830212-6
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2023.102281
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Detachable snare to prevent postpolypectomy bleeding.

Chu, Jacqueline N / Soltani, Amin K / Krishnan, Kumar

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

2020 Volume 5, Issue 11, Page(s) 510–512

Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Journal Article
ISSN	2468-4481
ISSN (online)	2468-4481
DOI	10.1016/j.vgie.2020.06.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current status of newer generation endoscopic ultrasound core needles in the diagnostic evaluation of gastrointestinal lesions

Soltani, Amin K / Krishnan, Kumar

Abstract	Endoscopic ultrasound-guided tissue acquisition is now an imperative technique for the diagnosis of multiple diseases in the gastrointestinal tract and nearby structures. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and fine needle biopsy via dedicated FNB needles (EUS-FNB) are two standard-essential tools for tissue acquisition. The choice of needle type is an important factor determining appropriate tissue acquisition. Multiple studies have compared EUS-FNA versus EUS-FNB on different lesions also there are several studies evaluated different needles in terms of sampling adequacy and cytological and histological accuracy. Prior studies comparing prior-generation FNB needles to FNA did not show an increased diagnostic yield with FNB. However, the newer-generation needles have demonstrated enhanced performance compared with their predecessors. As they may provide a large amount of tissue for the cytological and histological evaluation, rapid onsite specimen evaluation (ROSE), and immunohistochemical and molecular analyses, which may be very important for targeted therapy. In this review, we discuss current evidence and literature on the use of the newer generation needles for pancreatic and non-pancreatic lesions.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32680792
Database	COVID19

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Article ; Online: EUS-guided choledochoduodenostomy with use of a lumen-apposing metal stent: the freehand technique.

Krishnan, Kumar / Raza, Ali

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

2017 Volume 3, Issue 2, Page(s) 49–50

Language	English
Publishing date	2017-12-18
Publishing country	United States
Document type	Journal Article
ISSN	2468-4481
ISSN (online)	2468-4481
DOI	10.1016/j.vgie.2017.11.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Isolation, Expansion, and Endoscopic Delivery of Autologous Enteric Neuronal Stem Cells in Swine.

Hotta, Ryo / Pan, Weikang / Bhave, Sukhada / Nagy, Nandor / Stavely, Rhian / Ohkura, Takahiro / Krishnan, Kumar / de Couto, Geoffrey / Myers, Richard / Rodriguez-Borlado, Luis / Burns, Alan J / Goldstein, Allan M

Cell transplantation

2024 Volume 32, Page(s) 9636897231215233

Abstract: The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation, ... ...

Abstract	The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation, infection, or age-associated neurodegeneration lead to serious neurointestinal diseases. Despite the prevalence and severity of these diseases, effective treatments are lacking as they fail to directly address the underlying pathology. Neuronal stem cell therapy represents a promising approach to treating diseases of the ENS by replacing the absent or injured neurons, and an autologous source of stem cells would be optimal by obviating the need for immunosuppression. We utilized the swine model to address key questions concerning cell isolation, delivery, engraftment, and fate in a large animal relevant to human therapy. We successfully isolated neural stem cells from a segment of small intestine resected from 1-month-old swine. Enteric neuronal stem cells (ENSCs) were expanded as neurospheres that grew optimally in low-oxygen (5%) culture conditions. Enteric neuronal stem cells were labeled by lentiviral green fluorescent protein (GFP) transduction, then transplanted into the same swine from which they had been harvested. Endoscopic ultrasound was then utilized to deliver the ENSCs (10,000-30,000 neurospheres per animal) into the rectal wall. At 10 and 28 days following injection, autologously derived ENSCs were found to have engrafted within rectal wall, with neuroglial differentiation and no evidence of ectopic spreading. These findings strongly support the feasibility of autologous cell isolation and delivery using a clinically useful and minimally invasive technique, bringing us closer to first-in-human ENSC therapy for neurointestinal diseases.
MeSH term(s)	Humans ; Animals ; Swine ; Infant ; Neurons/metabolism ; Neural Stem Cells ; Enteric Nervous System ; Intestine, Small ; Neuroglia
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1135816-6
ISSN	1555-3892 ; 0963-6897
ISSN (online)	1555-3892
ISSN	0963-6897
DOI	10.1177/09636897231215233
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3556: Show issues

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Article ; Online: Endoscopic GERD therapy: a primer for the transoral incisionless fundoplication procedure.

Bazerbachi, Fateh / Krishnan, Kumar / Abu Dayyeh, Barham K

Gastrointestinal endoscopy

2019 Volume 90, Issue 3, Page(s) 370–383

Abstract: Patients with medically refractory GERD have the option of surgery but may opt for effective minimally invasive interventions, when available. However, the primary GERD pharmacologic therapy, proton pump inhibitors, does not satisfactorily address the ... ...

Abstract	Patients with medically refractory GERD have the option of surgery but may opt for effective minimally invasive interventions, when available. However, the primary GERD pharmacologic therapy, proton pump inhibitors, does not satisfactorily address the pathophysiology of the disease. Moreover, a therapeutic gap exists in those severely symptomatic patients who fail medical management and who are poor candidates for surgical fundoplication. Recently, a revival of minimally invasive endoscopic interventions aiming to correct the antireflux barrier has followed existing device modifications, enhancing their safety and efficacy profile. Of these technologies, the trans-oral incisionless fundoplication (TIF) technique, in its current 2.0 iteration, has been studied in several randomized controlled trials with favorable outcomes and a low rate of adverse events. In this review, we discuss the landscape of endoscopic GERD therapy, focusing on recent updates in the TIF 2.0 procedure with the EsophyX-Z device (EndoGastricSolutions, Redmond, Wash, USA). We discuss the evolution, differences, and improvements in this technique across different generations of the EsophyX device. We also present a framework for candidate selection, based on medical and anatomic considerations. When streamlined within a milieu of comprehensive multidisciplinary programs, these improved endoscopic interventions can provide viable avenues for a carefully selected patients population, bridging therapy gaps, and selectively targeting the primary pathophysiology of the disease.
MeSH term(s)	Endoscopy, Digestive System/methods ; Fundoplication/methods ; Gastroesophageal Reflux/surgery ; Humans ; Minimally Invasive Surgical Procedures ; Natural Orifice Endoscopic Surgery ; Proton Pump Inhibitors/therapeutic use
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2019-05-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2019.05.028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article ; Online: Distribution of Heavy Metals in Sediments and Soft Tissues of the Cerithidea obtusa from Sepang River, Malaysia

Krishnan Kumar / Elias Saion / Chee Kong Yap / Prakash Balu / Wan Hee Cheng / Mee Yoke Chong

Indonesian Journal of Chemistry, Vol 22, Iss 4, Pp 1070-

2022 Volume 1080

Abstract: The main purpose of the research was to analyze the distribution of Arsenic (As), Cadmium (Cd), Copper (Cu), Iron (Fe), Nickel (Ni), Cobalt (Co), Mangan (Mn), and Zinc (Zn) in soft tissues, shells, and associated surface sediments of Cerithidea obtusa (C. ...

Abstract	The main purpose of the research was to analyze the distribution of Arsenic (As), Cadmium (Cd), Copper (Cu), Iron (Fe), Nickel (Ni), Cobalt (Co), Mangan (Mn), and Zinc (Zn) in soft tissues, shells, and associated surface sediments of Cerithidea obtusa (C. obtusa) mangrove snails collected from Sungai Besar Sepang. The concentration of iron (Fe) was found to be the highest in relation to other toxic elements in sediments, soft tissues, and shells of C. obtusa. The concentrations of Cu and Zn in soft tissues of C. obtusa were found to exceed the concentrations in sediments, indicating bioaccumulation of these metals. Metal pollution was assessed with the Enrichment Factor (EF), Geoaccumulation Index (Igeo), and Pollution Factor (CF). EF, Igeo, and CF were 0.34 to 22.41, -3.37 to 2.65, and 0.14 to 9.42, respectively. The results indicate that sediments in Sungai Besar Sepang are contaminated with As and Zn. According to the bivalve bioaccumulation results, the soft tissues of C. obtusa act as a macro-concentrator for Cu and Zn. As a result, it is suggested that ongoing monitoring of releases of heavy metals from anthropogenic sources and stricter environmental protection measures should be implemented.
Keywords	enrichment ; bio-accumulation ; trace elements ; neutron activation analysis ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Department of Chemistry, Universitas Gadjah Mada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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