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  1. Article ; Online: 3D RNA-scaffolded wireframe origami

    Molly F. Parsons / Matthew F. Allan / Shanshan Li / Tyson R. Shepherd / Sakul Ratanalert / Kaiming Zhang / Krista M. Pullen / Wah Chiu / Silvi Rouskin / Mark Bathe

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold ... ...

    Abstract Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.
    Keywords Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

    Matthew J. Gorman / Nita Patel / Mimi Guebre-Xabier / Alex L. Zhu / Caroline Atyeo / Krista M. Pullen / Carolin Loos / Yenny Goez-Gazi / Ricardo Carrion, Jr. / Jing-Hui Tian / Dansu Yuan / Kathryn A. Bowman / Bin Zhou / Sonia Maciejewski / Marisa E. McGrath / James Logue / Matthew B. Frieman / David Montefiori / Colin Mann /
    Sharon Schendel / Fatima Amanat / Florian Krammer / Erica Ollmann Saphire / Douglas A. Lauffenburger / Ann M. Greene / Alyse D. Portnoff / Michael J. Massare / Larry Ellingsworth / Gregory Glenn / Gale Smith / Galit Alter

    Cell Reports Medicine, Vol 2, Iss 9, Pp 100405- (2021)

    2021  

    Abstract: Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a ... ...

    Abstract Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a spectrum of antibody titers is urgently required. Thus, we profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX-CoV2373) at two doses, administered as a single- or two-dose regimen. Both antigen dose and boosting significantly altered neutralization titers and Fc-effector profiles, driving unique vaccine-induced antibody fingerprints. Combined differences in antibody effector functions and neutralization were associated with distinct levels of protection in the upper and lower respiratory tract. Moreover, NVX-CoV2373 elicited antibodies that functionally targeted emerging SARS-CoV-2 variants. Collectively, the data presented here suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
    Keywords Fc-function ; antibodies ; COVID-19 ; Fc-receptors ; correlates ; vaccination ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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