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  1. Book ; Online: Kosten- und Erlössituation der extrakorporalen Nierenersatztherapie

    Krohn, Markus

    Eine Analyse im Kontext der stationären Leistungserbringung

    (Gesundheitsmanagement und Gesundheitsökonomik)

    2023  

    Author's details von Markus Krohn
    Series title Gesundheitsmanagement und Gesundheitsökonomik
    Keywords Health services administration
    Language German
    Size 1 Online-Ressource (XXIII, 264 S. 102 Abb., 51 Abb. in Farbe)
    Edition 1st ed. 2023
    Publisher Springer Fachmedien Wiesbaden ; Imprint: Springer Gabler
    Publishing place Wiesbaden
    Document type Book ; Online
    HBZ-ID HT030062941
    ISBN 978-3-658-41789-5 ; 9783658417888 ; 3-658-41789-7 ; 3658417889
    DOI 10.1007/978-3-658-41789-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Kosten- und Erlössituation der extrakorporalen Nierenersatztherapie

    Krohn, Markus

    Eine Analyse im Kontext der stationären Leistungserbringung

    (Gesundheitsmanagement und Gesundheitsökonomik)

    2023  

    Series title Gesundheitsmanagement und Gesundheitsökonomik
    Keywords Health economics ; Kostenanalyse ; Monte-Carlo-Simulation ; Dialyse ; Gesundheitsmanagement ; Fallpauschalen ; DRG
    Language German
    Size 1 electronic resource (264 pages)
    Publisher Springer Nature
    Publishing place Wiesbaden
    Document type Book ; Online
    Note German
    HBZ-ID HT030374464
    ISBN 9783658417888 ; 3658417889
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Audio / Video ; Thesis: Pausierung der DNA-abhängigen RNA-Polymerase als ein Mittel der globalen Transkriptionskontrolle in Escherichia coli

    Krohn, Michael

    (Berichte aus der Biologie)

    1994  

    Author's details Michael Krohn
    Series title Berichte aus der Biologie
    Keywords Escherichia coli / genetics ; RNA, Ribosomal / genetics ; Transcription, Genetic / physiology ; Transcription Factors / metabolism ; RNA Polymerases / metabolism ; DNA, Superhelical / metabolism ; Templates ; rRNA Operon ; Plasmids ; Escherichia coli ; DNS-abhängige-RNS-Polymerasen ; Genregulation ; Transkription ; Guanosintetraphosphat
    Subject Genetische Regulation ; Transkription ; Genaktivität ; EC 2.7.7.6 ; DNA-abhängige-RNA-Polymerasen ; RNS-Polymerasen ; Colibakterium ; Kolibakterium ; E. coli
    Language German
    Size XIII, 159, A6 S. : graph. Darst.
    Edition Als Ms. gedr.
    Publisher Shaker
    Publishing place Aachen
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 1994
    HBZ-ID HT006473456
    ISBN 3-8265-0389-9 ; 978-3-8265-0389-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 B 406 order for loan Magazin

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  4. Article: Personalbedarf im OP - Methoden und Implikationen

    Krohn, Markus / Flessa, Steffen

    Im OP

    2020  Volume 10, Issue 2, Page(s) 81–86

    Abstract: Wie viele OP-Pflegende benötigt eine Klinik – und wie viele kann sie sich leisten? Schritt für Schritt erklären die beiden Autoren verschiedene Methoden, mit denen der Personalbedarf im OP geplant werden kann. Denn nur, wenn genügend Mitarbeiter ... ...

    Abstract Wie viele OP-Pflegende benötigt eine Klinik – und wie viele kann sie sich leisten? Schritt für Schritt erklären die beiden Autoren verschiedene Methoden, mit denen der Personalbedarf im OP geplant werden kann. Denn nur, wenn genügend Mitarbeiter vorhanden sind, können Arbeitsbelastungen und Stressfaktoren reduziert werden.
    Keywords Berechnung ; Stellenzahl ; Ergebnisse
    Language German
    Document type Article
    ZDB-ID 2579066-3
    ISSN 1611-7913 ; 1611-7905
    ISSN (online) 1611-7913
    ISSN 1611-7905
    Database bibnet.org

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6965: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Novel In Vitro Models for Cell Differentiation and Drug Transport Studies of the Human Intestine.

    Przybylla, Randy / Krohn, Mathias / Sellin, Marie-Luise / Frank, Marcus / Oswald, Stefan / Linnebacher, Michael

    Cells

    2023  Volume 12, Issue 19

    Abstract: The most common in vitro model for absorption, distribution, metabolism, and excretion (ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and protein expression towards the small intestine and an, at best, fair ... ...

    Abstract The most common in vitro model for absorption, distribution, metabolism, and excretion (ADME) purposes is currently the Caco-2 cell line. However, clear differences in gene and protein expression towards the small intestine and an, at best, fair prediction accuracy of intestinal drug absorption restrict the usefulness of a model for intestinal epithelial cells. To overcome these limitations, we evaluated a panel of low-passaged patient-derived colorectal cancer cell lines of the HROC collection concerning similarities to small intestinal epithelial cells and their potential to predict intestinal drug absorption. After initial screening of a larger panel, ten cell lines with confluent outgrowth and long-lasting barrier-forming potential were further characterized in close detail. Tight junctional complexes and microvilli structures were detected in all lines, anda higher degree of differentiation was observed in 5/10 cell lines. All lines expressed multiple transporter molecules, with the expression levels in three lines being close to those of small intestinal epithelial cells. Compared with the Caco-2 model, three HROC lines demonstrated both higher similarity to jejunal epithelial tissue cells and higher regulatory potential of relevant drug transporters. In summary, these lines would be better-suited human small intestinal epithelium models for basic and translational research, especially for ADME studies.
    MeSH term(s) Humans ; Caco-2 Cells ; Biological Transport ; Epithelial Cells/metabolism ; Cell Differentiation ; Intestine, Small/metabolism ; Membrane Transport Proteins/metabolism
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12192371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Crossing brain barriers in health and disease: Impact of circadian rhythms.

    Santos, Cecília R A / Cipolla-Neto, José / Krohn, Markus / Gonçalves, Isabel / Quintela, Telma

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1176084

    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1176084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Kosten und Prozesse in der Sterilgutversorgung

    Fengler, J. / Fleßa, S. / Krohn, M.

    Zentralsterilization

    2019  Volume 27, Issue Suppl. Oct., Page(s) 56

    Language German ; English
    Document type Article
    ZDB-ID 1174544-7
    ISSN 1612-0108 ; 0942-6086
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4007: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice.

    Rai, Surya Prakash / Krohn, Markus / Pahnke, Jens

    Journal of Alzheimer's disease : JAD

    2020  Volume 75, Issue 4, Page(s) 1301–1317

    Abstract: Background: Spatial memory dysfunction has been demonstrated in mouse models of Alzheimer's disease (AD) which is consistent with the clinical finding that the early signature of AD includes difficulties in the formation and/or storage of a memory. A ... ...

    Abstract Background: Spatial memory dysfunction has been demonstrated in mouse models of Alzheimer's disease (AD) which is consistent with the clinical finding that the early signature of AD includes difficulties in the formation and/or storage of a memory. A stored memory-a long term memory-can be modulated via process called as memory retrieval that can either lead toward memory reconsolidation or even memory extinction.
    Objective: We aim to shed light on the fate of the spatial memory during memory reactivation and memory extinction using a water maze task.
    Methods: In Set-up I, we trained 3-month-old mice (wild-type mice and mice with cerebral β-amyloidosis) and assessed the fate of remote memory after four months of retention interval (RI). In Set-up II, we performed an early-extensive training at 2 months of age, retrained the same mice at 3 months of age, introduced four months of RI, and finally assessed remote spatial memory at 7 months of age.
    Results: We find in β-amyloidosis mice that memory reactivation problems were detectable at 7 months of age and were alleviated by cognitive overtraining. Similarly, forgetting of remote spatial memory was also minimized by cognitive overtraining. Finally, we show that the cognitive training facilitates the recovery of the reactivated spatial memory while reducing the ability to form new spatial memory in AD mice.
    Conclusion: This result may explain the rationality behind the cognitive reserve observed in AD patients and elderly with severe β-amyloidosis not corresponding to the actual low dementia symptoms.
    MeSH term(s) Alzheimer Disease/psychology ; Animals ; Cognitive Reserve ; Disease Models, Animal ; Extinction, Psychological ; Female ; Maze Learning ; Mental Recall ; Mice, Inbred C57BL ; Mice, Transgenic ; Spatial Memory
    Language English
    Publishing date 2020-05-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-200161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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  9. Book ; Thesis: Kontaktekzeme im Krankengut der Hautklinik der Medizinischen Universität zu Lübeck im Zeitraum 1977 bis 1981

    Krohn, Maren

    1986  

    Size 2 Mikrofiches : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lübeck, Med. Univ., Diss., 1987
    Note Manuskript: 95 Bl. : Ill., graph. Darst.
    HBZ-ID HT003394320
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 MB 123 order for loan Magazin

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  10. Book ; Online: The question of a frugal mindset in Western MNCs

    Krohn, Malte / Herstatt, Cornelius

    exploring an emerging phenomenon with a systematic literature review

    (Working paper / Hamburg University of Technology (TUHH), Institute for Technology and Innovation Management ; no. 103 (March 2018))

    2018  

    Abstract: Frugal innovation in the context of developed ecomomies has witnessed increasing interest in recent years. For Western multinational companies (MNCs) emerging markets represent promising opportunities for growth as well as the threat of new local ... ...

    Institution Technische Universität Hamburg / Institut für Technologie- und Innovationsmanagement
    Technische Universität Hamburg
    Author's details Malte Krohn, Cornelius Herstatt
    Series title Working paper / Hamburg University of Technology (TUHH), Institute for Technology and Innovation Management ; no. 103 (March 2018)
    Abstract Frugal innovation in the context of developed ecomomies has witnessed increasing interest in recent years. For Western multinational companies (MNCs) emerging markets represent promising opportunities for growth as well as the threat of new local competitors. Furthermore, economic developments drive the demand for frugal products within Western countries. Succesfully mastering this challenge means that Western MNCs have to challenge prevailing paradigms within their organizations. Literature suggests that these companies have to develop a frugal mindset to succeed in frugal innovation. However, to the best of our knowledge no publication addresses the phenomenon on an empirical basis or provides enough detail for further empirical investigation. To address this gap, we conducted a systematic literature review of 80 publications in the frugal innovation field. Building on the theroetical background of the global mindset concept, we assume that a mindset is a cognitive orientation that promotes task completion, which in turn improves task performance. Our qualitative analysis suggests that in the context of frugal innovation improved task performance would positively contribute to the following goals: (1) strategic alignment of innovating for cost conscious consumers, especially in emerging markets (2) deepening the understanding of cognitively remote customers' needs and the context in which they live or work and (3) satisfaction of these customers' needs with frugal solutions. Furthermore, we propose that a frugal mindset can be cultivated along the phases of (1) accepting the new realities of changing markets and competition, (2) a willingness to reconsider current approaches and (3) a willingness to take the necessary action and implement new approaches regarding the identified goals. By developing a definition based on this two-dimensional construct, we build on the theoretical foundations of a well-established mindset concept from the field of organizational behavior/strategic management and integrate various descriptions of the frugal mindset. This contribution provides a solid theoretical basis for further research.
    Keywords Frugal Innovation ; Frugal Mindset ; Global Mindset ; Organizational Behavior ; Path Dependency
    Language English
    Size 1 Online-Ressource (circa 27 Seiten), Illustrationen
    Document type Book ; Online
    Database ECONomics Information System

    Full text online

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