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Article ; Online: Influence of Dosing Regimen and Adjuvant Type on the Immunogenicity of Novel Recombinant Zika Virus-Like Particles.

Brzuska, Gabriela / Szewczyk, Boguslaw / Krol, Ewelina

2022 Volume 11, Issue 1, Page(s) e0288522

Abstract: Zika virus (ZIKV) is a reemerging mosquito-borne flavivirus that causes febrile illness and is also linked to Guillain-Barré syndrome as well as to microcephaly in newborns. Due to the risk of fetuses developing microcephaly, ZIKV is a serious problem ... ...

Abstract	Zika virus (ZIKV) is a reemerging mosquito-borne flavivirus that causes febrile illness and is also linked to Guillain-Barré syndrome as well as to microcephaly in newborns. Due to the risk of fetuses developing microcephaly, ZIKV is a serious problem for pregnant women. Although different types of vaccine antigens have been investigated, there is still no approved vaccine that prevents ZIKV. The aim of this study was to produce a potential anti-Zika virus vaccine candidate based on virus-like particles (VLPs) in mammalian cells and to analyze the role of dosing regimen and adjuvant type on the immunogenicity of the obtained antigen. Novel recombinant VLPs (F2A) were designed by introducing the optimized signal sequence of prM protein and by adding a self-cleavage peptide 2A between proteins prM and E. These modifications improved the formation of the glycoprotein E dimer. It has been shown that the increasing dosing regimen generates a significantly higher titer of antibodies; however, the adjuvant type does not affect this process. Sera from mice immunized using an increasing dosing schedule also showed higher neutralization activity against both Zika strains (H/PAN/2016/BEI-259634, a pandemic strain belonging to Asian lineage, and MR766, a reference strain from African lineage). In summary, this is the first report showing the influence of vaccination schedules and adjuvants on the immunogenicity of ZIKV virus-like particles.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Animals ; Mice ; Pregnancy ; Zika Virus/genetics ; Zika Virus Infection/prevention & control ; Antibodies, Neutralizing ; Microcephaly ; Antibodies, Viral ; Viral Vaccines ; Mammals
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Viral Vaccines
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02885-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Allyl Isothiocyanate on Oxidative and Inflammatory Stress in Type 2 Diabetic Rats.

Okulicz, Monika / Hertig, Iwona / Król, Ewelina / Szkudelski, Tomasz

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 17

Abstract: Oxidative stress and inflammation play a crucial role in the pathogenesis and progression of diabetes. Currently, there is a growing need to exploit plant-derived bioactive compounds to support conventional therapies. The purpose of this study was to ... ...

Abstract	Oxidative stress and inflammation play a crucial role in the pathogenesis and progression of diabetes. Currently, there is a growing need to exploit plant-derived bioactive compounds to support conventional therapies. The purpose of this study was to explore allyl isothiocyanate (AITC) potency in reducing oxidative and inflammatory stress along with its profitable modulation trace element status in pathological conditions such as diabetes. Two weeks of oral AITC treatments (2.5, 5, and 25 mg/kg body weight per day) were evaluated in Wistar rats with diabetes induced by a high-fat diet and streptozotocin. The study included AITC influence on antioxidant factors (SOD, CAT, GST, Nrf2), stress and inflammatory markers (cortisol, CRP, IL-1β, IL-6, TNFα, NF-κB), lipid peroxidation indices (TBARS, -SH groups), and trace element status (Fe, Zn, and Cu) in the detoxification and lymphoid organs. Independently of dose, AITC increased cortisol levels in rat blood serum and decreased total thiol groups (T-SH) and protein-bound thiol groups (PB-SH) collaterally with raised thiobarbituric acid reactive substances (TBARS) in diabetic rat liver. The inflammation and oxidative effects were enhanced by an AITC dose increase. The highest dose of AITC, 25 mg/kg b.w., strongly affected the inflammation process by increasing IL-6, IL-1β, and TNFα in the blood serum, and it upregulated Nrf2 transcription factor with increased SOD, GPx, and GST activities in the liver. AITC showed an equivocal effect on profitable modulation of disturbances in mineral homeostasis in the liver, kidney, and spleen. Our findings revealed that two-week AITC treatment exacerbated oxidative and inflammation status in diabetic rats.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/drug therapy ; Hydrocortisone ; Inflammation/drug therapy ; Interleukin-6/pharmacology ; Isothiocyanates ; NF-E2-Related Factor 2 ; Oxidative Stress ; Rats ; Rats, Wistar ; Sulfhydryl Compounds/pharmacology ; Superoxide Dismutase/pharmacology ; Thiobarbituric Acid Reactive Substances ; Trace Elements ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Antioxidants ; Interleukin-6 ; Isothiocyanates ; NF-E2-Related Factor 2 ; Sulfhydryl Compounds ; Thiobarbituric Acid Reactive Substances ; Trace Elements ; Tumor Necrosis Factor-alpha ; allyl isothiocyanate (BN34FX42G3) ; Superoxide Dismutase (EC 1.15.1.1) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27175568
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Article: Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet.

Kurek, Jakub Michał / Król, Ewelina / Staniek, Halina / Krejpcio, Zbigniew

Pharmaceuticals (Basel, Switzerland)

2022 Volume 15, Issue 10

Abstract: ... Stevia ... ...

Abstract	Stevia rebaudiana
Language	English
Publishing date	2022-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15101200
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Article ; Online: The Influence of Adjuvant Type on the Immunogenicity of RBD/N Cocktail Antigens as a Vaccine Candidate against SARS-CoV-2 Virus.

Brzuska, Gabriela / Zimna, Marta / Baranska, Klaudia / Szewczyk, Boguslaw / Strakova, Petra / Ruzek, Daniel / Krol, Ewelina

Microbiology spectrum

2023 Volume 11, Issue 3, Page(s) e0256422

Abstract: The emerging virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2 virus), agent of COVID-19, appeared in December 2019 in Wuhan, China, and became a serious threat to global health and public safety. Many COVID-19 vaccines have been approved ...

Abstract	The emerging virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2 virus), agent of COVID-19, appeared in December 2019 in Wuhan, China, and became a serious threat to global health and public safety. Many COVID-19 vaccines have been approved and licensed around the world. Most of the developed vaccines include S protein and induce an antibody-based immune response. Additionally, T-cell response to the SARS-CoV-2 antigens could be beneficial for combating the infection. The type of immune response is greatly dependent not only on the antigen, but also on adjuvants used in vaccine formulation. Here, we compared the effect of four different adjuvants (AddaS03, Alhydrogel/MPLA, Alhydrogel/ODN2395, Quil A) on the immunogenicity of a mixture of recombinant RBD and N SARS-CoV-2 proteins. We have analyzed the antibody and T-cell response specific to RBD and N proteins and assessed the impact of adjuvants on virus neutralization. Our results clearly indicated that Alhydrogel/MPLA and Alhydrogel/ODN2395 adjuvants elicited the higher titers of specific and cross-reactive antibodies to S protein variants from various SARS-CoV-2 and SARS-CoV-1 strains. Moreover, Alhydrogel/ODN2395 stimulated high cellular response to both antigens, as assessed by IFN-γ production. Importantly, sera collected from mice immunized with RBD/N cocktail in combination with these adjuvants exhibited neutralizing activity against the authentic SARS-CoV-2 virus as well as particles pseudotyped with S protein from various virus variants. The results from our study demonstrate the immunogenic potential of RBD and N antigens and point out the importance of adjuvants selection in vaccine formulation in order to enhance the immunological response.
MeSH term(s)	Animals ; Mice ; Humans ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/prevention & control ; Viral Vaccines ; Aluminum Hydroxide ; Antibodies, Viral ; Antibodies, Neutralizing ; Immunogenicity, Vaccine
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines ; Aluminum Hydroxide (5QB0T2IUN0) ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02564-22
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Article: The Interactive Effect of High Doses of Chromium(III) and Different Iron(III) Levels on the Carbohydrate Status, Lipid Profile, and Selected Biochemical Parameters in Female Wistar Rats

Staniek, Halina Zofia / Król, Ewelina / Wójciak, Rafał Wojciech

Nutrients. 2020 Oct. 08, v. 12, no. 10

2020

Abstract: The aim of the study was to evaluate the main and interactive effects of chromium(III) propionate complex (Cr3) supplementation and different iron supply on the carbohydrate metabolism, lipid profile and other selected biochemical parameters of rats. The ...

Abstract	The aim of the study was to evaluate the main and interactive effects of chromium(III) propionate complex (Cr3) supplementation and different iron supply on the carbohydrate metabolism, lipid profile and other selected biochemical parameters of rats. The experiment was carried out in a two-factor design, in which rats were fed a diet with different proportions of Fe(III) and Cr(III) for six weeks. Fifty-four healthy female Wistar rats were divided into nine experimental groups with different Fe(III) levels, i.e. adequate—control group (45 mg/kg)—100% recommended daily dietary dose of Fe for rodents, deficient (5 mg/kg) and oversupply (180 mg/kg—400%). At the same time they were supplemented with Cr(III) of doses 1 (adequate), 50 and 500 mg/kg of diet. The activity and concentrations of most biochemical parameters were measured with standard enzymatic, kinetic, and colorimetric methods. HOMA-IR and QUICKI indexes were calculated according to appropriate formulas. It was found that there was an interactive effect of high Cr(III) doses and different Fe(III) levels in the diet on the carbohydrate metabolism and insulin resistance indexes. The presented results suggested that iron deficient diet fed animals led to insulin resistance; however, an effect is attenuated by Cr(III) supplementation at high doses. There were no significant changes in the rats’ lipid profile (except for the high density lipoprotein cholesterol (HDL-C) level) and most of the other biochemical parameters, such as the leptin, aspartate aminotransferase (AST), alanine transaminase (ALT), total protein (TP), creatinine (Crea) and the urea (BUN) concentrations. The study proved that the Cr(III) supplementation, independently and in combination with diversified Fe(III) content in the diet, affected the carbohydrate metabolism and insulin resistance indexes but did not affect lipid profile and most of the other biochemical parameters in healthy rats. The findings proved the role of Fe and Cr(III) and their interactions on disturbances carbohydrates metabolism.
Keywords	alanine transaminase ; aspartate transaminase ; carbohydrate metabolism ; carbohydrates ; chromium ; colorimetry ; creatinine ; design ; diet ; dosage ; females ; high density lipoprotein cholesterol ; insulin resistance ; iron ; leptin ; lipid composition ; nutrients ; propionic acid ; protein content ; rats ; supply ; urea
Language	English
Dates of publication	2020-1008
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12103070
Database	NAL-Catalogue (AGRICOLA)

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Article: The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Król, Ewelina / Okulicz, Monika / Kupsz, Justyna

Biological trace element research. 2020 Dec., v. 198, no. 2

2020

Abstract: Taurine (Tau) is a β-sulphonated amino acid postulated to improve glucose homeostasis in insulin resistance and diabetes. Changes in carbohydrate metabolism are accompanied by oxidative stress, which may disturb the mineral balance. Therefore, the aim of ...

Abstract	Taurine (Tau) is a β-sulphonated amino acid postulated to improve glucose homeostasis in insulin resistance and diabetes. Changes in carbohydrate metabolism are accompanied by oxidative stress, which may disturb the mineral balance. Therefore, the aim of this study was to assess the effect of Tau supplementation on the levels of trace elements in rats fed either a standard (AIN-93M, 4% fat) diet or a modified high-fat diet (30% fat). For 8 weeks, male Wistar rats were fed these diets supplemented with 3% Tau. Taurine supplementation normalized increased serum insulin concentration and insulin resistance index; however, it did not improve serum CRP concentration in high-fat diet fed rats. The high-fat diet supplemented with Tau decreased the renal and splenic Zn levels, but the tissular Fe content did not change. The effect of Tau supplementation on the mineral balance to some extent depended on the fat content in the rats’ diet. The high-fat diet supplemented with Tau decreased the rats’ splenic Zn levels but increased their femur levels. In the group fed the standard diet, Tau reduced the rats’ femur Zn level, whereas their splenic Zn level was comparable. Tau supplementation decreased the renal Cu level and serum ceruloplasmin concentration in the rats fed the standard diet, but this effect was not observed in the rats fed the high-fat diet. In conclusion, supplementary taurine failed to ameliorate disturbances in mineral homeostasis caused by high-fat diet feeding and led to tissular redistribution of Zn and Cu in the rat.
Keywords	blood serum ; carbohydrate metabolism ; diabetes ; femur ; ferroxidase ; glucose ; high fat diet ; homeostasis ; insulin ; insulin resistance ; lipid content ; males ; oxidative stress ; rats ; research ; taurine
Language	English
Dates of publication	2020-12
Size	p. 592-601.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02100-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats.

Kurek, Jakub Michał / Król, Ewelina / Krejpcio, Zbigniew

Nutrients

2020 Volume 13, Issue 1

Abstract: A number of health-promoting properties ... ...

Abstract	A number of health-promoting properties of
MeSH term(s)	Animals ; Biomarkers/blood ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/drug therapy ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Diterpenes, Kaurane/pharmacology ; Glucosides/pharmacology ; Lipid Metabolism/drug effects ; Male ; Rats ; Rats, Wistar
Chemical Substances	Biomarkers ; Diterpenes, Kaurane ; Glucosides ; stevioside (0YON5MXJ9P) ; rebaudioside A (B3FUD0528F)
Language	English
Publishing date	2020-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13010112
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Article ; Online: The Interactive Effect of High Doses of Chromium(III) and Different Iron(III) Levels on the Carbohydrate Status, Lipid Profile, and Selected Biochemical Parameters in Female Wistar Rats.

Staniek, Halina Zofia / Król, Ewelina / Wójciak, Rafał Wojciech

Nutrients

2020 Volume 12, Issue 10

Abstract	The aim of the study was to evaluate the main and interactive effects of chromium(III) propionate complex (Cr3) supplementation and different iron supply on the carbohydrate metabolism, lipid profile and other selected biochemical parameters of rats. The experiment was carried out in a two-factor design, in which rats were fed a diet with different proportions of Fe(III) and Cr(III) for six weeks. Fifty-four healthy female Wistar rats were divided into nine experimental groups with different Fe(III) levels, i.e. adequate-control group (45 mg/kg)-100% recommended daily dietary dose of Fe for rodents, deficient (5 mg/kg) and oversupply (180 mg/kg-400%). At the same time they were supplemented with Cr(III) of doses 1 (adequate), 50 and 500 mg/kg of diet. The activity and concentrations of most biochemical parameters were measured with standard enzymatic, kinetic, and colorimetric methods. HOMA-IR and QUICKI indexes were calculated according to appropriate formulas. It was found that there was an interactive effect of high Cr(III) doses and different Fe(III) levels in the diet on the carbohydrate metabolism and insulin resistance indexes. The presented results suggested that iron deficient diet fed animals led to insulin resistance; however, an effect is attenuated by Cr(III) supplementation at high doses. There were no significant changes in the rats' lipid profile (except for the high density lipoprotein cholesterol (HDL-C) level) and most of the other biochemical parameters, such as the leptin, aspartate aminotransferase (AST),
MeSH term(s)	Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/metabolism ; Blood Urea Nitrogen ; Carbohydrate Metabolism ; Chromium/administration & dosage ; Chromium/pharmacology ; Creatinine/metabolism ; Dietary Supplements ; Drug Interactions ; Female ; Insulin Resistance ; Iron, Dietary/administration & dosage ; Iron, Dietary/pharmacology ; Leptin/metabolism ; Lipid Metabolism ; Micronutrients/administration & dosage ; Rats, Wistar
Chemical Substances	Iron, Dietary ; Leptin ; Micronutrients ; Chromium (0R0008Q3JB) ; Creatinine (AYI8EX34EU) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2020-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12103070
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Article ; Online: The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats.

Król, Ewelina / Okulicz, Monika / Kupsz, Justyna

Biological trace element research

2020 Volume 198, Issue 2, Page(s) 592–601

Abstract	Taurine (Tau) is a β-sulphonated amino acid postulated to improve glucose homeostasis in insulin resistance and diabetes. Changes in carbohydrate metabolism are accompanied by oxidative stress, which may disturb the mineral balance. Therefore, the aim of this study was to assess the effect of Tau supplementation on the levels of trace elements in rats fed either a standard (AIN-93M, 4% fat) diet or a modified high-fat diet (30% fat). For 8 weeks, male Wistar rats were fed these diets supplemented with 3% Tau. Taurine supplementation normalized increased serum insulin concentration and insulin resistance index; however, it did not improve serum CRP concentration in high-fat diet fed rats. The high-fat diet supplemented with Tau decreased the renal and splenic Zn levels, but the tissular Fe content did not change. The effect of Tau supplementation on the mineral balance to some extent depended on the fat content in the rats' diet. The high-fat diet supplemented with Tau decreased the rats' splenic Zn levels but increased their femur levels. In the group fed the standard diet, Tau reduced the rats' femur Zn level, whereas their splenic Zn level was comparable. Tau supplementation decreased the renal Cu level and serum ceruloplasmin concentration in the rats fed the standard diet, but this effect was not observed in the rats fed the high-fat diet. In conclusion, supplementary taurine failed to ameliorate disturbances in mineral homeostasis caused by high-fat diet feeding and led to tissular redistribution of Zn and Cu in the rat.
MeSH term(s)	Animals ; Dietary Supplements ; Insulin ; Male ; Rats ; Rats, Wistar ; Taurine/pharmacology ; Zinc
Chemical Substances	Insulin ; Taurine (1EQV5MLY3D) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2020-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02100-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Relationship between Dietary, Serum and Hair Levels of Minerals (Fe, Zn, Cu) and Glucose Metabolism Indices in Obese Type 2 Diabetic Patients

Król, Ewelina / Bogdański, Paweł / Suliburska, Joanna / Krejpcio, Zbigniew

Biological trace element research. 2019 May, v. 189, no. 1

2019

Abstract: The aim of this study was to assess the levels of Zn, Fe and Cu in the serum and hair, and dietary intake of type 2 diabetic patients and their association with glucose and lipid indices. The study was conducted on 62 people aged 40–78 years (31 diabetic ...

Abstract	The aim of this study was to assess the levels of Zn, Fe and Cu in the serum and hair, and dietary intake of type 2 diabetic patients and their association with glucose and lipid indices. The study was conducted on 62 people aged 40–78 years (31 diabetic patients and 31 healthy subjects, who were the control group). The content of trace elements in the hair and serum was analysed with the AAS method. The serum insulin, HbA1c, glucose, total cholesterol and triacylglycerol concentrations were measured by means of RIA, HPLC and colorimetric methods, respectively. The diabetic patients were found to have significantly higher dietary iron intake, higher hair Fe and lower serum Zn concentrations than the non-diabetic subjects, while the hair Zn and Cu contents were comparable in both groups. The serum Zn and Cu levels of the diabetic subjects were negatively correlated with the serum glucose, the serum Zn and Cu/Zn ratio was inversely correlated with the serum total cholesterol and the serum insulin level was positively associated with the hair Cu/Zn ratio. The results of this study indicate that the trace element status (Zn, Fe, Cu), as reflected in the blood serum and hair, may be disturbed due to metabolic derangement occurring in diabetes.
Keywords	blood glucose ; blood serum ; cholesterol ; colorimetry ; copper ; food intake ; glucose ; high performance liquid chromatography ; insulin ; iron ; metabolism ; minerals ; noninsulin-dependent diabetes mellitus ; patients ; radioimmunoassays ; triacylglycerols ; zinc
Language	English
Dates of publication	2019-05
Size	p. 34-44.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-018-1470-3
Database	NAL-Catalogue (AGRICOLA)

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