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  1. Article ; Online: Oral host-microbe interactions investigated in 3D organotypic models.

    Shang, Lin / Deng, Dongmei / Krom, Bastiaan P / Gibbs, Susan

    Critical reviews in microbiology

    2023  , Page(s) 1–20

    Abstract: The oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and ... ...

    Abstract The oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1053620-6
    ISSN 1549-7828 ; 1040-841X
    ISSN (online) 1549-7828
    ISSN 1040-841X
    DOI 10.1080/1040841X.2023.2211665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1025: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Role of the Oral Immune System in Oropharyngeal Candidiasis-Facilitated Invasion and Dissemination of

    Pasman, Raymond / Krom, Bastiaan P / Zaat, Sebastian A J / Brul, Stanley

    Frontiers in oral health

    2022  Volume 3, Page(s) 851786

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2022.851786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mechanisms of

    de Jongh, Caroline A / de Vries, Teun J / Bikker, Floris J / Gibbs, Susan / Krom, Bastiaan P

    Journal of oral microbiology

    2023  Volume 15, Issue 1, Page(s) 2205291

    Abstract: Introduction: The oral pathogen : Mechanisms: The first mechanism: proteolytic enzymes secreted by : Conclusion: More research could elucidate targets to ... ...

    Abstract Introduction: The oral pathogen
    Mechanisms: The first mechanism: proteolytic enzymes secreted by
    Conclusion: More research could elucidate targets to inhibit
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2523919-3
    ISSN 2000-2297
    ISSN 2000-2297
    DOI 10.1080/20002297.2023.2205291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions.

    Cornejo Ulloa, Pilar / Krom, Bastiaan P / van der Veen, Monique H

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 714229

    Abstract: Sex steroid hormones (SSH) are cholesterol-derived molecules. They are secreted into saliva and enter the oral cavity, triggering physiological responses from oral tissues, with possible clinical implications, such as gingival inflammation and bleeding. ... ...

    Abstract Sex steroid hormones (SSH) are cholesterol-derived molecules. They are secreted into saliva and enter the oral cavity, triggering physiological responses from oral tissues, with possible clinical implications, such as gingival inflammation and bleeding. SSH and hormonal changes affect not only oral host cells but also oral microorganisms. Historically, most research has focused on the effect of hormonal changes on specific bacteria and yeasts. Recently a broader effect of SSH on oral microorganisms was suggested. In order to assess the role of SSH in host-microbe interactions in the oral cavity, this review focuses on how and up to what extent SSH can influence the composition and behavior of the oral microbiome. The available literature was reviewed and a comprehensive hypothesis about the role of SSH in host-microbiome interactions is presented. The limited research available indicates that SSH may influence the balance between the host and its microbes in the oral cavity.
    MeSH term(s) Bacteria ; Gonadal Steroid Hormones ; Microbiota ; Mouth ; Saliva
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.714229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stable reconstructed human gingiva-microbe interaction model: Differential response to commensals and pathogens.

    Zhang, Yan / Shang, Lin / Roffel, Sanne / Krom, Bastiaan P / Gibbs, Susan / Deng, Dongmei

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 991128

    Abstract: Background: To investigate human oral health and disease, models are required which represent the interactions between the oral mucosa and microbiome. Our aim was to develop an organotypic model which maintains viability of both host and microbes for an ...

    Abstract Background: To investigate human oral health and disease, models are required which represent the interactions between the oral mucosa and microbiome. Our aim was to develop an organotypic model which maintains viability of both host and microbes for an extended period of time.
    Methods: Reconstructed Human Gingiva (RHG) were cultured air-lifted with or without penicillin-streptomycin (PS) and topically exposed to Streptococcus gordonii (commensal) or Aggregatibacter actinomycetemcomitans (pathogen) for 72 hours in agar. RHG histology, viability and cytokines (ELISA), and bacterial viability (colony forming units) and location (FISH) were assessed.
    Results: The low concentration of topically applied agar did not influence RHG viability. Topically applied bacteria in agar remained localized and viable for 72 hours and did not spill over to infect RHG culture medium. PS in RHG culture medium killed topically applied bacteria. Co-culture with living bacteria did not influence RHG viability (Ki67 expression, MTT assay) or histology (epithelium differentiation, Keratin10 expression). RHG exposed to S. gordonii (with or without PS) did not influence low level of IL-6, IL-8, CCL2, CCL5, CCL20 or CXCL1 secretion. However, all cytokines increased (except CCL2) when RHG were co-cultured with A. actinomycetemcomitans. The effect was significantly more in the presence of living, rather than dead, A. actinomycetemcomitans. Both bacteria resulted in increased expression of RHG antimicrobial peptides (AMPs) Elafin and HBD-2, with S. gordonii exposure resulting in the most Elafin secretion.
    Conclusion: This technical advance enables living human oral host-microbe interactions to be investigated during a 72-hour period and shows differences in innate immunology triggered by S. gordonii and A. actinomycetemcomitans.
    MeSH term(s) Humans ; Gingiva/microbiology ; Elafin ; Agar ; Aggregatibacter actinomycetemcomitans ; Cytokines
    Chemical Substances Elafin ; Agar (9002-18-0) ; Cytokines
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.991128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Porphyromonas gingivalis

    de Jongh, Caroline A / Bikker, Floris J / de Vries, Teun J / Werner, Arie / Gibbs, Susan / Krom, Bastiaan P

    Biofilm

    2023  Volume 7, Page(s) 100172

    Abstract: In the oral ... ...

    Abstract In the oral cavity
    Language English
    Publishing date 2023-12-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The effect of sex steroid hormones on the ecology of

    Cornejo Ulloa, Pilar / van der Veen, Monique H / Brandt, Bernd W / Buijs, Mark J / Krom, Bastiaan P

    Biofilm

    2023  Volume 6, Page(s) 100139

    Abstract: Sex steroid hormones (SSH) such as oestrogen, progesterone and testosterone are cholesterol derived molecules that regulate various physiological processes. They are present in both blood and saliva, where they come in contact with oral tissues and oral ... ...

    Abstract Sex steroid hormones (SSH) such as oestrogen, progesterone and testosterone are cholesterol derived molecules that regulate various physiological processes. They are present in both blood and saliva, where they come in contact with oral tissues and oral microorganisms. Several studies have confirmed the effect of these hormones on different periodontal-disease-associated bacteria, using single-species models. Bacteria can metabolize SSH, use them as alternative for vitamin K and also use them to induce the expression of virulence factors. However, it is still unclear what the effects of SSH are on the oral microbiome. In this study, we investigated the effects of four SSH on commensal
    Language English
    Publishing date 2023-06-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ica-status of clinical Staphylococcus epidermidis strains affects adhesion and aggregation: a thermodynamic analysis.

    Nuryastuti, Titik / Krom, Bastiaan P

    Antonie van Leeuwenhoek

    2017  Volume 110, Issue 11, Page(s) 1467–1474

    Abstract: Staphylococcus epidermidis is a major nosocomial pathogen associated with infections of indwelling medical devices. One important virulence factor of these organisms is their ability to adhere to devices and form biofilms. In this study, we evaluated the ...

    Abstract Staphylococcus epidermidis is a major nosocomial pathogen associated with infections of indwelling medical devices. One important virulence factor of these organisms is their ability to adhere to devices and form biofilms. In this study, we evaluated the effect of the ica operon on cell surface hydrophobicity, thermodynamics of adhesion, and biofilm formation for seven S. epidermidis strains. The surface free energy parameters of the bacterial cell surface and the substratum were determined by contact angle measurement. Biofilm formation was assayed using crystal violet staining. Results showed that ica-positive strains demonstrated a higher hydrophobic characteristic than ica-negative strains, suggesting that the ica-operon seems to determine the cell surface hydrophobicity of S. epidermidis. Interaction of ica-positive strains with a tissue-culture treated polystyrene surface was energetically favourable (ΔG
    Language English
    Publishing date 2017-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 214861-4
    ISSN 1572-9699 ; 0003-6072
    ISSN (online) 1572-9699
    ISSN 0003-6072
    DOI 10.1007/s10482-017-0899-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Staphylococcus-Candida Interaction Models: Antibiotic Resistance Testing and Host Interactions.

    Scheres, Nina / Krom, Bastiaan P

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1356, Page(s) 153–161

    Abstract: The fungus Candida albicans and bacterium Staphylococcus aureus can coexist in polymicrobial biofilms. S. aureus attaches strongly to hyphae, but not to the yeast form, of C. albicans with important consequences for virulence. Hyphae-associated S. aureus ...

    Abstract The fungus Candida albicans and bacterium Staphylococcus aureus can coexist in polymicrobial biofilms. S. aureus attaches strongly to hyphae, but not to the yeast form, of C. albicans with important consequences for virulence. Hyphae-associated S. aureus is less susceptible to antibiotic treatment. Furthermore, co-inoculation of C. albicans and S. aureus causes more severe and widespread infection than either microorganism alone. In this chapter, a basic in vitro model for studying the interaction between C. albicans hyphae and S. aureus is presented, which makes use of a fluorescently labeled S. aureus strain. Furthermore, two protocols are described that allow investigation of the effect of C. albicans and S. aureus interaction on antibiotic susceptibility or on interactions with the host. The latter focuses on phagocytosis of C. albicans-adhered S. aureus by macrophages. The protocols presented here may serve as a starting point to study the interaction of C. albicans with various other bacterial species.
    MeSH term(s) Animals ; Bacterial Adhesion ; Candida albicans/drug effects ; Candida albicans/physiology ; Candidiasis/microbiology ; Cell Line ; Coinfection ; Drug Resistance, Microbial ; Host-Pathogen Interactions ; Macrophages/immunology ; Macrophages/microbiology ; Mice ; Microbial Interactions ; Microbial Sensitivity Tests ; Microscopy, Fluorescence ; Phagocytosis ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology ; Time-Lapse Imaging
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3052-4_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The combination of diethyldithiocarbamate and copper ions is active against

    Kaul, Laurine / Abdo, Adrian I / Coenye, Tom / Krom, Bastiaan P / Hoogenkamp, Michel A / Zannettino, Andrew C W / Süss, Regine / Richter, Katharina

    Frontiers in microbiology

    2022  Volume 13, Page(s) 999893

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.999893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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