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  1. Article ; Online: [No title information]

    Kroman, Niels

    Ugeskrift for laeger

    2019  Volume 181, Issue 20A

    Title translation Hvor bevæger forskningen i behandlingen af cancer sig hen?
    Language Danish
    Publishing date 2019-10-15
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  2. Article ; Online: Pregnancy after cancer: is it possible and safe for the mother and the child?

    Kroman, Niels

    Acta obstetricia et gynecologica Scandinavica

    2019  Volume 98, Issue 5, Page(s) 678

    MeSH term(s) Cancer Survivors/psychology ; Child ; Child Health ; Female ; Humans ; Parturition/psychology ; Pregnancy ; Pregnancy, High-Risk ; Probability ; Women's Health
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.13596
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  3. Book ; Thesis: Prognostic influence of age and reproduktive factors in premenopausal breast cancer patients

    Kroman, Niels

    2001  

    Author's details Niels Kroman
    Language English
    Size 77 S. : Ill., graph. Darst.
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Copenhagen, Univ., Diss., 2001
    HBZ-ID HT013016305
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 E 1538 order for loan Magazin

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  4. Article ; Online: [No title information]

    Tvedskov, Tove Filtenborg / Lautrup, Marianne Djernes / Kroman, Niels Thorndal / Christiansen, Peer Michael

    Ugeskrift for laeger

    2024  Volume 186, Issue 12

    Abstract: Surgical treatment of breast cancer has changed towards less invasive procedures as summarised in this review. Breast conserving surgery (BCS) and radiotherapy (RT) are now recommended as standard of care. Several flexible marking methods for removal of ... ...

    Title translation Surgical treatment of breast cancer.
    Abstract Surgical treatment of breast cancer has changed towards less invasive procedures as summarised in this review. Breast conserving surgery (BCS) and radiotherapy (RT) are now recommended as standard of care. Several flexible marking methods for removal of non-palpable tumours have gradually replaced wire-guided localisation. Neoadjuvant systemic treatment increases tumour shrinkage and BCS and may lead to omission of axillary clearance (AC). The prognostic significance of AC in patients with metastases to 1-2 sentinel nodes at primary surgery is questioned. Results from the SENOMAC trial are expected to change guidelines from AC to axillary RT.
    MeSH term(s) Female ; Humans ; Axilla/pathology ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Mastectomy, Segmental ; Sentinel Lymph Node Biopsy
    Language Danish
    Publishing date 2024-03-27
    Publishing country Denmark
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    DOI 10.61409/V01230033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ASO Author Reflections: Comparison of Two-Step Methods for Targeted Axillary Dissection in Denmark.

    Munck, Frederikke / Kroman, Niels / Tvedskov, Tove

    Annals of surgical oncology

    2023  Volume 30, Issue 11, Page(s) 6370–6371

    MeSH term(s) Humans ; Female ; Lymph Node Excision ; Sentinel Lymph Node Biopsy ; Denmark ; Axilla ; Breast Neoplasms/surgery
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13804-w
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  6. Article: Radioactive seed localization of foreign body.

    Hylenius, Sine / Uldall, Wei / Qvamme, Gro / Kroman, Niels

    Acta radiologica open

    2022  Volume 11, Issue 8, Page(s) 20584601221088922

    Abstract: Radioactive seed localization is a method widely used within breast cancer treatment. This case represents a 43-year-old male patient with a foreign body in his left axilla. We used radioactive seed localization for marking the foreign body, which made ... ...

    Abstract Radioactive seed localization is a method widely used within breast cancer treatment. This case represents a 43-year-old male patient with a foreign body in his left axilla. We used radioactive seed localization for marking the foreign body, which made the subsequent surgery possible, quick, and minimal invasive.
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2818429-4
    ISSN 2058-4601
    ISSN 2058-4601
    DOI 10.1177/20584601221088922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Non-preventable cases of breast, prostate, lung, and colorectal cancer in 2050 in an elimination scenario of modifiable risk factors.

    Palshof, Frederik Knude / Mørch, Lina Steinrud / Køster, Brian / Engholm, Gerda / Storm, Hans Henrik / Andersson, Therese M-L / Kroman, Niels

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8577

    Abstract: Most Western countries have increasing number of new cancer cases per year. Cancer incidence is primarily influenced by basically avoidable risk factors and an aging population. Through hypothetical elimination scenarios of multiple major risk factors ... ...

    Abstract Most Western countries have increasing number of new cancer cases per year. Cancer incidence is primarily influenced by basically avoidable risk factors and an aging population. Through hypothetical elimination scenarios of multiple major risk factors for cancer, we estimated the number of new cancer cases that are non-preventable in 2050. We compare numbers of new postmenopausal breast, prostate, lung, and colorectal cancer cases in 2021 to projected numbers of new cases in 2050 under prevention scenarios regarding smoking, overweight and obesity, and alcohol consumption: no intervention, 50%, and 100% instant reduction. Cancer incidence data were derived from NORDCAN, and risk factor prevalence data from the Danish National Health Survey. Cancer projections were calculated with the Prevent program. Hypothetical 100% instant elimination of major risk factors for cancer in Denmark in 2022 will result in unchanged numbers of new breast and colorectal cancers in 2050. The number of new prostate cancers will increase by 25% compared to 2021. Unchanged risk factor levels will result in noticeable increase in cancer burden. Increase in life expectancy and age will entail an increase in cancer incidence, despite maximum effect of preventive actions in the population. Our results are important when planning future health care.
    MeSH term(s) Male ; Humans ; Aged ; Prostate ; Risk Factors ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/prevention & control ; Lung ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59314-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: ASO Author Reflections: The Role of Imaging Modalities in Omitting Surgery in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

    Palshof, Frederik K / Kroman, Niels / Tvedskov, Tove Filtenborg

    Annals of surgical oncology

    2021  Volume 28, Issue 12, Page(s) 7430–7431

    MeSH term(s) Breast ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy ; Neoadjuvant Therapy
    Language English
    Publishing date 2021-05-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10178-9
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  9. Article ; Online: Residual Axillary Metastases in Node-Positive Breast Cancer Patients After Neoadjuvant Treatment: A Register-Based Study.

    Munck, Frederikke / Jensen, Maj-Britt / Vejborg, Ilse / Gerlach, Maria K / Maraldo, Maja V / Kroman, Niels T / Tvedskov, Tove H F

    Annals of surgical oncology

    2024  

    Abstract: Background: Lymph node (LN) metastasis after neoadjuvant chemotherapy (NACT) generally warrants axillary lymph node dissection, which opposes guidelines of upfront surgery in many cases. We investigated the risk of having additional metastases in the ... ...

    Abstract Background: Lymph node (LN) metastasis after neoadjuvant chemotherapy (NACT) generally warrants axillary lymph node dissection, which opposes guidelines of upfront surgery in many cases. We investigated the risk of having additional metastases in the axilla when the LNs removed by targeted axillary dissection (TAD) harbored metastases after NACT. We aimed to identify subgroups suitable for de-escalated axillary treatment.
    Methods: This register-based study used data from the Danish Breast Cancer Cooperative Group database. Data were analyzed with logistic regression models. The primary outcome was the metastatic burden in non-TAD LNs in patients with positive TAD LNs after NACT.
    Results: Among 383 patients, < 66.6% positive TAD LNs (adjusted odds ratio [OR] 0.34, 95% confidence interval [CI] 0.17-0.62), only isolated tumor cells (ITCs) [OR 0.11, 95% CI < 0.01-0.82], and breast pathological complete response (pCR) [OR 0.07, 95% CI < 0.01-0.56] were associated with a low risk of having more than three positive non-TAD LNs. In 315 patients with fewer than three positive non-TAD LNs, the proportion of positive TAD LNs (OR 0.45, 95% CI 0.27-0.76 for 33.3-66.6% vs. > 66.6%), size of the TAD LN metastasis (OR 0.14, 95% CI 0.04-0.54 for ITC vs. macrometastasis), tumor size at diagnosis (OR 0.30, 95% CI 0.15-0.64 for 20-49 mm vs. ≥ 50 mm) and breast pCR (OR 0.38, 95% CI 0.15-0.96) were associated with residual LN metastases in the axilla.
    Conclusions: Breast pCR or ITC only in TAD LNs can, with reasonable certainty, preclude more than three positive non-TAD LNs. Additionally, patients with only ITCs in the TAD LN had a low risk of having any non-TAD LN metastases after NACT. De-escalated axillary treatment may be considered in both subgroups.
    Language English
    Publishing date 2024-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15354-1
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  10. Article ; Online: [Early detection and treatment of breast cancer].

    Kroman, Niels / Knop, Ann Søgaard

    Ugeskrift for laeger

    2018  Volume 180, Issue 46

    Abstract: Breast cancer is the most common cancer among Danish women. In Denmark, mammography screening has been implemented since 2010. The surgical approach has turned from mastectomy and axillary clearance to breast conserving surgery and sentinel node ... ...

    Abstract Breast cancer is the most common cancer among Danish women. In Denmark, mammography screening has been implemented since 2010. The surgical approach has turned from mastectomy and axillary clearance to breast conserving surgery and sentinel node procedure. The development of radiotherapy is heading towards shorter treatment periods and more precise targeting leading to reduced toxicity. Genomic profiling aims at giving a more personalised adjuvant medical treatment with a high predictive chance of response. Nowadays, more women are offered neoadjuvant treatment, where the systemic treatment is delivered before surgery in order to downsize the disease and reduce surgical treatment.
    MeSH term(s) Axilla ; Breast Neoplasms/diagnosis ; Breast Neoplasms/surgery ; Denmark ; Female ; Humans ; Lymph Node Excision ; Mastectomy ; Mastectomy, Segmental ; Neoplasm Staging ; Sentinel Lymph Node Biopsy
    Language Danish
    Publishing date 2018-11-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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