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  1. Book ; Online ; Thesis: Magnetic Resonance Imaging of Bone with Ultrashort Echo Time

    Kronthaler, Sophia [Verfasser] / Karampinos, Dimitrios [Akademischer Betreuer] / Menze, Björn [Gutachter] / Oei, Edwin H. G. [Gutachter] / Karampinos, Dimitrios [Gutachter]

    2023  

    Author's details Sophia Kronthaler ; Gutachter: Björn Menze, Edwin H. G. Oei, Dimitrios Karampinos ; Betreuer: Dimitrios Karampinos
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  2. Article ; Online: On quantification errors of

    Kronthaler, Sophia / Diefenbach, Maximilian N / Boehm, Christof / Zamskiy, Mark / Makowski, Marcus R / Baum, Thomas / Sollmann, Nico / Karampinos, Dimitrios C

    Magnetic resonance in medicine

    2022  Volume 88, Issue 3, Page(s) 1126–1139

    Abstract: Purpose: To study the effect of field inhomogeneity distributions in trabecularized bone regions on the gradient echo (GRE) signal with short TEs and to characterize quantification errors on : Methods: Field distortions were simulated based on a ... ...

    Abstract Purpose: To study the effect of field inhomogeneity distributions in trabecularized bone regions on the gradient echo (GRE) signal with short TEs and to characterize quantification errors on
    Methods: Field distortions were simulated based on a trabecular bone micro CT dataset. Simulations were performed for different bone volume fractions (BV/TV) and for different bone-fat composition values. A multi-TE UTE acquisition was developed to acquire multiple UTEs with random order to minimize eddy currents. The acquisition was validated in phantoms and applied in vivo in a volunteer's ankle and knee. Chemical shift encoded MRI (CSE-MRI) based on a Cartesian multi-TE GRE scan was acquired in the spine of patients with metastatic bone disease.
    Results: Simulations showed that signal deviations from the exponential signal decay at short TEs were more prominent for a higher BV/TV. UTE multi-TE measurements reproduced in vivo the simulation-based predicted behavior. In regions with high BV/TV, the presence of field inhomogeneities induced an
    Conclusion:
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Bone Marrow/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Protons ; Water
    Chemical Substances Protons ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29279
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  3. Article ; Online: Evaluation of a deep learning-based reconstruction method for denoising and image enhancement of shoulder MRI in patients with shoulder pain.

    Feuerriegel, Georg C / Weiss, Kilian / Kronthaler, Sophia / Leonhardt, Yannik / Neumann, Jan / Wurm, Markus / Lenhart, Nicolas S / Makowski, Marcus R / Schwaiger, Benedikt J / Woertler, Klaus / Karampinos, Dimitrios C / Gersing, Alexandra S

    European radiology

    2023  Volume 33, Issue 7, Page(s) 4875–4884

    Abstract: Objectives: To evaluate the diagnostic performance of an automated reconstruction algorithm combining MR imaging acquired using compressed SENSE (CS) with deep learning (DL) in order to reconstruct denoised high-quality images from undersampled MR ... ...

    Abstract Objectives: To evaluate the diagnostic performance of an automated reconstruction algorithm combining MR imaging acquired using compressed SENSE (CS) with deep learning (DL) in order to reconstruct denoised high-quality images from undersampled MR images in patients with shoulder pain.
    Methods: Prospectively, thirty-eight patients (14 women, mean age 40.0 ± 15.2 years) with shoulder pain underwent morphological MRI using a pseudo-random, density-weighted k-space scheme with an acceleration factor of 2.5 using CS only. An automated DL-based algorithm (CS DL) was used to create reconstructions of the same k-space data as used for CS reconstructions. Images were analyzed by two radiologists and assessed for pathologies, image quality, and visibility of anatomical landmarks using a 4-point Likert scale.
    Results: Overall agreement for the detection of pathologies between the CS DL reconstructions and CS images was substantial to almost perfect (κ 0.95 (95% confidence interval 0.82-1.00)). Image quality and the visibility of the rotator cuff, articular cartilage, and axillary recess were overall rated significantly higher for CS DL images compared to CS (p < 0.03). Contrast-to-noise ratios were significantly higher for cartilage/fluid (CS DL 198 ± 24.3, CS 130 ± 32.2, p = 0.02) and ligament/fluid (CS DL 184 ± 17.3, CS 141 ± 23.5, p = 0.03) and SNR values were significantly higher for ligaments and muscle of the CS DL reconstructions (p < 0.04).
    Conclusion: Evaluation of shoulder pathologies was feasible using a DL-based algorithm for MRI reconstruction and denoising. In clinical routine, CS DL may be beneficial in particular for reducing image noise and may be useful for the detection and better discrimination of discrete pathologies. Assessment of shoulder pathologies was feasible with improved image quality as well as higher SNR using a compressed sensing deep learning-based framework for image reconstructions and denoising.
    Key points: • Automated deep learning-based reconstructions showed a significant increase in signal-to-noise ratio and contrast-to-noise ratio (p < 0.04) with only a slight increase of reconstruction time of 40 s compared to CS. • All pathologies were accurately detected with no loss of diagnostic information or prolongation of the scan time. • Significant improvements of the image quality as well as the visibility of the rotator cuff, articular cartilage, and axillary recess were detected.
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Shoulder Pain/diagnostic imaging ; Shoulder/diagnostic imaging ; Deep Learning ; Magnetic Resonance Imaging/methods ; Image Enhancement/methods ; Signal-To-Noise Ratio ; Cartilage, Articular ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2023-02-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09472-9
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  4. Article ; Online: Geometric accuracy of magnetic resonance imaging-derived virtual 3-dimensional bone surface models of the mandible in comparison to computed tomography and cone beam computed tomography: A porcine cadaver study.

    Probst, Florian Andreas / Burian, Egon / Malenova, Yoana / Lyutskanova, Plamena / Stumbaum, Maria Juliane / Ritschl, Lucas Maximilian / Kronthaler, Sophia / Karampinos, Dimitrios / Probst, Monika

    Clinical implant dentistry and related research

    2021  Volume 23, Issue 5, Page(s) 779–788

    Abstract: Background: Providing accurate 3-dimensional virtual bone surface models is a prerequisite for virtual surgical planning and additive manufacturing in craniomaxillofacial surgery. For this purpose, magnetic resonance imaging (MRI) may be a radiation- ... ...

    Abstract Background: Providing accurate 3-dimensional virtual bone surface models is a prerequisite for virtual surgical planning and additive manufacturing in craniomaxillofacial surgery. For this purpose, magnetic resonance imaging (MRI) may be a radiation-free alternative to computed tomography (CT) and cone beam computed tomography (CBCT).
    Purpose: The aim of this study was to assess the geometric accuracy of 3-dimensional T1-weighted MRI-derived virtual bone surface models of the mandible in comparison to CT and CBCT.
    Materials and methods: Specimens of the mandible from porcine cadavers were scanned with (1) a 3-dimensional T1-weighted MRI sequence (0.6 mm isotropic voxel) optimized for bone imaging, (2) CT, and (3) CBCT. Cortical mandibular structures (n = 10) were segmented using semiautomated and manual techniques. Imaging-based virtual 3-dimensional models were aligned with a high-resolution optical 3-dimensional surface scan of the dissected bone (=ground truth) and global geometric deviations were calculated (mean surface distance [MSD]/root-mean-square distance [RMSD]). Agreement between the imaging modalities was assessed by equivalence testing and Bland-Altman analysis.
    Results: Intra- and inter-rater agreement was on a high level for all modalities. Global geometric deviations (MSD/RMSD) between optical scans and imaging modalities were 0.225 ± 0.020 mm/0.345 ± 0.074 mm for CT, 0.280 ± 0.067 mm/0.371 ± 0.074 mm for MRI, and 0.352 ± 0.076 mm/0.454 ± 0.071 mm for CBCT. All imaging modalities were statistically equivalent within an equivalence margin of ±0.3 mm, and Bland-Altman analysis indicated high agreement as well.
    Conclusions: The results of this study indicate that the accuracy and reliability of MRI-derived virtual 3-dimensional bone surface models is equal to CT and CBCT. MRI may be considered as a reliable alternative to CT and CBCT in computer-assisted craniomaxillofacial surgery.
    MeSH term(s) Animals ; Cadaver ; Cone-Beam Computed Tomography ; Magnetic Resonance Imaging ; Mandible/diagnostic imaging ; Reproducibility of Results ; Swine
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2094300-3
    ISSN 1708-8208 ; 1523-0899
    ISSN (online) 1708-8208
    ISSN 1523-0899
    DOI 10.1111/cid.13033
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  5. Article ; Online: Assessment of glenoid bone loss and other osseous shoulder pathologies comparing MR-based CT-like images with conventional CT.

    Feuerriegel, Georg C / Kronthaler, Sophia / Weiss, Kilian / Haller, Bernhard / Leonhardt, Yannik / Neumann, Jan / Pfeiffer, Daniela / Hesse, Nina / Erber, Bernd / Schwaiger, Benedikt J / Makowski, Marcus R / Woertler, Klaus / Karampinos, Dimitrios C / Wurm, Markus / Gersing, Alexandra S

    European radiology

    2023  Volume 33, Issue 12, Page(s) 8617–8626

    Abstract: Objectives: To evaluate and compare the diagnostic performance of CT-like images based on a 3D T1-weighted spoiled gradient-echo sequence (T1 GRE), an ultra-short echo time sequence (UTE), and a 3D T1-weighted spoiled multi-echo gradient-echo sequence ( ... ...

    Abstract Objectives: To evaluate and compare the diagnostic performance of CT-like images based on a 3D T1-weighted spoiled gradient-echo sequence (T1 GRE), an ultra-short echo time sequence (UTE), and a 3D T1-weighted spoiled multi-echo gradient-echo sequence (FRACTURE) with conventional CT in patients with suspected osseous shoulder pathologies.
    Materials and methods: Patients with suspected traumatic dislocation of the shoulder (n = 46, mean age 40 ± 14.5 years, 19 women) were prospectively recruited and received 3-T MR imaging including 3D T1 GRE, UTE, and 3D FRACTURE sequences. CT was performed in patients with acute fractures and served as standard of reference (n = 25). Agreement of morphological features between the modalities was analyzed including the glenoid bone loss, Hill-Sachs interval, glenoid track, and the anterior straight-line length. Agreement between the modalities was assessed using Bland-Altman plots, Student's t-test, and Pearson's correlation coefficient. Inter- and intrareader assessment was evaluated with weighted Cohen's κ and intraclass correlation coefficient.
    Results: All osseous pathologies were detected accurately on all three CT-like sequences (n = 25, κ = 1.00). No significant difference in the percentage of glenoid bone loss was found between CT (mean ± standard deviation, 20.3% ± 8.0) and CT-like MR images (FRACTURE 20.6% ± 7.9, T1 GRE 20.4% ± 7.6, UTE 20.3% ± 7.7, p > 0.05). When comparing the different measurements on CT-like images, measurements performed using the UTE images correlated best with CT.
    Conclusion: Assessment of bony Bankart lesions and other osseous pathologies was feasible and accurate using CT-like images based on 3-T MRI compared with conventional CT. Compared to the T1 GRE and FRACTURE sequence, the UTE measurements correlated best with CT.
    Clinical relevance statement: In an acute trauma setting, CT-like images based on a T1 GRE, UTE, or FRACTURE sequence might be a useful alternative to conventional CT scan sparing associated costs as well as radiation exposure.
    Key points: • No significant differences were found for the assessment of the glenoid bone loss when comparing measurements of CT-like MR images with measurements of conventional CT images. • Compared to the T1 GRE and FRACTURE sequence, the UTE measurements correlated best with CT whereas the FRACTURE sequence appeared to be the most robust regarding motion artifacts. • The T1 GRE sequence had the highest resolution with high bone contrast and detailed delineation of even small fractures but was more susceptible to motion artifacts.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Shoulder ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging/methods ; Shoulder Joint/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Bone Diseases, Metabolic ; Imaging, Three-Dimensional/methods
    Language English
    Publishing date 2023-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09939-9
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  6. Article ; Online: Comparing CT-Like Images Based on Ultra-Short Echo Time and Gradient Echo T1-Weighted MRI Sequences for the Assessment of Vertebral Disorders Using Histology and True CT as the Reference Standard.

    Gassert, Florian T / Kufner, Alexander / Renz, Martin / Gassert, Felix G / Bollwein, Christine / Kronthaler, Sophia / Feuerriegel, Georg C / Kirschke, Jan S / Ganter, Carl / Makowski, Marcus R / Braun, Christian / Schwaiger, Benedikt J / Woertler, Klaus / Karampinos, Dimitrios C / Gersing, Alexandra S

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 59, Issue 5, Page(s) 1542–1552

    Abstract: Background: Several magnetic resonance (MR) techniques have been suggested for radiation-free imaging of osseous structures.: Purpose: To compare the diagnostic value of ultra-short echo time and gradient echo T1-weighted MRI for the assessment of ... ...

    Abstract Background: Several magnetic resonance (MR) techniques have been suggested for radiation-free imaging of osseous structures.
    Purpose: To compare the diagnostic value of ultra-short echo time and gradient echo T1-weighted MRI for the assessment of vertebral pathologies using histology and computed tomography (CT) as the reference standard.
    Study type: Prospective.
    Subjects: Fifty-nine lumbar vertebral bodies harvested from 20 human cadavers (donor age 73 ± 13 years; 9 male).
    Field strength/sequence: Ultra-short echo time sequence optimized for both bone (UTEb) and cartilage (UTEc) imaging and 3D T1-weighted gradient-echo sequence (T1GRE) at 3 T; susceptibility-weighted imaging (SWI) gradient echo sequence at 1.5 T. CT was performed on a dual-layer dual-energy CT scanner using a routine clinical protocol.
    Assessment: Histopathology and conventional CT were acquired as standard of reference. Semi-quantitative and quantitative morphological features of degenerative changes of the spines were evaluated by four radiologists independently on CT and MR images independently and blinded to all other information. Features assessed were osteophytes, endplate sclerosis, visualization of cartilaginous endplate, facet joint degeneration, presence of Schmorl's nodes, and vertebral dimensions. Vertebral disorders were assessed by a pathologist on histology.
    Statistical tests: Agreement between T1GRE, SWI, UTEc, and UTEb sequences and CT imaging and histology as standard of reference were assessed using Fleiss' κ and intra-class correlation coefficients, respectively.
    Results: For the morphological assessment of osteophytes and endplate sclerosis, the overall agreement between SWI, T1GRE, UTEb, and UTEc with the reference standard (histology combined with CT) was moderate to almost perfect for all readers (osteophytes: SWI, κ range: 0.68-0.76; T1GRE: 0.92-1.00; UTEb: 0.92-1.00; UTEc: 0.77-0.85; sclerosis: SWI, κ range: 0.60-0.70; T1GRE: 0.77-0.82; UTEb: 0.81-0.92; UTEc: 0.61-0.71). For the visualization of the cartilaginous endplate, UTEc showed the overall best agreement with the reference standard (histology) for all readers (κ range: 0.85-0.93).
    Data conclusions: Morphological assessment of vertebral pathologies was feasible and accurate using the MR-based bone imaging sequences compared to CT and histopathology. T1GRE showed the overall best performance for osseous changes and UTEc for the visualization of the cartilaginous endplate.
    Level of evidence: 1 TECHNICAL EFFICACY: Stage 2.
    MeSH term(s) Humans ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Osteophyte ; Prospective Studies ; Sclerosis ; Magnetic Resonance Imaging/methods ; Tomography, X-Ray Computed/methods ; Lumbar Vertebrae/diagnostic imaging ; Reference Standards
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28927
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  7. Article ; Online: Evaluation of MR-derived simulated CT-like images and simulated radiographs compared to conventional radiography in patients with shoulder pain: a proof-of-concept study.

    Feuerriegel, Georg C / Kopp, Felix K / Pfeiffer, Daniela / Pogorzelski, Jonas / Wurm, Markus / Leonhardt, Yannik / Boehm, Christof / Kronthaler, Sophia / Karampinos, Dimitrios C / Neumann, Jan / Schwaiger, Benedikt J / Makowski, Marcus R / Woertler, Klaus / Gersing, Alexandra S

    BMC musculoskeletal disorders

    2022  Volume 23, Issue 1, Page(s) 122

    Abstract: Background: To evaluate the diagnostic value of MR-derived CT-like images and simulated radiographs compared with conventional radiographs in patients with suspected shoulder pathology.: Methods: 3 T MRI of the shoulder including a 3D T1-weighted ... ...

    Abstract Background: To evaluate the diagnostic value of MR-derived CT-like images and simulated radiographs compared with conventional radiographs in patients with suspected shoulder pathology.
    Methods: 3 T MRI of the shoulder including a 3D T1-weighted gradient echo sequence was performed in 25 patients (mean age 52.4 ± 18 years, 13 women) with suspected shoulder pathology. Subsequently a cone-beam forward projection algorithm was used to obtain intensity-inverted CT-like images and simulated radiographs. Two radiologists evaluated the simulated images separately and independently using the conventional radiographs as the standard of reference, including measurements of the image quality, acromiohumeral distance, critical shoulder angle, degenerative joint changes and the acromial type. Additionally, the CT-like MR images were evaluated for glenoid defects, subcortical cysts and calcifications. Agreement between the MR-derived simulated radiographs and conventional radiographs was calculated using Cohen's Kappa.
    Results: Measurements on simulated radiographs and conventional radiographs overall showed a substantial to almost perfect inter- and intra-rater agreement (κ = 0.69-1.00 and κ = 0.65-0.85, respectively). Image quality of the simulated radiographs was rated good to excellent (1.6 ± 0.7 and 1.8 ± 0.6, respectively) by the radiologists. A substantial agreement was found regarding diagnostically relevant features, assessed on Y- and anteroposterior projections (κ = 0.84 and κ = 0.69 for the measurement of the CSA; κ = 0.95 and κ = 0.60 for the measurement of the AHD; κ = 0.77 and κ = 0.77 for grading of the Samilson-Prieto classification; κ = 0.83 and κ = 0.67 for the grading of the Bigliani classification, respectively).
    Conclusion: In this proof-of-concept study, clinically relevant features of the shoulder joint were assessed reliably using MR-derived CT-like images and simulated radiographs with an image quality equivalent to conventional radiographs. MR-derived CT-like images and simulated radiographs may provide useful diagnostic information while reducing the amount of radiation exposure.
    MeSH term(s) Acromion ; Adult ; Aged ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Radiography ; Reproducibility of Results ; Shoulder Pain/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-022-05076-4
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  8. Article ; Online: Diagnostic value of water-fat-separated images and CT-like susceptibility-weighted images extracted from a single ultrashort echo time sequence for the evaluation of vertebral fractures and degenerative changes of the spine.

    Feuerriegel, Georg C / Kronthaler, Sophia / Boehm, Christof / Renz, Martin / Leonhardt, Yannik / Gassert, Florian / Foreman, Sarah C / Weiss, Kilian / Wurm, Markus / Liebig, Thomas / Makowski, Marcus R / Schwaiger, Benedikt J / Karampinos, Dimitrios C / Gersing, Alexandra S

    European radiology

    2022  Volume 33, Issue 2, Page(s) 1445–1455

    Abstract: Objectives: To evaluate the performance of single-echo Dixon water-fat imaging and computed tomography (CT)-like imaging based on a single ultrashort echo time (sUTE) MR sequence for imaging of vertebral fractures as well as degenerative bone changes of ...

    Abstract Objectives: To evaluate the performance of single-echo Dixon water-fat imaging and computed tomography (CT)-like imaging based on a single ultrashort echo time (sUTE) MR sequence for imaging of vertebral fractures as well as degenerative bone changes of the spine in comparison to conventional CT and MR sequences.
    Methods: Thirty patients with suspected acute vertebral fractures were examined using a 3-T MRI, including an sUTE sequence as well as short-tau inversion recovery (STIR) and T1-weighted sequences. During postprocessing, water-fat separation was performed by solving the smoothness-constrained inverse water-fat problem based on a single-complex UTE image. By removing the unwanted low-frequency phase terms, additional MR-based susceptibility-weighted-like (SW-like) images with CT-like contrast were created. Two radiologists evaluated semi-quantitative and quantitative features of fractures and degenerative changes independently and separately on CT and MR images.
    Results: In total, all 58 fractures were accurately detected of whom 24 were correctly classified as acute fractures with an edema detected on the water-fat-separated UTE images, using STIR and T1w sequences as standard of reference. For the morphological assessment of fractures and degenerative changes, the overall agreement between SW-like images and CT was substantial to excellent (e.g., Genant: κ 0.90 (95% confidence interval 0.54-1.00); AO/Magerl: κ 0.75 (95% confidence interval 0.43-1.00)). Overall inter-reader agreement for water-fat-separated UTE images and SW-like images was substantial to almost perfect.
    Conclusion: Detection and assessment of vertebral fractures and degenerative bone changes of the spine were feasible and accurate using water-fat-separated images as well as SW-like images, both derived from the same sUTE-Dixon sequence.
    Key points: • The detection of acute vertebral fractures was feasible using water-fat-separated images and CT-like images reconstructed from one sUTE sequence. • Assessment of the vertebral fractures using SW-like images with CT-like contrast was found to be comparable to conventional CT. • sUTE imaging of the spine can help reduce examination times and radiation exposure.
    MeSH term(s) Humans ; Water ; Spine ; Spinal Fractures/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Fractures, Bone ; Magnetic Resonance Imaging/methods
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-09061-2
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  9. Article ; Online: CT-like MR-derived Images for the Assessment of Craniosynostosis and other Pathologies of the Pediatric Skull.

    Leonhardt, Yannik / Kronthaler, Sophia / Feuerriegel, Georg / Karampinos, Dimitrios C / Schwaiger, Benedikt J / Pfeiffer, Daniela / Makowski, Marcus R / Koerte, Inga K / Liebig, Thomas / Woertler, Klaus / Steinborn, Marc-Matthias / Gersing, Alexandra S

    Clinical neuroradiology

    2022  Volume 33, Issue 1, Page(s) 57–64

    Abstract: Purpose: To evaluate the diagnostic value of CT-like images based on a 3D T1-weighted spoiled gradient echo-based sequence (T1SGRE) for the visualization of the pediatric skull and the identification of pathologies, such as craniosynostosis or fractures. ...

    Abstract Purpose: To evaluate the diagnostic value of CT-like images based on a 3D T1-weighted spoiled gradient echo-based sequence (T1SGRE) for the visualization of the pediatric skull and the identification of pathologies, such as craniosynostosis or fractures.
    Methods: In this prospective study, 20 patients with suspected craniosynostosis (mean age 1.26 ± 1.38 years, 10 females) underwent MR imaging including the T1SGRE sequence and 2 more patients were included who presented with skull fractures (0.5 and 6.3 years, both male). Additionally, the skull of all patients was assessed using radiography or CT in combination with ultrasound. Two radiologists, blinded to the clinical information, evaluated the CT-like images. The results were compared to the diagnosis derived from the other imaging modalities and intraoperative findings. Intrarater and interrater agreement was calculated using Cohen's κ.
    Results: Of the 22 patients 8 had a metopic, 4 a coronal and 2 a sagittal craniosynostosis and 2 patients showed a complex combination of craniosynostoses. The agreement between the diagnosis based on the T1SGRE and the final diagnosis was substantial (Cohen's κ = 0.92, 95% confidence interval (CI) 0.77-1.00 for radiologist 1 and κ = 0.76, CI 0.51-1.00 for radiologist 2). Of the patients with fractures, one presented with a ping pong fracture and one with a fracture of the temporal bone. Both radiologists could identify the fractures using the T1SGRE.
    Conclusion: The visualization of the pediatric skull and the assessment of sutures using a CT-like T1SGRE MR-sequence is feasible and comparable to other imaging modalities, and thus may help to reduce radiation exposure in pediatric patients. The technique may also be a promising imaging tool for other pathologies, such as fractures.
    MeSH term(s) Female ; Humans ; Child ; Male ; Infant ; Child, Preschool ; Prospective Studies ; Tomography, X-Ray Computed/methods ; Craniosynostoses/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Temporal Bone
    Language English
    Publishing date 2022-06-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-022-01182-x
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  10. Article ; Online: Trajectory correction based on the gradient impulse response function improves high-resolution UTE imaging of the musculoskeletal system.

    Kronthaler, Sophia / Rahmer, Jürgen / Börnert, Peter / Makowski, Marcus R / Schwaiger, Benedikt J / Gersing, Alexandra S / Karampinos, Dimitrios C

    Magnetic resonance in medicine

    2020  Volume 85, Issue 4, Page(s) 2001–2015

    Abstract: Purpose: UTE sequences typically acquire data during the ramping up of the gradient fields, which makes UTE imaging prone to eddy current and system delay effects. The purpose of this work was to use a simple gradient impulse response function (GIRF) ... ...

    Abstract Purpose: UTE sequences typically acquire data during the ramping up of the gradient fields, which makes UTE imaging prone to eddy current and system delay effects. The purpose of this work was to use a simple gradient impulse response function (GIRF) measurement to estimate the real readout gradient waveform and to demonstrate that precise knowledge of the gradient waveform is important in the context of high-resolution UTE musculoskeletal imaging.
    Methods: The GIRF was measured using the standard hardware of a 3 Tesla scanner and applied on 3D radial UTE data (TE: 0.14 ms). Experiments were performed on a phantom, in vivo on a healthy knee, and in vivo on patients with spine fractures. UTE images were reconstructed twice, first using the GIRF-corrected gradient waveforms and second using nominal-corrected waveforms, correcting for the low-pass filter characteristic of the gradient chain.
    Results: Images reconstructed with the nominal-corrected gradient waveforms exhibited blurring and showed edge artifacts. The blurring and the edge artifacts were reduced when the GIRF-corrected gradient waveforms were used, as shown in single-UTE phantom scans and in vivo dual-UTE gradient-echo scans in the knee. Further, the importance of the GIRF-based correction was indicated in UTE images of the lumbar spine, where thin bone structures disappeared when the nominal correction was employed.
    Conclusion: The presented GIRF-based trajectory correction method using standard scanner hardware can improve the quality of high-resolution UTE musculoskeletal imaging.
    MeSH term(s) Artifacts ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Musculoskeletal System ; Phantoms, Imaging
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28566
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